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Conserved domains on  [gi|564337707|ref|XP_006232944|]
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sodium channel modifier 1 isoform X1 [Rattus norvegicus]

Protein Classification

zf-SCNM1 and SCNM1_acidic domain-containing protein( domain architecture ID 11239327)

zf-SCNM1 and SCNM1_acidic domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCNM1_acidic pfam15805
Acidic C-terminal region of sodium channel modifier 1 SCNM1; SCNM1_acidic is the C-terminal ...
 147-192 6.22e-24

Acidic C-terminal region of sodium channel modifier 1 SCNM1; SCNM1_acidic is the C-terminal acidic region of eukaryotic sodium channel modifier protein 1. Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a. SCNM1 sits within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP.


:

Pssm-ID: 464884  Cd Length: 46  Bit Score: 88.99  E-value: 6.22e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564337707  147 SPTKRRVLNHYLTLRSSGWVPDGRGRWVKDENVEFDSDEEEPPDLP 192
Cdd:pfam15805   1 SPTRRRELEHYLRLRSSGWLQDGDGKWVKDENVEFDSDEEEPPPLP 46
zf-SCNM1 pfam15803
Zinc-finger of sodium channel modifier 1; zf-SCNM1 is a C2H2 type zinc-finger conserved in ...
 9-35 4.94e-11

Zinc-finger of sodium channel modifier 1; zf-SCNM1 is a C2H2 type zinc-finger conserved in eukaryotes found at the N-terminus of SCNM1, sodium channel modifier protein 1. Phylogenetic analysis of these zinc finger sequences places SCNM1 within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities.


:

Pssm-ID: 464882  Cd Length: 27  Bit Score: 55.05  E-value: 4.94e-11
                          10        20
                  ....*....|....*....|....*..
gi 564337707    9 CAICPHRPVLDTLAMLTAHRAGKKHLS 35
Cdd:pfam15803   1 CLVCSHRPVFDTILMLSVHRKGKKHLA 27
 
Name Accession Description Interval E-value
SCNM1_acidic pfam15805
Acidic C-terminal region of sodium channel modifier 1 SCNM1; SCNM1_acidic is the C-terminal ...
 147-192 6.22e-24

Acidic C-terminal region of sodium channel modifier 1 SCNM1; SCNM1_acidic is the C-terminal acidic region of eukaryotic sodium channel modifier protein 1. Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a. SCNM1 sits within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP.


Pssm-ID: 464884  Cd Length: 46  Bit Score: 88.99  E-value: 6.22e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564337707  147 SPTKRRVLNHYLTLRSSGWVPDGRGRWVKDENVEFDSDEEEPPDLP 192
Cdd:pfam15805   1 SPTRRRELEHYLRLRSSGWLQDGDGKWVKDENVEFDSDEEEPPPLP 46
zf-SCNM1 pfam15803
Zinc-finger of sodium channel modifier 1; zf-SCNM1 is a C2H2 type zinc-finger conserved in ...
 9-35 4.94e-11

Zinc-finger of sodium channel modifier 1; zf-SCNM1 is a C2H2 type zinc-finger conserved in eukaryotes found at the N-terminus of SCNM1, sodium channel modifier protein 1. Phylogenetic analysis of these zinc finger sequences places SCNM1 within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities.


Pssm-ID: 464882  Cd Length: 27  Bit Score: 55.05  E-value: 4.94e-11
                          10        20
                  ....*....|....*....|....*..
gi 564337707    9 CAICPHRPVLDTLAMLTAHRAGKKHLS 35
Cdd:pfam15803   1 CLVCSHRPVFDTILMLSVHRKGKKHLA 27
 
Name Accession Description Interval E-value
SCNM1_acidic pfam15805
Acidic C-terminal region of sodium channel modifier 1 SCNM1; SCNM1_acidic is the C-terminal ...
 147-192 6.22e-24

Acidic C-terminal region of sodium channel modifier 1 SCNM1; SCNM1_acidic is the C-terminal acidic region of eukaryotic sodium channel modifier protein 1. Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a. SCNM1 sits within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP.


Pssm-ID: 464884  Cd Length: 46  Bit Score: 88.99  E-value: 6.22e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564337707  147 SPTKRRVLNHYLTLRSSGWVPDGRGRWVKDENVEFDSDEEEPPDLP 192
Cdd:pfam15805   1 SPTRRRELEHYLRLRSSGWLQDGDGKWVKDENVEFDSDEEEPPPLP 46
zf-SCNM1 pfam15803
Zinc-finger of sodium channel modifier 1; zf-SCNM1 is a C2H2 type zinc-finger conserved in ...
 9-35 4.94e-11

Zinc-finger of sodium channel modifier 1; zf-SCNM1 is a C2H2 type zinc-finger conserved in eukaryotes found at the N-terminus of SCNM1, sodium channel modifier protein 1. Phylogenetic analysis of these zinc finger sequences places SCNM1 within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities.


Pssm-ID: 464882  Cd Length: 27  Bit Score: 55.05  E-value: 4.94e-11
                          10        20
                  ....*....|....*....|....*..
gi 564337707    9 CAICPHRPVLDTLAMLTAHRAGKKHLS 35
Cdd:pfam15803   1 CLVCSHRPVFDTILMLSVHRKGKKHLA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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