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Conserved domains on  [gi|564333462|ref|XP_006231337|]
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lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [Rattus norvegicus]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
7-394 1.38e-57

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 193.16  E-value: 1.38e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462   7 VICFVVGILLSGGPTGTISAVDPEANMNV-TEIIMHWGYPGEEHSVQTGDGYILGVHRIPhGRKNQFDKGPKPVVYLQHG 85
Cdd:PLN02872   4 LISLFISTSAGGVLTGQSNLLRRSPVESLcAQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  86 FLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTgQEQ 165
Cdd:PLN02872  83 LFMAGDAWFLNSPEQSLGFILADHGFDVWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462 166 LYYVGHSQGCTIGFIAFSQmPELAKKVKMFFALAPVLSLNFASGPMVKlgRLPDLLLEDL---FGQKQFLPQSAMVKWLS 242
Cdd:PLN02872 162 IFIVGHSQGTIMSLAALTQ-PNVVEMVEAAALLCPISYLDHVTAPLVL--RMVFMHLDQMvvaMGIHQLNFRSDVLVKLL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462 243 THICTHVIMkelCANIFFLICGFNeKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSdKNYFHYNQSY 322
Cdd:PLN02872 239 DSICEGHMD---CNDLLTSITGTN-CCFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVN 313
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564333462 323 PPLYSIKDMQLPTALWS--GGKDWLADTSDINILLTEIPT---LVYHKNipeWDHLDFIWGLDAPWRLYNEVVSLMK 394
Cdd:PLN02872 314 PPAFDLSLIPKSLPLWMgyGGTDGLADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
7-394 1.38e-57

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 193.16  E-value: 1.38e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462   7 VICFVVGILLSGGPTGTISAVDPEANMNV-TEIIMHWGYPGEEHSVQTGDGYILGVHRIPhGRKNQFDKGPKPVVYLQHG 85
Cdd:PLN02872   4 LISLFISTSAGGVLTGQSNLLRRSPVESLcAQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  86 FLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTgQEQ 165
Cdd:PLN02872  83 LFMAGDAWFLNSPEQSLGFILADHGFDVWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462 166 LYYVGHSQGCTIGFIAFSQmPELAKKVKMFFALAPVLSLNFASGPMVKlgRLPDLLLEDL---FGQKQFLPQSAMVKWLS 242
Cdd:PLN02872 162 IFIVGHSQGTIMSLAALTQ-PNVVEMVEAAALLCPISYLDHVTAPLVL--RMVFMHLDQMvvaMGIHQLNFRSDVLVKLL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462 243 THICTHVIMkelCANIFFLICGFNeKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSdKNYFHYNQSY 322
Cdd:PLN02872 239 DSICEGHMD---CNDLLTSITGTN-CCFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVN 313
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564333462 323 PPLYSIKDMQLPTALWS--GGKDWLADTSDINILLTEIPT---LVYHKNipeWDHLDFIWGLDAPWRLYNEVVSLMK 394
Cdd:PLN02872 314 PPAFDLSLIPKSLPLWMgyGGTDGLADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
35-96 8.14e-31

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 112.25  E-value: 8.14e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564333462   35 VTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTN 96
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTN 62
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
40-181 1.50e-06

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 49.50  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  40 MHWGYPGEEHSVQTGDGYILGVHRIPHgrknqfDKGPKPVVYL------QHGFLADSSNWvtnidnnslgfiLADAGFDV 113
Cdd:COG4757    1 MSTAASPESVTITAADGYPLAARLFPP------AGPPRAVVLInpatgvPQRFYRPFARY------------LAERGFAV 62
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564333462 114 W------MGNSRgNTWSRKHKtlsvsqdeywaFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGctiGFIA 181
Cdd:COG4757   63 LtydyrgIGLSR-PGSLRGFD-----------AGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG---GQLL 121
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
7-394 1.38e-57

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 193.16  E-value: 1.38e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462   7 VICFVVGILLSGGPTGTISAVDPEANMNV-TEIIMHWGYPGEEHSVQTGDGYILGVHRIPhGRKNQFDKGPKPVVYLQHG 85
Cdd:PLN02872   4 LISLFISTSAGGVLTGQSNLLRRSPVESLcAQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  86 FLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTgQEQ 165
Cdd:PLN02872  83 LFMAGDAWFLNSPEQSLGFILADHGFDVWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462 166 LYYVGHSQGCTIGFIAFSQmPELAKKVKMFFALAPVLSLNFASGPMVKlgRLPDLLLEDL---FGQKQFLPQSAMVKWLS 242
Cdd:PLN02872 162 IFIVGHSQGTIMSLAALTQ-PNVVEMVEAAALLCPISYLDHVTAPLVL--RMVFMHLDQMvvaMGIHQLNFRSDVLVKLL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462 243 THICTHVIMkelCANIFFLICGFNeKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSdKNYFHYNQSY 322
Cdd:PLN02872 239 DSICEGHMD---CNDLLTSITGTN-CCFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVN 313
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564333462 323 PPLYSIKDMQLPTALWS--GGKDWLADTSDINILLTEIPT---LVYHKNipeWDHLDFIWGLDAPWRLYNEVVSLMK 394
Cdd:PLN02872 314 PPAFDLSLIPKSLPLWMgyGGTDGLADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
35-96 8.14e-31

