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Conserved domains on  [gi|530426077|ref|XP_005260946|]
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syntaphilin isoform X3 [Homo sapiens]

Protein Classification

syntaphilin domain-containing protein( domain architecture ID 10633823)

syntaphilin domain-containing protein similar to Homo sapiens syntaphilin, a syntaxin-1 clamp that controls SNARE assembly, and syntabulin, a microtubule-associated protein implicated in syntaxin transport in neurons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 51-362 7.05e-170

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


:

Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 481.93  E-value: 7.05e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077   51 RTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQ 130
Cdd:pfam15290   1 NQGSPVNNRDAYGPSSLSSSSNSGSCKGSDSSPTRRRSGRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  131 DRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKL 210
Cdd:pfam15290  81 NRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  211 ETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVcGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDA 290
Cdd:pfam15290 161 ESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTYTKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  291 LeassllssgvdcgtEETSLHSSFGLGPRFPASNTYEKLL---CGMEAGVQA-----SCMQERAIQTDFVQYQPDLDTIL 362
Cdd:pfam15290 240 L--------------EEVFMSTAVEAGDLAPFSSTYEKLMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
 
Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 51-362 7.05e-170

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 481.93  E-value: 7.05e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077   51 RTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQ 130
Cdd:pfam15290   1 NQGSPVNNRDAYGPSSLSSSSNSGSCKGSDSSPTRRRSGRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  131 DRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKL 210
Cdd:pfam15290  81 NRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  211 ETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVcGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDA 290
Cdd:pfam15290 161 ESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTYTKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  291 LeassllssgvdcgtEETSLHSSFGLGPRFPASNTYEKLL---CGMEAGVQA-----SCMQERAIQTDFVQYQPDLDTIL 362
Cdd:pfam15290 240 L--------------EEVFMSTAVEAGDLAPFSSTYEKLMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 112-218 1.68e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.23  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 112 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDW--IEEECHRVEAQLALKEARkeIKQLKQVIDTVKNNl 189
Cdd:COG1579   12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELedLEKEIKRLELEIEEVEAR--IKKYEEQLGNVRNN- 88

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530426077 190 idKD-KGLQKyfvDINIQNKKLETL----LHSME 218
Cdd:COG1579   89 --KEyEALQK---EIESLKRRISDLedeiLELME 117
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 112-213 1.21e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  112 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQlsrMQEDWIEE--------ECHRVEAQLALKEARKEIKQLKQVID 183
Cdd:TIGR04523 269 LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---KEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQIS 345

                          90       100       110
                  ....*....|....*....|....*....|
gi 530426077  184 TVKNNLIDKDKGLQKYFVDINIQNKKLETL 213
Cdd:TIGR04523 346 QLKKELTNSESENSEKQRELEEKQNEIEKL 375
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
119-213 1.82e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 119 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEdwIEEEchrVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQK 198
Cdd:PRK03918 254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKE--LKEK---AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                         90
                 ....*....|....*
gi 530426077 199 YFVDINIQNKKLETL 213
Cdd:PRK03918 329 RIKELEEKEERLEEL 343
 
Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 51-362 7.05e-170

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 481.93  E-value: 7.05e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077   51 RTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQ 130
Cdd:pfam15290   1 NQGSPVNNRDAYGPSSLSSSSNSGSCKGSDSSPTRRRSGRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  131 DRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKL 210
Cdd:pfam15290  81 NRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  211 ETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVcGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDA 290
Cdd:pfam15290 161 ESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTYTKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  291 LeassllssgvdcgtEETSLHSSFGLGPRFPASNTYEKLL---CGMEAGVQA-----SCMQERAIQTDFVQYQPDLDTIL 362
Cdd:pfam15290 240 L--------------EEVFMSTAVEAGDLAPFSSTYEKLMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 112-218 1.68e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.23  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 112 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDW--IEEECHRVEAQLALKEARkeIKQLKQVIDTVKNNl 189
Cdd:COG1579   12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELedLEKEIKRLELEIEEVEAR--IKKYEEQLGNVRNN- 88

