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Conserved domains on  [gi|564339895|ref|XP_006233815|]
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ral guanine nucleotide dissociation stimulator isoform X5 [Rattus norvegicus]

Protein Classification

guanine nucleotide exchange factor( domain architecture ID 13898960)

Ras guanine nucleotide exchange factor activates Ras-like small GTPases by mediating the replacement of GDP with GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 308-570 2.35e-90

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


:

Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 284.92  E-value: 2.35e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 308 LLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKgkEHLAPTIRATVAQFNNVANCVITTCLGDQSmkASDRAR 387
Cdd:cd00155    1 FLSLDPKELAEQLTLLDFELFRKIEPFELLGSLWSKKDKN--IHLSPNLERFIERFNNLSNWVASEILLCTN--PKKRAR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 388 VVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFa 467
Cdd:cd00155   77 LLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSKLKKLFEELEELVDPSRNFKNYRKLLKSVGPNPP- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 468 tlemnprrtqrrqketgviqgTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSacNNYSIVPEE 547
Cdd:cd00155  156 ---------------------CVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQS--NSYELNRDE 212

                        250       260
                 ....*....|....*....|....*
gi 564339895 548 HFGAWFRA--MGRLSEAESYNLSCE 570
Cdd:cd00155  213 DILAFLWKllELILNEDELYELSLE 237
RA_RalGDS cd17209
Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) ...
 724-809 5.04e-59

Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins; RalGDS, also termed Ral guanine nucleotide exchange factor (RalGEF), is a guanine exchange factor (GEF) for the Ral family of small GTPases. It is the prototype of RalGDS family proteins that are involved in Ras and Ral signaling pathways as downstream effector proteins. RalGDS stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. It interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Moreover, RalGDS functions as a novel interacting partner for Rab7-interacting lysosomal protein (RILP), a key regulator for late endosomal/lysosomal trafficking. RILP suppresses invasion of breast cancer cells by inhibiting the GEF activity for RalA of RalGDS. RalGDS also plays a vital role in the regulation of Ral-dependent Weibel-Palade bodies (WPB) exocytosis from endothelial cells. In addition, RalGDS couples growth factor signaling to Akt activation by promoting PDK1-induced Akt phosphorylation. Members in this family have similar domain structure: a central CDC25 homology domain with an upstream Ras Exchange motif (REM), and a C-terminal Ras-associating (RA) domain. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair.


:

Pssm-ID: 340729  Cd Length: 86  Bit Score: 195.17  E-value: 5.04e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 724 DCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYD 803
Cdd:cd17209    1 DCCIIRVSLDVDNGNMYKSILVTSQDKTPVVIRKAMAKHNLDEEEPEDYELLQILSEDRELKIPDNANVFYAMNSTANYD 80


                 ....*.
gi 564339895 804 FILKKR 809
Cdd:cd17209   81 FVLKKR 86
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 57-181 1.27e-37

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


:

Pssm-ID: 214571  Cd Length: 127  Bit Score: 136.70  E-value: 1.27e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895    57 KVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYS-SEDGGPQDQLKNAISSILG 135
Cdd:smart00229   1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESwVEEKVNPRRVKNRVLNILR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 564339895   136 TWLDQYSEDFCQPP-DFPCLKQLvAYVQLNMPGSDLERRAHLLLAQL 181
Cdd:smart00229  81 TWVENYWEDFEDDPkLISFLLEF-LELVDDEKYPGLVTSLLNLLRRL 126
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
186-293 1.43e-08

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 58.71  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPA 265
Cdd:PRK07003 402 VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                         90       100
                 ....*....|....*....|....*...
gi 564339895 266 PELDPTVSqslhLEPAPVPAPALEPSWP 293
Cdd:PRK07003 482 SDAPPDAA----FEPAPRAAAPSAATPA 505
 
Name Accession Description Interval E-value
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 308-570 2.35e-90

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 284.92  E-value: 2.35e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 308 LLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKgkEHLAPTIRATVAQFNNVANCVITTCLGDQSmkASDRAR 387
Cdd:cd00155    1 FLSLDPKELAEQLTLLDFELFRKIEPFELLGSLWSKKDKN--IHLSPNLERFIERFNNLSNWVASEILLCTN--PKKRAR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 388 VVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFa 467
Cdd:cd00155   77 LLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSKLKKLFEELEELVDPSRNFKNYRKLLKSVGPNPP- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 468 tlemnprrtqrrqketgviqgTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSacNNYSIVPEE 547
Cdd:cd00155  156 ---------------------CVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQS--NSYELNRDE 212

                        250       260
                 ....*....|....*....|....*
gi 564339895 548 HFGAWFRA--MGRLSEAESYNLSCE 570
Cdd:cd00155  213 DILAFLWKllELILNEDELYELSLE 237
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
308-575 8.71e-89

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 281.06  E-value: 8.71e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   308 LLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLapTIRATVAQFNNVANCVITTCLGDQSmkASDRAR 387
Cdd:smart00147   1 LLLLDPKELAEQLTLLDFELFRKIDPSELLGSVWGKRSKKSPSPL--NLEAFIRRFNEVSNWVATEILKQTT--PKDRAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   388 VVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEgtskfa 467
Cdd:smart00147  77 LLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSKYKKLFEELEELLSPERNYKNYREALSSC------ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   468 tlemnprrtqrrqketgVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSAcnNYSIVPEE 547
Cdd:smart00147 151 -----------------NLPPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQ--PYNLRPNR 211

                          250       260       270
                   ....*....|....*....|....*....|.
gi 564339895   548 -HFGAWFRAMGRL--SEAESYNLSCELEPPS 575
Cdd:smart00147 212 sDIQSLLQQLLDHldEEEELYQLSLKIEPRV 242
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
 316-522 3.50e-71

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 231.71  E-value: 3.50e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  316 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKehlAPTIRATVAQFNNVANCVITTCLGDQSMKasDRARVVEHWIEV 395
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKKDKKEN---SPNIEAMIARFNKLSNWVASEILSEEDLK--KRAKVIKKFIKI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  396 ARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTskfatlemnprr 475
Cdd:pfam00617  77 AEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSKKYKKTLEELEKLMSPSRNFKNYREALSSASP------------ 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 564339895  476 tqrrqketgviqGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRR 522
Cdd:pfam00617 145 ------------PCIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKRR 179
RA_RalGDS cd17209
Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) ...
 724-809 5.04e-59

Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins; RalGDS, also termed Ral guanine nucleotide exchange factor (RalGEF), is a guanine exchange factor (GEF) for the Ral family of small GTPases. It is the prototype of RalGDS family proteins that are involved in Ras and Ral signaling pathways as downstream effector proteins. RalGDS stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. It interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Moreover, RalGDS functions as a novel interacting partner for Rab7-interacting lysosomal protein (RILP), a key regulator for late endosomal/lysosomal trafficking. RILP suppresses invasion of breast cancer cells by inhibiting the GEF activity for RalA of RalGDS. RalGDS also plays a vital role in the regulation of Ral-dependent Weibel-Palade bodies (WPB) exocytosis from endothelial cells. In addition, RalGDS couples growth factor signaling to Akt activation by promoting PDK1-induced Akt phosphorylation. Members in this family have similar domain structure: a central CDC25 homology domain with an upstream Ras Exchange motif (REM), and a C-terminal Ras-associating (RA) domain. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340729  Cd Length: 86  Bit Score: 195.17  E-value: 5.04e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 724 DCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYD 803
Cdd:cd17209    1 DCCIIRVSLDVDNGNMYKSILVTSQDKTPVVIRKAMAKHNLDEEEPEDYELLQILSEDRELKIPDNANVFYAMNSTANYD 80


                 ....*.
gi 564339895 804 FILKKR 809
Cdd:cd17209   81 FVLKKR 86
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 57-181 1.27e-37

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 136.70  E-value: 1.27e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895    57 KVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYS-SEDGGPQDQLKNAISSILG 135
Cdd:smart00229   1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESwVEEKVNPRRVKNRVLNILR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 564339895   136 TWLDQYSEDFCQPP-DFPCLKQLvAYVQLNMPGSDLERRAHLLLAQL 181
Cdd:smart00229  81 TWVENYWEDFEDDPkLISFLLEF-LELVDDEKYPGLVTSLLNLLRRL 126
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
 65-184 7.26e-29

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 111.74  E-value: 7.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  65 TLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRY----GCILPYSSEDGGPQDQLKNAISSILGTWLDQ 140
Cdd:cd06224    1 TLEALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYeiapPENLEYNDWDKKKSKPIRLRVLNVLRTWVEN 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564339895 141 YSEDFCqpPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDL 184
Cdd:cd06224   81 YPYDFF--DDEELLELLEEFLNRLVQEGALLQELKKLLRKLLKL 122
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
 60-158 2.33e-26

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 103.92  E-value: 2.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   60 TVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPY-----SSEDGGPQDQLKNAISSIL 134
Cdd:pfam00618   1 QVKAGTLEKLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLdlssdSYWISKKTLPIRIRVLSVL 80

                          90       100
                  ....*....|....*....|....
gi 564339895  135 GTWLDQYSEDFCQPPdfPCLKQLV 158
Cdd:pfam00618  81 RHWVENYFSDFNDDP--VLLSRLE 102
RA smart00314
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
 724-809 4.38e-19

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Kalhammer et al. have shown that not all RA domains bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase. Predicted RA domains in PLC210 and nore1 found to bind RasGTP. Included outliers (Grb7, Grb14, adenylyl cyclases etc.)


Pssm-ID: 214612  Cd Length: 90  Bit Score: 82.73  E-value: 4.38e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   724 DCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDeDEPEDYELLQIISEDHKLKIPENANVFYAMN----SA 799
Cdd:smart00314   1 DTFVLRVYVDDLPGGTYKTLRVSSRTTARDVIQQLLEKFHLT-DDPEEYVLVEVLPDGKERVLPDDENPLQLQKlwprRG 79

                           90
                   ....*....|
gi 564339895   800 ANYDFILKKR 809
Cdd:smart00314  80 PNLRFVLRKR 89
RA pfam00788
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
 724-809 9.36e-15

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.


Pssm-ID: 425871  Cd Length: 93  Bit Score: 70.44  E-value: 9.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  724 DCCIIRVSLDVDN-GNMYKSILVTSQDKAPTVIRKAMDKHNLDEDePEDYELL-QIISEDHKLKIPENANVFYAMN---- 797
Cdd:pfam00788   1 DDGVLKVYTEDGKpGTTYKTILVSSSTTAEEVIEALLEKFGLEDD-PRDYVLVeVLERGGGERRLPDDECPLQIQLqwpr 79

                          90
                  ....*....|..
gi 564339895  798 SAANYDFILKKR 809
Cdd:pfam00788  80 DASDSRFLLRKR 91
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
186-293 1.43e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 58.71  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPA 265
Cdd:PRK07003 402 VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                         90       100
                 ....*....|....*....|....*...
gi 564339895 266 PELDPTVSqslhLEPAPVPAPALEPSWP 293
Cdd:PRK07003 482 SDAPPDAA----FEPAPRAAAPSAATPA 505
Cuticle_3 pfam11018
Pupal cuticle protein C1; Insect cuticles are composite structures whose mechanical properties ...
 191-293 2.44e-05

Pupal cuticle protein C1; Insect cuticles are composite structures whose mechanical properties are optimized for biological function. The major components are the chitin filament system and the cuticular proteins, and the cuticle's properties are determined largely by the interactions between these two sets of molecules. The proteins can be ordered by species.


