NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530366456|ref|XP_005273309|]
View 

C4b-binding protein alpha chain isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 65-294 6.44e-52

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 179.08  E-value: 6.44e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  65 TLTETRFKTGTTLKYTCLPGYVRSHSTQTLT-CNSDGEWVYNTfCIYKRCRHPGELRNGQVEIKtDLSFGSQIEFSCSEG 143
Cdd:PHA02927  38 TDANANYNIGDTIEYLCLPGYRKQKMGPIYAkCTGTGWTLFNQ-CIKRRCPSPRDIDNGQLDIG-GVDFGSSITYSCNSG 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 144 FFLIGSTTSRCEVQDRG-VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVene 222
Cdd:PHA02927 116 YQLIGESKSYCELGSTGsMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSG--- 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530366456 223 tiGVWRpSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
Cdd:PHA02927 193 --GEWS-DPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
C4bp_oligo pfam18453
Oligomerization domain of C4b-binding protein alpha; This is the C-terminal oligomerization ...
 541-589 3.19e-30

Oligomerization domain of C4b-binding protein alpha; This is the C-terminal oligomerization domain found in C4b-binding protein (C4BP), which contains 14 cysteines that form 7 intermolecular disulfide bridges. C4BP is a plasma glycoprotein complex of 570 kDa, which is mainly produced in the liver. C4BP is the major inhibitor of complement activation, the major isoform consists of 7alpha and one beta-chain where each alpha-chain comprises eight complement control domain proteins (CCPs) and a C-terminal oligomerization domain. This domain carries a stretch of 42-45 amino acids that has been shown to be required for ring formation.


:

Pssm-ID: 436513  Cd Length: 49  Bit Score: 112.54  E-value: 3.19e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530366456  541 ETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSAR 589
Cdd:pfam18453   1 EFPEGCEQVLTGKKLMQCLPNPEDVKMALEVYKLSLEIELLELQIDKAK 49
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 298-538 2.24e-29

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 117.06  E-value: 2.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 298 SCINLPDIP-HASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNlRWTPYQGCEALCCPEPK-LNNGEI 375
Cdd:PHA02927  19 SCCTIPSRPiNMKFKNSVETDANANYNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQCIKRRCPSPRdIDNGQL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 376 TQHRKSrpanhcvyfYGDEISFSC----HETSRFSAICQ----GDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFF 446
Cdd:PHA02927  98 DIGGVD---------FGSSITYSCnsgyQLIGESKSYCElgstGSMVWNPEAPICESVkCQSPPSISNGRHNGYEDFYTD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 447 KEEIIYECDKGYILVGQAKLSCSYSHWSAPaPQCKAL-CRKPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSIT 524
Cdd:PHA02927 169 GSVVTYSCNSGYSLIGNSGVLCSGGEWSDP-PTCQIVkCPHPTISNGYLSSGfKRSYSYNDNVDFKCKYGYKLSGSSSST 247

                        250
                 ....*....|....
gi 530366456 525 CSGNRTWYPEVPKC 538
Cdd:PHA02927 248 CSPGNTWQPELPKC 261
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 65-294 6.44e-52

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 179.08  E-value: 6.44e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  65 TLTETRFKTGTTLKYTCLPGYVRSHSTQTLT-CNSDGEWVYNTfCIYKRCRHPGELRNGQVEIKtDLSFGSQIEFSCSEG 143
Cdd:PHA02927  38 TDANANYNIGDTIEYLCLPGYRKQKMGPIYAkCTGTGWTLFNQ-CIKRRCPSPRDIDNGQLDIG-GVDFGSSITYSCNSG 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 144 FFLIGSTTSRCEVQDRG-VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVene 222
Cdd:PHA02927 116 YQLIGESKSYCELGSTGsMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSG--- 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530366456 223 tiGVWRpSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
Cdd:PHA02927 193 --GEWS-DPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
C4bp_oligo pfam18453
Oligomerization domain of C4b-binding protein alpha; This is the C-terminal oligomerization ...
 541-589 3.19e-30

Oligomerization domain of C4b-binding protein alpha; This is the C-terminal oligomerization domain found in C4b-binding protein (C4BP), which contains 14 cysteines that form 7 intermolecular disulfide bridges. C4BP is a plasma glycoprotein complex of 570 kDa, which is mainly produced in the liver. C4BP is the major inhibitor of complement activation, the major isoform consists of 7alpha and one beta-chain where each alpha-chain comprises eight complement control domain proteins (CCPs) and a C-terminal oligomerization domain. This domain carries a stretch of 42-45 amino acids that has been shown to be required for ring formation.


