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Conserved domains on  [gi|530403467|ref|XP_005267567|]
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low-density lipoprotein receptor-related protein 10 isoform X1 [Homo sapiens]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 12869389)

protein containing domains CUB, LDLa, and PRK04654

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 407-441 2.57e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 2.57e-12
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530403467 407 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 441
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 200-310 9.43e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 9.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467 200 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 273
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530403467 274 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 310
Cdd:cd00041   77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 6.33e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 6.33e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530403467 148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 182
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 2.21e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 49.72  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR---SPLQPLI-SLC-EAPPSP 104
Cdd:cd00041    5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpSTSSPLLgRFCgSTLPPP 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 530403467 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041   85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
PRK04654 super family cl31366
sec-independent translocase; Provisional
 581-683 4.19e-05

sec-independent translocase; Provisional


The actual alignment was detected with superfamily member PRK04654:

Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 45.19  E-value: 4.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467 581 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 648
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530403467 649 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 683
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 338-361 6.73e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 6.73e-05
                         10        20
                 ....*....|....*....|....
gi 530403467 338 RCYSEAQRCDGSWDCADGTDEEDC 361
Cdd:cd00112   12 RCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 407-441 2.57e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 2.57e-12
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530403467 407 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 441
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 200-310 9.43e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 9.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467 200 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 273
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530403467 274 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 310
Cdd:cd00041   77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 6.33e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 6.33e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530403467 148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 182
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 407-438 9.04e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 9.04e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530403467   407 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 438
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
407-441 5.23e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.95  E-value: 5.23e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530403467  407 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 441
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 148-179 3.21e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.21e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530403467   148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 179
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 2.21e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 49.72  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR---SPLQPLI-SLC-EAPPSP 104
Cdd:cd00041    5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpSTSSPLLgRFCgSTLPPP 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 530403467 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041   85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
148-182 4.31e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 4.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530403467  148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 182
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 209-310 5.23e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 48.54  E-value: 5.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467   209 GVFSSPGYthLASVSHPQSCHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPGppESSRLLRSLTHfSNGKAVT 283
Cdd:smart00042   1 GTITSPNY--PQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdnCEYDYVEIYDGPS--ASSPLLGRFCG-SEAPPPV 75

                           90       100
                   ....*....|....*....|....*..
gi 530403467   284 VETLSGQAVVSYHTVAWSNGRGFNATY 310
Cdd:smart00042  76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
200-310 1.70e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 47.29  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467  200 CNVTLEDFYGVFSSPGYTHlasvSHPQS--CHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPgpPESSRLLRS 272
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELedhdeCGYDYVEIRDGP--SASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 530403467  273 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 310
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
PRK04654 PRK04654
sec-independent translocase; Provisional
 581-683 4.19e-05

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 45.19  E-value: 4.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467 581 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 648
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530403467 649 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 683
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 338-361 6.73e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 6.73e-05
                         10        20
                 ....*....|....*....|....
gi 530403467 338 RCYSEAQRCDGSWDCADGTDEEDC 361
Cdd:cd00112   12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 338-358 1.39e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.84  E-value: 1.39e-03
                           10        20
                   ....*....|....*....|.
gi 530403467   338 RCYSEAQRCDGSWDCADGTDE 358
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-133 1.58e-03

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 38.53  E-value: 1.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467    40 GTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR------SPLqpLISLC--EAPPSPLQL 107
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYdgpsasSPL--LGRFCgsEAPPPVISS 78

                           90       100
                   ....*....|....*....|....*.
gi 530403467   108 PGGNVTITYSYAGARApmGQGFLLSY 133
Cdd:smart00042  79 SSNSLTLTFVSDSSVQ--KRGFSARY 102
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
338-361 6.17e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 6.17e-03
                          10        20
                  ....*....|....*....|....
gi 530403467  338 RCYSEAQRCDGSWDCADGTDEEDC 361
Cdd:pfam00057  14 ECIPRSWVCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 407-441 2.57e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 2.57e-12
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530403467 407 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 441
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 200-310 9.43e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 9.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467 200 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 273
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530403467 274 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 310
Cdd:cd00041   77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 6.33e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 6.33e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 530403467 148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 182
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 407-438 9.04e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 9.04e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530403467   407 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 438
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
407-441 5.23e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.95  E-value: 5.23e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530403467  407 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 441
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 148-179 3.21e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.21e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530403467   148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 179
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 2.21e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 49.72  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR---SPLQPLI-SLC-EAPPSP 104
Cdd:cd00041    5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpSTSSPLLgRFCgSTLPPP 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 530403467 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041   85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
148-182 4.31e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 4.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530403467  148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 182
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 209-310 5.23e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 48.54  E-value: 5.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467   209 GVFSSPGYthLASVSHPQSCHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPGppESSRLLRSLTHfSNGKAVT 283
Cdd:smart00042   1 GTITSPNY--PQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdnCEYDYVEIYDGPS--ASSPLLGRFCG-SEAPPPV 75

                           90       100
                   ....*....|....*....|....*..
gi 530403467   284 VETLSGQAVVSYHTVAWSNGRGFNATY 310
Cdd:smart00042  76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
200-310 1.70e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 47.29  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467  200 CNVTLEDFYGVFSSPGYTHlasvSHPQS--CHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPgpPESSRLLRS 272
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELedhdeCGYDYVEIRDGP--SASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 530403467  273 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 310
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
PRK04654 PRK04654
sec-independent translocase; Provisional
 581-683 4.19e-05

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 45.19  E-value: 4.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467 581 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 648
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530403467 649 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 683
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 338-361 6.73e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 6.73e-05
                         10        20
                 ....*....|....*....|....
gi 530403467 338 RCYSEAQRCDGSWDCADGTDEEDC 361
Cdd:cd00112   12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 338-358 1.39e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.84  E-value: 1.39e-03
                           10        20
                   ....*....|....*....|.
gi 530403467   338 RCYSEAQRCDGSWDCADGTDE 358
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-133 1.58e-03

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 38.53  E-value: 1.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467    40 GTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR------SPLqpLISLC--EAPPSPLQL 107
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYdgpsasSPL--LGRFCgsEAPPPVISS 78

                           90       100
                   ....*....|....*....|....*.
gi 530403467   108 PGGNVTITYSYAGARApmGQGFLLSY 133
Cdd:smart00042  79 SSNSLTLTFVSDSSVQ--KRGFSARY 102
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 579-689 4.55e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 4.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403467 579 TPARASEArsqvTPSAAPLEALDGGTGPAREGGAVggqdgeQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSL 658
Cdd:PRK14951 380 TPARPEAA----APAAAPVAQAAAAPAPAAAPAAA------ASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530403467 659 LSGVVQALRGRLLPSLGPPGPTRSPPGPHTA 689
Cdd:PRK14951 450 APPAQAAPETVAIPVRVAPEPAVASAAPAPA 480
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 577-648 5.82e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 5.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530403467 577 TNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGP 648
Cdd:PRK07764 428 APQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
338-361 6.17e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 6.17e-03
                          10        20
                  ....*....|....*....|....
gi 530403467  338 RCYSEAQRCDGSWDCADGTDEEDC 361
Cdd:pfam00057  14 ECIPRSWVCDGDPDCGDGSDEENC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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