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Conserved domains on  [gi|530415325|ref|XP_005260194|]
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DNA-binding protein RFXANK isoform X6 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
93-248 2.24e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.85  E-value: 2.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 172
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530415325 173 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 248
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
93-248 2.24e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.85  E-value: 2.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 172
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530415325 173 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 248
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
127-217 2.61e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 2.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  127 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 206
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 530415325  207 ALLARGADLTT 217
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 116-231 5.55e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 5.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 116 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 175
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530415325 176 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 231
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 188-216 5.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 530415325   188 NGGTPLLYAVRGNHVKCVEALLARGADLT 216
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 125-217 3.03e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 125 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 196
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96

                         90       100
                 ....*....|....*....|.
gi 530415325 197 VRGNHVKCVEALLARGADLTT 217
Cdd:cd22192   97 VVNQNLNLVRELIARGADVVS 117
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
93-248 2.24e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.85  E-value: 2.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 172
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530415325 173 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 248
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-237 9.68e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 9.68e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  89 DSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGY 168
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530415325 169 TDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 237
Cdd:COG0666  133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
93-253 3.12e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.89  E-value: 3.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 172
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 173 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSN 252
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                 .
gi 530415325 253 L 253
Cdd:COG0666  283 L 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
88-237 1.51e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 1.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  88 LDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGG 167
Cdd:COG0666   19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 168 YTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 237
Cdd:COG0666   99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168
Ank_2 pfam12796
Ankyrin repeats (3 copies);
127-217 2.61e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 2.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  127 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 206
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 530415325  207 ALLARGADLTT 217
Cdd:pfam12796  79 LLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
93-226 5.08e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.24  E-value: 5.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 172
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530415325 173 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPM 226
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 116-231 5.55e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 5.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 116 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 175
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530415325 176 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 231
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
Ank_2 pfam12796
Ankyrin repeats (3 copies);
160-245 1.74e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 1.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  160 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAdlTTEADSGYTPMDLAVALGYRK-VQ 238
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEiVK 78


                  ....*..
gi 530415325  239 QVIENHI 245
Cdd:pfam12796  79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
93-186 5.98e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 5.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325   93 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEwgadpHILAKER---ESALSLASTGGYT 169
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLE-----HADVNLKdngRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 530415325  170 DIVGLLLERDVDINIYD 186
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 116-243 8.91e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.30  E-value: 8.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 116 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 195
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530415325 196 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 243
Cdd:PHA02874 197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINN 244
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
103-237 1.76e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.05  E-value: 1.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 103 DQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 182
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530415325 183 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 237
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 135-252 6.37e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 6.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 135 EIETVRFLLEWGADPHILAKERESALSLASTGGYT-----DIVGLLLERDVDINIYDWNGGTPLLYAV--RGNHVKCVEA 207
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEY 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530415325 208 LLARGADLTTEADSGYTPmdLAVALGYRKvqqvIENHILKLFQSN 252
Cdd:PHA03100 127 LLDNGANVNIKNSDGENL--LHLYLESNK----IDLKILKLLIDK 165
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 93-214 1.35e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.78  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 172
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530415325 173 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 214
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 59-250 4.29e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.53  E-value: 4.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  59 SSPQGSSLKHSTTLTNRQRGNEVSAlPATLDSLSIHQLAA-QGELDQLKEHLRK---GDNLVNKPDergftpliWASAFG 134
Cdd:PTZ00322   1 MSFLVCSVASSAFAAQLFFGTEGSR-KRRAKPISFERMAAiQEEIARIDTHLEAleaTENKDATPD--------HNLTTE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 135 EIetvrfllewgADP---HILAKEresALSLASTGgytDIVG--LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 209
Cdd:PTZ00322  72 EV----------IDPvvaHMLTVE---LCQLAASG---DAVGarILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLL 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 530415325 210 ARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQ 250
Cdd:PTZ00322 136 EFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 135-243 2.77e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.90  E-value: 2.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 135 EIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 214
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         90       100       110
                 ....*....|....*....|....*....|
gi 530415325 215 LTTEADSGYTPMDLAVALG-YRKVQQVIEN 243
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGdYACIKLLIDH 212
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 116-184 2.49e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 2.49e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530415325 116 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 184
Cdd:PHA03100 185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA03095 PHA03095
ankyrin-like protein; Provisional
 109-231 3.14e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 3.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 109 LRKGDNlVNKPDERGFTPL--IWASAFGEIETVRFLLEWGADP-----------HILA---KERES-------------- 158
Cdd:PHA03095 139 LRKGAD-VNALDLYGMTPLavLLKSRNANVELLRLLIDAGADVyavddrfrsllHHHLqsfKPRARivreliragcdpaa 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 159 -------ALSLASTGGYTD--IVGLLLERDVDINIYDWNGGTPLLYA-VRGNHVKCVEaLLARGADLTTEADSGYTPMDL 228
Cdd:PHA03095 218 tdmlgntPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAaVFNNPRACRR-LIALGADINAVSSDGNTPLSL 296


