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Conserved domains on  [gi|530362294|ref|XP_005270764|]
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N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2 [Homo sapiens]

Protein Classification

dimethylarginine dimethylaminohydrolase family protein( domain architecture ID 1904273)

dimethylarginine dimethylaminohydrolase (DdaH) family protein similar to Pseudomonas aeruginosa N(G),N(G)-dimethylarginine dimethylaminohydrolase that hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DdaH super family cl43535
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
8-181 5.29e-17

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1834:

Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 76.37  E-value: 5.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362294   8 DMMKEALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSFCSM 85
Cdd:COG1834   94 AAYREWLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTAFCP 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362294  86 AGPNLIAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYEKLK 158
Cdd:COG1834  172 LAPGLALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNAALR 236

                        170       180
                 ....*....|....*....|....*
gi 530362294 159 DHML--IPVSMSELEKVDGLLTCCS 181
Cdd:COG1834  237 AAGFevIEVDLSEFLKGGGGFHCLT 261
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
8-181 5.29e-17

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 76.37  E-value: 5.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362294   8 DMMKEALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSFCSM 85
Cdd:COG1834   94 AAYREWLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTAFCP 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362294  86 AGPNLIAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYEKLK 158
Cdd:COG1834  172 LAPGLALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNAALR 236

                        170       180
                 ....*....|....*....|....*
gi 530362294 159 DHML--IPVSMSELEKVDGLLTCCS 181
Cdd:COG1834  237 AAGFevIEVDLSEFLKGGGGFHCLT 261
PRK01388 PRK01388
arginine deiminase; Provisional
 20-85 1.40e-04

arginine deiminase; Provisional


Pssm-ID: 234949  Cd Length: 406  Bit Score: 41.30  E-value: 1.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530362294  20 NIVEMKDENATLDGGDVLFTGRE-FFVGLSKRTNQRGAEILADT-FKDYAVSTVPVAD------GLHLKSFCSM 85
Cdd:PRK01388 203 PVWDDRHGNATLEGGDVLVLGKGvVAIGMSERTSPQAIEQLARSlFKKGAAKRVLAVEipksraFMHLDTVFTM 276
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
8-181 5.29e-17

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 76.37  E-value: 5.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362294   8 DMMKEALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSFCSM 85
Cdd:COG1834   94 AAYREWLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTAFCP 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530362294  86 AGPNLIAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYEKLK 158
Cdd:COG1834  172 LAPGLALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNAALR 236

                        170       180
                 ....*....|....*....|....*
gi 530362294 159 DHML--IPVSMSELEKVDGLLTCCS 181
Cdd:COG1834  237 AAGFevIEVDLSEFLKGGGGFHCLT 261
PRK01388 PRK01388
arginine deiminase; Provisional
 20-85 1.40e-04

arginine deiminase; Provisional


Pssm-ID: 234949  Cd Length: 406  Bit Score: 41.30  E-value: 1.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530362294  20 NIVEMKDENATLDGGDVLFTGRE-FFVGLSKRTNQRGAEILADT-FKDYAVSTVPVAD------GLHLKSFCSM 85
Cdd:PRK01388 203 PVWDDRHGNATLEGGDVLVLGKGvVAIGMSERTSPQAIEQLARSlFKKGAAKRVLAVEipksraFMHLDTVFTM 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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