|
Name |
Accession |
Description |
Interval |
E-value |
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
9-506 |
0e+00 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 694.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16159 27 TPNIDRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPIRSGMASSHGMRVILFTASSGGLPPNETTFAEVLKQQGYSTAL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLthLIPV 168
Cdd:cd16159 107 IGKWHLGLHCESRNDFCHHPLNHGFDYFYGLPLTNLKDCGDGSNGEYDLSFDPLFPLLTAFVLITALTIFLLLY--LGAV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 SWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHI 248
Cdd:cd16159 185 SKRFFVFLLILSLLFISLFFLLLITNRYFNCILMRNHEVVEQPMSLENLTQRLTKEAISFLERNKERPFLLVMSFLHVHT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 249 PLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGG 328
Cdd:cd16159 265 ALFTSKKFKGRSKHGRYGDNVEEMDWSVGQILDALDELGLKDNTFVYFTSDNGGHLEEISVGGEYGGGNGGIYGGKKMGG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 329 WEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLH 408
Cdd:cd16159 345 WEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLPSDRIIDGRDLMPLLTGQEKRSPHEFLFHYCGAELH 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 409 AARWHQRDRGTMWKVHFVTPVFQPEGAGaCYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPvFYQVMERVQ 488
Cdd:cd16159 425 AVRYRPRDGGAVWKAHYFTPNFYPGTEG-CCGTLLCRCFGDSVTHHDPPLLFDLSADPSESNPLDPTDEP-YQEIIKKIL 502
|
490
....*....|....*...
gi 530421114 489 QAVWEHQRTLSPVPLQLD 506
Cdd:cd16159 503 EAVAEHQSSIEPVESQLS 520
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
9-470 |
2.32e-138 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 405.79 E-value: 2.32e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigYRVLQWTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16026 27 TPNIDRLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGL-----PGVVGPPGSKGGLPPDEITIAEVLKKAGYRTAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGlncesasDH-CHHPLHHGFDHFYGMPFSLMGDCARWELSEKRvnleqklnflfqvlalvaltlvagklthlip 167
Cdd:cd16026 102 VGKWHLG-------HQpEFLPTRHGFDEYFGIPYSNDMWPFPLYRNDPP------------------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 168 vswmpviwsalsavlllassyfvgalivHADCFLMRNHTITEQPMcFQRT-TPLILQEVASFLKRNKHGPFLLFVSFLHV 246
Cdd:cd16026 144 ----------------------------GPLPPLMENEEVIEQPA-DQSSlTQRYTDEAVDFIERNKDQPFFLYLAHTMP 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 247 HIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSD---------HGGSleNQL-----GNTQ 312
Cdd:cd16026 195 HVPLFASEKFKGRSGAGLYGDVVEELDWSVGRILDALKELGLEENTLVIFTSDngpwleyggHGGS--AGPlrggkGTTW 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 313 YGGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQ 392
Cdd:cd16026 273 EGG-----------------VRVPFIAWWPGVIPAGTVSDELASTMDLLPTLAALAGAPLPEDRVIDGKDISPLLLGGSK 335
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530421114 393 HSDHEFLMHYCERFLHAARWHQrdrgtmWKVHFVTPVFQPEGAGacygrkvcpcfGEKVVHHDPPLLFDLSRDPSETH 470
Cdd:cd16026 336 SPPHPFFYYYDGGDLQAVRSGR------WKLHLPTTYRTGTDPG-----------GLDPTKLEPPLLYDLEEDPGETY 396
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
3-487 |
4.53e-120 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 360.59 E-value: 4.53e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 3 HLHHSWTPnIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSsiGYRV-LQWTgaSGGLPTNETTFAKILKE 81
Cdd:cd16160 22 HPTQERGP-IDDMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMYG--GTRVfLPWD--IGGLPKTEVTMAEALKE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 82 KGYATGLIGKWHLGLNCESASDHCHHPLHHGFDhFYG--MPFSLMGDCARWELSekrvnleqklnflfqvlalvaltlva 159
Cdd:cd16160 97 AGYTTGMVGKWHLGINENNHSDGAHLPSHHGFD-FVGtnLPFTNSWACDDTGRH-------------------------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 160 gklthlipvswmpviwsalsavlllassyfvgalIVHAD---CFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGP 236
Cdd:cd16160 150 ----------------------------------VDFPDrsaCFLYYNDTIVEQPIQHEHLTETLVGDAKSFIEDNQENP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 237 FLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG------------GSL 304
Cdd:cd16160 196 FFLYFSFPQTHTPLFASKRFKGKSKRGRYGDNINEMSWAVGEVLDTLVDTGLDQNTLVFFLSDHGphveycleggstGGL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 305 ENQLGNTQYGGwngiykggkgmggweggIRVPGIFRWPGVLPaGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 384
Cdd:cd16160 276 KGGKGNSWEGG-----------------IRVPFIAYWPGTIK-PRVSHEVVSTMDIFPTFVDLAGGTLPTDRIYDGLSIT 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 385 PLLLGTAQHSDHEFLMHYCERfLHAARWHQrdrgtmWKVHFVT---PVFQPEGAGACYGRKVCP------CFGEKVVHHD 455
Cdd:cd16160 338 DLLLGEADSPHDDILYYCCSR-LMAVRYGS------YKIHFKTqplPSQESLDPNCDGGGPLSDyivcydCEDECVTKHN 410
|
490 500 510
....*....|....*....|....*....|..
gi 530421114 456 PPLLFDLSRDPSETHILTPASEPVFYQVMERV 487
Cdd:cd16160 411 PPLIFDVEKDPGEQYPLQPSVYEHMLEAVEKL 442
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
7-528 |
1.17e-85 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 273.17 E-value: 1.17e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 7 SWTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYrvlqwTGASGGLPTNETTFAKILKEKGYAT 86
Cdd:cd16158 25 SSTPNLDRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGVFY-----PGSRGGLPLNETTIAEVLKTVGYQT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 87 GLIGKWHLGLNCESAsdhcHHPLHHGFDHFYGMPFSL-MGDCArwelsekrvnleqklnflfqvlalvaltlvagKLTHL 165
Cdd:cd16158 100 AMVGKWHLGVGLNGT----YLPTHQGFDHYLGIPYSHdQGPCQ--------------------------------NLTCF 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 166 IPvswmpviwsalsavlllASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFL----KRNKhgPFLLFV 241
Cdd:cd16158 144 PP-----------------NIPCFGGCDQGEVPCPLFYNESIVQQPVDLLTLEERYAKFAKDFIadnaKEGK--PFFLYY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 242 SFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG------------GSLENQLG 309
Cdd:cd16158 205 ASHHTHYPQFAGQKFAGRSSRGPFGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGpstmrksrggnaGLLKCGKG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 310 NTQYGGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIgEPTSLMDVFPTVVRLAGGEVPqDRVIDGQDLLPLLLG 389
Cdd:cd16158 285 TTYEGG-----------------VREPAIAYWPGRIKPGVTH-ELASTLDILPTIAKLAGAPLP-NVTLDGVDMSPILFE 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 390 TAQHSDHEFLMHYC----ERFLHAARWHQrdrgtmWKVHFVT---PVFQPEGAGACYGRKvcpcfgeKVVHHDPPLLFDL 462
Cdd:cd16158 346 QGKSPRQTFFYYPTspdpDKGVFAVRWGK------YKAHFYTqgaAHSGTTPDKDCHPSA-------ELTSHDPPLLFDL 412
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 463 SRDPSETHILTpaSEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNiwrPWLQPC----CGPFPLCWC 528
Cdd:cd16158 413 SQDPSENYNLL--GLPEYNQVLKQIQQVKERFEASMKFGESEINKGED---PALEPCckpgCTPKPSCCQ 477
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
9-473 |
4.41e-81 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 257.85 E-value: 4.41e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASlCTPSRAAFLTGRYPVRSGMvssigYRVlQWTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16142 29 TPNIDRLAKEGLRFTSFYVEPS-CTPGRAAFITGRHPIRTGL-----TTV-GLPGSPGGLPPWEPTLAELLKDAGYATAQ 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNCEsasdhcHHPLHHGFDHFYGMPFSLMGDcarwELSEKRVNleqklnflfqvlalvaltlvagklthlipv 168
Cdd:cd16142 102 FGKWHLGDEDG------RLPTDHGFDEFYGNLYHTIDE----EIVDKAID------------------------------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllassyfvgalivhadcFLMRNHtiteqpmcfqrttplilqevasflKRNKhgPFLLFVSFLHVHI 248
Cdd:cd16142 142 -------------------------------FIKRNA------------------------KADK--PFFLYVNFTKMHF 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 249 PLITMENFLGKSL-HGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG-----------GSLENQLGNTQYGGW 316
Cdd:cd16142 165 PTLPSPEFEGKSSgKGKYADSMVELDDHVGQILDALDELGIADNTIVIFTTDNGpeqdvwpdggyTPFRGEKGTTWEGGV 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 317 ngiykggkgmggweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVP------QDRVIDGQDLLPLLLGT 390
Cdd:cd16142 245 -----------------RVPAIVRWPGKIKPGRVSNEIVSHLDWFPTLAALAGAPDPkdkllgKDRHIDGVDQSPFLLGK 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 391 AQHSDHEFLMHYCERFLHAARWHQrdrgtmWKVHFVtpVFQPEGAGACYGRKVCPCfgekvvhhdpPLLFDLSRDPSETH 470
Cdd:cd16142 308 SEKSRRSEFFYFGEGELGAVRWKN------WKVHFK--AQEDTGGPTGEPFYVLTF----------PLIFNLRRDPKERY 369
|
...