                 ...
gi 530415325 229 AVA 231
Cdd:PHA03095 297 MVR 299
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 135-248 3.62e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 3.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 135 EIETVRFLLEWGADPHILAKER-ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 213
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 530415325 214 DLTTEADSGYTPMDLAVAlgyrkvqQVIENHILKL 248
Cdd:PHA02878 226 STDARDKCGNTPLHISVG-------YCKDYDILKL 253
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 100-244 4.05e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 4.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 100 GELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 179
Cdd:PHA02875  13 GELDIARRLLDIGIN-PNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLG 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530415325 180 VDIN--IYDwNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 244
Cdd:PHA02875  92 KFADdvFYK-DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157
Ank_5 pfam13857
Ankyrin repeats (many copies);
174-229 7.25e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.11  E-value: 7.25e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530415325  174 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 229
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 93-247 1.11e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNLvNKPDERGFTPLIWASAFGEIETVRFLLEWGAdpHILAKERESALSLASTGGYTDIV 172
Cdd:PHA02874 161 IHIAIKHNFFDIIKLLLEKGAYA-NVKDNNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNRSA 237

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530415325 173 GLLLERDVDINIYDWNGGTPLLYAVRGN-HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK--VQQVIENHILK 247
Cdd:PHA02874 238 IELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDpvIKDIIANAVLI 315
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 77-254 1.15e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.37  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  77 RGNEVSALpatlDSLSIHQLAAQGELDQLKEH----LRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 152
Cdd:PHA02876 330 LGADVNAA----DRLYITPLHQASTLDRNKDIvitlLELGAN-VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEAL 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 153 AKERESAL--SLASTGGYTDiVGLLLERDVDINIYDWNGGTPLLYAVRGN-HVKCVEALLARGADLTTEADSGYTPmdLA 229
Cdd:PHA02876 405 SQKIGTALhfALCGTNPYMS-VKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYP--LL 481

                        170       180
                 ....*....|....*....|....*
gi 530415325 230 VALGYRKVQQVIENHILKLFQSNLV 254
Cdd:PHA02876 482 IALEYHGIVNILLHYGAELRDSRVL 506
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 92-234 1.31e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  92 SIHQLAAQGELdQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI 171
Cdd:PHA02876 148 LIKERIQQDEL-LIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 172 VGLLLERDVDINIYD------------------WNGG-----------TPLLYAVRGNHV-KCVEALLARGADLTTEADS 221
Cdd:PHA02876 227 IKAIIDNRSNINKNDlsllkairnedletslllYDAGfsvnsiddcknTPLHHASQAPSLsRLVPKLLERGADVNAKNIK 306

