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Conserved domains on  [gi|530361777|ref|XP_005270514|]
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podocan isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-372 2.89e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 107 QLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLTNLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 186
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 187 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSSL 264
Cdd:COG4886  159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 265 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSN 343
Cdd:COG4886  231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        250       260
                 ....*....|....*....|....*....
gi 530361777 344 QLREQGIHPLAFQGLKRLHTVHLYNNALE 372
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 181-588 3.35e-19

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 92.22  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 181 KIYGLTFgQKPNLRSVYLHNNKLAdAGLPDNMFNGSSNVEVLILSSN-FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFS 259
Cdd:PLN00113  84 KISSAIF-RLPYIQTINLSNNQLS-GPIPDDIFTTSSSLRYLNLSNNnFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 260 ELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPA--GLPRSLVLLHLEKNAIRS------------- 323
Cdd:PLN00113 162 SFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQLVgQIPRelGQMKSLKWIYLGYNNLSGeipyeiggltsln 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 324 ----VDANVLTPIRS-------LEYLLLHSNQLREQgIHPLAFqGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH--- 389
Cdd:PLN00113 240 hldlVYNNLTGPIPSslgnlknLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHlfs 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 390 NQITGIGREDFATTYFLEELNLSYNRItSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVK--RNELAALA 467
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLIlfSNSLEGEI 396

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 468 RGALVGMAQLRELYLTSNRLRSRAlgPRAWVDLAHLQLLDIAGNQLT--------EIPeglpeSLEYLYLQNNKISAVPA 539
Cdd:PLN00113 397 PKSLGACRSLRRVRLQDNSFSGEL--PSEFTKLPLVYFLDISNNNLQgrinsrkwDMP-----SLQMLSLARNKFFGGLP 469

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 530361777 540 NAFDSTpNLKGIFLRFNKLAvgSVVDSAFRRLKHLQVLDIEGNLEFGDI 588
Cdd:PLN00113 470 DSFGSK-RLENLDLSRNQFS--GAVPRKLGSLSELMQLKLSENKLSGEI 515
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-98 4.35e-04

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 4.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530361777    68 CPRDCACSqEGVVDCGGIDLREFPGDLPEHT 98
Cdd:smart00013   2 CPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-372 2.89e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 107 QLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLTNLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 186
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 187 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSSL 264
Cdd:COG4886  159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 265 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSN 343
Cdd:COG4886  231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        250       260
                 ....*....|....*....|....*....
gi 530361777 344 QLREQGIHPLAFQGLKRLHTVHLYNNALE 372
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-308 1.93e-21

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 99.00  E-value: 1.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  55 SPEEPGPG-PAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELSRlhRLETLNLQNNRLT 133
Cdd:PRK15370 157 APAKEAANrEEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSNQLT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 134 SrgLPEKAFEHLTNLNylyLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD--- 210
Cdd:PRK15370 234 S--IPATLPDTIQEME---LSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgit 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 211 --NMFNGS---------SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsSLRELYLQNNYLT 275
Cdd:PRK15370 308 hlNVQSNSltalpetlpPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALT 380

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 530361777 276 D--EGLDnetfwklSSLEYLDLSSNNLSRVPAGLP 308
Cdd:PRK15370 381 NlpENLP-------AALQIMQASRNNLVRLPESLP 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 181-588 3.35e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 92.22  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 181 KIYGLTFgQKPNLRSVYLHNNKLAdAGLPDNMFNGSSNVEVLILSSN-FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFS 259
Cdd:PLN00113  84 KISSAIF-RLPYIQTINLSNNQLS-GPIPDDIFTTSSSLRYLNLSNNnFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 260 ELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPA--GLPRSLVLLHLEKNAIRS------------- 323
Cdd:PLN00113 162 SFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQLVgQIPRelGQMKSLKWIYLGYNNLSGeipyeiggltsln 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 324 ----VDANVLTPIRS-------LEYLLLHSNQLREQgIHPLAFqGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH--- 389
Cdd:PLN00113 240 hldlVYNNLTGPIPSslgnlknLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHlfs 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 390 NQITGIGREDFATTYFLEELNLSYNRItSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVK--RNELAALA 467
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLIlfSNSLEGEI 396

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 468 RGALVGMAQLRELYLTSNRLRSRAlgPRAWVDLAHLQLLDIAGNQLT--------EIPeglpeSLEYLYLQNNKISAVPA 539
Cdd:PLN00113 397 PKSLGACRSLRRVRLQDNSFSGEL--PSEFTKLPLVYFLDISNNNLQgrinsrkwDMP-----SLQMLSLARNKFFGGLP 469

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 530361777 540 NAFDSTpNLKGIFLRFNKLAvgSVVDSAFRRLKHLQVLDIEGNLEFGDI 588
Cdd:PLN00113 470 DSFGSK-RLENLDLSRNQFS--GAVPRKLGSLSELMQLKLSENKLSGEI 515
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
247-558 1.44e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 247 NNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 326
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 327 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGrEDFATTY 404
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 405 FLEELNLSYNRITSpqvhrdafrklrllrsldlsgnrlhtLPPGLPR--NVHVLKVKRNELAALArGALVGMAQLRELYL 482
Cdd:COG4886  160 NLKSLDLSNNQLTD--------------------------LPEELGNltNLKELDLSNNQITDLP-EPLGNLTNLEELDL 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530361777 483 TSNRLRSRalgPRAWVDLAHLQLLDIAGNQLTEIPE--GLPeSLEYLYLQNNKISAVPANAfdSTPNLKGIFLRFNKL 558
Cdd:COG4886  213 SGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
238-300 9.55e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 9.55e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361777  238 PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 300
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 222-424 2.43e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 2.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 222 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 299
Cdd:cd21340    7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 300 LSRVpAGL--PRSLVLLHLEKNAIRS-----VDANVLTPI-RSLEYLLLHSNQLREqgIHPLAfqGLKRLhtvhlynnal 371
Cdd:cd21340   80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDS--LEPLA--PLRNL---------- 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530361777 372 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQVHRD 424
Cdd:cd21340  145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
LRR_8 pfam13855
Leucine rich repeat;
451-513 5.35e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361777  451 RNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSraLGPRAWVDLAHLQLLDIAGNQL 513
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 314-556 3.99e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 314 LHLEKNAIRSVDAnvLTPIRSLEYLLLHSNQLREqgIHPLAFqgLKRLHTVHLYNNALERVP--SGLPRrvrtlmilhnq 391
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITK--IENLEF--LTNLTHLYLQNNQIEKIEnlENLVN----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 392 itgigredfattyfLEELNLSYNRITspqvhrdafrklrllrsldlsgnrlhtlppglprnvhVLKvkrnelaalargAL 471
Cdd:cd21340   70 --------------LKKLYLGGNRIS-------------------------------------VVE------------GL 86