gi 530421114 471 ILT 473
Cdd:cd16142 370 DVT 372
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
9-473 |
3.07e-80 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 255.86 E-value: 3.07e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRvlqwtgASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16161 28 TPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFLPT------SVGGLPLNETTLAEVLRQAGYATGM 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNcesasdHCHHPLHHGFDHFYGMPFSlmGDCarwELSEKRVNLeqklnflfqvlalvaltlvagklthlipv 168
Cdd:cd16161 102 IGKWHLGQR------EAYLPNSRGFDYYFGIPFS--HDS---SLADRYAQF----------------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllassyfvgalivhADCFLMRNhtiteqpmcfqrttplilqevasflkRNKHGPFLLFVSFLHVHI 248
Cdd:cd16161 142 ----------------------------ATDFIQRA--------------------------SAKDRPFFLYAALAHVHV 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 249 PLITMENFLGKSLH-GLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG-----GSLENQLGNTQY---GGWNGI 319
Cdd:cd16161 168 PLANLPRFQSPTSGrGPYGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGpwevkCELAVGPGTGDWqgnLGGSVA 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 320 YKGGKGMGgweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQhSDHEFL 399
Cdd:cd16161 248 KASTWEGG-----HREPAIVYWPGRIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSK-TGHRCL 321
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530421114 400 MHYCE-----RFLHAARWHQrdrgtmWKVHFVTpvfqpEGAGACygrkvCPCFGEKvVHHDPPLLFDLSRDPSETHILT 473
Cdd:cd16161 322 FHPNSgaagaGALSAVRCGD------YKAHYAT-----GGALAC-----CGSTGPK-LYHDPPLLFDLEVDPAESFPLT 383
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
9-470 |
1.65e-74 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 241.32 E-value: 1.65e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGyrvlqwtGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:COG3119 49 TPNIDRLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTDNGE-------GYNGGLPPDEPTLAELLKEAGYRTAL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLncesasdhchhplhhgfdhfygmpfslmgdcarwelsekrvnleqklnflfqvlalvaltlvagklthlipv 168
Cdd:COG3119 122 FGKWHLYL------------------------------------------------------------------------ 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllassyfvgalivhadcflmrnhtiteqpmcfqrtTPLILQEVASFLKRNKHG--PFLLFVSFLHV 246
Cdd:COG3119 130 -------------------------------------------------TDLLTDKAIDFLERQADKdkPFFLYLAFNAP 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 247 HIPLITMENFLGK-----------------------SLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGS 303
Cdd:COG3119 161 HAPYQAPEEYLDKydgkdiplppnlaprdlteeelrRARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNGPS 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 304 LENQlG-----NTQY-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrv 377
Cdd:COG3119 241 LGEH-GlrggkGTLYeGG-----------------IRVPLIVRWPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIPED-- 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 378 IDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRdrgtmWKVHFvtpvfqpegagaCYGRKvcpcfgekvvhhDPP 457
Cdd:COG3119 301 LDGRSLLPLLTGEKAEWRDYLYWEYPRGGGNRAIRTGR-----WKLIR------------YYDDD------------GPW 351
|
490
....*....|...
gi 530421114 458 LLFDLSRDPSETH 470
Cdd:COG3119 352 ELYDLKNDPGETN 364
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
9-506 |
3.62e-74 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 242.76 E-value: 3.62e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGAS--GGLPTNETTFAKILKEKGYAT 86
Cdd:cd16157 27 TPNLDRMAAEGMLFTDFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQNivGGIPDSEILLPELLKKAGYRN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 87 GLIGKWHLGLNCEsasdhcHHPLHHGFDHFYGMPfslmgDCARWELSEKRvnleqklnflfqvlalvaltlvagklTHLI 166
Cdd:cd16157 107 KIVGKWHLGHRPQ------YHPLKHGFDEWFGAP-----NCHFGPYDNKA--------------------------YPNI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 167 PV--SWmpviwsalsavlLLASSYFVGALIvhadcflmrNHTITEQPMcfqrtTPLILQEVASFLKR--NKHGPFLLFVS 242
Cdd:cd16157 150 PVyrDW------------EMIGRYYEEFKI---------DKKTGESNL-----TQIYLQEALEFIEKqhDAQKPFFLYWA 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 243 FLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLenqLGNTQYGGWNgIYKG 322
Cdd:cd16157 204 PDATHAPVYASKPFLGTSQRGLYGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNGAAL---ISAPEQGGSN-GPFL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 323 GKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLgtAQHSDHEFLMHY 402
Cdd:cd16157 280 CGKQTTFEGGMREPAIAWWPGHIKPGQVSHQLGSLMDLFTTSLALAGLPIPSDRAIDGIDLLPVLL--NGKEKDRPIFYY 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 403 CERFLHAARWHQrdrgtmWKVHFVT----PVFQPEGAGACYGRKVCPCFGEKVVHH-DPPLLFDLSRDPSETHILTPASe 477
Cdd:cd16157 358 RGDELMAVRLGQ------YKAHFWTwsnsWEEFRKGINFCPGQNVPGVTTHNQTDHtKLPLLFHLGRDPGEKYPISFKS- 430
|
490 500
....*....|....*....|....*....
gi 530421114 478 PVFYQVMERVQQAVWEHQRTLSPVPLQLD 506
Cdd:cd16157 431 AEYKQAMPRISKVVQQHQKTLVPGEPQLN 459
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
9-470 |
5.31e-74 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 240.91 E-value: 5.31e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGA-------SGGLPTNETTFAKILKE 81
Cdd:cd16144 26 TPNIDRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGITDVIPGRRGPPDNTklipppsTTRLPLEEVTIAEALKD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 82 KGYATGLIGKWHLGLNcesasdHCHHPLHHGFDH------------FYGMPFSLMGDCARWELSEKRVNleqklnflfqv 149
Cdd:cd16144 106 AGYATAHFGKWHLGGE------GGYGPEDQGFDVniggtgnggppsYYFPPGKPNPDLEDGPEGEYLTD----------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 150 lalvALTlvagklthlipvswmpviwsalsavlllassyfvgalivhadcflmrnhtiteqpmcfqrttplilQEVASFL 229
Cdd:cd16144 169 ----RLT------------------------------------------------------------------DEAIDFI 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 230 KRNKHGPFLLFVSFLHVHIPLI----TMENFLGKSLHGLYGDN-------VEEMDWMVGRILDTLDVEGLSNSTLIYFTS 298
Cdd:cd16144 179 EQNKDKPFFLYLSHYAVHTPIQarpeLIEKYEKKKKGLRKGQKnpvyaamIESLDESVGRILDALEELGLADNTLVIFTS 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 299 DHGG-SLENQLGNTQY-----------GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR 366
Cdd:cd16144 259 DNGGlSTRGGPPTSNAplrggkgslyeGG-----------------IRVPLIVRWPGVIKPGSVSDVPVIGTDLYPTFLE 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 367 LAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYcerFLHAARWHQRDRGTM----WK-VHFvtpvfqpegagacygr 441
Cdd:cd16144 322 LAGGPLPPPQHLDGVSLVPLLKGGEADLPRRALFWH---FPHYHGQGGRPASAIrkgdWKlIEF---------------- 382
|
490 500 510
....*....|....*....|....*....|
gi 530421114 442 kvcpcfgekvvHHDPPL-LFDLSRDPSETH 470
Cdd:cd16144 383 -----------YEDGRVeLYNLKNDIGETN 401
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
9-470 |
1.35e-73 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 239.03 E-value: 1.35e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssiGYRVLQWTGASGgLPTNETTFAKILKEKGYATGL 88
Cdd:cd16143 27 TPNIDRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRL----KGGVLGGFSPPL-IEPDRVTLAKMLKQAGYRTAM 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLN------CESASDHCHH----------PLHHGFDHFYGMPFSlmgdcarwelsekrvnleqklnflfQVLal 152
Cdd:cd16143 102 VGKWHLGLDwkkkdgKKAATGTGKDvdyskpikggPLDHGFDYYFGIPAS-------------------------EVL-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 153 valtlvagklthlipvswmpviwsalsavlllassyfvgalivhadcflmrnhtiteqpmcfqrttPLILQEVASFLKRN 232
Cdd:cd16143 155 ------------------------------------------------------------------PTLTDKAVEFIDQH 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 233 KHG--PFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGN 310
Cdd:cd16143 169 AKKdkPFFLYFALPAPHTPIVPSPEFQGKSGAGPYGDFVYELDWVVGRILDALKELGLAENTLVIFTSDNGPSPYADYKE 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 311 TQ-----------------Y-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEV 372
Cdd:cd16143 249 LEkfghdpsgplrgmkadiYeGG-----------------HRVPFIVRWPGKIPAGSVSDQLVSLTDLFATLAAIVGQKL 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 373 PQDRVIDGQDLLPLLLGTAQHSDHEFLMHycerflHAARWHQRDRGTMWKVhfvtpVFQPEGAGACYGRKvcpcfgeKVV 452
Cdd:cd16143 312 PDNAAEDSFSFLPALLGPKKQEVRESLVH------HSGNGSFAIRKGDWKL-----IDGTGSGGFSYPRG-------KEK 373
|
490
....*....|....*....
