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Conserved domains on  [gi|564335006|ref|XP_006231917|]
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occludin isoform X1 [Rattus norvegicus]

Protein Classification

MARVEL and Occludin_ELL domain-containing protein( domain architecture ID 10472796)

MARVEL and Occludin_ELL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 421-520 3.72e-35

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


:

Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 126.88  E-value: 3.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006  421 YPPITSDQQRQLYKRNFDAGLQEYKSLLAELDEVNKELSRLDRELDDYREESEEYMAAADE-YNRLKQVKGSADYKSKKN 499
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSKEYQDIAEEiLQEYKKKKKDPEYQEKKK 80

                          90       100
                  ....*....|....*....|.
gi 564335006  500 YCKQLKSKLSHIKRMVGDYDR 520
Cdd:pfam07303  81 RCEYLHNKLSHIKRLILEYDQ 101
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 57-263 1.18e-14

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


:

Pssm-ID: 366555  Cd Length: 136  Bit Score: 70.82  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006   57 KWTSPPGVIRILSmlvIVMCIAVFACVASTLAwdraygtgifggsmnypygsgfgsygggfggygygygygygGYTDPRA 136
Cdd:pfam01284   1 FLLTPLGILRILQ---LVFAIIVLGLIASLIA-----------------------------------------YAGSYPS 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006  137 AKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQasgsmygsqiytic 216
Cdd:pfam01284  37 AVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSE-------------- 102

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 564335006  217 sqfytpggtglyvDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIVF 263
Cdd:pfam01284 103 -------------NQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
 
Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 421-520 3.72e-35

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 126.88  E-value: 3.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006  421 YPPITSDQQRQLYKRNFDAGLQEYKSLLAELDEVNKELSRLDRELDDYREESEEYMAAADE-YNRLKQVKGSADYKSKKN 499
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSKEYQDIAEEiLQEYKKKKKDPEYQEKKK 80

                          90       100
                  ....*....|....*....|.
gi 564335006  500 YCKQLKSKLSHIKRMVGDYDR 520
Cdd:pfam07303  81 RCEYLHNKLSHIKRLILEYDQ 101
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 57-263 1.18e-14

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 70.82  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006   57 KWTSPPGVIRILSmlvIVMCIAVFACVASTLAwdraygtgifggsmnypygsgfgsygggfggygygygygygGYTDPRA 136
Cdd:pfam01284   1 FLLTPLGILRILQ---LVFAIIVLGLIASLIA-----------------------------------------YAGSYPS 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006  137 AKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQasgsmygsqiytic 216
Cdd:pfam01284  37 AVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSE-------------- 102

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 564335006  217 sqfytpggtglyvDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIVF 263
Cdd:pfam01284 103 -------------NQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
bZIP_Maf_large cd14718
Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a ...
 428-473 1.41e-03

Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain; Maf proteins are Basic leucine zipper (bZIP) transcription factors that may participate in the activator protein-1 (AP-1) complex, which is implicated in many cell functions including proliferation, apoptosis, survival, migration, tumorigenesis, and morphogenesis, among others. Maf proteins fall into two groups: small and large. The large Mafs (c-Maf, MafA, MafB, and neural retina leucine zipper or NRL) contain an N-terminal transactivation domain, a linker region of varying size, an anxillary DNA-binding domain, a C-terminal bZIP domain. They function as critical regulators of terminal differentiation in the blood and in many tissues such as bone, brain, kidney, pancreas, and retina. MafA and MafB also play crucial roles in islet beta cells; they regulate genes essential for glucose sensing and insulin secretion cooperatively and sequentially. Large Mafs are also implicated in oncogenesis; MafB and c-Maf chromosomal translocations result in multiple myelomas. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269866  Cd Length: 70  Bit Score: 37.26  E-value: 1.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 564335006 428 QQRQ-LYKRNfdaglqeyKSLLAELDEVNKELSRLDRELDDYREESE 473
Cdd:cd14718   29 QQRHvLESEK--------CQLQQQVEQLKQEVSRLARERDAYKEKYE 67
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 139-265 7.66e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 38.71  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006 139 GFLLAMAAFCFIA------SLVIFVTSVIRSGMSrtrryylivIIVSAILGIMVF---IATIVYIMGVNPTAQASGSMYG 209
Cdd:cd17504  253 GLVISAVGLLLLAllhsslWALVVALLLIGIGLG---------LAFASLPNIVVEsvpPDRTGIATGMNTVLRTIGSAIG 323

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564335006 210 SQI-YTICSQFYTPGGTGLYvdqylyhycvvdPQEAiAIVLGFMIIVAFALIIVFAV 265
Cdd:cd17504  324 PAIaGAILTTYTVSITSGGV------------PTEG-AYVLAFLIGAALALAALLLS 367
 
Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 421-520 3.72e-35

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 126.88  E-value: 3.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006  421 YPPITSDQQRQLYKRNFDAGLQEYKSLLAELDEVNKELSRLDRELDDYREESEEYMAAADE-YNRLKQVKGSADYKSKKN 499
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSKEYQDIAEEiLQEYKKKKKDPEYQEKKK 80

                          90       100
                  ....*....|....*....|.
gi 564335006  500 YCKQLKSKLSHIKRMVGDYDR 520
Cdd:pfam07303  81 RCEYLHNKLSHIKRLILEYDQ 101
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 57-263 1.18e-14

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 70.82  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006   57 KWTSPPGVIRILSmlvIVMCIAVFACVASTLAwdraygtgifggsmnypygsgfgsygggfggygygygygygGYTDPRA 136
Cdd:pfam01284   1 FLLTPLGILRILQ---LVFAIIVLGLIASLIA-----------------------------------------YAGSYPS 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006  137 AKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQasgsmygsqiytic 216
Cdd:pfam01284  37 AVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSE-------------- 102

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 564335006  217 sqfytpggtglyvDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIVF 263
Cdd:pfam01284 103 -------------NQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
bZIP_Maf_large cd14718
Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a ...
 428-473 1.41e-03

Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain; Maf proteins are Basic leucine zipper (bZIP) transcription factors that may participate in the activator protein-1 (AP-1) complex, which is implicated in many cell functions including proliferation, apoptosis, survival, migration, tumorigenesis, and morphogenesis, among others. Maf proteins fall into two groups: small and large. The large Mafs (c-Maf, MafA, MafB, and neural retina leucine zipper or NRL) contain an N-terminal transactivation domain, a linker region of varying size, an anxillary DNA-binding domain, a C-terminal bZIP domain. They function as critical regulators of terminal differentiation in the blood and in many tissues such as bone, brain, kidney, pancreas, and retina. MafA and MafB also play crucial roles in islet beta cells; they regulate genes essential for glucose sensing and insulin secretion cooperatively and sequentially. Large Mafs are also implicated in oncogenesis; MafB and c-Maf chromosomal translocations result in multiple myelomas. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269866  Cd Length: 70  Bit Score: 37.26  E-value: 1.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 564335006 428 QQRQ-LYKRNfdaglqeyKSLLAELDEVNKELSRLDRELDDYREESE 473
Cdd:cd14718   29 QQRHvLESEK--------CQLQQQVEQLKQEVSRLARERDAYKEKYE 67
BBP1_C pfam15272
Spindle pole body component BBP1, C-terminal; This C-terminal domain of BBP1, a spindle pole ...
 443-520 3.60e-03

Spindle pole body component BBP1, C-terminal; This C-terminal domain of BBP1, a spindle pole body component, carries coiled-coils that are necessary for the localization of BBP1 to the spindle pole body (SPB). Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge


Pssm-ID: 405864 [Multi-domain]  Cd Length: 183  Bit Score: 38.53  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006  443 EYKSLLAELDEVNKELSRLDRELDDYREESEE--------YMAAADEY-NRLKQVKGSADykskkNYCKqLKSKLSHIKR 513
Cdd:pfam15272   5 EYLELLDKLDKNNRALHLLNKDVRERDEHYQLqetsykkkYLQTRNELiNELKQSKKLYD-----NYYK-LYSKYQQLKK 78


                  ....*..
gi 564335006  514 MVGDYDR 520
Cdd:pfam15272  79 ISNESLD 85
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 139-265 7.66e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 38.71  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335006 139 GFLLAMAAFCFIA------SLVIFVTSVIRSGMSrtrryylivIIVSAILGIMVF---IATIVYIMGVNPTAQASGSMYG 209
Cdd:cd17504  253 GLVISAVGLLLLAllhsslWALVVALLLIGIGLG---------LAFASLPNIVVEsvpPDRTGIATGMNTVLRTIGSAIG 323

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564335006 210 SQI-YTICSQFYTPGGTGLYvdqylyhycvvdPQEAiAIVLGFMIIVAFALIIVFAV 265
Cdd:cd17504  324 PAIaGAILTTYTVSITSGGV------------PTEG-AYVLAFLIGAALALAALLLS 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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