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 472 VGMAQLRELYLTSNRLRSR---ALGPRAWVDLAH-LQLLDIAGNQLTEIpEGLP--ESLEYLYLQNNKISAVP--ANAFD 543
Cdd:cd21340   87 ENLTNLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplRNLEQLDASNNQISDLEelLDLLS 165

                        250
                 ....*....|...
gi 530361777 544 STPNLKGIFLRFN 556
Cdd:cd21340  166 SWPSLRELDLTGN 178
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-98 4.35e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 4.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530361777    68 CPRDCACSqEGVVDCGGIDLREFPGDLPEHT 98
Cdd:smart00013   2 CPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-372 2.89e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 107 QLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLTNLNYLYLANNKLTLAPRFLPNAlisvdfaanyltkiyglt 186
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPLGNL------------------ 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 187 fgqkPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHL--PPALYKLHLKNNKLEKIPPgAFSELSSL 264
Cdd:COG4886  159 ----TNLKSLDLSNNQLTD--LPEELGN-LTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 265 RELYLQNNYLTdeglDNETFWKLSSLEYLDLSSNNLSRVPAGLP-RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSN 343
Cdd:COG4886  231 ETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        250       260
                 ....*....|....*....|....*....
gi 530361777 344 QLREQGIHPLAFQGLKRLHTVHLYNNALE 372
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-375 1.63e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 1.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 101 LSLQNNQLEKIyPEELSRLHRLETLNLQNNRLTSrgLPEkAFEHLTNLNYLYLANNKLTLAPRFLPN--ALISVDFAANY 178
Cdd:COG4886  118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPE-PLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 179 LTKIyGLTFGQKPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVP--KHLpPALYKLHLKNNKLEKIPPG 256
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTD--LPEPLAN-LTNLETLDLSNNQLTDLPelGNL-TNLEELDLSNNQLTDLPPL 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 257 AfsELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLE 336
Cdd:COG4886  269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 530361777 337 YLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVP 375
Cdd:COG4886  347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-308 1.93e-21

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 99.00  E-value: 1.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  55 SPEEPGPG-PAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIyPEELSRlhRLETLNLQNNRLT 133
Cdd:PRK15370 157 APAKEAANrEEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSNQLT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 134 SrgLPEKAFEHLTNLNylyLANNKLTLAPRFLPNALISVDFAANYLTKIYGlTFGQKPNLRSVYLHNNKLADAGLPD--- 210
Cdd:PRK15370 234 S--IPATLPDTIQEME---LSINRITELPERLPSALQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSgit 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 211 --NMFNGS---------SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKL----EKIPPgafselsSLRELYLQNNYLT 275
Cdd:PRK15370 308 hlNVQSNSltalpetlpPGLKTLEAGENALTSLPASLPPELQVLDVSKNQItvlpETLPP-------TITTLDVSRNALT 380

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 530361777 276 D--EGLDnetfwklSSLEYLDLSSNNLSRVPAGLP 308
Cdd:PRK15370 381 NlpENLP-------AALQIMQASRNNLVRLPESLP 408
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-372 1.51e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 1.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  98 TNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAAN 177
Cdd:COG4886   20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 178 YLTKIYGLTFGQKPNLRSVYLHNNKLADagLPDNMFNgSSNVEVLILSSNFLRHVPKHLP--PALYKLHLKNNKLEKIPP 255
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELAN-LTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 256 gAFSELSSLRELYLQNNYLTDEGldnETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDAnvLTPIR 333
Cdd:COG4886  177 -ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLT 250

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 530361777 334 SLEYLLLHSNQLREqgIHPLAfqGLKRLHTVHLYNNALE 372
Cdd:COG4886  251 NLEELDLSNNQLTD--LPPLA--NLTNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 181-588 3.35e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 92.22  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 181 KIYGLTFgQKPNLRSVYLHNNKLAdAGLPDNMFNGSSNVEVLILSSN-FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFS 259
Cdd:PLN00113  84 KISSAIF-RLPYIQTINLSNNQLS-GPIPDDIFTTSSSLRYLNLSNNnFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 260 ELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPA--GLPRSLVLLHLEKNAIRS------------- 323
Cdd:PLN00113 162 SFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQLVgQIPRelGQMKSLKWIYLGYNNLSGeipyeiggltsln 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 324 ----VDANVLTPIRS-------LEYLLLHSNQLREQgIHPLAFqGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH--- 389
Cdd:PLN00113 240 hldlVYNNLTGPIPSslgnlknLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHlfs 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 390 NQITGIGREDFATTYFLEELNLSYNRItSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVK--RNELAALA 467
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLIlfSNSLEGEI 396

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 468 RGALVGMAQLRELYLTSNRLRSRAlgPRAWVDLAHLQLLDIAGNQLT--------EIPeglpeSLEYLYLQNNKISAVPA 539
Cdd:PLN00113 397 PKSLGACRSLRRVRLQDNSFSGEL--PSEFTKLPLVYFLDISNNNLQgrinsrkwDMP-----SLQMLSLARNKFFGGLP 469

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 530361777 540 NAFDSTpNLKGIFLRFNKLAvgSVVDSAFRRLKHLQVLDIEGNLEFGDI 588
Cdd:PLN00113 470 DSFGSK-RLENLDLSRNQFS--GAVPRKLGSLSELMQLKLSENKLSGEI 515
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 118-588 3.38e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 92.22  E-value: 3.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 118 RLHRLETLNLQNNRLtSRGLPEKAFEHLTNLNYLYLANNKLTLA-PR-FLPNaLISVDFAANYLT-KIYgLTFGQKPNLR 194
Cdd:PLN00113  91 RLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTGSiPRgSIPN-LETLDLSNNMLSgEIP-NDIGSFSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 195 SVYLHNNKLAdAGLPDNMFNGSSnVEVLILSSN-FLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQN 271
Cdd:PLN00113 168 VLDLGGNVLV-GKIPNSLTNLTS-LEFLTLASNqLVGQIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 272 NYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL--PRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLreQ 348
Cdd:PLN00113 246 NNLT--GPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF--T 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 349 GIHPLAFQGLKRLHTVHLYNNALE-RVPSGLPRR--VRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSpqvhrda 425
Cdd:PLN00113 322 GKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnnLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEG------- 394

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 426 frklrllrsldlsgnrlhTLPPGLP--RNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRaLGPRAWvDLAHL 503
Cdd:PLN00113 395 ------------------EIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR-INSRKW-DMPSL 454

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 504 QLLDIAGNQLTeipEGLPES-----LEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAvgSVVDSAFRRLKHLQVLD 578
Cdd:PLN00113 455 QMLSLARNKFF---GGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVSLD 529

                        490
                 ....*....|
gi 530361777 579 IEGNLEFGDI 588
Cdd:PLN00113 530 LSHNQLSGQI 539
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-417 6.32e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 6.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 106 NQLEKIYPEELSRLHRLETLNLQNNRLTsrGLPEKAFEHLTNLNYLYLANNKLT--LAPR-FLPNALISVDFAANYLTKI 182
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLT--GPIPSSLGNLKNLQYLFLYQNKLSgpIPPSiFSLQKLISLDLSDNSLSGE 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 183 YGLTFGQKPNLRSVYLHNNKL------ADAGLP--------DNMFNGS--------SNVEVLILSSNFLR-HVPKHLPPA 239
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFtgkipvALTSLPrlqvlqlwSNKFSGEipknlgkhNNLTVLDLSTNNLTgEIPEGLCSS 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 240 --LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEgLDNEtFWKLSSLEYLDLSSNNLS-RVPAG---LPrSLVL 313
Cdd:PLN00113 380 gnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGE-LPSE-FTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQM 456

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 314 LHLEKNairSVDANVLTPIRS--LEYLLLHSNQLreQGIHPLAFQGLKRLHTVHLYNNALE-RVPSGLP--RRVRTLMIL 388
Cdd:PLN00113 457 LSLARN---KFFGGLPDSFGSkrLENLDLSRNQF--SGAVPRKLGSLSELMQLKLSENKLSgEIPDELSscKKLVSLDLS 531

                        330       340
                 ....*....|....*....|....*....
gi 530361777 389 HNQITGIGREDFATTYFLEELNLSYNRIT 417
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-560 2.02e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 2.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 101 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTsrGLPEKAFEHLTNLNYLYLANNKLT-LAPRFL-------------- 165
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQLVgQIPRELgqmkslkwiylgyn 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 166 ------PN------ALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAgLPDNMFnGSSNVEVLILSSNFLR-HV 232
Cdd:PLN00113 223 nlsgeiPYeiggltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSgEI 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 233 PKHLP--PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNetFWKLSSLEYLDLSSNNLS-RVPAGLPR 309
Cdd:PLN00113 301 PELVIqlQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKN--LGKHNNLTVLDLSTNNLTgEIPEGLCS 378

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 310 S--LVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLreQGIHPLAFQGLKRLHTVHLYNNALE-RVPSG---LPrRVR 383
Cdd:PLN00113 379 SgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF--SGELPSEFTKLPLVYFLDISNNNLQgRINSRkwdMP-SLQ 455

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 384 TLMILHNQITGiGREDFATTYFLEELNLSYNRITSpqvhrdafrklrllrsldLSGNRLHTLPpglprNVHVLKVKRNEL 463
Cdd:PLN00113 456 MLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSG------------------AVPRKLGSLS-----ELMQLKLSENKL 511

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 464 AALARGALVGMAQLRELYLTSNRLRSRAlgPRAWVDLAHLQLLDIAGNQLT-EIPEGLP--ESLEYLYLQNNKISAvpan 540
Cdd:PLN00113 512 SGEIPDELSSCKKLVSLDLSHNQLSGQI--PASFSEMPVLSQLDLSQNQLSgEIPKNLGnvESLVQVNISHNHLHG---- 585

                        490       500
                 ....*....|....*....|
gi 530361777 541 afdSTPNlKGIFLRFNKLAV 560
Cdd:PLN00113 586 ---SLPS-TGAFLAINASAV 601
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
200-535 7.08e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 7.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 200 NNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNyltdegl 279
Cdd:COG4886   34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 280 dnETFWKLSSLEYLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDAnVLTPIRSLEYLLLHSNQLREQgihPLAFQG 357
Cdd:COG4886  107 --EELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL---PEELGN 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 358 LKRLHTVHLYNNALERVPSGLPRRVRtlmilhnqitgigredfattyfLEELNLSYNRITSpqvhrdafrklrllrsldl 437
Cdd:COG4886  181 LTNLKELDLSNNQITDLPEPLGNLTN----------------------LEELDLSGNQLTD------------------- 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 438 sgnrlhtLPPGLPRnvhvlkvkrnelaalargalvgMAQLRELYLTSNRLRS-RALGprawvDLAHLQLLDIAGNQLTEI 516
Cdd:COG4886  220 -------LPEPLAN----------------------LTNLETLDLSNNQLTDlPELG-----NLTNLEELDLSNNQLTDL 265

                        330       340
                 ....*....|....*....|
gi 530361777 517 PEGLP-ESLEYLYLQNNKIS 535
Cdd:COG4886  266 PPLANlTNLKTLDLSNNQLT 285
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
139-466 2.26e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 2.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 139 EKAFEHL-----TNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKiygLTFGQKPNLRSVYLHNNKLAD--AGLPDN 211
Cdd:PRK15370 166 EEAVQRMrdclkNNKTELRLKILGLTTIPACIPEQITTLILDNNELKS---LPENLQGNIKTLYANSNQLTSipATLPDT 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 212 mfngssnVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPpgafselsslrelylqnNYLTDEgldnetfwklssLE 291
Cdd:PRK15370 243 -------IQEMELSINRITELPERLPSALQSLDLFHNKISCLP-----------------ENLPEE------------LR 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 292 YLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVltpirsleylllhsnqlreqgihPLAfqglkrLHTVHLYNNAL 371
Cdd:PRK15370 287 YLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETL-----------------------PPG------LKTLEAGENAL 337

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 372 ERVPSGLPRRVRTLMILHNQITgIGREDFATTyfLEELNLSYNRITSpqvhrdafrklrllrsldlsgnrlhtLPPGLPR 451
Cdd:PRK15370 338 TSLPASLPPELQVLDVSKNQIT-VLPETLPPT--ITTLDVSRNALTN--------------------------LPENLPA 388

                        330
                 ....*....|....*
gi 530361777 452 NVHVLKVKRNELAAL 466
Cdd:PRK15370 389 ALQIMQASRNNLVRL 403
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
300-540 4.15e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 4.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 300 LSRVPAGLPRSLVLLHLEKNAIRSVDANvltpirsleyllLHSNqlreqgihplafqglkrLHTVHLYNNALERVPSGLP 379
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPEN------------LQGN-----------------IKTLYANSNQLTSIPATLP 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 380 RRVRTLMILHNQITGIgREDFATTyfLEELNLSYNRITS-PQVHRDAFRKLRLLRsldlsgNRLHTLPPGLPRNVHVLKV 458
Cdd:PRK15370 241 DTIQEMELSINRITEL-PERLPSA--LQSLDLFHNKISClPENLPEELRYLSVYD------NSIRTLPAHLPSGITHLNV 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 459 KRNELAALARGALVGmaqLRELYLTSNRLRS--RALGPRawvdlahLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISA 536
Cdd:PRK15370 312 QSNSLTALPETLPPG---LKTLEAGENALTSlpASLPPE-------LQVLDVSKNQITVLPETLPPTITTLDVSRNALTN 381


                 ....
gi 530361777 537 VPAN 540
Cdd:PRK15370 382 LPEN 385
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
247-558 1.44e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 247 NNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 326
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 327 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGrEDFATTY 404
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 405 FLEELNLSYNRITSpqvhrdafrklrllrsldlsgnrlhtLPPGLPR--NVHVLKVKRNELAALArGALVGMAQLRELYL 482
Cdd:COG4886  160 NLKSLDLSNNQLTD--------------------------LPEELGNltNLKELDLSNNQITDLP-EPLGNLTNLEELDL 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530361777 483 TSNRLRSRalgPRAWVDLAHLQLLDIAGNQLTEIPE--GLPeSLEYLYLQNNKISAVPANAfdSTPNLKGIFLRFNKL 558
Cdd:COG4886  213 SGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
238-300 9.55e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 9.55e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361777  238 PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNL 300
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 222-424 2.43e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 2.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 222 LILSSNFLRHVPK-HLPPALYKLHLKNNKLEKIPpgAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNN 299
Cdd:cd21340    7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKiENLEN-----LVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 300 LSRVpAGL--PRSLVLLHLEKNAIRS-----VDANVLTPI-RSLEYLLLHSNQLREqgIHPLAfqGLKRLhtvhlynnal 371
Cdd:cd21340   80 ISVV-EGLenLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDS--LEPLA--PLRNL---------- 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530361777 372 ervpsglprrvRTLMILHNQITGIGR--EDFATTYFLEELNLSYNRITSPQVHRD 424
Cdd:cd21340  145 -----------EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRD 188
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
55-385 2.47e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 66.72  E-value: 2.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  55 SPEEPGPGPAAVSCP-RDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKI--YPEElsrlhrLETLNLQNNR 131
Cdd:PRK15387 180 APAEESRGRAAVVQKmRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLpaLPPE------LRTLEVSGNQ 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 132 LTSRG-LPEKAFEhltnlnyLYLANNKLTLAPRfLPNALISVDFAANYLTKIYGLtfgqKPNLRSVYLHNNKLAD-AGLP 209
Cdd:PRK15387 254 LTSLPvLPPGLLE-------LSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLPVL----PPGLQELSVSDNQLASlPALP 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 210 DNM-----FNGS--------SNVEVLILSSNFLRHVPKhLPPALYKLHLKNNKLEKIPpgafSELSSLRELYLQNNYLTD 276
Cdd:PRK15387 322 SELcklwaYNNQltslptlpSGLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTS 396

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 277 EGLdnetfwKLSSLEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVDANvLTPIRSLEYLLLHSNQLREQgihplAFQ 356
Cdd:PRK15387 397 LPV------LPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPES-LIHLSSETTVNLEGNPLSER-----TLQ 463

                        330       340       350
                 ....*....|....*....|....*....|..
gi 530361777 357 GLKRLHTVHLYNNAL---ERVPSGLPRRVRTL 385
Cdd:PRK15387 464 ALREITSAPGYSGPIirfDMAGASAPRETRAL 495
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 119-343 6.35e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 6.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 119 LHRLETLNLQNNRLTSRGlpekAFEHLTNLNYLYLANNKltlaprflpnalisvdfaanyLTKIYGLTFGqkPNLRSVYL 198
Cdd:cd21340    1 LKRITHLYLNDKNITKID----NLSLCKNLKVLYLYDNK---------------------ITKIENLEFL--TNLTHLYL 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 199 HNNKladaglpdnmfngssnvevlILSSNFLRHVPKhlppaLYKLHLKNNKLEKIppGAFSELSSLRELYLQNNYL-TDE 277
Cdd:cd21340   54 QNNQ--------------------IEKIENLENLVN-----LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLpPGE 106

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530361777 278 GL--DNETFWKLS-SLEYLDLSSNNLSRV-PAGLPRSLVLLHLEKNAIRSVD--ANVLTPIRSLEYLLLHSN 343
Cdd:cd21340  107 KLtfDPRSLAALSnSLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-303 9.24e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 9.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 100 HLSLQNNQLEKIypEELSRLHRLETLNLQNNRLTS-RGLpekafEHLTNLNYLYLANNKltlaprflpnalisvdfaany 178
Cdd:cd21340    6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKiENL-----EFLTNLTHLYLQNNQ--------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 179 LTKIYGLtfGQKPNLRSVYLHNNKLadaglpdnmfngsSNVEVLilssnflrhvpkHLPPALYKLHLKNNKLekiPPG-- 256
Cdd:cd21340   58 IEKIENL--ENLVNLKKLYLGGNRI-------------SVVEGL------------ENLTNLEELHIENQRL---PPGek 107

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530361777 257 -AFSELS------SLRELYLQNNYLTDegLDNetFWKLSSLEYLDLSSNNLSRV 303
Cdd:cd21340  108 lTFDPRSlaalsnSLRVLNISGNNIDS--LEP--LAPLRNLEQLDASNNQISDL 157
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 214-594 4.77e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 4.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 214 NGSSNVEVLILSSnflRHVPKHLPPALYKL------HLKNNKLE-KIPPGAFSELSSLRELYLQNNYLTdeGLDNETFwk 286
Cdd:PLN00113  66 NNSSRVVSIDLSG---KNISGKISSAIFRLpyiqtiNLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT--GSIPRGS-- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 287 LSSLEYLDLSSNNLS-RVPA--GLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLreQGIHPLAFQGLKRLHT 363
Cdd:PLN00113 139 IPNLETLDLSNNMLSgEIPNdiGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL--VGQIPRELGQMKSLKW 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 364 VHL-YNNALERVPsglprrvrtlmilhNQITGIGRedfattyfLEELNLSYNRITSPqvhrdafrklrllrsldlsgnrl 442
Cdd:PLN00113 217 IYLgYNNLSGEIP--------------YEIGGLTS--------LNHLDLVYNNLTGP----------------------- 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 443 htLPPglprnvhvlkvkrnelaalargALVGMAQLRELYLTSNRLRSRAlgPRAWVDLAHLQLLDIAGNQLT-EIPEGLP 521
Cdd:PLN00113 252 --IPS----------------------SLGNLKNLQYLFLYQNKLSGPI--PPSIFSLQKLISLDLSDNSLSgEIPELVI 305

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530361777 522 E--SLEYLYLQNNKISAVPANAFDSTPnlkgiflrfnklavgsvvdsafrrlkHLQVLDIEGNLEFGDISKDRGR 594
Cdd:PLN00113 306 QlqNLEILHLFSNNFTGKIPVALTSLP--------------------------RLQVLQLWSNKFSGEIPKNLGK 354
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 234-417 5.34e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 5.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 234 KHLPPALYKLHLKNNKLEKIPPG------AFSELSSLRELYLQNNYLTDEGLDN-ETFWKLSSLEYLDLSSNNLS----- 301
Cdd:cd00116   47 LRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGdrglr 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 302 ---RVPAGLPRSLVLLHLEKNAIRSVD----ANVLTPIRSLEYLLLHSNQLREQGIHPLAfQGLK---RLHTVHLYNNAL 371
Cdd:cd00116  127 llaKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALA-EGLKancNLEVLDLNNNGL 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530361777 372 ERVPSGL-------PRRVRTLMILHNQITGIGREDFATTYF-----LEELNLSYNRIT 417
Cdd:cd00116  206 TDEGASAlaetlasLKSLEVLNLGDNNLTDAGAAALASALLspnisLLTLSLSCNDIT 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 101-304 8.83e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 8.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 101 LSLQNNQLEKIypEELSRLHRLETLNLQNNRLTS-RGLpekafEHLTNLNYLYLANNKltlaprflpnalISVdfaanyl 179
Cdd:cd21340   29 LYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKiENL-----ENLVNLKKLYLGGNR------------ISV------- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 180 tkIYGLTfgQKPNLRSVYLHNNKLAdaglPDNMFngSSNVEVLILSSNFLRHvpkhlppalykLHLKNNKLEKIPPgaFS 259
Cdd:cd21340   83 --VEGLE--NLTNLEELHIENQRLP----PGEKL--TFDPRSLAALSNSLRV-----------LNISGNNIDSLEP--LA 139

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 530361777 260 ELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 304
Cdd:cd21340  140 PLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 101-374 2.25e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 101 LSLQNNQLEKIYPEELSRLHR-LETLNLQNNRLTSRGLP--EKAFEHLTNLNYLYLANNKLTLAPRFLpnalisvDFAAN 177
Cdd:cd00116    3 LSLKGELLKTERATELLPKLLcLQVLRLEGNTLGEEAAKalASALRPQPSLKELCLSLNETGRIPRGL-------QSLLQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 178 YLTKIYGLT-------------------FGQKPNLRSVYLHNNKLADAGLPdnmfngssnvevlilssnFLRHVPKHLPP 238
Cdd:cd00116   76 GLTKGCGLQeldlsdnalgpdgcgvlesLLRSSSLQELKLNNNGLGDRGLR------------------LLAKGLKDLPP 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 239 ALYKLHLKNNKLEKIP----PGAFSELSSLRELYLQNNYLTDEGLDN--ETFWKLSSLEYLDLSSNnlsrvpaglprslV 312
Cdd:cd00116  138 ALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEVLDLNNN-------------G 204

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530361777 313 LLHLEKNAIrsvdANVLTPIRSLEYLLLHSNQLREQGIHPLAFQ---GLKRLHTVHLYNNALERV 374
Cdd:cd00116  205 LTDEGASAL----AETLASLKSLEVLNLGDNNLTDAGAAALASAllsPNISLLTLSLSCNDITDD 265
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
290-556 3.08e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.71  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 290 LEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVDAnvlTPiRSLEYLLLHSNQLREQGIHPLAFQGLKrlhtvhLYNN 369
Cdd:PRK15387 244 LRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLPA---LP-SGLCKLWIFGNQLTSLPVLPPGLQELS------VSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 370 ALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITS-PQVHRDAFRklrllrsLDLSGNRLHTLPpG 448
Cdd:PRK15387 313 QLASLPA-LPSELCKLWAYNNQLTSLP----TLPSGLQELSVSDNQLASlPTLPSELYK-------LWAYNNRLTSLP-A 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 449 LPRNVHVLKVKRNELAALArgalVGMAQLRELYLTSNRLRSRALGPRAWVDLAhlqlldIAGNQLTEIPEGLPE--SLEY 526
Cdd:PRK15387 380 LPSGLKELIVSGNRLTSLP----VLPSELKELMVSGNRLTSLPMLPSGLLSLS------VYRNQLTRLPESLIHlsSETT 449

                        250       260       270
                 ....*....|....*....|....*....|...
gi 530361777 527 LYLQNNKISAVPANAF---DSTPNLKGIFLRFN 556
Cdd:PRK15387 450 VNLEGNPLSERTLQALreiTSAPGYSGPIIRFD 482
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
414-540 3.58e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 3.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 414 NRITSPQVHRDAFRKLRLLRSLDLSGnrLHTLPPGLPRNVHVLKVKRNELAALARGAlvgMAQLRELYLTSNRLRS---- 489
Cdd:PRK15370 164 NREEAVQRMRDCLKNNKTELRLKILG--LTTIPACIPEQITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSipat 238

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361777 490 -------RALGPRAWVDL-----AHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPAN 540
Cdd:PRK15370 239 lpdtiqeMELSINRITELperlpSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAH 301
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
359-582 4.21e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 4.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 359 KRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIgREDFATTyfLEELNLSYNRITSpqvhrdafrklrllrsldls 438
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDT--IQEMELSINRITE-------------------- 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 439 gnrlhtLPPGLPRNVHVLKVKRNELAALargalvgmaqlrelyltsnrlrsralgPRAWVDlaHLQLLDIAGNQLTEIPE 518
Cdd:PRK15370 256 ------LPERLPSALQSLDLFHNKISCL---------------------------PENLPE--ELRYLSVYDNSIRTLPA 300

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530361777 519 GLPESLEYLYLQNNKISAVPANAfdsTPNLKgiFLRFNKLAVGSVVDSAfrrLKHLQVLDIEGN 582
Cdd:PRK15370 301 HLPSGITHLNVQSNSLTALPETL---PPGLK--TLEAGENALTSLPASL---PPELQVLDVSKN 356
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
208-492 7.21e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.55  E-value: 7.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 208 LPDNMfngSSNVEVLILSSNFLRHVPKhLPPALYKLHLKNNKLEKIP---PGafselssLRELYLQNNYLTD-EGLDnet 283
Cdd:PRK15387 216 LPDCL---PAHITTLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLPvlpPG-------LLELSIFSNPLTHlPALP--- 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 284 fwklSSLEYLDLSSNNLSRVPAgLPRSLVLLHLEKNAIRSVDAnvlTPiRSLEYLLLHSNQLREQGIHPLAFQGLKrlht 363
Cdd:PRK15387 282 ----SGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLPA---LP-SELCKLWAYNNQLTSLPTLPSGLQELS---- 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 364 vhLYNNALERVPSgLPRRVRTLMILHNQITGIGredfATTYFLEELNLSYNRITSPQVHRDAFRKLRLLrsldlsGNRLH 443
Cdd:PRK15387 349 --VSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPVLPSELKELMVS------GNRLT 415

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 530361777 444 TLPPgLPRNVHVLKVKRNELAALARgALVGMAQLRELYLTSNRLRSRAL 492
Cdd:PRK15387 416 SLPM-LPSGLLSLSVYRNQLTRLPE-SLIHLSSETTVNLEGNPLSERTL 462
LRR_8 pfam13855
Leucine rich repeat;
101-158 2.19e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.19e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530361777  101 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSrgLPEKAFEHLTNLNYLYLANNKL 158
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
191-274 2.47e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  191 PNLRSVYLHNNKLADagLPDNMFNGSSNVEVLILSsnflrhvpkhlppalyklhlkNNKLEKIPPGAFSELSSLRELYLQ 270
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLS---------------------NNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 530361777  271 NNYL 274
Cdd:pfam13855  58 GNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 243-440 4.18e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 243 LHLKNNKLEKIppGAFSELSSLRELYLQNNYLTD-EGLDNetfwkLSSLEYLDLSSNNLSRVP--AGLPRsLVLLHLEKN 319
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKiENLEF-----LTNLTHLYLQNNQIEKIEnlENLVN-LKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 320 AIRSVDAnvLTPIRSLEYLLLHSNQLREQgiHPLAFQglkrlhtvhlynnalERVPSGLPRRVRTLMILHNQITGIgrED 399
Cdd:cd21340   79 RISVVEG--LENLTNLEELHIENQRLPPG--EKLTFD---------------PRSLAALSNSLRVLNISGNNIDSL--EP 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 530361777 400 FATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGN 440
Cdd:cd21340  138 LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-418 4.97e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 4.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  75 SQEGVVDCGGIDLREFPGDLPEHTNHLS---LQNNQLEKIYPEELSRL--HRLETLNLQNNRLTSRGLPekafehltnln 149
Cdd:COG5238   64 RFEGQGDPGLNPVALEKAAEAFPTQLLVvdwEGAEEVSPVALAETATAvaTPPPDLRRIMAKTLEDSLI----------- 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 150 yLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLT-------FGQKPNLRSVYLHNNKLADAGLPD--NMFNGSSNVE 220
Cdd:COG5238  133 -LYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLaaismakALQNNSVETVYLGCNQIGDEGIEElaEALTQNTTVT 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 221 VLILSSNflrHVPKHLPPALYKlHLKNNKlekippgafselsSLRELYLQNNYLTDEGLDN--ETFWKLSSLEYLDLSSN 298
Cdd:COG5238  212 TLWLKRN---PIGDEGAEILAE-ALKGNK-------------SLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGN 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 299 NLSrvpaglprslvllhlEKNAIRSvdANVLTPIRSLEYLLLHSNQLREQGIHPLA--FQGLKRLHTVHL-YNNALERVP 375
Cdd:COG5238  275 QIG---------------AEGAIAL--AKALQGNTTLTSLDLSVNRIGDEGAIALAegLQGNKTLHTLNLaYNGIGAQGA 337

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530361777 376 SGLPRRVRTLMILH------NQITGIGREDFATtyFLE------ELNLSYNRITS 418
Cdd:COG5238  338 IALAKALQENTTLHsldlsdNQIGDEGAIALAK--YLEgnttlrELNLGKNNIGK 390
LRR_8 pfam13855
Leucine rich repeat;
451-513 5.35e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361777  451 RNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSraLGPRAWVDLAHLQLLDIAGNQL 513
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
262-345 9.93e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 9.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  262 SSLRELYLQNNYLTDegLDNETFWKLSSLEYLDLSSNNLSrvpaglprslvllhleknairSVDANVLTPIRSLEYLLLH 341
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT---------------------TLSPGAFSGLPSLRYLDLS 57


                  ....
gi 530361777  342 SNQL 345
Cdd:pfam13855  58 GNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
363-571 2.56e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.55  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 363 TVHLYNNALERVPSgLPRRVRTLMILHNQITGIGredfattyFLEELNLSYNRITSPQVHRDAFrkLRLLRSLDLSGNRL 442
Cdd:PRK15387 226 TLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLP--------VLPPGLLELSIFSNPLTHLPAL--PSGLCKLWIFGNQL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 443 HTLPPgLPRNVHVLKVKRNELAALArgALVgmAQLRELYLTSNRLRSRALGPRAwvdlahLQLLDIAGNQLTEIPEgLPE 522
Cdd:PRK15387 295 TSLPV-LPPGLQELSVSDNQLASLP--ALP--SELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLPT-LPS 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 530361777 523 SLEYLYLQNNKISAVPAnafdSTPNLKGIFLRFNKLAVGSVVDSAFRRL 571
Cdd:PRK15387 363 ELYKLWAYNNRLTSLPA----LPSGLKELIVSGNRLTSLPVLPSELKEL 407
LRR_8 pfam13855
Leucine rich repeat;
523-583 2.98e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 2.98e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530361777  523 SLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLavGSVVDSAFRRLKHLQVLDIEGNL 583
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
476-534 3.96e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.96e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361777  476 QLRELYLTSNRLRSraLGPRAWVDLAHLQLLDIAGNQLTEIPE----GLPeSLEYLYLQNNKI 534
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
121-203 1.10e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  121 RLETLNLQNNRLTSrgLPEKAFEHLTNLNYLYLANNKLTlapRFLPNALisvdfaanyltkiYGLtfgqkPNLRSVYLHN 200
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT---TLSPGAF-------------SGL-----PSLRYLDLSG 58


                  ...
gi 530361777  201 NKL 203
Cdd:pfam13855  59 NRL 61
LRR_8 pfam13855
Leucine rich repeat;
502-558 5.39e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 5.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  502 HLQLLDIAGNQLTEIPEGL---PESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 558
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 75-298 1.26e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  75 SQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLE----KIYPEELSRLHRLETLNLQNNRLTSRGLPE--KAFEHLTNL 148
Cdd:cd00116  116 NNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 149 NYLYLANNKLTLAPrflpnaliSVDFAAnyltkiyglTFGQKPNLRSVYLHNNKLADAGLPDnmfngssnvevlILSSNf 228
Cdd:cd00116  196 EVLDLNNNGLTDEG--------ASALAE---------TLASLKSLEVLNLGDNNLTDAGAAA------------LASAL- 245

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530361777 229 lrhvpKHLPPALYKLHLKNNKLEKIPPGAFSEL----SSLRELYLQNNYLTDEG---LDNETFWKLSSLEYLDLSSN 298
Cdd:cd00116  246 -----LSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGEEGaqlLAESLLEPGNELESLWVKDD 317
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 314-556 3.99e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 314 LHLEKNAIRSVDAnvLTPIRSLEYLLLHSNQLREqgIHPLAFqgLKRLHTVHLYNNALERVP--SGLPRrvrtlmilhnq 391
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITK--IENLEF--LTNLTHLYLQNNQIEKIEnlENLVN----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 392 itgigredfattyfLEELNLSYNRITspqvhrdafrklrllrsldlsgnrlhtlppglprnvhVLKvkrnelaalargAL 471
Cdd:cd21340   70 --------------LKKLYLGGNRIS-------------------------------------VVE------------GL 86

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 472 VGMAQLRELYLTSNRLRSR---ALGPRAWVDLAH-LQLLDIAGNQLTEIpEGLP--ESLEYLYLQNNKISAVP--ANAFD 543
Cdd:cd21340   87 ENLTNLEELHIENQRLPPGeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplRNLEQLDASNNQISDLEelLDLLS 165

                        250
                 ....*....|...
gi 530361777 544 STPNLKGIFLRFN 556
Cdd:cd21340  166 SWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 266-587 4.05e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 266 ELYLQNNYLTDEGLDnETFWKLSSLEYLDLSSNNLSRVPAglprslvllhleknairSVDANVLTPIRSLEYLLLHSNQL 345
Cdd:cd00116    2 QLSLKGELLKTERAT-ELLPKLLCLQVLRLEGNTLGEEAA-----------------KALASALRPQPSLKELCLSLNET 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 346 REQ----GIHPLAFQGLKRLHTVHLYNNALervpsglprrvrtlmilhnQITGIGR-EDFATTYFLEELNLSYNRItspq 420
Cdd:cd00116   64 GRIprglQSLLQGLTKGCGLQELDLSDNAL-------------------GPDGCGVlESLLRSSSLQELKLNNNGL---- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 421 vhrdafrklrllrsLDLSGNRLHTLPPGLPRNVHVLKVKRNEL-----AALArGALVGMAQLRELYLTSNRLRS---RAL 492
Cdd:cd00116  121 --------------GDRGLRLLAKGLKDLPPALEKLVLGRNRLegascEALA-KALRANRDLKELNLANNGIGDagiRAL 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 493 GpRAWVDLAHLQLLDIAGNQLTE-----IPEGLPE--SLEYLYLQNNKISAVPANAFDS-----TPNLKGIFLRFNKLAV 560
Cdd:cd00116  186 A-EGLKANCNLEVLDLNNNGLTDegasaLAETLASlkSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDITD 264

                        330       340
                 ....*....|....*....|....*....
gi 530361777 561 GSVVDSA--FRRLKHLQVLDIEGNlEFGD 587
Cdd:cd00116  265 DGAKDLAevLAEKESLLELDLRGN-KFGE 292
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-98 4.35e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 4.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530361777    68 CPRDCACSqEGVVDCGGIDLREFPGDLPEHT 98
Cdd:smart00013   2 CPAPCNCS-GTAVDCSGRGLTEVPLDLPPDT 31
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
442-539 5.87e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 442 LHTLPPGLPRNVHVLKVKRNELAALArgALVgmAQLRELYLTSNRLRSRALGPRAWVDLA-------HLQLLD------- 507
Cdd:PRK15387 213 LTTLPDCLPAHITTLVIPDNNLTSLP--ALP--PELRTLEVSGNQLTSLPVLPPGLLELSifsnpltHLPALPsglcklw 288

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530361777 508 IAGNQLTEIPEgLPESLEYLYLQNNKISAVPA 539
Cdd:PRK15387 289 IFGNQLTSLPV-LPPGLQELSVSDNQLASLPA 319
LRR_8 pfam13855
Leucine rich repeat;
406-487 1.62e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777  406 LEELNLSYNRITSpqVHRDAFRklrllrsldlsgnrlhtlppGLPrNVHVLKVKRNELAALARGALVGMAQLRELYLTSN 485
Cdd:pfam13855   3 LRSLDLSNNRLTS--LDDGAFK--------------------GLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 530361777  486 RL 487
Cdd:pfam13855  60 RL 61
LRR_8 pfam13855
Leucine rich repeat;
96-132 3.53e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530361777   96 EHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL 132
Cdd:pfam13855  25 SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 240-307 3.79e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 3.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530361777 240 LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTdeGLDNETFWKLSSLEYLDLSSNNLS-RVPAGL 307
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN--GSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 263-300 5.06e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530361777  263 SLRELYLQNNYLTDEGLdnetFWKLSSLEYLDLSSNNL 300
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNK 35
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-158 6.47e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 6.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530361777  121 RLETLNLQNNRLTSRGLPEKafehLTNLNYLYLANNKL 158
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAK----LPNLETLDLSGNNK 35
LRR_8 pfam13855
Leucine rich repeat;
309-371 7.84e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361777  309 RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLreQGIHPLAFQGLKRLHTVHLYNNAL 371
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 305-558 9.55e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 9.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 305 AGLPRSLVLLHLEKNAIRSVDANVLTPIRsleyLLLHSNQL-REQGIHPLAFQGLKRLHTVHLYNN-----ALERVPSGL 378
Cdd:COG5238  129 DSLILYLALPRRINLIQVLKDPLGGNAVH----LLGLAARLgLLAAISMAKALQNNSVETVYLGCNqigdeGIEELAEAL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 379 --PRRVRTLMILHNQITGIGREDFA----TTYFLEELNLSYNRITSPQVHrdAFRKLRLLrsldlsGNRLHTLppGLPRN 452
Cdd:COG5238  205 tqNTTVTTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIGDEGVI--ALAEALKN------NTTVETL--YLSGN 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361777 453 vhvlKVKRNELAALARgALVGMAQLRELYLTSNRlrsraLGPRAWVDLA-HLQ------LLDIAGNQLTE-----IPEGL 520
Cdd:COG5238  275 ----QIGAEGAIALAK-ALQGNTTLTSLDLSVNR-----IGDEGAIALAeGLQgnktlhTLNLAYNGIGAqgaiaLAKAL 344

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530361777 521 PE--SLEYLYLQNNKIS----AVPANAFDSTPNLKGIFLRFNKL 558
Cdd:COG5238  345 QEntTLHSLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKNNI 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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