gi 530421114 453 HHDPP-LLFDLSRDPSETH 470
Cdd:cd16143 374 LGLPPgQLYNLSTDPGESN 392
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
9-382 |
6.04e-59 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 195.35 E-value: 6.04e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGmvssigyrVLQWTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16022 26 TPNLDRLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRHG--------VRGNVGNGGGLPPDEPTLAELLKEAGYRTAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHlglncesasdhchhplhhgfdhfygmpfslmgdcarwelsekrvnleqklnflfqvlalvaltlvagklthlipv 168
Cdd:cd16022 98 IGKWH--------------------------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllassyfvgalivhadcflmrnhtiteqpmcfqrttplilQEVASFLKRNKHG-PFLLFVSFLHVH 247
Cdd:cd16022 103 ------------------------------------------------------DEAIDFIERRDKDkPFFLYVSFNAPH 128
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 248 IPLItmenflgkslhglYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENqlGNTQYGGWNGIYKGgkgmg 327
Cdd:cd16022 129 PPFA-------------YYAMVSAIDDQIGRILDALEELGLLDNTLIVFTSDHGDMLGD--HGLRGKKGSLYEGG----- 188
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 530421114 328 gweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvIDGQD 382
Cdd:cd16022 189 -----IRVPFIVRWPGKIPAGQVSDALVSLLDLLPTLLDLAGIEPPEG--LDGRS 236
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
9-470 |
6.73e-58 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 198.16 E-value: 6.73e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQ-HISaaSLCTPSRAAFLTGRYPVRSGMVSSIGYRVLqwtgasggLPTNETTFAKILKEKGYATG 87
Cdd:cd16146 26 TPNLDRLAAESVRFTNfHVS--PVCAPTRAALLTGRYPFRTGVWHTILGRER--------MRLDETTLAEVFKDAGYRTG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 88 LIGKWHLGLNcesasdHCHHPLHHGFDHFYGMPFSLMGDCARWELSEkrvnleqklnflfqvlalvaltlvagklthlip 167
Cdd:cd16146 96 IFGKWHLGDN------YPYRPQDRGFDEVLGHGGGGIGQYPDYWGND--------------------------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 168 vswmpviwsalsavlllassYFvgalivhaDCFLMRNHTITE-QPMCfqrtTPLILQEVASFLKRNKHGPFLLFVSFLHV 246
Cdd:cd16146 137 --------------------YF--------DDTYYHNGKFVKtEGYC----TDVFFDEAIDFIEENKDKPFFAYLATNAP 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 247 HIPLITMEN----FLGKSLH----GLYGdNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGN-------- 310
Cdd:cd16146 185 HGPLQVPDKyldpYKDMGLDdklaAFYG-MIENIDDNVGRLLAKLKELGLEENTIVIFMSDNGPAGGVPKRFnagmrgkk 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 311 -TQY-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLL 388
Cdd:cd16146 264 gSVYeGG-----------------HRVPFFIRWPGKILAGKDVDTLTAHIDLLPTLLDLCGVKLPEGIKLDGRSLLPLLK 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 389 GTAQHSDHEFLmhycerFLHaarWHQRDRGTMWKVHFVtpVFQPEgagacYgRKVCPcfgekvvHHDPPLLFDLSRDPSE 468
Cdd:cd16146 327 GESDPWPERTL------FTH---SGRWPPPPKKKRNAA--VRTGR-----W-RLVSP-------KGFQPELYDIENDPGE 382
|
..
gi 530421114 469 TH 470
Cdd:cd16146 383 EN 384
|
|
| Sulfatase_C |
pfam14707 |
C-terminal region of aryl-sulfatase; |
394-528 |
1.12e-57 |
|
C-terminal region of aryl-sulfatase;
Pssm-ID: 405407 [Multi-domain] Cd Length: 122 Bit Score: 187.91 E-value: 1.12e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 394 SDHEFLMHYCERFLHAARWHQrdrgtmWKVHFVTPVFQPEGAGACYGRKVCpcfgekVVHHDPPLLFDLSRDPSETHILT 473
Cdd:pfam14707 1 SPHEFLFHYCGAALHAVRWGP------YKAHFFTPSFDPPGAEGCYGSKVP------VTHHDPPLLFDLERDPSEKYPLS 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 530421114 474 PASePVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWC 528
Cdd:pfam14707 69 PDS-PEYPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCCPTFPACTC 122
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
9-470 |
1.65e-57 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 197.43 E-value: 1.65e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigyRVLQWTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16145 26 TPNLDRLAAEGMRFTQHYAGAPVCAPSRASLLTGLHTGHTRV------RGNSEPGGQDPLPPDDVTLAEVLKKAGYATAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNcesasDHCHHPLHHGFDHFYGmpfslmgdcarwelsekrvnleqklnFLFQVLAlvaltlvagkltHlipv 168
Cdd:cd16145 100 FGKWGLGGP-----GTPGHPTKQGFDYFYG--------------------------YLDQVHA------------H---- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllasSYFVGALIVHADCFLMRNHTIT-------EQPMCFQRTTPLILQEVASFLKRNKHGPFLLFV 241
Cdd:cd16145 133 ------------------NYYPEYLWRNGEKVPLPNNVIPpldegnnAGGGGGTYSHDLFTDEALDFIRENKDKPFFLYL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 242 SFLHVHIPLIT-------MENFLGKSLHGLYGDNVEE--------MDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLEn 306
Cdd:cd16145 195 AYTLPHAPLQVpddgpykYKPKDPGIYAYLPWPQPEKayaamvtrLDRDVGRILALLKELGIDENTLVVFTSDNGPHSE- 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 307 qlGNTQY--------------------GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR 366
Cdd:cd16145 274 --GGSEHdpdffdsngplrgykrslyeGG-----------------IRVPFIARWPGKIPAGSVSDHPSAFWDFMPTLAD 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 367 LAGGEVPQDrvIDGQDLLPLLLGTAQHSDHEFLmhYCERFLH----AARWHQrdrgtmWKVhfvtpVFQPEGAGacygrk 442
Cdd:cd16145 335 LAGAEPPED--IDGISLLPTLLGKPQQQQHDYL--YWEFYEGggaqAVRMGG------WKA-----VRHGKKDG------ 393
|
490 500
....*....|....*....|....*...
gi 530421114 443 vcpcfgekvvhhdPPLLFDLSRDPSETH 470
Cdd:cd16145 394 -------------PFELYDLSTDPGETN 408
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
9-472 |
3.23e-54 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 188.16 E-value: 3.23e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVsSIGYRvlqwtgasggLPTNETTFAKILKEKGYATGL 88
Cdd:cd16034 27 TPNLDRLAKEGVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVF-GNDVP----------LPPDAPTIADVLKDAGYRTGY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNCESASDHCHH----PLHHGFDHFYGMpfslmgdcarwelsekrvnleqklnflfqvlalvaltlvagklth 164
Cdd:cd16034 96 IGKWHLDGPERNDGRADDYtpppERRHGFDYWKGY--------------------------------------------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 165 lipvswmpviwsalsavlllassyfvgalivhaDCFLMRNHTI----TEQPMCFQRTTPLILQEVA-SFLKRNKHG--PF 237
Cdd:cd16034 131 ---------------------------------ECNHDHNNPHyyddDGKRIYIKGYSPDAETDLAiEYLENQADKdkPF 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 238 LLFVSF------------------------LHVHIPLITMENF-LGKSLHGLYGdNVEEMDWMVGRILDTLDVEGLSNST 292
Cdd:cd16034 178 ALVLSWnpphdpyttapeeyldmydpkkllLRPNVPEDKKEEAgLREDLRGYYA-MITALDDNIGRLLDALKELGLLENT 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 293 LIYFTSDHG---GSLENQLGNTQYGGwngiykggkgmggwegGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAG 369
Cdd:cd16034 257 IVVFTSDHGdmlGSHGLMNKQVPYEE----------------SIRVPFIIRYPGKIKAGRVVDLLINTVDIMPTLLGLCG 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 370 GEVPQDrvIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTM----WKvhFVtpvfqpegagacygrkvcp 445
Cdd:cd16034 321 LPIPDT--VEGRDLSPLLLGGKDDEPDSVLLQCFVPFGGGSARDGGEWRGVrtdrYT--YV------------------- 377
|
490 500
....*....|....*....|....*..
gi 530421114 446 cfgekVVHHDPPLLFDLSRDPSETHIL 472
Cdd:cd16034 378 -----RDKNGPWLLFDNEKDPYQLNNL 399
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
9-412 |
6.43e-53 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 183.95 E-value: 6.43e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTqHISAASLCTPSRAAFLTGRYPVRSGMVSsigyrvlqwtgasGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16151 26 TPNIDALAAEGVRFN-NAYAQPLCTPSRVQLMTGKYNFRNYVVF-------------GYLDPKQKTFGHLLKDAGYATAI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNcESASDHchhPLHHGFDHFygmpfslmgdCArWELSEKRVNLEQKLNFLFQVLAlvaltlvaGKLTHLIPV 168
Cdd:cd16151 92 AGKWQLGGG-RGDGDY---PHEFGFDEY----------CL-WQLTETGEKYSRPATPTFNIRN--------GKLLETTEG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 SWMPVIWSAlsavlllassyfvgalivhadcFLMRnhtiteqpmcfqrttplilqevasFLKRNKHGPFLLFVSFLHVHI 248
Cdd:cd16151 149 DYGPDLFAD----------------------FLID------------------------FIERNKDQPFFAYYPMVLVHD 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 249 PL----------ITMENFLGKSLHglYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG--GSLENQLGNTQY-GG 315
Cdd:cd16151 183 PFvptpdspdwdPDDKRKKDDPEY--FPDMVAYMDKLVGKLVDKLEELGLRENTIIIFTGDNGthRPITSRTNGREVrGG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 316 wngiykggkGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLG-TAQHS 394
Cdd:cd16151 261 ---------KGKTTDAGTHVPLIVNWPGLIPAGGVSDDLVDFSDFLPTLAELAGAPLPEDYPLDGRSFAPQLLGkTGSPR 331
|
410 420
....*....|....*....|....*
gi 530421114 395 DHEFLMHY-------CERFLHAARW 412
Cdd:cd16151 332 REWIYWYYrnphkkfGSRFVRTKRY 356
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
9-470 |
3.45e-52 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 182.36 E-value: 3.45e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASlCTPSRAAFLTGRYPVRSGMvssiGYRVLqWTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16029 26 TPNLDALAADGVILNNYYVQPI-CTPSRAALMTGRYPIHTGM----QHGVI-LAGEPYGLPLNETLLPQYLKELGYATHL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGlncesasdHCHH---PLHHGFDHFYGMpFSLMGDcarwelsekrvnleqklnflfqvlalvaltlvagkltHL 165
Cdd:cd16029 100 VGKWHLG--------FYTWeytPTNRGFDSFYGY-YGGAED-------------------------------------YY 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 166 IPVSWMPVIWSalsavlllassyfvgalivhaDCFLMRNHTIT-EQPMCFqrTTPLILQEVASFLKR-NKHGPFLLFVSF 243
Cdd:cd16029 134 THTSGGANDYG---------------------NDDLRDNEEPAwDYNGTY--STDLFTDRAVDIIENhDPSKPLFLYLAF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 244 LHVHIPL------ITMENFLGKSLHG----LYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLG---- 309
Cdd:cd16029 191 QAVHAPLqvppeyADPYEDKFAHIKDedrrTYAAMVSALDESVGNVVDALKAKGMLDNTLIVFTSDNGGPTGGGDGgsny 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 310 ------NTQY-GGwngiykggkgmggweggIRVPGiFRWPGVLP--AGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDG 380
Cdd:cd16029 271 plrggkNTLWeGG-----------------VRVPA-FVWSPLLPpkRGTVSDGLMHVTDWLPTLLSLAGGDPDDLPPLDG 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 381 QDLLPLLLGTAQHSDHEFLmhycerflhaarwHQRDRgtmwkvhfvtPVFQPEGAGACYGRKvcpcfgeKVVHHDPplLF 460
Cdd:cd16029 333 VDQWDALSGGAPSPRTEIL-------------LNIDD----------ITRTTGGAAIRVGDW-------KLIVGKP--LF 380
|
490
....*....|
gi 530421114 461 DLSRDPSETH 470
Cdd:cd16029 381 NIENDPCERN 390
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
9-369 |
2.44e-48 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 169.53 E-value: 2.44e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGyrvlqwtgasGGLPTNETTFAKILKEKGYATGL 88
Cdd:pfam00884 26 TPFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVSTP----------VGLPRTEPSLPDLLKRAGYNTGA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNCESAsdhchhPLHHGFDHFYGmpfslmgdcaRWELSEKRVNLEqklnflfqvlalvaltlvagklthlipv 168
Cdd:pfam00884 96 IGKWHLGWYNNQS------PCNLGFDKFFG----------RNTGSDLYADPP---------------------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllassyfvgalivhadcflmRNHTITEQPMCF-QRTTPLILQevasfLKRNKHGPFLLFVSFLHVH 247
Cdd:pfam00884 132 ----------------------------------DVPYNCSGGGVSdEALLDEALE-----FLDNNDKPFFLVLHTLGSH 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 248 IPL------------ITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGG 315
Cdd:pfam00884 173 GPPyypdrypekyatFKPSSCSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHGESLGEGGGYLHGGK 252
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 530421114 316 WNgiykggkgmGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAG 369
Cdd:pfam00884 253 YD---------NAPEGGYRVPLLIWSPGGKAKGQKSEALVSHVDLFPTILDLAG 297
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
9-496 |
1.88e-46 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 166.53 E-value: 1.88e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssIGYRVLQWTgasggLPTNETTFAKILKEKGYATGL 88
Cdd:cd16027 25 TPNLDRLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGA---HGLRSRGFP-----LPDGVKTLPELLREAGYYTGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLglNCESASDHCHHPLHHGFDHFYGMPFslMGDCARWElseKRVNLEQKlnFLFQVlalvaltlvAGKLTHlipV 168
Cdd:cd16027 97 IGKTHY--NPDAVFPFDDEMRGPDDGGRNAWDY--ASNAADFL---NRAKKGQP--FFLWF---------GFHDPH---R 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 SWMPVIWSAL----SAVLLlaSSYFVgalivhaDcflmrnhtiteqpmcfqrtTPLILQEVASFLkrnkhgpfllfvsfl 244
Cdd:cd16027 156 PYPPGDGEEPgydpEKVKV--PPYLP-------D-------------------TPEVREDLADYY--------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 245 hvhiplitmenflgkslhglygDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGwngiykggk 324
Cdd:cd16027 193 ----------------------DEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHGMPFPRAKGTLYDSG--------- 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 325 gmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvIDGQDLLPLLLG-TAQHSDHEFLMH-- 401
Cdd:cd16027 242 --------LRVPLIVRWPGKIKPGSVSDALVSFIDLAPTLLDLAGIEPPEY--LQGRSFLPLLKGeKDPGRDYVFAERdr 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 402 -----YCERFLHAARWHqrdrgtmwkvhfvtpvfqpegagacYgrkvcpcfgekVVHHDPPLLFDLSRDPSETHILtpAS 476
Cdd:cd16027 312 hdetyDPIRSVRTGRYK-------------------------Y-----------IRNYMPEELYDLKNDPDELNNL--AD 353
|
490 500
....*....|....*....|
gi 530421114 477 EPVFYQVMERVQQAVWEHQR 496
Cdd:cd16027 354 DPEYAEVLEELRAALDAWMK 373
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
9-489 |
7.08e-43 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 158.08 E-value: 7.08e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssigyrvlqwTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16031 28 TPNIDRLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVT----------DNNGPLFDASQPTYPKLLRKAGYQTAF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGLNCESASDhchhplhhGFDHFYGMP---------FSLMGDCARWELSEKRVNLEQKLNFL--------Fqvla 151
Cdd:cd16031 98 IGKWHLGSGGDLPPP--------GFDYWVSFPgqgsyydpeFIENGKRVGQKGYVTDIITDKALDFLkerdkdkpF---- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 152 lvALTlVAGKLTHLipvSWMPViwsalsavlllassyfvgalIVHADcfLMRNHTITE-----------QPMCFQRTTPL 220
Cdd:cd16031 166 --CLS-LSFKAPHR---PFTPA--------------------PRHRG--LYEDVTIPEpetfddddyagRPEWAREQRNR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 221 I-LQEVASFLKRNKHGpfllfvsflhvhiplITMENFLGkSLHGlygdnveeMDWMVGRILDTLDVEGLSNSTLIYFTSD 299
Cdd:cd16031 218 IrGVLDGRFDTPEKYQ---------------RYMKDYLR-TVTG--------VDDNVGRILDYLEEQGLADNTIIIYTSD 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 300 HGgsleNQLGNTQYGG-WNgiykggkgmgGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvI 378
Cdd:cd16031 274 NG----FFLGEHGLFDkRL----------MYEESIRVPLIIRDPRLIKAGTVVDALVLNIDFAPTILDLAGVPIPED--M 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 379 DGQDLLPLLLGTAQHS-DHEFLMHYCE--RFLHAARWH--QRDRgtmWK-VHFvtpvfqpegagacygrkvcpcfgekvv 452
Cdd:cd16031 338 QGRSLLPLLEGEKPVDwRKEFYYEYYEepNFHNVPTHEgvRTER---YKyIYY--------------------------- 387
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 530421114 453 HHDPPL--LFDLSRDPSETH--ILTPASEPVFYQVMERVQQ 489
Cdd:cd16031 388 YGVWDEeeLYDLKKDPLELNnlANDPEYAEVLKELRKRLEE 428
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
6-466 |
1.63e-41 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 151.54 E-value: 1.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 6 HSW--TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRsgmvssIGYrvlqWTGASGgLPTNETTFAKILKEKG 83
Cdd:cd16037 21 HPVvrTPNLDRLAARGTRFENAYTPSPICVPSRASFLTGRYVHE------TGV----WDNADP-YDGDVPSWGHALRAAG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 84 YATGLIGKWHLGLNCEsasdhchhplHHGFDHfygmpfslmgdcarwelsekrvnleqklnflfqvlalvaltlvagklt 163
Cdd:cd16037 90 YETVLIGKLHFRGEDQ----------RHGFRY------------------------------------------------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 164 hlipvswmpviwsalsavlllassyfvgalivhaDcflmRNhtiteqpmcfqrttplILQEVASFLKRNKH--GPFLLFV 241
Cdd:cd16037 112 ----------------------------------D----RD----------------VTEAAVDWLREEAAddKPWFLFV 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 242 SFLHVHIPLITMENFLGKSLHGL---YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGgsleNQLG-------NT 311
Cdd:cd16037 138 GFVAPHFPLIAPQEFYDLYVRRAraaYYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDHG----DMLGerglwgkST 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 312 QYggwngiykggkgmggwEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRviDGQDLLPLLLGTA 391
Cdd:cd16037 214 MY----------------EESVRVPMIISGPGI-PAGKRVKTPVSLVDLAPTILEAAGAPPPPDL--DGRSLLPLAEGPD 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 392 QHSDHEFlmhyCErfLHAARwhQRDRGTM-----WK-VHFVtpvfqpegagacygrkvcpcfgekvvhHDPPLLFDLSRD 465
Cdd:cd16037 275 DPDRVVF----SE--YHAHG--SPSGAFMlrkgrWKyIYYV---------------------------GYPPQLFDLEND 319
|
.