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 112.25  E-value: 8.14e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564333462   35 VTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTN 96
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTN 62
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
78-378 1.75e-27

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 109.13  E-value: 1.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462   78 PVVYLQHGFLADSSNWVTNIDNnslgfiLADAGFDVWMGNSRGNTWSRKHKTLSvsqdeywAFSFDEMAKYdlpasINYI 157
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQD-------DYRTDDLAED-----LEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  158 LNKTGQEQLYYVGHSQGCTIGFIAFSQMPElakKVKMFFALAPVLslnfasgPMVKLGRLPDLLLEDLFGQKQFLPQSAM 237
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGALD-------PPHELDEADRFILALFPGFFDGFVADFA 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  238 VKWLSTHICTHVIMKELCANIFFLIcgfNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWgssdknyfh 317
Cdd:pfam00561 133 PNPLGRLVAKLLALLLLRLRLLKAL---PLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE--------- 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564333462  318 ynqsypplysikdmqlPTALWSGGKDWLADtSDINILLTEIPTLVYHKNIPEWDHLDFIWG 378
Cdd:pfam00561 201 ----------------PTLIIWGDQDPLVP-PQALEKLAQLFPNARLVVIPDAGHFAFLEG 244
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
40-181 1.50e-06

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 49.50  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  40 MHWGYPGEEHSVQTGDGYILGVHRIPHgrknqfDKGPKPVVYL------QHGFLADSSNWvtnidnnslgfiLADAGFDV 113
Cdd:COG4757    1 MSTAASPESVTITAADGYPLAARLFPP------AGPPRAVVLInpatgvPQRFYRPFARY------------LAERGFAV 62
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564333462 114 W------MGNSRgNTWSRKHKtlsvsqdeywaFSFDEMAKYDLPASINYILNKTGQEQLYYVGHSQGctiGFIA 181
Cdd:COG4757   63 LtydyrgIGLSR-PGSLRGFD-----------AGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG---GQLL 121
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
47-200 5.42e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 46.92  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  47 EEHSVQTGDGYILGVHRIPHgrknqfDKGPKPVVYLQHGFLADSSNWVtnidnnSLGFILADAGFDVWMGNSRGNTWSRK 126
Cdd:COG2267    4 RLVTLPTRDGLRLRGRRWRP------AGSPRGTVVLVHGLGEHSGRYA------ELAEALAAAGYAVLAFDLRGHGRSDG 71
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564333462 127 HKTLSVsqdeywafSFDEMAKyDLPASINYILNKTGQeQLYYVGHSQGctiGFIAFSQMPELAKKVKMFFALAP 200
Cdd:COG2267   72 PRGHVD--------SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMG---GLIALLYAARYPDRVAGLVLLAP 132
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
73-174 6.08e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 41.74  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  73 DKGPKPVVYLqHGFLADSSNWVTNIDNnslgfiLADAGFDVWmgnsrgntwsrkhkTLSVSQDeywAFSFDEMAKYdLPA 152
Cdd:COG1075    2 AATRYPVVLV-HGLGGSAASWAPLAPR------LRAAGYPVY--------------ALNYPST---NGSIEDSAEQ-LAA 56
                         90       100
                 ....*....|....*....|..
gi 564333462 153 SINYILNKTGQEQLYYVGHSQG 174
Cdd:COG1075   57 FVDAVLAATGAEKVDLVGHSMG 78
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
76-225 1.54e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 42.97  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462   76 PKPVVYLQHGFlADSSNWVTNidnnsLGFILADAGFDVWMGNSRGntwsrkHKtLSVSQDEYWAfSFDEMAKyDLPASIN 155
Cdd:pfam12146   3 PRAVVVLVHGL-GEHSGRYAH-----LADALAAQGFAVYAYDHRG------HG-RSDGKRGHVP-SFDDYVD-DLDTFVD 67
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564333462  156 YILNKTGQEQLYYVGHSQGctiGFIAFSQMPELAKKVKMFFALAPVLSLN--FASGPMVKLGRLPDLLLEDL 225
Cdd:pfam12146  68 KIREEHPGLPLFLLGHSMG---GLIAALYALRYPDKVDGLILSAPALKIKpyLAPPILKLLAKLLGKLFPRL 136
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
50-204 9.80e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 37.30  E-value: 9.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564333462  50 SVQTGDGYIL-GVHRIPHgrknqfDKGPKPVVYLQHGFlaDSSNWVTNIDNNSLgfiLADAGFDVWMGNSRGNTWSRKHk 128
Cdd:COG1506    1 TFKSADGTTLpGWLYLPA------DGKKYPVVVYVHGG--PGSRDDSFLPLAQA---LASRGYAVLAPDYRGYGESAGD- 68
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564333462 129 tlsvsqdeywaFSFDEMAkyDLPASINYILNKTG--QEQLYYVGHSQGctiGFIAFSQMPELAKKVKMFFALAPVLSL 204
Cdd:COG1506   69 -----------WGGDEVD--DVLAAIDYLAARPYvdPDRIGIYGHSYG---GYMALLAAARHPDRFKAAVALAGVSDL 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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