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Conserved domains on  [gi|530417401|ref|XP_005259385|]
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zinc finger protein 527 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-458 7.53e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 296 KPYECKECNKAFRQSAHLAQHQR--IHTGE--KPFACNE--CGKAFSRYAFLVEHQRIHTGEKPYECK--ECNKAFRQSA 367
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 368 HLNQHQRIH-----TGEKPYEC--NQCGKAFSRRIALTLHQRIHTGEKP--FKCSECGKTFGYRSHLNQHQRIHTGEKPY 438
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 530417401 439 ECIKCGKFFRTDSqLNRHHR 458
Cdd:COG5048  448 LCSILKSFRRDLD-LSNHGK 466
KRAB super family cl42959
krueppel associated box;
21-42 3.11e-05

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 41.81  E-value: 3.11e-05
                           10        20
                   ....*....|....*....|..
gi 530417401    21 LGLSISKPNMISLLEQGKEPWM 42
Cdd:smart00349  40 LGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-531 1.58e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....
gi 530417401  508 YLNQHQRIHTGEKPYECSECGKAF 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-476 7.37e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.37e-04
                          10        20
                  ....*....|....*....|....
gi 530417401  453 LNRHHRIHTGERPFECSKCGKAFS 476
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-505 9.11e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.11e-03
                          10        20
                  ....*....|....*....|..
gi 530417401  484 HKRSHAGEKPYECNKCGKAFSC 505
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-458 7.53e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 296 KPYECKECNKAFRQSAHLAQHQR--IHTGE--KPFACNE--CGKAFSRYAFLVEHQRIHTGEKPYECK--ECNKAFRQSA 367
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 368 HLNQHQRIH-----TGEKPYEC--NQCGKAFSRRIALTLHQRIHTGEKP--FKCSECGKTFGYRSHLNQHQRIHTGEKPY 438
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 530417401 439 ECIKCGKFFRTDSqLNRHHR 458
Cdd:COG5048  448 LCSILKSFRRDLD-LSNHGK 466
KRAB smart00349
krueppel associated box;
21-42 3.11e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 41.81  E-value: 3.11e-05
                           10        20
                   ....*....|....*....|..
gi 530417401    21 LGLSISKPNMISLLEQGKEPWM 42
Cdd:smart00349  40 LGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 4.82e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.82e-05
                          10        20
                  ....*....|....*....|....*.
gi 530417401  368 HLNQHQRIHTGEKPYECNQCGKAFSR 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-531 1.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....
gi 530417401  508 YLNQHQRIHTGEKPYECSECGKAF 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-476 7.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.37e-04
                          10        20
                  ....*....|....*....|....
gi 530417401  453 LNRHHRIHTGERPFECSKCGKAFS 476
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-505 9.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.11e-03
                          10        20
                  ....*....|....*....|..
gi 530417401  484 HKRSHAGEKPYECNKCGKAFSC 505
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-458 7.53e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 296 KPYECKECNKAFRQSAHLAQHQR--IHTGE--KPFACNE--CGKAFSRYAFLVEHQRIHTGEKPYECK--ECNKAFRQSA 367
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 368 HLNQHQRIH-----TGEKPYEC--NQCGKAFSRRIALTLHQRIHTGEKP--FKCSECGKTFGYRSHLNQHQRIHTGEKPY 438
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 530417401 439 ECIKCGKFFRTDSqLNRHHR 458
Cdd:COG5048  448 LCSILKSFRRDLD-LSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-577 2.13e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 296 KPYECKECNKAFRQSAHLAQHQRIHTGEKPFACN--ECGKAFSRYAFLVEHQRIHTGEKP-------------------- 353
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 354 -------YECKECNKAFRQSAHLNQHQRIHTGEKPYEC------------------------NQCGKAFSRRIALTLHQR 402
Cdd:COG5048  112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 403 IHTGEKPFKCSECGKTFGYRSHLNQHQRIHTGEKPYECIKCGKFFRTDSQLNRHHRIHTGERPFECSKCGKAF--SDALV 480
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 481 LIHHKRSHAGE-----KPYECNKCGKAFSCGSYLNQHQR--IHTGE--KPYECSE--CGKAFHQILSLRLHQRIHAGEKP 549
Cdd:COG5048  272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350
                 ....*....|....*....|....*....|
gi 530417401 550 YKCNECGNNFSCVSAL--RRHQRIHNRETL 577
Cdd:COG5048  352 AKEKLLNSSSKFSPLLnnEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-508 2.85e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 247 CGDAFSCYSFFTQPQRIHSGEKPYACNDCGKAFSHDFFLSEHQRTHIgEKPYECKECNKAFRQSAHLAQHQRIHTGEKPF 326
Cdd:COG5048  177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 327 ACNECGKAFSRYAFLVEHQRIHTGE-------KPYECKECNKAFRQSAHLNQHQR--IHTGE--KPYEC--NQCGKAFSR 393
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 394 RIALTLHQRIHTGEKPFKC--SECGKTFG------YRSHLNQHQRIHTgEKPYECI--KCGKFFRTDSQLNRHHRIHTGE 463
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSF 414

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530417401 464 RP--FECSKCGKAFSDALVLIHHKRSHAGEKPYECNKCGKAFSCGSY 508
Cdd:COG5048  415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-487 3.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 169 PQNSVIIEYKRLHAEKESLIGNECEEFNQSTYLSKDIGIPPGEKPYESHDFSKLLSFHSLFTQHQTTHFGKLPHGYDEcg 248
Cdd:COG5048  133 RDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYS-- 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 249 dafscYSFFTQPQRIHSGEKPYACNDCGKAFSHDFFLSEHQRTHIGEKPYECKECNKAFRQSAHLAQHQRIHTGE----- 323
Cdd:COG5048  211 -----IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekg 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 324 --KPFACNECGKAFSRYAFLVEHQR--IHTGE--KPYECKE--CNKAFRQSAHLNQHQRIHTGEKPYEC--NQCGKAFS- 392
Cdd:COG5048  286 fsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSp 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 393 ----RRIALTLHQRIHTGEKPFKCSE------CGKTFGYRSHLNQH--QRIHtgekPYECIKCGKFFRTDSQLNRHHRIH 460
Cdd:COG5048  366 llnnEPPQSLQQYKDLKNDKKSETLSnscirnFKRDSNLSLHIITHlsFRPY----NCKNPPCSKSFNRHYNLIPHKKIH 441

                        330       340
                 ....*....|....*....|....*..
gi 530417401 461 TGERPFECSKCGKaFSDALVLIHHKRS 487
Cdd:COG5048  442 TNHAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-563 2.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 195 FNQSTYLSKDIGIPPGEKPYESHDFSKLLSF---HSLFTQHQTTHFGKLphgYDECGDAFSCYSFFTQPQRIHSGE---K 268
Cdd:COG5048   43 FSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrpLELSRHLRTHHNNPS---DLNSKSLPLSNSKASSSSLSSSSSnsnD 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 269 PYACNDCGKAFSHDFFL--SEHQRTHIGEKPYE-CKECNKAFRQSAHLAQ-------------------HQRIHTGEKPF 326
Cdd:COG5048  120 NNLLSSHSLPPSSRDPQlpDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSNVSTSIPSS 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 327 ACNECGKAFSRYAFLVEHQRIHTGEKPYECKECNKAFRQSA------HLNQHQRIHTGEKPYECNQCGKAFSRRIALTLH 400
Cdd:COG5048  200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 401 QRIHTG-EKPFKCSECGKTFGYRSHLNQHQR--IHTGE--KPYEC--IKCGKFFRTDSQLNRHHRIHTGERPFEC--SKC 471
Cdd:COG5048  280 SSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNS 359

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530417401 472 GKAFSDALV-----LIHHKRSHAGEKPYEC--NKCGKAFSCGSYLNQHQRIHTGEKPYEC--SECGKAFHQILSLRLHQR 542
Cdd:COG5048  360 SSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKK 439

                        410       420
                 ....*....|....*....|.
gi 530417401 543 IHAGEKPYKCNECGNNFSCVS 563
Cdd:COG5048  440 IHTNHAPLLCSILKSFRRDLD 460
KRAB smart00349
krueppel associated box;
21-42 3.11e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 41.81  E-value: 3.11e-05
                           10        20
                   ....*....|....*....|..
gi 530417401    21 LGLSISKPNMISLLEQGKEPWM 42
Cdd:smart00349  40 LGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 4.82e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.82e-05
                          10        20
                  ....*....|....*....|....*.
gi 530417401  368 HLNQHQRIHTGEKPYECNQCGKAFSR 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 1.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 530417401  312 HLAQHQRIHTGEKPFACNECGKAFSR 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-531 1.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....
gi 530417401  508 YLNQHQRIHTGEKPYECSECGKAF 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 2.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 530417401  424 HLNQHQRIHTGEKPYECIKCGKFFRT 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-476 7.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.37e-04
                          10        20
                  ....*....|....*....|....
gi 530417401  453 LNRHHRIHTGERPFECSKCGKAFS 476
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-365 7.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.74e-04
                          10        20
                  ....*....|....*....|....*
gi 530417401  341 LVEHQRIHTGEKPYECKECNKAFRQ 365
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 9.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.52e-04
                          10        20
                  ....*....|....*....|....
gi 530417401  396 ALTLHQRIHTGEKPFKCSECGKTF 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-309 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*
gi 530417401  285 LSEHQRTHIGEKPYECKECNKAFRQ 309
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 410-432 4.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|...
gi 530417401  410 FKCSECGKTFGYRSHLNQHQRIH 432
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 354-376 5.33e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.33e-03
                          10        20
                  ....*....|....*....|...
gi 530417401  354 YECKECNKAFRQSAHLNQHQRIH 376
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-505 9.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.11e-03
                          10        20
                  ....*....|....*....|..
gi 530417401  484 HKRSHAGEKPYECNKCGKAFSC 505
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 298-320 9.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.52e-03
                          10        20
                  ....*....|....*....|...
gi 530417401  298 YECKECNKAFRQSAHLAQHQRIH 320
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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