Pssm-ID: 436513  Cd Length: 49  Bit Score: 112.54  E-value: 3.19e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530366456  541 ETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSAR 589
Cdd:pfam18453   1 EFPEGCEQVLTGKKLMQCLPNPEDVKMALEVYKLSLEIELLELQIDKAK 49
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 298-538 2.24e-29

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 117.06  E-value: 2.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 298 SCINLPDIP-HASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNlRWTPYQGCEALCCPEPK-LNNGEI 375
Cdd:PHA02927  19 SCCTIPSRPiNMKFKNSVETDANANYNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQCIKRRCPSPRdIDNGQL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 376 TQHRKSrpanhcvyfYGDEISFSC----HETSRFSAICQ----GDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFF 446
Cdd:PHA02927  98 DIGGVD---------FGSSITYSCnsgyQLIGESKSYCElgstGSMVWNPEAPICESVkCQSPPSISNGRHNGYEDFYTD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 447 KEEIIYECDKGYILVGQAKLSCSYSHWSAPaPQCKAL-CRKPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSIT 524
Cdd:PHA02927 169 GSVVTYSCNSGYSLIGNSGVLCSGGEWSDP-PTCQIVkCPHPTISNGYLSSGfKRSYSYNDNVDFKCKYGYKLSGSSSST 247

                        250
                 ....*....|....
gi 530366456 525 CSGNRTWYPEVPKC 538
Cdd:PHA02927 248 CSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 175-235 3.60e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 3.60e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530366456 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVEnetiGVWRPSPPTCE 235
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 175-234 2.81e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 2.81e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456   175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVEnetiGVWRPSPPTC 234
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
484-538 1.73e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.66  E-value: 1.73e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366456  484 CRKPE-LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
242-294 1.99e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.66  E-value: 1.99e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530366456  242 PDVSHGEmVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 487-539 3.31e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 52.85  E-value: 3.31e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530366456 487 PELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 487-538 3.98e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.83  E-value: 3.98e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530366456   487 PELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 65-294 6.44e-52

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 179.08  E-value: 6.44e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  65 TLTETRFKTGTTLKYTCLPGYVRSHSTQTLT-CNSDGEWVYNTfCIYKRCRHPGELRNGQVEIKtDLSFGSQIEFSCSEG 143
Cdd:PHA02927  38 TDANANYNIGDTIEYLCLPGYRKQKMGPIYAkCTGTGWTLFNQ-CIKRRCPSPRDIDNGQLDIG-GVDFGSSITYSCNSG 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 144 FFLIGSTTSRCEVQDRG-VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVene 222
Cdd:PHA02927 116 YQLIGESKSYCELGSTGsMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSG--- 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530366456 223 tiGVWRpSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
Cdd:PHA02927 193 --GEWS-DPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
C4bp_oligo pfam18453
Oligomerization domain of C4b-binding protein alpha; This is the C-terminal oligomerization ...
 541-589 3.19e-30

Oligomerization domain of C4b-binding protein alpha; This is the C-terminal oligomerization domain found in C4b-binding protein (C4BP), which contains 14 cysteines that form 7 intermolecular disulfide bridges. C4BP is a plasma glycoprotein complex of 570 kDa, which is mainly produced in the liver. C4BP is the major inhibitor of complement activation, the major isoform consists of 7alpha and one beta-chain where each alpha-chain comprises eight complement control domain proteins (CCPs) and a C-terminal oligomerization domain. This domain carries a stretch of 42-45 amino acids that has been shown to be required for ring formation.


Pssm-ID: 436513  Cd Length: 49  Bit Score: 112.54  E-value: 3.19e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530366456  541 ETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSAR 589
Cdd:pfam18453   1 EFPEGCEQVLTGKKLMQCLPNPEDVKMALEVYKLSLEIELLELQIDKAK 49
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 298-538 2.24e-29

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 117.06  E-value: 2.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 298 SCINLPDIP-HASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNlRWTPYQGCEALCCPEPK-LNNGEI 375
Cdd:PHA02927  19 SCCTIPSRPiNMKFKNSVETDANANYNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQCIKRRCPSPRdIDNGQL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 376 TQHRKSrpanhcvyfYGDEISFSC----HETSRFSAICQ----GDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFF 446
Cdd:PHA02927  98 DIGGVD---------FGSSITYSCnsgyQLIGESKSYCElgstGSMVWNPEAPICESVkCQSPPSISNGRHNGYEDFYTD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 447 KEEIIYECDKGYILVGQAKLSCSYSHWSAPaPQCKAL-CRKPELVNGRLSVD-KDQYVEPENVTIQCDSGYGVVGPQSIT 524
Cdd:PHA02927 169 GSVVTYSCNSGYSLIGNSGVLCSGGEWSDP-PTCQIVkCPHPTISNGYLSSGfKRSYSYNDNVDFKCKYGYKLSGSSSST 247

                        250
                 ....*....|....
gi 530366456 525 CSGNRTWYPEVPKC 538
Cdd:PHA02927 248 CSPGNTWQPELPKC 261
PHA02639 PHA02639
EEV host range protein; Provisional
 113-301 4.27e-25

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 105.52  E-value: 4.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 113 CRHPGELRNGQV-EIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEEN 191
Cdd:PHA02639  22 CDKPDDISNGFItELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGKIYNKRE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 192 FYAYGFSVTYSCDP----RFSLLGHASISCTVENEtigvWRPSPPTCEKITCRKPDVSHGeMVSGF--GPIYNYKDTIVF 265
Cdd:PHA02639 102 MYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKS----WKPDPPICKMINCRFPALQNG-YINGIpsNKKFYYKTRVGF 176

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 530366456 266 KCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCIN 301
Cdd:PHA02639 177 SCKSGFDLVGEKYSTCNINATWFPSIPTCVRNKPID 212
PHA02831 PHA02831
EEV host range protein; Provisional
 175-301 6.57e-20

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 90.05  E-value: 6.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCD----PRFSLLGHASISCTVenetiGVWRPSPPTCEKITCRKPDVSHGeMV 250
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACKvnklEKYSIVGNETVKCIN-----KQWVPKYPVCKLIRCKYPALQNG-FL 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530366456 251 SGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCIN 301
Cdd:PHA02831 152 NVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDKVHN 202
PHA02817 PHA02817
EEV Host range protein; Provisional
 170-297 2.59e-18

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 84.22  E-value: 2.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 170 CEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDP-----RFSLLGHASISCtvenETIGVWRPSPPTCEKITCRKPDV 244
Cdd:PHA02817  19 CDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIIC----EKDGKWNKEFPVCKIIRCRFPAL 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530366456 245 SHGeMVSGF--GPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPN 297
Cdd:PHA02817  95 QNG-FVNGIpdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSRD 148
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 182-422 1.32e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.16  E-value: 1.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 182 RNGRHSGEENFYAYGFSVTYSCDP--RFSLLGHASISCTVENETIGvwrpspPTCEKITCRKP-DVSHGEMVSGFgpiYN 258
Cdd:PHA02927  33 KNSVETDANANYNIGDTIEYLCLPgyRKQKMGPIYAKCTGTGWTLF------NQCIKRRCPSPrDIDNGQLDIGG---VD 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 259 YKDTIVFKCQKGFVLRGSSVIHCDADSK----WNPSPPACEPNSCINLPDIPHASWETYprptkEDVYVVGTVLRYRCHP 334
Cdd:PHA02927 104 FGSSITYSCNSGYQLIGESKSYCELGSTgsmvWNPEAPICESVKCQSPPSISNGRHNGY-----EDFYTDGSVVTYSCNS 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 335 GYKPTTDepTTVICQKNlRWTPYQGCEALCCPEPKLNNGEITQHRKSRpanhcvYFYGDEISFSCHETSRF----SAICQ 410
Cdd:PHA02927 179 GYSLIGN--SGVLCSGG-EWSDPPTCQIVKCPHPTISNGYLSSGFKRS------YSYNDNVDFKCKYGYKLsgssSSTCS 249

                        250
                 ....*....|..
gi 530366456 411 GDGTWSPRTPSC 422
Cdd:PHA02927 250 PGNTWQPELPKC 261
PHA02639 PHA02639
EEV host range protein; Provisional
 358-543 3.05e-15

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 76.63  E-value: 3.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 358 QGCEALCCPEPK-LNNGEITQHRKSrpanhcvYFYGDEISFSCHET-----SRFSAICQ--GDGTWSPRTPSCG-DICNF 428
Cdd:PHA02639  15 HGVKSIYCDKPDdISNGFITELMEK-------YEIGKLIEYTCNTDyaligDRFRTCIKdkNNAIWSNKAPFCMlKECND 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 429 PPKIAHGHYKQSSSYSFFKEEIIYECD--KG--YILVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELVNGRLS--VDKDQ 500
Cdd:PHA02639  88 PPSIINGKIYNKREMYKVGDEIYYVCNehKGvqYSLVGNEKITCIQDKsWKPDPPICKMInCRFPALQNGYINgiPSNKK 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530366456 501 YVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETP 543
Cdd:PHA02639 168 FYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVRNKP 210
PHA02831 PHA02831
EEV host range protein; Provisional
 71-236 2.85e-14

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 73.10  E-value: 2.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  71 FKTGTTLKYTCLPGYvrshSTQTLTCNsDGEWVYNTFCIYKR-CRHPGELRNGQVEIKTD-LSFGSQIEFSCS----EGF 144
Cdd:PHA02831  40 YEENENLEYKCNNNF----DKVFVTCN-NGSWSTKNMCIGKRnCKDPVTILNGYIKNKKDqYSFGDSVTYACKvnklEKY 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 145 FLIGSTTSRCEVQDrgvgWSHPLPQCEIVKCKPPPdIRNG-RHSGEENFYaYGFSVTYSCDPRFSLLGHASISCTVENet 223
Cdd:PHA02831 115 SIVGNETVKCINKQ----WVPKYPVCKLIRCKYPA-LQNGfLNVFEKKFY-YGDIVNFKCKKGFILLGSSVSTCDINS-- 186

                        170
                 ....*....|...
gi 530366456 224 igVWRPSPPTCEK 236
Cdd:PHA02831 187 --IWYPGIPKCVK 197
PHA02831 PHA02831
EEV host range protein; Provisional
 388-538 9.77e-14

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 71.56  E-value: 9.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 388 VYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHYKQSSSYSFFKEEIIYECD----KGYILVG 462
Cdd:PHA02831  39 VYEENENLEYKCNNNFDKVFVTCNNGSWSTKNMCIGKRnCKDPVTILNGYIKNKKDQYSFGDSVTYACKvnklEKYSIVG 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530366456 463 QAKLSCSYSHWSAPAPQCKAL-CRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Cdd:PHA02831 119 NETVKCINKQWVPKYPVCKLIrCKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 175-235 3.60e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 3.60e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530366456 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVEnetiGVWRPSPPTCE 235
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 42-294 8.60e-12

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 66.65  E-value: 8.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  42 LLPAVLGNCGPPPTLSFAapmDITLTETRFKTGTTLKYTCLPGYVRSHSTQTltCNSDgEWVYNTFCiYKRCR---HPGE 118
Cdd:PHA02954  12 VLPAVVYSTCTVPTMNNA---KLTSTETSFNDKQKVTFTCDSGYYSLDPNAV--CETD-KWKYENPC-KKMCTvsdYVSE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 119 LRNgqveiKTDLSFGSQIEFSCSEGffligSTTSRCEVQDRGVGWSHPLpQCEIVKCKPPpDIRNGRHSGEENFYAYGFS 198
Cdd:PHA02954  85 LYD-----KPLYEVNSTITLICKDE-----TKYFRCEEKNGNTSWNDTV-TCPNAECQPL-QLEHGSCQPVKEKYSFGEH 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 199 VTYSCDPRFSLLGHASISCTVENETIgvwrpsPPTCEKiTCRKPDVSHGeMVSgfGPIYNYKDTIVFKCQKGFVLRGSSV 278
Cdd:PHA02954 153 ITINCDVGYEVIGASYISCTANSWNV------IPSCQQ-KCDIPSLSNG-LIS--GSTFSIGGVIHLSCKSGFTLTGSPS 222

                        250
                 ....*....|....*.
gi 530366456 279 IHCdADSKWNPSPPAC 294
Cdd:PHA02954 223 STC-IDGKWNPVLPIC 237
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 242-295 6.24e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.86  E-value: 6.24e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530366456 242 PDVSHGEMVSGFGPiYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACE 295
Cdd:cd00033    5 PVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 175-234 2.81e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 2.81e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456   175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVEnetiGVWRPSPPTC 234
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 113-171 6.72e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.16  E-value: 6.72e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 113 CRHPGELRNGQVE-IKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQdrgVGWSHPLPQCE 171
Cdd:cd00033    1 CPPPPVPENGTVTgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN---GGWSPPPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 106-236 1.01e-09

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 58.80  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 106 TFCIYKRCRHPGELRNGQV-EIKTDLSFGSQIEFSCSEG-----FFLIGSTTSRCEVQDRgvgWSHPLPQCEIVKCKPPP 179
Cdd:PHA02817  17 SLCDLNKCCYPPSIKNGYIyNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGK---WNKEFPVCKIIRCRFPA 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 180 dIRNGRHSG---EENFYaYGFSVTYSCDPRFSLLGHASISCTVENEtigvWRPSPPTCEK 236
Cdd:PHA02817  94 -LQNGFVNGipdSKKFY-YESEVSFSCKPGFVLIGTKYSVCGINSS----WIPKVPICSR 147
Sushi pfam00084
Sushi repeat (SCR repeat);
484-538 1.73e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.66  E-value: 1.73e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366456  484 CRKPE-LVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
242-294 1.99e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.66  E-value: 1.99e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530366456  242 PDVSHGEmVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
Cdd:pfam00084   5 PDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 239-294 2.20e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 2.20e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366456   239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPAC 294
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 487-539 3.31e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 52.85  E-value: 3.31e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530366456 487 PELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 426-481 4.86e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 52.47  E-value: 4.86e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530366456 426 CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCK 481
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCtENGGWSPPPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 426-538 9.99e-09

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 56.10  E-value: 9.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 426 CNFPPKIAHGH-YKQSSSYSFfKEEIIYECDKG-----YILVGQAKLSCSYS-HWSAPAPQCKAL-CRKPELVNGRLS-- 495
Cdd:PHA02817  24 CCYPPSIKNGYiYNKKTEYNI-GSNVTFFCGNNtrgvrYTLVGEKNIICEKDgKWNKEFPVCKIIrCRFPALQNGFVNgi 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530366456 496 VDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Cdd:PHA02817 103 PDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPIC 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 113-170 1.29e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 1.29e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 530366456   113 CRHPGELRNGQVE-IKTDLSFGSQIEFSCSEGFFLIGSTTSRCevQDRGVgWSHPLPQC 170
Cdd:smart00032   1 CPPPPDIENGTVTsSSGTYSYGDTVTYSCDPGYTLIGSSTITC--LENGT-WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 487-538 3.98e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.83  E-value: 3.98e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530366456   487 PELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKC 538
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 357-480 5.00e-08

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 53.79  E-value: 5.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 357 YQGCEA-LCCPEPKLNNGEITQHRKsrpanhcVYFYGDEISFSCHETSRF---------SAICQGDGTWSPRTPSCGDI- 425
Cdd:PHA02817  16 YSLCDLnKCCYPPSIKNGYIYNKKT-------EYNIGSNVTFFCGNNTRGvrytlvgekNIICEKDGKWNKEFPVCKIIr 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530366456 426 CNFpPKIAHGHYK--QSSSYSFFKEEIIYECDKGYILVGQAKLSCSY-SHWSAPAPQC 480
Cdd:PHA02817  89 CRF-PALQNGFVNgiPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGInSSWIPKVPIC 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 426-480 5.24e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 5.24e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530366456   426 CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQC 480
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITClENGTWSPPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 49-170 5.73e-08

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 54.23  E-value: 5.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  49 NCGPPPTLSFAapmDITLTETRFKTGTTLKYTCLPGYVRSHS---TQTLTCnSDGEWV-YNTFCIYKRCRHPGeLRNGQV 124
Cdd:PHA02831  77 NCKDPVTILNG---YIKNKKDQYSFGDSVTYACKVNKLEKYSivgNETVKC-INKQWVpKYPVCKLIRCKYPA-LQNGFL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 530366456 125 EI-KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRgvgWSHPLPQC 170
Cdd:PHA02831 152 NVfEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI---WYPGIPKC 195
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 330-582 5.85e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 54.71  E-value: 5.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 330 YRCHPGYKptTDEPTTViCQKNlRWTPYQGCEALCCPEPKLnngeitqhrkSRPANHCVYFYGDEISFSCHETSRFSAiC 409
Cdd:PHA02954  46 FTCDSGYY--SLDPNAV-CETD-KWKYENPCKKMCTVSDYV----------SELYDKPLYEVNSTITLICKDETKYFR-C 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 410 Q---GDGTWSPrTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSApAPQCKALCRK 486
Cdd:PHA02954 111 EeknGNTSWND-TVTCPNAECQPLQLEHGSCQPVKEKYSFGEHITINCDVGYEVIGASYISCTANSWNV-IPSCQQKCDI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 487 PELVNGRLSvdKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRtWYPEVPKCewetpegceqVLTGKRLMQCLPNPED-- 564
Cdd:PHA02954 189 PSLSNGLIS--GSTFSIGGVIHLSCKSGFTLTGSPSSTCIDGK-WNPVLPIC----------VRSNEEFDPVDDGPDDet 255

                        250       260
                 ....*....|....*....|
gi 530366456 565 --VKMALEVYKLSLEIEQLE 582
Cdd:PHA02954 256 dlSKLSKDVVQYEQEIESLE 275
Sushi pfam00084
Sushi repeat (SCR repeat);
175-234 1.28e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 1.28e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTveneTIGVWRPSPPTC 234
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQ----EDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
299-356 1.20e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.95  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530366456  299 CINLPDIPHASWETyprptKEDVYVVGTVLRYRCHPGYKPTTDEptTVICQKNLRWTP 356
Cdd:pfam00084   1 CPPPPDIPNGKVSA-----TKNEYNYGASVSYECDPGYRLVGSP--TITCQEDGTWSP 51
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 365-422 5.27e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 5.27e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530366456   365 CPEPK-LNNGEITQHRKSrpanhcvYFYGDEISFSCHE----TSRFSAICQGDGTWSPRTPSC 422
Cdd:smart00032   1 CPPPPdIENGTVTSSSGT-------YSYGDTVTYSCDPgytlIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 50-102 7.21e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 7.21e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530366456  50 CGPPPTLSFAapmDITLTETRFKTGTTLKYTCLPGYVRSHSTqTLTCNSDGEW 102
Cdd:cd00033    1 CPPPPVPENG---TVTGSKGSYSYGSTVTYSCNEGYTLVGSS-TITCTENGGW 49
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 299-356 7.36e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 7.36e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530366456 299 CINLPDIPHASWETYprptkEDVYVVGTVLRYRCHPGYKPTtdEPTTVICQKNLRWTP 356
Cdd:cd00033    1 CPPPPVPENGTVTGS-----KGSYSYGSTVTYSCNEGYTLV--GSSTITCTENGGWSP 51
PHA02831 PHA02831
EEV host range protein; Provisional
 233-422 1.04e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 47.29  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 233 TCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFvlrGSSVIHCDADSkWNPSppacepNSCI---NLPDiPHAS 309
Cdd:PHA02831  16 TWCICVFNKNDAKYSNVDSYENKVYEENENLEYKCNNNF---DKVFVTCNNGS-WSTK------NMCIgkrNCKD-PVTI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 310 WETYPRpTKEDVYVVGTVLRYRCHPG----YKPTTDEptTVICqKNLRWTP-YQGCEALCCPEPKLNNGEITQHRKSrpa 384
Cdd:PHA02831  85 LNGYIK-NKKDQYSFGDSVTYACKVNklekYSIVGNE--TVKC-INKQWVPkYPVCKLIRCKYPALQNGFLNVFEKK--- 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530366456 385 nhcvYFYGDEISFSCHETSRFS----AICQGDGTWSPRTPSC 422
Cdd:PHA02831 158 ----FYYGDIVNFKCKKGFILLgssvSTCDINSIWYPGIPKC 195
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 299-356 1.08e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.90  E-value: 1.08e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530366456   299 CINLPDIPHASWETYPRPtkedvYVVGTVLRYRCHPGYKPTtdEPTTVICQKNLRWTP 356
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT-----YSYGDTVTYSCDPGYTLI--GSSTITCLENGTWSP 51
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 50-102 2.80e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.74  E-value: 2.80e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530366456    50 CGPPPTLSFAapmDITLTETRFKTGTTLKYTCLPGYVRSHSTqTLTCNSDGEW 102
Cdd:smart00032   1 CPPPPDIENG---TVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGTW 49
Sushi pfam00084
Sushi repeat (SCR repeat);
365-422 2.82e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 41.72  E-value: 2.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530366456  365 CPEPK-LNNGEITQHRKSrpanhcvYFYGDEISFSCHE----TSRFSAICQGDGTWSPRTPSC 422
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNE-------YNYGASVSYECDPgyrlVGSPTITCQEDGTWSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 239-356 7.08e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.55  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 239 CRKPDVSHGEMVSGfGPIYNYKDTIVFKCQKG-----FVLRGSSVIHCDADSKWNPSPPACEPNSCiNLPDIPHASWETY 313
Cdd:PHA02817  25 CYPPSIKNGYIYNK-KTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCKIIRC-RFPALQNGFVNGI 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530366456 314 PRPTKedvYVVGTVLRYRCHPGYKpTTDEPTTvICQKNLRWTP 356
Cdd:PHA02817 103 PDSKK---FYYESEVSFSCKPGFV-LIGTKYS-VCGINSSWIP 140
PHA02817 PHA02817
EEV Host range protein; Provisional
 94-170 8.27e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.16  E-value: 8.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456  94 LTCNSDGEWvYNTF--CIYKRCRHPGeLRNGQVEIKTD---LSFGSQIEFSCSEGFFLIGSTTSRCEVQDrgvGWSHPLP 168
Cdd:PHA02817  69 IICEKDGKW-NKEFpvCKIIRCRFPA-LQNGFVNGIPDskkFYYESEVSFSCKPGFVLIGTKYSVCGINS---SWIPKVP 143


                 ..
gi 530366456 169 QC 170
Cdd:PHA02817 144 IC 145
Sushi pfam00084
Sushi repeat (SCR repeat);
50-102 1.11e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 40.18  E-value: 1.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530366456   50 CGPPPTLSFAapmDITLTETRFKTGTTLKYTCLPGYVRShSTQTLTCNSDGEW 102
Cdd:pfam00084   1 CPPPPDIPNG---KVSATKNEYNYGASVSYECDPGYRLV-GSPTITCQEDGTW 49
PHA02817 PHA02817
EEV Host range protein; Provisional
 484-539 1.33e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 43.78  E-value: 1.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530366456 484 CRKPELVNGRLSVDKDQYVEPENVTIQCDSG-----YGVVGPQSITCSGNRTWYPEVPKCE 539
Cdd:PHA02817  25 CYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCK 85
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 365-422 1.56e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 1.56e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530366456 365 CPEPK-LNNGEITQHRKSrpanhcvYFYGDEISFSCHE----TSRFSAICQGDGTWSPRTPSC 422
Cdd:cd00033    1 CPPPPvPENGTVTGSKGS-------YSYGSTVTYSCNEgytlVGSSTITCTENGGWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 365-539 3.92e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.77  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 365 CPEPKLNNGEITQHRKSRPANHCVYFYGDeisfSCHETSRFSAICQGDgTWSPRTPsCGDICNFPPKIAHGHYKQsssys 444
Cdd:PHA02954  21 CTVPTMNNAKLTSTETSFNDKQKVTFTCD----SGYYSLDPNAVCETD-KWKYENP-CKKMCTVSDYVSELYDKP----- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530366456 445 ffkeeiIYECDKGYILV--GQAK-LSCSY----SHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGV 517
Cdd:PHA02954  90 ------LYEVNSTITLIckDETKyFRCEEkngnTSWNDTVTCPNAECQPLQLEHGSCQPVKEKYSFGEHITINCDVGYEV 163

                        170       180
                 ....*....|....*....|..
gi 530366456 518 VGPQSITCSGNRtwYPEVPKCE 539
Cdd:PHA02954 164 IGASYISCTANS--WNVIPSCQ 183
Sushi pfam00084
Sushi repeat (SCR repeat);
113-170 3.87e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 35.94  E-value: 3.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530366456  113 CRHPGELRNGQVE-IKTDLSFGSQIEFSCSEGFFLIGSTTSRCevqDRGVGWSHPLPQC 170
Cdd:pfam00084   1 CPPPPDIPNGKVSaTKNEYNYGASVSYECDPGYRLVGSPTITC---QEDGTWSPPFPEC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH