cotranscriptional regulator ARB2A isoform X17 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Arb2 super family | cl10738 | Arb2 domain; This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also ... |
149-198 | 3.75e-03 | ||
Arb2 domain; This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Functional studies show that the Arb2 domain is necessary for centromeric heterochromatin silencing suggesting a model where the Arb2 domain, through residues N562 and Y563, acts as an anchor that connects the HDAC activity of Clr3 to the SHREC complex. SHREC (Snf2/Hdac Repressive) complex in fission yeast drives transcriptional gene silencing in heterochromatin. The actual alignment was detected with superfamily member pfam09757: Pssm-ID: 401634 Cd Length: 252 Bit Score: 37.94 E-value: 3.75e-03
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| Name | Accession | Description | Interval | E-value | ||
| Arb2 | pfam09757 | Arb2 domain; This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also ... |
149-198 | 3.75e-03 | ||
Arb2 domain; This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Functional studies show that the Arb2 domain is necessary for centromeric heterochromatin silencing suggesting a model where the Arb2 domain, through residues N562 and Y563, acts as an anchor that connects the HDAC activity of Clr3 to the SHREC complex. SHREC (Snf2/Hdac Repressive) complex in fission yeast drives transcriptional gene silencing in heterochromatin. Pssm-ID: 401634 Cd Length: 252 Bit Score: 37.94 E-value: 3.75e-03
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| Name | Accession | Description | Interval | E-value | ||
| Arb2 | pfam09757 | Arb2 domain; This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also ... |
149-198 | 3.75e-03 | ||
Arb2 domain; This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Functional studies show that the Arb2 domain is necessary for centromeric heterochromatin silencing suggesting a model where the Arb2 domain, through residues N562 and Y563, acts as an anchor that connects the HDAC activity of Clr3 to the SHREC complex. SHREC (Snf2/Hdac Repressive) complex in fission yeast drives transcriptional gene silencing in heterochromatin. Pssm-ID: 401634 Cd Length: 252 Bit Score: 37.94 E-value: 3.75e-03
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