NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530380599|ref|XP_005268526|]
View 

WD repeat-containing protein 55 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-332 3.08e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 3.08e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  39 APASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 119 ERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319  155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530380599 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVV 332
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-332 3.08e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 3.08e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  39 APASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 119 ERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319  155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530380599 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVV 332
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-324 5.17e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 5.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  83 HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPL 161
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 162 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNG 241
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 242 FGaTSDRFALRAESIDCMVPV-TESLLCTGSTDGVIRAVNILPNRVVGSVGQHTgEPVEELALSHCGRFLASSGHDQRLK 320
Cdd:cd00200  167 GK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE-NGVNSVAFSPDGYLLASGSEDGTIR 244


                 ....
gi 530380599 321 FWDM 324
Cdd:cd00200  245 VWDL 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-323 2.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530380599   283 PNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWD 323
Cdd:smart00320   1 SGELLKTLKGHTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 44-118 8.14e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530380599   44 LAFHPARDLLAAGDVDGDVFVFSYSCQEgetkeLWS---SGHHLKAcRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQR-----VWTlspDKEDLEV-TSLAWRPDGKLLAVGYSDGTVRLLDAENGKI 72
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-332 3.08e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 3.08e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  39 APASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 119 ERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319  155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530380599 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVV 332
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
38-325 8.35e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 8.35e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  38 EAPASGLAFHPARDLLAAGDVDGDVFVFSyscqEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQ 117
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWD----LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 118 LERRVsKAHGAPINSL-LLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFN 196
Cdd:COG2319  196 LLRTL-TGHTGAVRSVaFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 197 IKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PVTESLLcTGSTDG 274
Cdd:COG2319  275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAfsPDGKTLA-SGSDDG 352

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530380599 275 VIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMA 325
Cdd:COG2319  353 TVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-324 5.17e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 5.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  83 HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPL 161
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 162 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNG 241
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 242 FGaTSDRFALRAESIDCMVPV-TESLLCTGSTDGVIRAVNILPNRVVGSVGQHTgEPVEELALSHCGRFLASSGHDQRLK 320
Cdd:cd00200  167 GK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE-NGVNSVAFSPDGYLLASGSEDGTIR 244


                 ....
gi 530380599 321 FWDM 324
Cdd:cd00200  245 VWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-323 1.40e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 1.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  38 EAPASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKElwsSGHHLKAcRAVAFSEDGQKLITVSKDKAIHVLDVEQGQ 117
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPV-RDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 118 LERRVsKAHGAPINSL-LLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFN 196
Cdd:cd00200   85 CVRTL-TGHTSYVSSVaFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 197 IKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLfnWN-GFGATSDRFALRAESIDCMVP-VTESLLCTGSTDG 274
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL--WDlSTGKCLGTLRGHENGVNSVAFsPDGYLLASGSEDG 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530380599 275 VIRAVNILPNRVVGSVGQHTgEPVEELALSHCGRFLASSGHDQRLKFWD 323
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGHT-NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-330 1.17e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 1.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  39 APASGLAFHPARDLLAAGDVDGDVFVFSyscqEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319   37 AAVASLAASPDGARLAAGAGDLTLLLLD----AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 119 eRRVSKAHGAPINSLLL-VDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319  113 -LRTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAfsP-DGRLLASGSADGT 269

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530380599 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAV 330
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323
WD40 COG2319
WD40 repeat [General function prediction only];
38-241 4.07e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.07e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  38 EAPASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQ 117
Cdd:COG2319  204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLA----TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 118 LeRRVSKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFN 196
Cdd:COG2319  280 L-LRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 530380599 197 IKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNG 241
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
76-356 5.18e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 5.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  76 ELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQ 155
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 156 RKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIY 235
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 236 LFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASS 313
Cdd:COG2319  188 LWDLAT-GKLLRTLTGHTGAVRSVAfsP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASG 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 530380599 314 GHDQRLKFWDmaqlravvVDDYRRRKKKGGPLRALSSKTWSTD 356
Cdd:COG2319  265 SADGTVRLWD--------LATGELLRTLTGHSGGVNSVAFSPD 299
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 167-330 1.93e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 1.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 167 HEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATS 246
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 247 DRFALRAESIDCMVPV-TESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMA 325
Cdd:cd00200   87 RTLTGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIKLWDLR 165


                 ....*
gi 530380599 326 QLRAV 330
Cdd:cd00200  166 TGKCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
91-330 5.92e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 5.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599  91 AFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEY 170
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 171 IADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFA 250
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380599 251 LRAESIDCMV--PVTESLLcTGSTDGVIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLR 328
Cdd:COG2319  160 GHSGAVTSVAfsPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237


                 ..
gi 530380599 329 AV 330
Cdd:COG2319  238 LL 239
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-323 2.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530380599   283 PNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWD 323
Cdd:smart00320   1 SGELLKTLKGHTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 75-112 6.95e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.95e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530380599    75 KELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLD 112
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 44-118 8.14e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530380599   44 LAFHPARDLLAAGDVDGDVFVFSYSCQEgetkeLWS---SGHHLKAcRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQR-----VWTlspDKEDLEV-TSLAWRPDGKLLAVGYSDGTVRLLDAENGKI 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH