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Conserved domains on  [gi|530398485|ref|XP_005271781|]
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T-cell surface glycoprotein CD3 gamma chain isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgC1_CD3_gamma_delta cd07691
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; ...
 35-105 1.18e-31

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains; The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


:

Pssm-ID: 409488  Cd Length: 69  Bit Score: 109.17  E-value: 1.18e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530398485  35 DYQED-GSVLLTCDaEAKNITWFKDGKMIGFLteDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQ 105
Cdd:cd07691    1 SVKENeDKVFLKCN-SASSITWKKGTEGIEAS--DKTDLDLGSRINDPRGTYQCKGSENKEKTLQVHYRMCQ 69
 
Name Accession Description Interval E-value
IgC1_CD3_gamma_delta cd07691
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; ...
 35-105 1.18e-31

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains; The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409488  Cd Length: 69  Bit Score: 109.17  E-value: 1.18e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530398485  35 DYQED-GSVLLTCDaEAKNITWFKDGKMIGFLteDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQ 105
Cdd:cd07691    1 SVKENeDKVFLKCN-SASSITWKKGTEGIEAS--DKTDLDLGSRINDPRGTYQCKGSENKEKTLQVHYRMCQ 69
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 39-103 4.61e-31

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 107.34  E-value: 4.61e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530398485   39 DGSVLLTCDAEAKNITWFKDGKMIGFltEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRM 103
Cdd:pfam16680   1 DGKVLLTCNSSSKSITWLKDGKGIKS--TNTKTLDLGKFSEDPRGLYQCQGEKKKSSTLQVYYRM 63
 
Name Accession Description Interval E-value
IgC1_CD3_gamma_delta cd07691
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; ...
 35-105 1.18e-31

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains; The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409488  Cd Length: 69  Bit Score: 109.17  E-value: 1.18e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530398485  35 DYQED-GSVLLTCDaEAKNITWFKDGKMIGFLteDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQ 105
Cdd:cd07691    1 SVKENeDKVFLKCN-SASSITWKKGTEGIEAS--DKTDLDLGSRINDPRGTYQCKGSENKEKTLQVHYRMCQ 69
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 39-103 4.61e-31

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 107.34  E-value: 4.61e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530398485   39 DGSVLLTCDAEAKNITWFKDGKMIGFltEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRM 103
Cdd:pfam16680   1 DGKVLLTCNSSSKSITWLKDGKGIKS--TNTKTLDLGKFSEDPRGLYQCQGEKKKSSTLQVYYRM 63
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 38-90 7.33e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.08  E-value: 7.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530398485   38 EDGSVLLTCDAEAK---NITWFKDGKMIGFLTEDKKKWNLGSN--------AKDpRGMYQCKGS 90
Cdd:pfam13927  15 EGETVTLTCEATGSpppTITWYKNGEPISSGSTRSRSLSGSNStltisnvtRSD-AGTYTCVAS 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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