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Conserved domains on  [gi|530372036|ref|XP_005264995|]
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kelch domain-containing protein 8B isoform X3 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 19803719)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-347 1.91e-43

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 151.46  E-value: 1.91e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLMDEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 137 ---PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVlgtpiplTGGRQGKLPVTAFEAFDLEARTWTRHP 213
Cdd:COG3055   81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYV-------VGGWDDGGNVAWVEVYDPATGTWTQLA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 214 SLPSRRAFAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPRslrMRDKRADFVVGSLGGHIVA 292
Cdd:COG3055  154 PLPTPRDHLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLAP---LPTARAGHAAAVLGGKILV 211

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530372036 293 IGGLGNqpcPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQG 347
Cdd:COG3055  212 FGGESG---FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-86 1.73e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.10  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036   3 AGGGRAF-----AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:COG3055  174 VIGGRNGsgfsnTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250


                 ....*....
gi 530372036  78 GKQVLVVGG 86
Cdd:COG3055  251 DGKVYVIGG 259
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-347 1.91e-43

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 151.46  E-value: 1.91e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLMDEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 137 ---PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVlgtpiplTGGRQGKLPVTAFEAFDLEARTWTRHP 213
Cdd:COG3055   81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYV-------VGGWDDGGNVAWVEVYDPATGTWTQLA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 214 SLPSRRAFAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPRslrMRDKRADFVVGSLGGHIVA 292
Cdd:COG3055  154 PLPTPRDHLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLAP---LPTARAGHAAAVLGGKILV 211

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530372036 293 IGGLGNqpcPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQG 347
Cdd:COG3055  212 FGGESG---FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA03098 PHA03098
kelch-like protein; Provisional
 7-217 5.81e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 82.12  E-value: 5.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036   7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGlPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:PHA03098 319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI-SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  87 VDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRV--YEPRRDCWLSLPSMPTP 164
Cdd:PHA03098 398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVesYNPVTNKWTELSSLNFP 477

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530372036 165 CYGASTFLHGNKIYVLgtpipltGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 217
Cdd:PHA03098 478 RINASLCIFNNKIYVV-------GGDKYEYYINEIEVYDDKTNTWTLFCKFPK 523
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-86 1.73e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.10  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036   3 AGGGRAF-----AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:COG3055  174 VIGGRNGsgfsnTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250


                 ....*....
gi 530372036  78 GKQVLVVGG 86
Cdd:COG3055  251 DGKVYVIGG 259
Kelch_6 pfam13964
Kelch motif;
285-326 8.23e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 8.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 530372036  285 SLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTAR 326
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
129-174 2.32e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.00  E-value: 2.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 530372036   129 VYALGGMGPDTApQAQVRVYEPRRDCWLSLPSMPTP-CYGASTFLHG 174
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNKWTPLPSMPTPrSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
20-69 6.42e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 6.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530372036   20 CRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTAR 69
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
32-79 8.08e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 8.08e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530372036    32 HLLVLGGCGRaGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGK 79
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-347 1.91e-43

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 151.46  E-value: 1.91e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLMDEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 137 ---PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVlgtpiplTGGRQGKLPVTAFEAFDLEARTWTRHP 213
Cdd:COG3055   81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYV-------VGGWDDGGNVAWVEVYDPATGTWTQLA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 214 SLPSRRAFAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPRslrMRDKRADFVVGSLGGHIVA 292
Cdd:COG3055  154 PLPTPRDHLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLAP---LPTARAGHAAAVLGGKILV 211

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530372036 293 IGGLGNqpcPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQG 347
Cdd:COG3055  212 FGGESG---FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
11-259 5.26e-34

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 126.81  E-value: 5.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  11 WQVFPPMPTCRVYGTVA-HQDGHLLVLGGCGRA---GLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:COG3055   50 WSELAPLPGPPRHHAAAvAQDGKLYVFGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  87 VDEvQSPVAAVEAFLMDEGRWERRATLPQAAMGV-ATVERDGMVYALGGMGPDTAPQAqvrvyeprrdcWLSLPSMPTPC 165
Cdd:COG3055  130 WDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSNT-----------WTTLAPLPTAR 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 166 YGASTFLHGNKIYVlgtpiplTGGRQGKLpvTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGphnf 245
Cdd:COG3055  198 AGHAAAVLGGKILV-------FGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPG---- 264

                        250
                 ....*....|....
gi 530372036 246 ySRPHFVNTVEMFD 259
Cdd:COG3055  265 -VRTPLVTSAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 7-217 5.81e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 82.12  E-value: 5.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036   7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGlPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:PHA03098 319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI-SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  87 VDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRV--YEPRRDCWLSLPSMPTP 164
Cdd:PHA03098 398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVesYNPVTNKWTELSSLNFP 477

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530372036 165 CYGASTFLHGNKIYVLgtpipltGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 217
Cdd:PHA03098 478 RINASLCIFNNKIYVV-------GGDKYEYYINEIEVYDDKTNTWTLFCKFPK 523
PHA03098 PHA03098
kelch-like protein; Provisional
 23-266 9.45e-15

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 75.19  E-value: 9.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  23 YGTVAHQDgHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLM 102
Cdd:PHA03098 288 FGSVVLNN-VIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYN-SISLNTVESWKP 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 103 DEGRWERRATL--PQAAMGVATVerDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVL 180
Cdd:PHA03098 366 GESKWREEPPLifPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVI 443

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 181 G--TPIPLTGGrqgklpVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGlqqpgphnfYSRPHFVNTVEMF 258
Cdd:PHA03098 444 GgiSYIDNIKV------YNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG---------DKYEYYINEIEVY 508


                 ....*...
gi 530372036 259 DLEHGSWT 266
Cdd:PHA03098 509 DDKTNTWT 516
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-86 1.73e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.10  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036   3 AGGGRAF-----AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:COG3055  174 VIGGRNGsgfsnTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250


                 ....*....
gi 530372036  78 GKQVLVVGG 86
Cdd:COG3055  251 DGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 129-343 1.43e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 65.56  E-value: 1.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 129 VYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLgtpipltGGRQGKLPVTAFEAFDLEART 208
Cdd:PHA03098 297 IYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVI-------GGIYNSISLNTVESWKPGESK 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 209 WTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGphnfysrpHFVNTVEMFDLEHGSWTKLprsLRMRDKRADFVVGSLGG 288
Cdd:PHA03098 370 WREEPPLIFPRYNPCVVNVNNLIYVIGGISKND--------ELLKTVECFSLNTNKWSKG---SPLPISHYGGCAIYHDG 438

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530372036 289 HIVAIGGLG--NQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 343
Cdd:PHA03098 439 KIYVIGGISyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG 495
PHA03098 PHA03098
kelch-like protein; Provisional
 73-295 5.01e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 63.63  E-value: 5.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  73 AAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDtAPQAQVRVYEPRR 152
Cdd:PHA03098 289 GSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGE 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 153 DCWLSLPSMPTPCYGASTFLHGNKIYVLGtpipltGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVF 232
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIG------GISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIY 441

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530372036 233 SLGGLqqpgphNFYSRPHFVNTVEMFDLEHGSWTKLPrslRMRDKRADFVVGSLGGHIVAIGG 295
Cdd:PHA03098 442 VIGGI------SYIDNIKVYNIVESYNPVTNKWTELS---SLNFPRINASLCIFNNKIYVVGG 495
PLN02153 PLN02153
epithiospecifier protein
 114-343 5.74e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 63.08  E-value: 5.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 114 PQAAMGVATVerDGMVYALGG-MGPDTAPQAQVRVYEPRRDCWLSLPSMPTP----CYGASTFLHGNKIYvlgtpipLTG 188
Cdd:PLN02153  22 PRCSHGIAVV--GDKLYSFGGeLKPNEHIDKDLYVFDFNTHTWSIAPANGDVprisCLGVRMVAVGTKLY-------IFG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 189 GRQGKLPVTAFEAFDLEARTWTRHPSL-----PSRRAFAGCAMAEGSVFSLGGLQQPGPHNfysRPHFVNTVEMFDLEHG 263
Cdd:PLN02153  93 GRDEKREFSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGLMK---TPERFRTIEAYNIADG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 264 SWTKLPRSLRMRDKR--ADFVVgsLGGHIVAIGGLGNQPCPLG-------SVESFSLARRRW---EALPAMPTARCSCSS 331
Cdd:PLN02153 170 KWVQLPDPGENFEKRggAGFAV--VQGKIWVVYGFATSILPGGksdyesnAVQFFDPASGKWtevETTGAKPSARSVFAH 247

