F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 530367267 153 SPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 199
Cdd:cd22109    1 SLESLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 530367267 153 SPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 199
Cdd:cd22109    1 SLESLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

transcriptional regulator ICP4; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367267    9 ASSRVPAASQSSGCYDSDSLELPRPEEG----------APEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNwqr 78
Cdd:PHA03307  234 ASSSDSSSSESSGCGWGPENECPLPRPApitlptriweASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPS--- 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367267   79 rPRRHSTEGEEGDVSDVGSRTTESEAEGPLdAPRPGPAMAGPLSSCRLSARPEGGS-GRGRRAERVSPSRSNEVISPEIL 157
Cdd:PHA03307  311 -SPRASSSSSSSRESSSSSTSSSSESSRGA-AVSPGPSPSRSPSPSRPPPPADPSSpRKRPRPSRAPSSPAASAGRPTRR 388

                  ....*.
gi 530367267  158 KMRAAL 163
Cdd:PHA03307  389 RARAAV 394

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 530367267 153 SPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 199
Cdd:cd22109    1 SLESLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 530367267 154 PEILKMraalfcIFTYLDTRTLLHAAEVCRDWRFVARHPAVW 195
Cdd:cd22125    5 PEILAM------IFSYLDVRDKGRAAQVCTAWRDAAYHKSVW 40

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530367267 163 LFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 199
Cdd:cd22132    9 LLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELF 45

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                         10        20
                 ....*....|....*....|....*...
gi 530367267 163 LFCIFTYLDTRTLLHAAEVCRDWRFVAR 190
Cdd:cd09917    8 LLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 530367267 164 FCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTR 197
Cdd:cd22147   11 LKILSYLDAKSLCRAAQVSKKWRNLADDDELWKR 44

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 530367267 166 IFTYLDTRTLLHAAEVCRDWRFVARHPAVWT 196
Cdd:cd22173   14 IFSFLDPRSLCRAAQVSWHWKFLAEQDCLWM 44

transcriptional regulator ICP4; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367267    9 ASSRVPAASQSSGCYDSDSLELPRPEEG----------APEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNwqr 78
Cdd:PHA03307  234 ASSSDSSSSESSGCGWGPENECPLPRPApitlptriweASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPS--- 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367267   79 rPRRHSTEGEEGDVSDVGSRTTESEAEGPLdAPRPGPAMAGPLSSCRLSARPEGGS-GRGRRAERVSPSRSNEVISPEIL 157
Cdd:PHA03307  311 -SPRASSSSSSSRESSSSSTSSSSESSRGA-AVSPGPSPSRSPSPSRPPPPADPSSpRKRPRPSRAPSSPAASAGRPTRR 388

                  ....*.
gi 530367267  158 KMRAAL 163
Cdd:PHA03307  389 RARAAV 394

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530367267 163 LFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTR 197
Cdd:cd22091    9 LLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKR 43

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 530367267 166 IFTYLDTRTLLHAAEVCRDWR-FVARHPAVW 195
Cdd:cd22113   12 IFSQLDVQSLCRASQTCKTWNdLIENSDYLW 42

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530367267  162 ALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTR 197
Cdd:pfam00646   8 LLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 530367267 166 IFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRV 198
Cdd:cd22134   15 IFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRI 47