![](files/infoQ.gif)
spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 isoform X1 [Homo sapiens]
basic helix-loop-helix domain-containing protein( domain architecture ID 14441525)
basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor; similar to Homo sapiens spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1/2
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | ||
bHLH_SOHLH1_2 | cd18908 | basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ... |
53-111 | 1.45e-26 | ||
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. : Pssm-ID: 381478 [Multi-domain] Cd Length: 59 Bit Score: 100.88 E-value: 1.45e-26
|
||||||
Name | Accession | Description | Interval | E-value | ||
bHLH_SOHLH1_2 | cd18908 | basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ... |
53-111 | 1.45e-26 | ||
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. Pssm-ID: 381478 [Multi-domain] Cd Length: 59 Bit Score: 100.88 E-value: 1.45e-26
|
||||||
HLH | pfam00010 | Helix-loop-helix DNA-binding domain; |
56-102 | 4.27e-05 | ||
Helix-loop-helix DNA-binding domain; Pssm-ID: 459628 [Multi-domain] Cd Length: 53 Bit Score: 40.91 E-value: 4.27e-05
|
||||||
HLH | smart00353 | helix loop helix domain; |
60-102 | 2.63e-04 | ||
helix loop helix domain; Pssm-ID: 197674 [Multi-domain] Cd Length: 53 Bit Score: 38.74 E-value: 2.63e-04
|
||||||
Name | Accession | Description | Interval | E-value | ||
bHLH_SOHLH1_2 | cd18908 | basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ... |
53-111 | 1.45e-26 | ||
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. Pssm-ID: 381478 [Multi-domain] Cd Length: 59 Bit Score: 100.88 E-value: 1.45e-26
|
||||||
bHLH_SOHLH_like | cd19683 | basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ... |
62-110 | 2.30e-08 | ||
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules. Pssm-ID: 381526 Cd Length: 58 Bit Score: 50.04 E-value: 2.30e-08
|
||||||
bHLH-O_HES7 | cd11462 | basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split 7 (HES-7) ... |
62-108 | 3.22e-06 | ||
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split 7 (HES-7) and similar proteins; HES-7, also termed Class B basic helix-loop-helix protein 37 (bHLHb37), or bHLH factor Hes7, is a bHLH-O transcriptional repressor that is expressed in an oscillatory manner and acts as a key regulator of the pace of the segmentation clock. It is regulated by the Notch and Fgf/Mapk pathways. HES-7 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Pssm-ID: 381468 [Multi-domain] Cd Length: 61 Bit Score: 44.26 E-value: 3.22e-06
|
||||||
bHLH_SF | cd00083 | basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ... |
62-102 | 3.72e-05 | ||
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis. Pssm-ID: 381392 [Multi-domain] Cd Length: 46 Bit Score: 40.58 E-value: 3.72e-05
|
||||||
HLH | pfam00010 | Helix-loop-helix DNA-binding domain; |
56-102 | 4.27e-05 | ||
Helix-loop-helix DNA-binding domain; Pssm-ID: 459628 [Multi-domain] Cd Length: 53 Bit Score: 40.91 E-value: 4.27e-05
|
||||||
bHLH_TCFL5 | cd18909 | basic helix-loop-helix (bHLH) domain found in transcription factor-like 5 protein (TCFL5) and ... |
62-102 | 8.42e-05 | ||
basic helix-loop-helix (bHLH) domain found in transcription factor-like 5 protein (TCFL5) and similar proteins; TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules. Pssm-ID: 381479 Cd Length: 60 Bit Score: 40.31 E-value: 8.42e-05
|
||||||
bHLH_AtbHLH_like | cd11393 | basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ... |
58-117 | 9.61e-05 | ||
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses. Pssm-ID: 381399 [Multi-domain] Cd Length: 53 Bit Score: 39.86 E-value: 9.61e-05
|
||||||
bHLH_AtBIM_like | cd11453 | basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ... |
52-126 | 1.16e-04 | ||
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes. Pssm-ID: 381459 Cd Length: 77 Bit Score: 40.15 E-value: 1.16e-04
|
||||||
HLH | smart00353 | helix loop helix domain; |
60-102 | 2.63e-04 | ||
helix loop helix domain; Pssm-ID: 197674 [Multi-domain] Cd Length: 53 Bit Score: 38.74 E-value: 2.63e-04
|
||||||
bHLH-O_HES5 | cd11461 | basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar ... |
57-108 | 5.13e-04 | ||
basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar proteins; HES-5, also termed Class B basic helix-loop-helix protein 38 (bHLHb38), or hairy and enhancer of split 5, is a bHLH-O transcription factor that is involved in cell differentiation and proliferation in a variety of tissues. HES-5 is an essential effector for Notch signaling. It acts as a transducer of Notch signals in brain vascular development. It also acts as a key mediator of Wnt-3a-induced neuronal differentiation and plays a crucial role in normal inner ear hair cell development. HES-5 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Pssm-ID: 381467 [Multi-domain] Cd Length: 59 Bit Score: 38.09 E-value: 5.13e-04