gi 530421114 466 P 466
Cdd:cd16037 320 P 320
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
9-470 |
4.46e-40 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 149.90 E-value: 4.46e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQ-HisAASLCTPSRAAFLTGRYPVRSGMvSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATG 87
Cdd:cd16025 27 TPNLDALAAEGLRFTNfH--TTALCSPTRAALLTGRNHHQVGM-GTMAELATGKPGYEGYLPDSAATIAEVLKDAGYHTY 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 88 LIGKWHLGLN----CESASDH-----------------------CHHPLH---------HG-FDhfygmpfslMGdcarW 130
Cdd:cd16025 104 MSGKWHLGPDdyysTDDLTDKaieyideqkapdkpfflylafgaPHAPLQapkewidkyKGkYD---------AG----W 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 131 E-LSEKRvnLE-QKlnflfqvlalvALTLVAG--KLTHLIPvsWMPViWSALSAvlllassyfvgalivhadcflmrnht 206
Cdd:cd16025 171 DaLREER--LErQK-----------ELGLIPAdtKLTPRPP--GVPA-WDSLSP-------------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 207 itEQPMCFQRttpliLQEV-ASFlkrnkhgpfllfvsflhvhiplitmenflgkslhglygdnVEEMDWMVGRILDTLDV 285
Cdd:cd16025 209 --EEKKLEAR-----RMEVyAAM----------------------------------------VEHMDQQIGRLIDYLKE 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 286 EGLSNSTLIYFTSDHGGSLEN---QLGNTQY---------GGwngiykggkgmggweggIRVPGIFRWP-GVLPAGRVIG 352
Cdd:cd16025 242 LGELDNTLIIFLSDNGASAEPgwaNASNTPFrlykqasheGG-----------------IRTPLIVSWPkGIKAKGGIRH 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 353 EPTSLMDVFPTVVRLAGGEVPQDRV------IDGQDLLPLLLGTAQHSDHEFLmhYCERFLHAARWHQRdrgtmWKVhfv 426
Cdd:cd16025 305 QFAHVIDIAPTILELAGVEYPKTVNgvpqlpLDGVSLLPTLDGAAAPSRRRTQ--YFELFGNRAIRKGG-----WKA--- 374
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 530421114 427 tpvfqpegagacygrkvcpcfgekVVHHDPPL------LFDLSRDPSETH 470
Cdd:cd16025 375 ------------------------VALHPPPGwgdqweLYDLAKDPSETH 400
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
9-493 |
1.51e-37 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 143.13 E-value: 1.51e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGyrvlqWTGA-SGGLPTNETTFAKILKEKGYATG 87
Cdd:cd16033 26 TPNIDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVE-----NAGAySRGLPPGVETFSEDLREAGYRNG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 88 LIGKWHLGLNCESASDHC--HHPLHHGFDHFYgmpfslmGDCARWELSEkrvnLEQKlnflfqvlalvaltlvaGKlthl 165
Cdd:cd16033 101 YVGKWHVGPEETPLDYGFdeYLPVETTIEYFL-------ADRAIEMLEE----LAAD-----------------DK---- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 166 iPvsWMpvIWSAlsavlllassyFVGAlivHADCFLmrnhtitEQPMcFQRTTPLILQEVASF---------LKRNKHGP 236
Cdd:cd16033 149 -P--FF--LRVN-----------FWGP---HDPYIP-------PEPY-LDMYDPEDIPLPESFaddfedkpyIYRRERKR 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 237 FLLFVSFLHVHIPLITmeNFLGkslhglygdNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQlgntqyGGW 316
Cdd:cd16033 202 WGVDTEDEEDWKEIIA--HYWG---------YITLIDDAIGRILDALEELGLADDTLVIFTSDHGDALGAH------RLW 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 317 NGIYKGGKGMGgweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvIDGQDLLPLLLGT------ 390
Cdd:cd16033 265 DKGPFMYEETY------RIPLIIKWPGVIAAGQVVDEFVSLLDLAPTILDLAGVDVPPK--VDGRSLLPLLRGEqpedwr 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 391 ----AQHSDHEFLmhYCERFLHAARWHQrdrgtmwkvhfvtpVFQPEGagacygrkvcpcFGEkvvhhdpplLFDLSRDP 466
Cdd:cd16033 337 devvTEYNGHEFY--LPQRMVRTDRYKY--------------VFNGFD------------IDE---------LYDLESDP 379
|
490 500
....*....|....*....|....*..
gi 530421114 467 SETHILtpASEPVFYQVMERVQQAVWE 493
Cdd:cd16033 380 YELNNL--IDDPEYEEILREMRTRLYE 404
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
5-385 |
6.05e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 134.98 E-value: 6.05e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 5 HHSWTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPvrsgmvssigyrvLQWTGASGGLPTNETTFAKILKEKGY 84
Cdd:cd16148 22 DRVTTPNLDRLAAEGVVFDNHYSGSNPTLPSRFSLFTGLYP-------------FYHGVWGGPLEPDDPTLAEILRKAGY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 85 ATGLIgkwhlglncesaSDHCHHPLHHGFDH--FYGMPFSLMGDCARWELSEkrvnleqklnflfqvlalvaltlvagkl 162
Cdd:cd16148 89 YTAAV------------SSNPHLFGGPGFDRgfDTFEDFRGQEGDPGEEGDE---------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 163 thlipvswmpviwsalsavlllassyfvgalivhadcflmrnhtiteqpmcfqrTTPLILQEVASFLKRNKHG-PFLLFV 241
Cdd:cd16148 129 ------------------------------------------------------RAERVTDRALEWLDRNADDdPFFLFL 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 242 SFLHVHIPLitmenflgkslhgLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLeNQLGNTQYGGWNgiyk 321
Cdd:cd16148 155 HYFDPHEPY-------------LYDAEVRYVDEQIGRLLDKLKELGLLEDTLVIVTSDHGEEF-GEHGLYWGHGSN---- 216
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530421114 322 ggkgmgGWEGGIRVPGIFRWPGVLPAGRvIGEPTSLMDVFPTVVRLAGGEVPQDrvIDGQDLLP 385
Cdd:cd16148 217 ------LYDEQLHVPLIIRWPGKEPGKR-VDALVSHIDIAPTLLDLLGVEPPDY--SDGRSLLP 271
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
9-466 |
1.41e-33 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 130.01 E-value: 1.41e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigyrvlqWTGASGgLPTNETTFAKILKEKGYATGL 88
Cdd:cd16032 26 TPNLDRLAARGVVFDNAYCNSPLCAPSRASMMTGRLPSRIGA----------YDNAAE-FPADIPTFAHYLRAAGYRTAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLglncesasdhCHHPLHHGFDHfygmpfslmgDcarwelsekrvnlEQklnflfqvlalvaltlvagklthlipv 168
Cdd:cd16032 95 SGKMHF----------VGPDQLHGFDY----------D-------------EE--------------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpVIWSALSAVLLLAssyfvgalivhadcflmRNHTiteqpmcfqrttplilqevasflKRnkhgPFLLFVSFLHVHI 248
Cdd:cd16032 115 ----VAFKAVQKLYDLA-----------------RGED-----------------------GR----PFFLTVSFTHPHD 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 249 PLITMENFLG----KSLHGLYGdNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGgsleNQLGntQYGGWngiykggK 324
Cdd:cd16032 147 PYVIPQEYWDlyvrRARRAYYG-MVSYVDDKVGQLLDTLERTGLADDTIVIFTSDHG----DMLG--ERGLW-------Y 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 325 GMGGWEGGIRVPGIFRWPGvLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRV-IDGQDLLPLLLGTAQHSDHEFLMHYC 403
Cdd:cd16032 213 KMSFFEGSARVPLIISAPG-RFAPRRVAEPVSLVDLLPTLVDLAGGGTAPHVPpLDGRSLLPLLEGGDSGGEDEVISEYL 291
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 404 ErflhaarwhqrdrgtmwkvhfvtpvfqpEGAGAcygrkvcPCF-----GEKVVH--HDPPLLFDLSRDP 466
Cdd:cd16032 292 A----------------------------EGAVA-------PCVmirrgRWKFIYcpGDPDQLFDLEADP 326
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
9-496 |
1.59e-32 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 129.69 E-value: 1.59e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssigyrvlqWTGASggLPTNETTFAKILKEKGYATGL 88
Cdd:cd16028 26 TPNLDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSV---------WNGTP--LDARHLTLALELRKAGYDPAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHL-----GLNCESASDHCHHPLHHGFDHFYGMPFslmgdcARWELSEKRVNLEQKLNFLfqvlalvalTLVAGK-- 161
Cdd:cd16028 95 FGYTDTspdprGLAPLDPRLLSYELAMPGFDPVDRLDE------YPAEDSDTAFLTDRAIEYL---------DERQDEpw 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 162 ---LTHLIPvSWmPVIWSALSAVLLLASSyfVGALIvhadcflmRNHTITEQpmcfQRTTPLIlqevASFLKRNKHGpfl 238
Cdd:cd16028 160 flhLSYIRP-HP-PFVAPAPYHALYDPAD--VPPPI--------RAESLAAE----AAQHPLL----AAFLERIESL--- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 239 lfvSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGgsleNQLGNTQYGGwng 318
Cdd:cd16028 217 ---SFSPGAANAADLDDEEVAQMRATYLGLIAEVDDHLGRLFDYLKETGQWDDTLIVFTSDHG----EQLGDHWLWG--- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 319 iykggkGMGGWEGGIRVPGIFRWPGVL---PAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvIDGQDLLPLLLG------ 389
Cdd:cd16028 287 ------KDGFFDQAYRVPLIVRDPRREadaTRGQVVDAFTESVDVMPTILDWLGGEIPHQ--CDGRSLLPLLAGaqpsdw 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 390 -TAQHSDHEFlmhycerFLHAARWHQRDRGTmwkvhfvtpvfQPEGAGACYGRkvcpcfGE--KVVHHD--PPLLFDLSR 464
Cdd:cd16028 359 rDAVHYEYDF-------RDVSTRRPQEALGL-----------SPDECSLAVIR------DErwKYVHFAalPPLLFDLKN 414
|
490 500 510
....*....|....*....|....*....|..
gi 530421114 465 DPSETHILtpASEPVFYQVMERVQQAVWEHQR 496
Cdd:cd16028 415 DPGELRDL--AADPAYAAVVLRYAQKLLSWRM 444
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
9-385 |
2.65e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 124.66 E-value: 2.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16149 26 TPNLDRLAAEGVRFENFFCTSPVCSPARASLLTGRMPSQHGIHDWIVEGSHGKTKKPEGYLEGQTTLPEVLQDAGYRCGL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLGlncesasdhchhplhhgfdhfygmpfslmgdcarwelsekrvnleqklnflfqvlalvaltlvagklthlipv 168
Cdd:cd16149 106 SGKWHLG------------------------------------------------------------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllassyfvgaliVHADCFLMRNHtiteqpmcfqrttplilqevasflKRNKhgPFLLFVSFLHVHI 248
Cdd:cd16149 113 --------------------------DDAADFLRRRA------------------------EAEK--PFFLSVNYTAPHS 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 249 PlitmenflgkslHGlYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLenqlgnTQYGGW---------NGI 319
Cdd:cd16149 141 P------------WG-YFAAVTGVDRNVGRLLDELEELGLTENTLVIFTSDNGFNM------GHHGIWgkgngtfplNMY 201
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530421114 320 YKGgkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLP 385
Cdd:cd16149 202 DNS----------VKVPFIIRWPGVVPAGRVVDSLVSAYDFFPTLLELAGVDPPADPRLPGRSFAD 257
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
9-489 |
4.45e-31 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 123.88 E-value: 4.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigYRvlqwtgASGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16152 27 TPNLDALAEEGVLFENAFTPQPVCGPARACLQTGLYPTETGC-----FR------NGIPLPADEKTLAHYFRDAGYETGY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLglncesasdhchhplhhgfdhfygmpfslmgdcarwelsekrvnleqklnflfqvlalvaltlvAGklthlipv 168
Cdd:cd16152 96 VGKWHL----------------------------------------------------------------AG-------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 swmpviwsalsavlllassYFVGALIVHADCFLMrnhtiteqpmcfqrttplilqevasflKRNKHGPFLLFVSFLHVHi 248
Cdd:cd16152 104 -------------------YRVDALTDFAIDYLD---------------------------NRQKDKPFFLFLSYLEPH- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 249 plitMEN------------------FLGKSLHGLYGD----------NVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDH 300
Cdd:cd16152 137 ----HQNdrdryvapegsaerfanfWVPPDLAALPGDwaeelpdylgCCERLDENVGRIRDALKELGLYDNTIIVFTSDH 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 301 GGSLENQlgNTQYggwngiykggkGMGGWEGGIRVPGIFRWPGVLpAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvIDG 380
Cdd:cd16152 213 GCHFRTR--NAEY-----------KRSCHESSIRVPLVIYGPGFN-GGGRVEELVSLIDLPPTLLDAAGIDVPEE--MQG 276
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 381 QDLLPLLLGTAQHSDHEFLMHYCE----RFLHAARW----HQRDRGtmWKVHFVTPVFQPEgagacygrkvcpcfgekvv 452
Cdd:cd16152 277 RSLLPLVDGKVEDWRNEVFIQISEsqvgRAIRTDRWkysvAAPDKD--GWKDSGSDVYVED------------------- 335
|
490 500 510
....*....|....*....|....*....|....*..
gi 530421114 453 hhdppLLFDLSRDPSETHILtpASEPVFYQVMERVQQ 489
Cdd:cd16152 336 -----YLYDLEADPYELVNL--IGRPEYREVAAELRE 365
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
9-477 |
2.35e-29 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 120.93 E-value: 2.35e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssiGYrvlqwtgASGGLPTNETTFAKILKEKGYATGL 88
Cdd:PRK13759 32 TPNLDMLASEGYNFENAYSAVPSCTPARAALLTGLSQWHHGRV---GY-------GDVVPWNYKNTLPQEFRDAGYYTQC 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHLglncesasdhchHPLH--HGFDHfygmpfSLMGDcarWELSEKRVNLEQKLNFLFQVLALVALTLVaGKLTHLI 166
Cdd:PRK13759 102 IGKMHV------------FPQRnlLGFHN------VLLHD---GYLHSGRNEDKSQFDFVSDYLAWLREKAP-GKDPDLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 167 PVSWMPVIWSAlsavlllassyfvgalivhadcflmRNHTITEQpmcfQRTTPLILQEVASFLKR-NKHGPFLLFVSFLH 245
Cdd:PRK13759 160 DIGWDCNSWVA-------------------------RPWDLEER----LHPTNWVGSESIEFLRRrDPTKPFFLKMSFAR 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 246 VHIPLITMENFL-------------------------GKSLHGLYGD---------------NVEEMDWMVGRILDTLDV 285
Cdd:PRK13759 211 PHSPYDPPKRYFdmykdadipdphigdweyaedqdpeGGSIDALRGNlgeeyarraraayygLITHIDHQIGRFLQALKE 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 286 EGLSNSTLIYFTSDHGgsleNQLGNTQ-------YGGwngiykggkgmggwegGIRVPGIFRWPG---VLPAGRVIGEPT 355
Cdd:PRK13759 291 FGLLDNTIILFVSDHG----DMLGDHYlfrkgypYEG----------------SAHIPFIIYDPGgllAGNRGTVIDQVV 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 356 SLMDVFPTVVRLAGGEVPQDrvIDGQDLLPLLLG-TAQHSDHEFLMH-YCERFLHaarWHQRDRGT-MWkvHFVTPVFQp 432
Cdd:PRK13759 351 ELRDIMPTLLDLAGGTIPDD--VDGRSLKNLIFGqYEGWRPYLHGEHaLGYSSDN---YLTDGKWKyIW--FSQTGEEQ- 422
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 530421114 433 egagacygrkvcpcfgekvvhhdpplLFDLSRDPSETHILTPASE 477
Cdd:PRK13759 423 --------------------------LFDLKKDPHELHNLSPSEK 441
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
9-396 |
4.12e-28 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 116.52 E-value: 4.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYrvlqWTGASGglptNETTFAKILKEKGYATGL 88
Cdd:cd16030 27 TPNIDRLAARGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGVYDNNSY----FRKVAP----DAVTLPQYFKENGYTTAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHlglncesasdhchhplHHGFDHFYGMPFSlmgdcarWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPV 168
Cdd:cd16030 99 VGKIF----------------HPGIPDGDDDPAS-------WDEPPNPPGPEKYPPGKLCPGKKGGKGGGGGPAWEAADV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 --SWMPVIWSALSAVLLLAS------SYFVGA--------LIVHADCFLMRNHTITEQPMCFQRT-TPLI----LQEVas 227
Cdd:cd16030 156 pdEAYPDGKVADEAIEQLRKlkdsdkPFFLAVgfykphlpFVAPKKYFDLYPLESIPLPNPFDPIdLPEVawndLDDL-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 228 flkRNKHGPFLLFVSFLHVHIPlitmENFLGKSLHGLYGdNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGslenQ 307
Cdd:cd16030 234 ---PKYGDIPALNPGDPKGPLP----DEQARELRQAYYA-SVSYVDAQVGRVLDALEELGLADNTIVVLWSDHGW----H 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 308 LGntQYGGW---------NgiykggkgmggweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGgeVPQDRVI 378
Cdd:cd16030 302 LG--EHGHWgkhtlfeeaT----------------RVPLIIRAPGVTKPGKVTDALVELVDIYPTLAELAG--LPAPPCL 361
|
410
....*....|....*...
gi 530421114 379 DGQDLLPLLLGTAQHSDH 396
Cdd:cd16030 362 EGKSLVPLLKNPSAKWKD 379
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
10-402 |
6.65e-25 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 104.98 E-value: 6.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 10 PNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVlQWTgasggLPTNETTFAKILKEKGYATGLI 89
Cdd:cd16035 27 PARERLAANGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTDTLGSPM-QPL-----LSPDVPTLGHMLRAAGYYTAYK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 90 GKWHLglncesasdhchhplhhgfdhfygmpfslmgdcarwelsekrvnleqklnflfqvlalvaltlvagklthlipvs 169
Cdd:cd16035 101 GKWHL--------------------------------------------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 170 wmpviwsalsavlllaSSYFVGALivhadcflMRNHTITEQPMCFqrttpliLQEVASflKRNKHGPFLLFVSFL--H-V 246
Cdd:cd16035 106 ----------------SGAAGGGY--------KRDPGIAAQAVEW-------LRERGA--KNADGKPWFLVVSLVnpHdI 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 247 HIPLITMENFlgKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG------GSLENqlGNTQYGgwngiy 320
Cdd:cd16035 153 MFPPDDEERW--RRFRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDHGemggahGLRGK--GFNAYE------ 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 321 kggkgmggweGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVID----GQDLLPLLLGTAQHSDH 396
Cdd:cd16035 223 ----------EALHVPLIISHPDLFGTGQTTDALTSHIDLLPTLLGLAGVDAEARATEApplpGRDLSPLLTDADADAVR 292
|
....*..
gi 530421114 397 E-FLMHY 402
Cdd:cd16035 293 DgILFTY 299
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
14-381 |
2.97e-23 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 101.86 E-value: 2.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 14 RLAEDGVKLTQHISAASLCTPSRAAFLTGRYP----VRSGMVSSIGYRVLQWTGAsgglptNETTFAKILKEKGYATGLI 89
Cdd:cd16147 28 LLADQGTTFTNAFVTTPLCCPSRASILTGQYAhnhgVTNNSPPGGGYPKFWQNGL------ERSTLPVWLQEAGYRTAYA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 90 GKWhlgLN-CESASDHCHHPLhhGFDHFYGMPFslmgdcarwelsekrvnleqklNFLFQVLALVALTLVAGklthliPV 168
Cdd:cd16147 102 GKY---LNgYGVPGGVSYVPP--GWDEWDGLVG----------------------NSTYYNYTLSNGGNGKH------GV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 169 SWmpviwsalsavlllASSYFvgalivhadcflmrnhtiteqpmcfqrtTPLILQEVASFLKR--NKHGPFLLFVSFLHV 246
Cdd:cd16147 149 SY--------------PGDYL----------------------------TDVIANKALDFLRRaaADDKPFFLVVAPPAP 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 247 HIPLI----TMENFLGKSLHGLYG---------------------DNVEEMDW--------------MVGRILDTLDVEG 287
Cdd:cd16147 187 HGPFTpaprYANLFPNVTAPPRPPpnnpdvsdkphwlrrlpplnpTQIAYIDElyrkrlrtlqsvddLVERLVNTLEATG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 288 LSNSTLIYFTSDHG---GSLENQLGNTQ-YggwngiykggkgmggwEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPT 363
Cdd:cd16147 267 QLDNTYIIYTSDNGyhlGQHRLPPGKRTpY----------------EEDIRVPLLVRGPGI-PAGVTVDQLVSNIDLAPT 329
|
410
....*....|....*...
gi 530421114 364 VVRLAGGEVPQDrvIDGQ 381
Cdd:cd16147 330 ILDLAGAPPPSD--MDGR 345
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
9-486 |
7.11e-23 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 100.33 E-value: 7.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQ-HI----SAAsLCTPSRAAFLTGRYPVRSGMvssigyrvlqwtGASGGLPTNETTFAKILKEKG 83
Cdd:cd16155 28 TPNLDRLARRGTSFTNaYNmggwSGA-VCVPSRAMLMTGRTLFHAPE------------GGKAAIPSDDKTWPETFKKAG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 84 YATGLIGKWHLGLnCESASDHCHHP--------LHHGFDH---FYGMPFSLMgdcarwelseKRVNLEqklnflfqvlal 152
Cdd:cd16155 95 YRTFATGKWHNGF-ADAAIEFLEEYkdgdkpffMYVAFTAphdPRQAPPEYL----------DMYPPE------------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 153 valtlvagklTHLIPVSWMPViwsalsavlllassY-FVGALIVHADcflmrnhtitEQPMCFQRTTplilQEVASFLKR 231
Cdd:cd16155 152 ----------TIPLPENFLPQ--------------HpFDNGEGTVRD----------EQLAPFPRTP----EAVRQHLAE 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 232 NkhgpfllfvsflhvhiplitmenflgkslhglYGdNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG------GSLE 305
Cdd:cd16155 194 Y--------------------------------YA-MITHLDAQIGRILDALEASGELDNTIIVFTSDHGlavgshGLMG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 306 NQlgNTQYGGWngiykggkgmggweggiRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvIDGQDLLP 385
Cdd:cd16155 241 KQ--NLYEHSM-----------------RVPLIISGPGI-PKGKRRDALVYLQDVFPTLCELAGIEIPES--VEGKSLLP 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 386 LLLG-TAQHSDHEFLMhycerFLHAARWHQRDRgtmWKVHFVTPvfqpegagacygrkvcpcfGEKVVhhdppLLFDLSR 464
Cdd:cd16155 299 VIRGeKKAVRDTLYGA-----YRDGQRAIRDDR---WKLIIYVP-------------------GVKRT-----QLFDLKK 346
|
490 500
....*....|....*....|..
gi 530421114 465 DPSETHILtpASEPVFYQVMER 486
Cdd:cd16155 347 DPDELNNL--ADEPEYQERLKK 366
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
6-470 |
1.24e-22 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 100.39 E-value: 1.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 6 HSWTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYP-VRsgmvssiGYRVLQWTgasggLPTNETTFAKILKEKGY 84
Cdd:cd16150 23 AAVTPNLDALAAEGVRFSNAYCQNPVCSPSRCSFLTGWYPhVN-------GHRTLHHL-----LRPDEPNLLKTLKDAGY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 85 ATGLIGKWHLGLNCESASDHChhplhhgfdhfygmpfslmgdcarwelSEKRVNLEQKLNFLFQvlalvaltlvagkltH 164
Cdd:cd16150 91 HVAWAGKNDDLPGEFAAEAYC---------------------------DSDEACVRTAIDWLRN---------------R 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 165 LIPVSWmpviwsalsaVLLLASSY----FVgaliVHADCFLMrnhtITEQPMCFQRTTPLILQEVASFLK-RNKHGpfll 239
Cdd:cd16150 129 RPDKPF----------CLYLPLIFphppYG----VEEPWFSM----IDREKLPPRRPPGLRAKGKPSMLEgIEKQG---- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 240 FVSflhvhiplITMENFlgKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHG-------------GSLEN 306
Cdd:cd16150 187 LDR--------WSEERW--RELRATYLGMVSRLDHQFGRLLEALKETGLYDDTAVFFFSDHGdytgdyglvekwpNTFED 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 307 QLgntqyggwngiykggkgmggweggIRVPGIFRWPGvLPAGRVIGEPTSLMDVFPTVVRLAGgeVPQDRVIDGQDLLPL 386
Cdd:cd16150 257 CL------------------------TRVPLIIKPPG-GPAGGVSDALVELVDIPPTLLDLAG--IPLSHTHFGRSLLPV 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 387 LLG-TAQHSDHEFlmhyCE-RFLHAARWHqrdrgtMWKVHFVTPVFQPEG----AGACYGRKVcpcfgeKVVHHD----- 455
Cdd:cd16150 310 LAGeTEEHRDAVF----SEgGRLHGEEQA------MEGGHGPYDLKWPRLlqqeEPPEHTKAV------MIRTRRykyvy 373
|
490
....*....|....*....
gi 530421114 456 ----PPLLFDLSRDPSETH 470
Cdd:cd16150 374 rlyePDELYDLEADPLELH 392
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
9-387 |
8.26e-22 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 98.22 E-value: 8.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigyrvlqWTGaSGGLPTNETTFAKILKEKGYATGL 88
Cdd:cd16156 26 TPNLDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGS----------WTN-CMALGDNVKTIGQRLSDNGIHTAY 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 89 IGKWHL------GLN-CESASDHchhplhhgfDHFYGMPFSLMgdcarwELSEKRVnleqklnflfqvlalvaltlvagk 161
Cdd:cd16156 95 IGKWHLdggdyfGNGiCPQGWDP---------DYWYDMRNYLD------ELTEEER------------------------ 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 162 lthlipvswmpVIWSalsavLLLASSYfvgalivhadcflmrNHTITEQPMCFQRTTPLILQevasFLKRNKHGPFLLFV 241
Cdd:cd16156 136 -----------RKSR-----RGLTSLE---------------AEGIKEEFTYGHRCTNRALD----FIEKHKDEDFFLVV 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 242 SFLHVHIPLI------TM-------------ENFLGKSLH------GLYGDNVEEM--------------DWMVGRILDT 282
Cdd:cd16156 181 SYDEPHHPFLcpkpyaSMykdfefpkgenayDDLENKPLHqrlwagAKPHEDGDKGtikhplyfgcnsfvDYEIGRVLDA 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 283 LDvEGLSNSTLIYfTSDHGGSLENQL----GNTQYggwngiykggkgmggwEGGIRVPGIFRWPGVLPAGRVIGEPTSLM 358
Cdd:cd16156 261 AD-EIAEDAWVIY-TSDHGDMLGAHKlwakGPAVY----------------DEITNIPLIIRGKGGEKAGTVTDTPVSHI 322
|
410 420
....*....|....*....|....*....
gi 530421114 359 DVFPTVVRLAGgeVPQDRVIDGQDLLPLL 387
Cdd:cd16156 323 DLAPTILDYAG--IPQPKVLEGESILATI 349
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
4-383 |
1.18e-21 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 95.13 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 4 LHHSWTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYrvlqWTGASGGLPtnetTFAKILKEKG 83
Cdd:cd16153 32 LGYVESPNIDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRTGVYGFEAA----HPALDHGLP----TFPEVLKKAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 84 YATGLIGKWHlglncesasdhchhplhhgfdhfygmpfslmgdcarwelsekrvnLEQKLNFLFQvlALVALTLVAGKlt 163
Cdd:cd16153 104 YQTASFGKSH---------------------------------------------LEAFQRYLKN--ANQSYKSFWGK-- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 164 hlipVSWMPviwsalsavlllassyfvgalivhadcflmrnhtiteqpmcfqrttplilqevasflKRNKhgPFLLFVSF 243
Cdd:cd16153 135 ----IAKGA---------------------------------------------------------DSDK--PFFVRLSF 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 244 LHVHIPLITMENFLGK-SLHGL--YGDNveemdwMVGRILDTLDVEGLSN---STLIYFTSDHGGSLENQLGNTQYGGWN 317
Cdd:cd16153 152 LQPHTPVLPPKEFRDRfDYYAFcaYGDA------QVGRAVEAFKAYSLKQdrdYTIVYVTGDHGWHLGEQGILAKFTFWP 225
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530421114 318 giykggkgmggweGGIRVPGIFRWPGVL--PAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDL 383
Cdd:cd16153 226 -------------QSHRVPLIVVSSDKLkaPAGKVRHDFVEFVDLAPTLLAAAGVDVDAPDYLDGRDL 280
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
9-368 |
1.05e-20 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 91.33 E-value: 1.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKL-TQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQwTGASGGLPTNETTFAKILKEKGYATG 87
Cdd:cd00016 26 TPNLKRLASEGATFnFRSVSPPTSSAPNHAALLTGAYPTLHGYTGNGSADPEL-PSRAAGKDEDGPTIPELLKQAGYRTG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 88 LIGkwhlglncesasdhchhplhhgfdhfygmpfslmgdcarwelsekrvnLEQKLNFLfqvlalvaltlvagklthlip 167
Cdd:cd00016 105 VIG------------------------------------------------LLKAIDET--------------------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 168 vswmpviwsalsavlllassyfvgalivhadcflmrnhtiteqpmcfqrttplilqevasflkrNKHGPFLLFVSFLHVH 247
Cdd:cd00016 116 ----------------------------------------------------------------SKEKPFVLFLHFDGPD 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 248 IPLitmenFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENqLGNTqyggwngiYKGGKGMG 327
Cdd:cd00016 132 GPG-----HAYGPNTPEYYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGGIDKG-HGGD--------PKADGKAD 197
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 530421114 328 GWEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVRLA 368
Cdd:cd00016 198 KSHTGMRVPFIAYGPGV-KKGGVKHELISQYDIAPTLADLL 237
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
9-394 |
4.05e-20 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 92.03 E-value: 4.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTqHISAASLCTPSRAAFLTGRYPVRSGmVSSIGYRVLQwtgasgglpTNETTFAKILKE---KGYA 85
Cdd:cd16154 28 TPTLDSLANSGIVFD-NLWATPACSPTRATILTGKYGFRTG-VLAVPDELLL---------SEETLLQLLIKDattAGYS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 86 TGLIGKWHLGlNCESasdhcHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKlnflfqvlalvalTLVAGKLTHL 165
Cdd:cd16154 97 SAVIGKWHLG-GNDN-----SPNNPGGIPYYAGILGGGVQDYYNWNLTNNGQTTNST-------------EYATTKLTNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 166 iPVSWmpviwsalsavlllassyfvgalivhadcflmrnhtITEQpmcfqrTTP--LILQEVASflkrnkHGPFllfvsf 243
Cdd:cd16154 158 -AIDW------------------------------------IDQQ------TKPwfLWLAYNAP------HTPF------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 244 lhvHIPLITMENflgKSLHGLY---GDN--------VEEMDWMVGRILDTLDVEGLSNsTLIYFTSDHG--GSLENQLGN 310
Cdd:cd16154 183 ---HLPPAELHS---RSLLGDSadiEANprpyylaaIEAMDTEIGRLLASIDEEEREN-TIIIFIGDNGtpGQVVDLPYT 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 311 TQY-------GGwngiykggkgmggweggIRVPGIFRWPGVlpaGRVIGEPTSLM---DVFPTVVRLAGGEVPQdrVIDG 380
Cdd:cd16154 256 RNHakgslyeGG-----------------INVPLIVSGAGV---ERANERESALVnatDLYATIAELAGVDAAE--IHDS 313
|
410
....*....|....
gi 530421114 381 QDLLPLLLGTAQHS 394
Cdd:cd16154 314 VSFKPLLSDVNAST 327
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
232-467 |
6.92e-13 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 70.26 E-value: 6.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 232 NKHGPFLLFVSFLHVH-IPLITM-ENFLG-KSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGgslENQL 308
Cdd:cd16171 162 NLTQPFALYLGLNLPHpYPSPSMgENFGSiRNIRAFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHG---ELAM 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 309 GNTQYggwngiykggKGMGGWEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDrvIDGQDLLPLLL 388
Cdd:cd16171 239 EHRQF----------YKMSMYEGSSHVPLLIMGPGI-KAGQQVSDVVSLVDIYPTMLDIAGVPQPQN--LSGYSLLPLLS 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 389 GTAQHSDH-----------EFlmHYCErfLHAARWHQRDrgTMWKvhFVTpvfqpegagacYGRkvcpcfGEKVvhhdPP 457
Cdd:cd16171 306 ESSIKESPsrvphpdwvlsEF--HGCN--VNASTYMLRT--NSWK--YIA-----------YAD------GNSV----PP 356
|
250
....*....|
gi 530421114 458 LLFDLSRDPS 467
Cdd:cd16171 357 QLFDLSKDPD 366
|
|
| YejM |
COG3083 |
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall ... |
202-384 |
1.85e-08 |
|
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];
Pssm-ID: 442317 [Multi-domain] Cd Length: 603 Bit Score: 56.84 E-value: 1.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 202 MRNHTITEQPMCFQRTTpLILQEVASFL-KRNKHGPFLLFVSFLHVHI------------------PLITMENFLGKSLH 262
Cdd:COG3083 348 VSLPRLHTPGGPAQRDR-QITAQWLQWLdQRDSDRPWFSYLFLDAPHAysfpadypkpfqpsedcnYLALDNESDPTPFK 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 263 GLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSL----ENQLG-NTQYGGWNgiykggkgmggweggIRVPG 337
Cdd:COG3083 427 NRYRNAVHYVDSQIGRVLDTLEQRGLLENTIVIITADHGEEFnengQNYWGhNSNFSRYQ---------------LQVPL 491
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 530421114 338 IFRWPGVLPagRVIGEPTSLMDVFPTVV-RLAGGEVPqdrVID---GQDLL 384
Cdd:COG3083 492 VIHWPGTPP--QVISKLTSHLDIVPTLMqRLLGVQNP---ASDysqGEDLF 537
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
222-384 |
2.27e-08 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 56.59 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 222 LQEVASFLKRNKhGPFLLFVsflhvhiplITMEN---F-----------LGKSLHGLYGDNVEEMDWMVGRILDTLDVEG 287
Cdd:COG1368 372 FDKALEELEKLK-KPFFAFL---------ITLSNhgpYtlpeedkkipdYGKTTLNNYLNAVRYADQALGEFIEKLKKSG 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 288 LSNSTLIYFTSDHGGSLEnqlGNTQYggwngiykggkgmGGWEGGIRVPGIFRWPGvLPAGRVIGEPTSLMDVFPTVVRL 367
Cdd:COG1368 442 WYDNTIFVIYGDHGPRSP---GKTDY-------------ENPLERYRVPLLIYSPG-LKKPKVIDTVGSQIDIAPTLLDL 504
|
170
....*....|....*..
gi 530421114 368 AGGEVPQDRVIdGQDLL 384
Cdd:COG1368 505 LGIDYPSYYAF-GRDLL 520
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
222-369 |
7.24e-08 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 53.84 E-value: 7.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 222 LQEVASFLKRNKHGPFLLFVsflhvhiplITMENflgkslHGLYGDN-----------------------VEEMDWMVGR 278
Cdd:cd16015 143 FDQALEELEELKKKPFFIFL---------VTMSN------HGPYDLPeekkdeplkveedktelenylnaIHYTDKALGE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 279 ILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIykggkgmggweggiRVPGIFRWPGVLPaGRVIGEPTSLM 358
Cdd:cd16015 208 FIEKLKKSGLYENTIIVIYGDHLPSLGSDYDETDEDPLDLY--------------RTPLLIYSPGLKK-PKKIDRVGSQI 272
|
170
....*....|.
gi 530421114 359 DVFPTVVRLAG 369
Cdd:cd16015 273 DIAPTLLDLLG 283
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
9-139 |
7.20e-06 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 48.21 E-value: 7.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530421114 9 TPNIDRLAEDGVKLTQHISAA-SLCTPSRAAFLTGRYPVRSGMVSSIGYR--------VLQWTGASGGLPT--NETTFAK 77
Cdd:COG1524 44 APNLAALAARGVYARPLTSVFpSTTAPAHTTLLTGLYPGEHGIVGNGWYDpelgrvvnSLSWVEDGFGSNSllPVPTIFE 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530421114 78 ILKEKGYATGLIGKWHLGlncESASDHCHHPLHH-GFDHFYGMPFS--LMGDCARWELSEKRVNL 139
Cdd:COG1524 124 RARAAGLTTAAVFWPSFE---GSGLIDAARPYPYdGRKPLLGNPAAdrWIAAAALELLREGRPDL 185
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
9-52 |
5.98e-03 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 38.94 E-value: 5.98e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 530421114 9 TPNIDRLAEDGVKLTQHISAA-SLCTPSRAAFLTGRYPVRSGMVS 52
Cdd:pfam01663 20 TPNLAALAKEGVSAPNLTPVFpTLTFPNHYTLVTGLYPGSHGIVG 64
|
|
| |
