NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530380615|ref|XP_005268534|]
View 

transmembrane and coiled-coil domain-containing protein 6 isoform X1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
23-394 1.11e-09

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 60.67  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615  23 RREREAALRKARREQQLVSKRLLRnDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQ---HPET 99
Cdd:COG5064   29 REEQQVELRKQKREELLNKRRNLA-DVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSketSPPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 100 QQTFIrlEGSMRTLVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNL 176
Cdd:COG5064  108 QPVID--AGVVPRFVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 177 IVESEAVRRQLLPQGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEAPekiiPSSilastlpQHMLQMLQPGPKL-- 252
Cdd:COG5064  185 AGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPP----PDW-------SNISQALPILAKLiy 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 253 --NPGVAVEFAWCLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLSN 318
Cdd:COG5064  254 srDPEVLVDACWAISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVGN 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530380615 319 LLTEAAVETvggQMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 394
Cdd:COG5064  312 IVTGSDDQT---QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
23-394 1.11e-09

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 60.67  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615  23 RREREAALRKARREQQLVSKRLLRnDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQ---HPET 99
Cdd:COG5064   29 REEQQVELRKQKREELLNKRRNLA-DVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSketSPPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 100 QQTFIrlEGSMRTLVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNL 176
Cdd:COG5064  108 QPVID--AGVVPRFVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 177 IVESEAVRRQLLPQGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEAPekiiPSSilastlpQHMLQMLQPGPKL-- 252
Cdd:COG5064  185 AGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPP----PDW-------SNISQALPILAKLiy 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 253 --NPGVAVEFAWCLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLSN 318
Cdd:COG5064  254 srDPEVLVDACWAISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVGN 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530380615 319 LLTEAAVETvggQMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 394
Cdd:COG5064  312 IVTGSDDQT---QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
23-394 1.11e-09

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 60.67  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615  23 RREREAALRKARREQQLVSKRLLRnDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQ---HPET 99
Cdd:COG5064   29 REEQQVELRKQKREELLNKRRNLA-DVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSketSPPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 100 QQTFIrlEGSMRTLVGLLTSNQA-LLQLEAARCLHELSH--SEQSTVAEAClPATSYLLTYLSSHSSDFIELCLYTLGNL 176
Cdd:COG5064  108 QPVID--AGVVPRFVEFMDEIQRdMLQFEAAWALTNIASgtTQQTKVVVDA-GAVPLFIQLLSSTEDDVREQAVWALGNI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 177 IVESEAVRRQLLPQGIVPALAACIQS--PHVAVLEALGYALSQLLQAEEAPekiiPSSilastlpQHMLQMLQPGPKL-- 252
Cdd:COG5064  185 AGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPP----PDW-------SNISQALPILAKLiy 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530380615 253 --NPGVAVEFAWCLHYIicSQVSNpllighgalstlglllldlaGAVQKTEDAG-----LELLA-------CPVLRCLSN 318
Cdd:COG5064  254 srDPEVLVDACWAISYL--SDGPN--------------------EKIQAVLDVGipgrlVELLShesakiqTPALRSVGN 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530380615 319 LLTEAAVETvggQMQLRdervVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPV 394
Cdd:COG5064  312 IVTGSDDQT---QVIIN----CGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSS 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH