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Conserved domains on  [gi|530430174|ref|XP_005276976|]
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inward rectifier potassium channel 18 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
296-468 1.47e-114

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


:

Pssm-ID: 465439  Cd Length: 174  Bit Score: 336.49  E-value: 1.47e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  296 LLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHE 375
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEVIPLYQVDLDLGVDTGSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  376 IDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKN-QYKIDYSHFHKTYEVP 454
Cdd:pfam17655  81 IDEDSPLYDLSAKDLLEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKEgRYVVDYSNFDKTVEVP 160
                         170
                  ....*....|....
gi 530430174  455 sTPRCSAKDLVENK 468
Cdd:pfam17655 161 -TPHCSAKELDEKK 173
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
149-289 3.47e-90

Inward rectifier potassium channel transmembrane domain;


:

Pssm-ID: 460023  Cd Length: 141  Bit Score: 272.90  E-value: 3.47e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  149 VKKNGQCNIAFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEGHGRTPCVMQ 228
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDQRPDDGHTPCVYN 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530430174  229 VHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQSIVGCIIDSFMIGAIMAKMARP 289
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMARP 141
IRK_N pfam08466
Inward rectifier potassium channel N-terminal; This metazoan domain is found to the N-terminus ...
104-148 2.52e-21

Inward rectifier potassium channel N-terminal; This metazoan domain is found to the N-terminus of the pfam01007 domain in Inward rectifier potassium channels (KIR2 or IRK2).


:

Pssm-ID: 462486  Cd Length: 45  Bit Score: 87.03  E-value: 2.52e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 530430174  104 TAASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHTRRRCRNRF 148
Cdd:pfam08466   1 MGSGRAHRYSIVSSEEDGLKLSTMAAVNGFGNGKIHTRRKCRSRF 45
PHA03247 super family cl33720
large tegument protein UL36; Provisional
11-111 1.09e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174   11 GPHKSSPCQLVASR----RRLSAPALAASfwrvqesgAEPLSQHSLRGPPCRQLPTSRPRQKQCPPFRPCVPAPQRHGAA 86
Cdd:PHA03247 2866 PPSRSPAAKPAAPArppvRRLARPAVSRS--------TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
                          90       100
                  ....*....|....*....|....*
gi 530430174   87 LPGASLgvsqgPPTPGMTAASRANP 111
Cdd:PHA03247 2938 RPQPPL-----APTTDPAGAGEPSG 2957
 
Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
296-468 1.47e-114

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 336.49  E-value: 1.47e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  296 LLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHE 375
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEVIPLYQVDLDLGVDTGSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  376 IDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKN-QYKIDYSHFHKTYEVP 454
Cdd:pfam17655  81 IDEDSPLYDLSAKDLLEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKEgRYVVDYSNFDKTVEVP 160
                         170
                  ....*....|....
gi 530430174  455 sTPRCSAKDLVENK 468
Cdd:pfam17655 161 -TPHCSAKELDEKK 173
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
149-289 3.47e-90

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 272.90  E-value: 3.47e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  149 VKKNGQCNIAFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEGHGRTPCVMQ 228
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDQRPDDGHTPCVYN 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530430174  229 VHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQSIVGCIIDSFMIGAIMAKMARP 289
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMARP 141
IRK_N pfam08466
Inward rectifier potassium channel N-terminal; This metazoan domain is found to the N-terminus ...
104-148 2.52e-21

Inward rectifier potassium channel N-terminal; This metazoan domain is found to the N-terminus of the pfam01007 domain in Inward rectifier potassium channels (KIR2 or IRK2).


Pssm-ID: 462486  Cd Length: 45  Bit Score: 87.03  E-value: 2.52e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 530430174  104 TAASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHTRRRCRNRF 148
Cdd:pfam08466   1 MGSGRAHRYSIVSSEEDGLKLSTMAAVNGFGNGKIHTRRKCRSRF 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
11-111 1.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174   11 GPHKSSPCQLVASR----RRLSAPALAASfwrvqesgAEPLSQHSLRGPPCRQLPTSRPRQKQCPPFRPCVPAPQRHGAA 86
Cdd:PHA03247 2866 PPSRSPAAKPAAPArppvRRLARPAVSRS--------TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
                          90       100
                  ....*....|....*....|....*
gi 530430174   87 LPGASLgvsqgPPTPGMTAASRANP 111
Cdd:PHA03247 2938 RPQPPL-----APTTDPAGAGEPSG 2957
 
Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
296-468 1.47e-114

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 336.49  E-value: 1.47e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  296 LLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHE 375
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEVIPLYQVDLDLGVDTGSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  376 IDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKN-QYKIDYSHFHKTYEVP 454
Cdd:pfam17655  81 IDEDSPLYDLSAKDLLEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKEgRYVVDYSNFDKTVEVP 160
                         170
                  ....*....|....
gi 530430174  455 sTPRCSAKDLVENK 468
Cdd:pfam17655 161 -TPHCSAKELDEKK 173
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
149-289 3.47e-90

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 272.90  E-value: 3.47e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174  149 VKKNGQCNIAFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEGHGRTPCVMQ 228
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDQRPDDGHTPCVYN 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530430174  229 VHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQSIVGCIIDSFMIGAIMAKMARP 289
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMARP 141
IRK_N pfam08466
Inward rectifier potassium channel N-terminal; This metazoan domain is found to the N-terminus ...
104-148 2.52e-21

Inward rectifier potassium channel N-terminal; This metazoan domain is found to the N-terminus of the pfam01007 domain in Inward rectifier potassium channels (KIR2 or IRK2).


Pssm-ID: 462486  Cd Length: 45  Bit Score: 87.03  E-value: 2.52e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 530430174  104 TAASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHTRRRCRNRF 148
Cdd:pfam08466   1 MGSGRAHRYSIVSSEEDGLKLSTMAAVNGFGNGKIHTRRKCRSRF 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
11-111 1.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530430174   11 GPHKSSPCQLVASR----RRLSAPALAASfwrvqesgAEPLSQHSLRGPPCRQLPTSRPRQKQCPPFRPCVPAPQRHGAA 86
Cdd:PHA03247 2866 PPSRSPAAKPAAPArppvRRLARPAVSRS--------TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
                          90       100
                  ....*....|....*....|....*
gi 530430174   87 LPGASLgvsqgPPTPGMTAASRANP 111
Cdd:PHA03247 2938 RPQPPL-----APTTDPAGAGEPSG 2957
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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