|
||||||
bHLH_AtFAMA_like | cd11448 | basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar ... |
62-102 | 9.20e-04 | ||
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as FAMA, MUTE and SPEECHLESS, which work together to regulate the sequential cell fate specification during stomatal development and differentiation. FAMA, also termed AtbHLH97, or EN 14, is a transcription activator required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. It mediates the formation of stomata. MUTE, also termed AtbHLH45, or EN 20, is required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. It promotes the conversion of the leaf epidermis into stomata. SPEECHLESS, also termed AtbHLH98, or EN 19, is required for the initiation and the formation of stomata, by promoting the first asymmetric cell divisions. FAMA, MUTE and SPEECHLESS form heterodimers with SCREAM/ICE1 and SCRM2 to regulate transcription of genes during stomatal development. Pssm-ID: 381454 Cd Length: 74 Bit Score: 37.71 E-value: 9.20e-04
|
||||||
bHLH_O_HES | cd11410 | basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ... |
62-102 | 1.85e-03 | ||
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) family; The HES family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. HES family proteins form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system. Pssm-ID: 381416 [Multi-domain] Cd Length: 54 Bit Score: 36.29 E-value: 1.85e-03
|
||||||
bHLH-PAS_ARNTL2_PASD9 | cd11469 | basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor ... |
62-110 | 1.92e-03 | ||
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 2 (ARNTL2) and similar proteins; ARNTL2, also termed Basic-helix-loop-helix-PAS protein MOP9, or brain and muscle ARNT-like 2 (BMAL2), or CYCLE-like factor (CLIF), or Class E basic helix-loop-helix protein 6 (bHLHe6), or member of PAS protein 9, or PAS domain-containing protein 9 (PASD9), is a neuronal bHLH-PAS transcriptional factor, regulating cell cycle progression and preventing cell death, whose sustained expression might ensure brain neuron survival. It also plays important roles in tumor angiogenesis. ARNT-2 heterodimerize with other bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM). Pssm-ID: 381475 Cd Length: 60 Bit Score: 36.55 E-value: 1.92e-03
|
||||||
bHLH-O_HERP_like | cd11389 | basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ... |
57-102 | 2.90e-03 | ||
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP)-like family; The HERP-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this family. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. Pssm-ID: 381395 [Multi-domain] Cd Length: 55 Bit Score: 35.76 E-value: 2.90e-03
|
||||||
bHLH_PAS | cd11391 | basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found ... |
56-103 | 3.60e-03 | ||
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found in a large group of bHLH transcription regulators that are involved in gene expression responding to environmental change and controlling aspects of neural development, including proteins from aryl hydrocarbon receptor nuclear translocator (ARNT) family, hypoxia-inducible factor (HIF) family, aryl hydrocarbon receptor (AhR) family, neuronal PAS domain-containing protein (NPAS) family, Circadian locomotor output cycles protein kaput (CLOCK)-like family, and single-minded (SIM) family. bHLH-PAS transcriptional regulatory factors have a bHLH DNA-binding domain followed by two PAS domains and a C-terminal activation or repression domain. bHLH-PAS family members can be divided into class I and class II based on their dimerization partner. bHLH-PAS class I factors include AhR, HIF and SIM. The best characterized bHLH-PAS Class II protein is the ubiquitous ARNT. Some members of bHLH-PAS family act as transcriptional coactivators (such as NCoA) that lack the ability to dimerize and bind DNA. Pssm-ID: 381397 [Multi-domain] Cd Length: 55 Bit Score: 35.25 E-value: 3.60e-03
|
||||||
bHLHzip_TFAP4 | cd11419 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ... |
55-102 | 6.15e-03 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Pssm-ID: 381425 Cd Length: 61 Bit Score: 34.98 E-value: 6.15e-03
|
||||||
Blast search parameters | ||||
|