                        170
                 ....*....|...
gi 530415325 222 GYTPMDLAVALGY 234
Cdd:PHA02876 307 GETPLYLMAKNGY 319
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 100-230 2.21e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 100 GELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL---- 175
Cdd:PHA02874  12 GDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLidng 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530415325 176 -------------------LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAV 230
Cdd:PHA02874  92 vdtsilpipciekdmiktiLDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI 165
Ank_4 pfam13637
Ankyrin repeats (many copies);
156-209 4.42e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 4.42e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530415325  156 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 209
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 116-230 6.38e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 6.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 116 VNKPDE-RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLL 194
Cdd:PHA02878 160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530415325 195 YAV-RGNHVKCVEALLARGADLTTEAD-SGYTPMDLAV 230
Cdd:PHA02878 240 ISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI 277
PHA03095 PHA03095
ankyrin-like protein; Provisional
 102-227 8.44e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.64  E-value: 8.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 102 LDQLKEHLRKGDNlVNKPDERGFTPL-IWASAFGE--IETVRFLLEWGADphILAKER--ESALSLASTGGYT-DIVGLL 175
Cdd:PHA03095  27 VEEVRRLLAAGAD-VNFRGEYGKTPLhLYLHYSSEkvKDIVRLLLEAGAD--VNAPERcgFTPLHLYLYNATTlDVIKLL 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530415325 176 LERDVDINIYDWNGGTPL-LYAVRGN-HVKCVEALLARGADLTTEADSGYTPMD 227
Cdd:PHA03095 104 IKAGADVNAKDKVGRTPLhVYLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLA 157
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 84-184 1.47e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  84 LPATLDSLSIHQLAAQGELDQLkEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SALSL 162
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGI-ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCY 208

                         90       100
                 ....*....|....*....|..
gi 530415325 163 ASTGGYTDIVGLLLERDVDINI 184
Cdd:PHA02875 209 AIENNKIDIVRLFIKRGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 93-215 1.56e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  93 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFG-EIETVRFLLEWGADPHILAKERESALSLAST-GGYTD 170
Cdd:PHA02876 277 LHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKD 356

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530415325 171 IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 215
Cdd:PHA02876 357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 116-241 2.01e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 116 VNKPDERgfTPLIWASAFGEIETVRFLLEWG--ADpHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL 193
Cdd:PHA02875  63 VKYPDIE--SELHDAVEEGDVKAVEELLDLGkfAD-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530415325 194 LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 241
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
Ank_5 pfam13857
Ankyrin repeats (many copies);
109-163 4.96e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 4.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530415325  109 LRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 163
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
142-196 3.49e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 3.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530415325  142 LLEWG-ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 196
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
125-176 3.71e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 3.71e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530415325  125 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 176
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 96-234 3.85e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  96 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 175
Cdd:PLN03192 498 LQHHKELHDLNVGDLLGDNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVL 577

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 176 LERDVDINIYDWNGGTPL--------------LY-----------------AVRGNHVKCVEALLARGADLTTEADSGYT 224
Cdd:PLN03192 578 LKHACNVHIRDANGNTALwnaisakhhkifriLYhfasisdphaagdllctAAKRNDLTAMKELLKQGLNVDSEDHQGAT 657

                        170
                 ....*....|
gi 530415325 225 PMDLAVALGY 234
Cdd:PLN03192 658 ALQVAMAEDH 667
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 87-236 5.90e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.90  E-value: 5.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  87 TLDSLSIHQLAAQGE-LDQLKEHLRKGDNlVNKPDergfTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLAS- 164
Cdd:PHA02876 208 ALDDLSVLECAVDSKnIDTIKAIIDNRSN-INKND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASq 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530415325 165 TGGYTDIVGLLLERDVDINIYDWNGGTPL-LYAVRGNHVKCVEALLARGADLTTeADSGY-TPMDLAVALGYRK 236
Cdd:PHA02876 283 APSLSRLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA-ADRLYiTPLHQASTLDRNK 355
PHA03095 PHA03095
ankyrin-like protein; Provisional
 116-221 1.08e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 116 VNKPDERGFTPLIWASAFGEIETVRFLLEWGAdphilakeresalslastggytdivglllerdvDINIYDWNGGTPLLY 195
Cdd:PHA03095 250 INARNRYGQTPLHYAAVFNNPRACRRLIALGA---------------------------------DINAVSSDGNTPLSL 296

                         90       100
                 ....*....|....*....|....*.
gi 530415325 196 AVRGNHVKCVEALLARGADLTTEADS 221
Cdd:PHA03095 297 MVRNNNGRAVRAALAKNPSAETVAAT 322
Ank_4 pfam13637
Ankyrin repeats (many copies);
93-143 3.97e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 3.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530415325   93 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLL 143
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 122-151 4.18e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 4.18e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530415325  122 RGFTPLIWASA-FGEIETVRFLLEWGADPHI 151
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNA 31
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 188-216 5.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 530415325   188 NGGTPLLYAVRGNHVKCVEALLARGADLT 216
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02791 PHA02791
ankyrin-like protein; Provisional
 104-223 6.49e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 40.41  E-value: 6.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 104 QLKEHLRKGDNLvnKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILakERESALSLASTGGYTDIVGLLLERDVDIN 183
Cdd:PHA02791  13 QLKSFLSSKDAF--KADVHGHSALYYAIADNNVRLVCTLLNAGALKNLL--ENEFPLHQAATLEDTKIVKILLFSGMDDS 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530415325 184 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 223
Cdd:PHA02791  89 QFDDKGNTALYYAVDSGNMQTVKLFVKKNWRLMFYGKTGW 128
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 188-215 7.98e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 7.98e-04
                          10        20
                  ....*....|....*....|....*...
gi 530415325  188 NGGTPLLYAVRGNHVKCVEALLARGADL 215
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 188-215 1.41e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|....*....
gi 530415325  188 NGGTPLLYAV-RGNHVKCVEALLARGADL 215
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADV 29
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 85-198 1.64e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325  85 PATLDSLSIHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPL-IWASAFGEIETVRFLLEWGADPHILAKERE-SALSL 162
Cdd:PHA02878 197 PDKTNNSPLHHAVKHYNKPIVHILLENGAS-TDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYILGlTALHS 275

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530415325 163 ASTGgyTDIVGLLLERDVDINIYDWNGGTPLLYAVR 198
Cdd:PHA02878 276 SIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAVK 309
Ank_4 pfam13637
Ankyrin repeats (many copies);
189-237 1.97e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530415325  189 GGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 237
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEV 49
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 122-151 2.92e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 2.92e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 530415325  122 RGFTPLIWASAFGEIETVRFLLEWGADPHI 151
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 125-217 3.03e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 125 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 196
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96

                         90       100
                 ....*....|....*....|.
gi 530415325 197 VRGNHVKCVEALLARGADLTT 217
Cdd:cd22192   97 VVNQNLNLVRELIARGADVVS 117
PHA02792 PHA02792
ankyrin-like protein; Provisional
 181-245 5.65e-03

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 38.01  E-value: 5.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530415325 181 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 245
Cdd:PHA02792 402 DINKIDKHGRSILYYCIESHSVSLVEWLIDNGADINITTKYGSTCIGICVILAHACIPEIAELYI 466
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 115-255 5.91e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 37.68  E-value: 5.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 115 LVNKPDE----RGFTPLIWASAFGEIETVRFLLEWGAD--------------PHILAKERESALSLASTGGYTDIVGLLL 176
Cdd:cd22192   77 LVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADvvspratgtffrpgPKNLIYYGEHPLSFAACVGNEEIVRLLI 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530415325 177 ERDVDINIYDWNGGTPL-LYAVRGNHVKCVEA---LLARGADLTTEA------DSGYTPMDLAVALGyrkvQQVIENHIL 246
Cdd:cd22192  157 EHGADIRAQDSLGNTVLhILVLQPNKTFACQMydlILSYDKEDDLQPldlvpnNQGLTPFKLAAKEG----NIVMFQHLV 232

                        170
                 ....*....|..
gi 530415325 247 ---KLFQSNLVP 255
Cdd:cd22192  233 qkrRHIQWTYGP 244
PHA03095 PHA03095
ankyrin-like protein; Provisional
 170-228 8.23e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.31  E-value: 8.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530415325 170 DIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC---VEALLARGADLTTEADSGYTPMDL 228
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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