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530426077 190 idKD-KGLQKyfvDINIQNKKLETL----LHSME 218
Cdd:COG1579   89 --KEyEALQK---EIESLKRRISDLedeiLELME 117
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 132-221 5.30e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 47.61  E-value: 5.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 132 RLQDRDTEIDDLKTQ-------LSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKnNLIDKDKGLQKyfvdiN 204
Cdd:COG1579   11 DLQELDSELDRLEHRlkelpaeLAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE-ARIKKYEEQLG-----N 84

                         90
                 ....*....|....*...
gi 530426077 205 IQN-KKLETLLHSMEVAQ 221
Cdd:COG1579   85 VRNnKEYEALQKEIESLK 102
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
114-226 1.07e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 114 QKEvcIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQE--DWIEEECHRVEAQLA-----LKEARKEIKQLKQVIDTVK 186
Cdd:COG4372   44 QEE--LEQLREELEQAREELEQLEEELEQARSELEQLEEelEELNEQLQAAQAELAqaqeeLESLQEEAEELQEELEELQ 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 530426077 187 N---NLIDKDKGLQ----KYFVDINIQNKKLETLLHSMEVAQNGMAK 226
Cdd:COG4372  122 KerqDLEQQRKQLEaqiaELQSEIAEREEELKELEEQLESLQEELAA 168
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 112-213 1.21e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  112 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQlsrMQEDWIEE--------ECHRVEAQLALKEARKEIKQLKQVID 183
Cdd:TIGR04523 269 LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---KEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQIS 345

                          90       100       110
                  ....*....|....*....|....*....|
gi 530426077  184 TVKNNLIDKDKGLQKYFVDINIQNKKLETL 213
Cdd:TIGR04523 346 QLKKELTNSESENSEKQRELEEKQNEIEKL 375
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
119-213 1.82e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 119 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEdwIEEEchrVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQK 198
Cdd:PRK03918 254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKE--LKEK---AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                         90
                 ....*....|....*
gi 530426077 199 YFVDINIQNKKLETL 213
Cdd:PRK03918 329 RIKELEEKEERLEEL 343
BAR pfam03114
BAR domain; BAR domains are dimerization, lipid binding and curvature sensing modules found in ...
 149-222 3.24e-04

BAR domain; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like pfam00169 and pfam00787 domains in beta centaurins and sorting nexins respectively.


Pssm-ID: 460810 [Multi-domain]  Cd Length: 235  Bit Score: 42.32  E-value: 3.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530426077  149 RMQEDWieEECHRVEAQLALKEARKEIKQ-LKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQN 222
Cdd:pfam03114  80 AGKDLG--EDSSFGKALEDYGEALKRLAQlLEQLDDRVETNFLDPLRNLLKEFKEIQKHRKKLERKRLDYDAAKT 152
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
112-227 6.60e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 6.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 112 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDW--IEEECHRVEAQLA-----LKEARKEIKQLKQVIDT 184
Cdd:COG4372   61 LEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELesLQEEAEELQEELEelqkeRQDLEQQRKQLEAQIAE 140

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530426077 185 VKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKE 227
Cdd:COG4372  141 LQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQ 183
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 113-227 7.76e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.31  E-value: 7.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  113 QQKEVCIRHLKARLKDTQDRLQDRDTE-------IDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTV 185
Cdd:TIGR04523 303 QKEQDWNKELKSELKNQEKKLEEIQNQisqnnkiISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSY 382

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 530426077  186 KN---NLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKE 227
Cdd:TIGR04523 383 KQeikNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKE 427
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 138-213 1.00e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 1.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530426077  138 TEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKglqkyfvDINIQNKKLETL 213
Cdd:TIGR04523 218 SQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQK-------ELEQNNKKIKEL 286
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 112-216 1.05e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  112 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQED--WIEEECHRVEAQLALKEarKEIKQLKQVI----DTV 185
Cdd:TIGR04523 365 LEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLnqQKDEQIKKLQQEKELLE--KEIERLKETIiknnSEI 442

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 530426077  186 KnNLIDKDKGLQKYFVDIN----IQNKKLETLLHS 216
Cdd:TIGR04523 443 K-DLTNQDSVKELIIKNLDntreSLETQLKVLSRS 476
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 119-213 1.60e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  119 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRM--QEDWIEEECHRVEAQLalKEARKEIKQLKQVIDTVKNNLIDKDKGL 196
Cdd:TIGR04523  77 IKILEQQIKDLNDKLKKNKDKINKLNSDLSKInsEIKNDKEQKNKLEVEL--NKLEKQKKENKKNIDKFLTEIKKKEKEL 154

                          90
                  ....*....|....*..
gi 530426077  197 QKYFVDINIQNKKLETL 213
Cdd:TIGR04523 155 EKLNNKYNDLKKQKEEL 171
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 106-221 2.32e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 106 EQYLTPLQQKevcIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTV 185
Cdd:COG4942   26 EAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530426077 186 KNNLIDKDKGLQKyfvdiNIQNKKLETLLHSMEVAQ 221
Cdd:COG4942  103 KEELAELLRALYR-----LGRQPPLALLLSPEDFLD 133
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
119-226 3.54e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.89  E-value: 3.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 119 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQedwieEECHRVEAQlaLKEARKEIKQLKQvidtvknNLIDKDKGLQK 198
Cdd:COG4372   26 IAALSEQLRKALFELDKLQEELEQLREELEQAR-----EELEQLEEE--LEQARSELEQLEE-------ELEELNEQLQA 91

                         90       100
                 ....*....|....*....|....*...
gi 530426077 199 YFVDINIQNKKLETLLHSMEVAQNGMAK 226
Cdd:COG4372   92 AQAELAQAQEELESLQEEAEELQEELEE 119
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 110-216 4.30e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.43  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 110 TPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDwieeechrveaqlaLKEARKEIKQLKQVIDTVKNNL 189
Cdd:COG3883   16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAE--------------LEALQAEIDKLQAEIAEAEAEI 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 530426077 190 IDKDKGLQKYFVDINIQ---NKKLETLLHS 216
Cdd:COG3883   82 EERREELGERARALYRSggsVSYLDVLLGS 111
46 PHA02562
endonuclease subunit; Provisional
 122-221 4.53e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 39.61  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077 122 LKARLKDTQDRLQDRDTEIDDLKTQLsRMQEDWIEE-----ECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGL 196
Cdd:PHA02562 172 NKDKIRELNQQIQTLDMKIDHIQQQI-KTYNKNIEEqrkknGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDI 250

                         90       100
                 ....*....|....*....|....*..
gi 530426077 197 QKYFVDINiqnkKLETLLH--SMEVAQ 221
Cdd:PHA02562 251 EDPSAALN----KLNTAAAkiKSKIEQ 273
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 119-216 6.80e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 36.85  E-value: 6.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  119 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEEchrveaqlalKEARKEIKQLKQVIDtvknnlidkdkglqk 198
Cdd:pfam07926  59 LQALREELNELKAEIAELKAEAESAKAELEESEESWEEQK----------KELEKELSELEKRIE--------------- 113

                          90
                  ....*....|....*...
gi 530426077  199 yfvDINIQNKkletLLHS 216
Cdd:pfam07926 114 ---DLNEQNK----LLHD 124
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
119-218 7.42e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530426077  119 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQE----------------DW--IEEECHRVEAQLA--------LKEAR 172
Cdd:COG4913   612 LAALEAELAELEEELAEAEERLEALEAELDALQErrealqrlaeyswdeiDVasAEREIAELEAELErldassddLAALE 691

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 530426077  173 KEIKQLKQVIDTVKNNLIDKDK---GLQKYFVDINIQNKKLETLLHSME 218
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGeigRLEKELEQAEEELDELQDRLEAAE 740
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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