                        250
                 ....*....|..
gi 530372036 332 LQAGPRLFVIGG 343
Cdd:PLN02153 248 AVVGKYIIIFGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 155-344 2.46e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 58.63  E-value: 2.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 155 WLSLPSMPTPCYGASTFLHgNKIYVLGtpipltGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSL 234
Cdd:PHA03098 276 INTIIDIHYVYCFGSVVLN-NVIYFIG------GMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVI 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036 235 GGLQQPGPhnfysrphfVNTVEMFDLEHGSWTKLPRslrMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARR 314
Cdd:PHA03098 349 GGIYNSIS---------LNTVESWKPGESKWREEPP---LIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTN 416

                        170       180       190
                 ....*....|....*....|....*....|
gi 530372036 315 RWEALPAMPTARCSCSSLQAGPRLFVIGGV 344
Cdd:PHA03098 417 KWSKGSPLPISHYGGCAIYHDGKIYVIGGI 446
Kelch_6 pfam13964
Kelch motif;
285-326 8.23e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 8.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 530372036  285 SLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTAR 326
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 278-323 2.25e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530372036  278 RADFVVGSLGGHIVAIGGLGNQpCPLGSVESFSLARRRWEALPAMP 323
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
129-174 2.32e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.00  E-value: 2.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 530372036   129 VYALGGMGPDTApQAQVRVYEPRRDCWLSLPSMPTP-CYGASTFLHG 174
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNKWTPLPSMPTPrSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
20-69 6.42e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 6.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 530372036   20 CRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTAR 69
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
176-229 6.97e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 6.97e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 530372036   176 KIYVlgtpiplTGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEG 229
Cdd:smart00612   1 KIYV-------VGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
32-79 8.08e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 8.08e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530372036    32 HLLVLGGCGRaGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGK 79
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02790 PHA02790
Kelch-like protein; Provisional
 49-181 1.14e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 43.88  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372036  49 AETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSpvaaVEAFLMDEGRWERRATLPQAAMGVATVERDGM 128
Cdd:PHA02790 289 AIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTS----VERWFHGDAAWVNMPSLLKPRCNPAVASINNV 364

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530372036 129 VYALGGMG-PDTAPQAQVrvyePRRDCWLSLPSMPTPCYGASTFLHGNKIYVLG 181
Cdd:PHA02790 365 IYVIGGHSeTDTTTEYLL----PNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG 414
Kelch smart00612
Kelch domain;
289-331 1.37e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 1.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 530372036   289 HIVAIGGL-GNQPcpLGSVESFSLARRRWEALPAMPTARCSCSS 331
Cdd:smart00612   1 KIYVVGGFdGGQR--LKSVEVYDPETNKWTPLPSMPTPRSGHGV 42
Kelch_6 pfam13964
Kelch motif;
114-164 5.07e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 5.07e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530372036  114 PQAAMGVATVerDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTP 164
Cdd:pfam13964   1 PRTFHSVVSV--GGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 164-216 5.39e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 5.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530372036  164 PCYGASTFLHGNKIYVLGtpipltgGRQGKLPVTAFEAFDLEARTWTRHPSLP 216
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIG-------GFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 218-269 8.23e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 8.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530372036  218 RRAFAGCAMAEGSVFSLGGlqqpgphnfYSRPHFVNTVEMFDLEHGSWTKLP 269
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG---------FDGNQSLNSVEVYDPETNTWSKLP 43
Kelch_6 pfam13964
Kelch motif;
164-219 1.38e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 1.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530372036  164 PCYGASTFLHGNKIYVLGtpipltGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRR 219
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFG------GYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
246-288 1.83e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 1.83e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 530372036   246 YSRPHFVNTVEMFDLEHGSWTKLPrslRMRDKRADFVVGSLGG 288
Cdd:smart00612   8 FDGGQRLKSVEVYDPETNKWTPLP---SMPTPRSGHGVAVING 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
30-77 4.17e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 4.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530372036   30 DGHLLVLGGCGRAG-LPLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:pfam13415   1 GDKLYIFGGLGFDGqTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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