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Conserved domains on  [gi|530404134|ref|XP_005267890|]
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mis18-binding protein 1 isoform X1 [Homo sapiens]

Protein Classification

mis18-binding family protein( domain architecture ID 10557545)

mis18-binding family protein contains a SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain that binds DNA and may function as a transcription factor, and a SANTA (SANT Associated) domain which may play a role in regulating chromatin remodeling and in protein-protein interactions; such as human mis18-binding protein 1

CATH:  1.20.58.1880
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  8882580|16877755
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
 383-470 2.44e-33

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


:

Pssm-ID: 462689  Cd Length: 87  Bit Score: 123.52  E-value: 2.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404134   383 VQLQEWMIKsINNNTaICVEGKLIDVTNIY-WHSNVIIERIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMF 461
Cdd:pfam09133    1 VTLKDWWLK-KVSKT-LAVEGFRRDSDGIRvFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78


                   ....*....
gi 530404134   462 GFPENWKEH 470
Cdd:pfam09133   79 GFPENWKEY 87
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 879-925 2.75e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 2.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 530404134  879 EWNEKELQKLHCAFAslpKHKPGFWSEVAAAVGSRSPEECQRKYMEN 925
Cdd:cd00167     1 PWTEEEDELLLEAVK---KYGKNNWEKIAKELPGRTPKQCRERWRNL 44
 
Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
 383-470 2.44e-33

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


Pssm-ID: 462689  Cd Length: 87  Bit Score: 123.52  E-value: 2.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404134   383 VQLQEWMIKsINNNTaICVEGKLIDVTNIY-WHSNVIIERIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMF 461
Cdd:pfam09133    1 VTLKDWWLK-KVSKT-LAVEGFRRDSDGIRvFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78


                   ....*....
gi 530404134   462 GFPENWKEH 470
Cdd:pfam09133   79 GFPENWKEY 87
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 879-925 2.75e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 2.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 530404134  879 EWNEKELQKLHCAFAslpKHKPGFWSEVAAAVGSRSPEECQRKYMEN 925
Cdd:cd00167     1 PWTEEEDELLLEAVK---KYGKNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
878-927 3.37e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.91  E-value: 3.37e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 530404134    878 KEWNEKELQKLHCAFAslpKHKPGFWSEVAAAVGSRSPEECQRKYMENPR 927
Cdd:smart00717    2 GEWTEEEDELLIELVK---KYGKNNWEKIAKELPGRTAEQCRERWRNLLK 48
 
Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
 383-470 2.44e-33

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


Pssm-ID: 462689  Cd Length: 87  Bit Score: 123.52  E-value: 2.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404134   383 VQLQEWMIKsINNNTaICVEGKLIDVTNIY-WHSNVIIERIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMF 461
Cdd:pfam09133    1 VTLKDWWLK-KVSKT-LAVEGFRRDSDGIRvFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78


                   ....*....
gi 530404134   462 GFPENWKEH 470
Cdd:pfam09133   79 GFPENWKEY 87
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 879-925 2.75e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 2.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 530404134  879 EWNEKELQKLHCAFAslpKHKPGFWSEVAAAVGSRSPEECQRKYMEN 925
Cdd:cd00167     1 PWTEEEDELLLEAVK---KYGKNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
878-927 3.37e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.91  E-value: 3.37e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 530404134    878 KEWNEKELQKLHCAFAslpKHKPGFWSEVAAAVGSRSPEECQRKYMENPR 927
Cdd:smart00717    2 GEWTEEEDELLIELVK---KYGKNNWEKIAKELPGRTAEQCRERWRNLLK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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