Pssm-ID: 431611 [Multi-domain]  Cd Length: 182  Bit Score: 45.91  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  191 PEALSPAPVLSLKPASQLEPAPALLLT----PSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAP 266
Cdd:pfam11018  48 PKTLYSAPAPVVTKSAYAAPAPVVTTYahaaPAPVVAKTVYAAPAVVVYAAPAPVVAKTVTYAAPAVHYAAPAPVVAKTV 127

                          90       100
                  ....*....|....*....|....*..
gi 564339895  267 ELDPTVsQSLHlEPAPVPAPALEPSWP 293
Cdd:pfam11018 128 YAAPAV-QHYA-APAPVEAAAHAAPVV 152
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 180-292 2.69e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.91  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 180 QLEDLEPSEVEPEALSPA--PVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSP---------VVAPASEL 248
Cdd:NF040712 208 EPADARPEEVEPAPAAEGapATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPdeatrdagePPAPGAAE 287

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564339895 249 EPALEPPLDPEPTlAPAPELDPTVSQSLHLEPAPVPAP------ALEPSW 292
Cdd:NF040712 288 TPEAAEPPAPAPA-APAAPAAPEAEEPARPEPPPAPKPkrrrrrASVPSW 336
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
169-266 4.39e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 40.75  E-value: 4.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 169 DLERRAHLLLAQLEDLEpSEVEPEALSPAPVLslkpasqlEPAPAlllTPSRAVASTPVREPAPVPVlASSPVVAPASEL 248
Cdd:COG5373   18 GLLGRVARLRRRVEELE-AELAEAAEAASAPA--------EPEPE---AAAAATAAAPEAAPAPVPE-APAAPPAAAEAP 84

                         90
                 ....*....|....*....
gi 564339895 249 EPA-LEPPLDPEPTLAPAP 266
Cdd:COG5373   85 APAaAAPPAEAEPAAAPAA 103
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 205-299 6.63e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.99  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 205 ASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPA--SELEPALEPPLDP-EPTLAPAPELDPTVSQSLHLEPA 281
Cdd:NF041121  12 AAQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPepPAPEPAPLPAPYPgSLAPPPPPPPGPAGAAPGAALPV 91

                         90
                 ....*....|....*...
gi 564339895 282 PVPAPAlepswPLPETTE 299
Cdd:NF041121  92 RVPAPP-----ALPNPLE 104
 
Name Accession Description Interval E-value
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 308-570 2.35e-90

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 284.92  E-value: 2.35e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 308 LLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKgkEHLAPTIRATVAQFNNVANCVITTCLGDQSmkASDRAR 387
Cdd:cd00155    1 FLSLDPKELAEQLTLLDFELFRKIEPFELLGSLWSKKDKN--IHLSPNLERFIERFNNLSNWVASEILLCTN--PKKRAR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 388 VVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFa 467
Cdd:cd00155   77 LLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSKLKKLFEELEELVDPSRNFKNYRKLLKSVGPNPP- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 468 tlemnprrtqrrqketgviqgTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSacNNYSIVPEE 547
Cdd:cd00155  156 ---------------------CVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQS--NSYELNRDE 212

                        250       260
                 ....*....|....*....|....*
gi 564339895 548 HFGAWFRA--MGRLSEAESYNLSCE 570
Cdd:cd00155  213 DILAFLWKllELILNEDELYELSLE 237
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
308-575 8.71e-89

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 281.06  E-value: 8.71e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   308 LLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLapTIRATVAQFNNVANCVITTCLGDQSmkASDRAR 387
Cdd:smart00147   1 LLLLDPKELAEQLTLLDFELFRKIDPSELLGSVWGKRSKKSPSPL--NLEAFIRRFNEVSNWVATEILKQTT--PKDRAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   388 VVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEgtskfa 467
Cdd:smart00147  77 LLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSKYKKLFEELEELLSPERNYKNYREALSSC------ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   468 tlemnprrtqrrqketgVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSAcnNYSIVPEE 547
Cdd:smart00147 151 -----------------NLPPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQ--PYNLRPNR 211

                          250       260       270
                   ....*....|....*....|....*....|.
gi 564339895   548 -HFGAWFRAMGRL--SEAESYNLSCELEPPS 575
Cdd:smart00147 212 sDIQSLLQQLLDHldEEEELYQLSLKIEPRV 242
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
 316-522 3.50e-71

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 231.71  E-value: 3.50e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  316 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKehlAPTIRATVAQFNNVANCVITTCLGDQSMKasDRARVVEHWIEV 395
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKKDKKEN---SPNIEAMIARFNKLSNWVASEILSEEDLK--KRAKVIKKFIKI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  396 ARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTskfatlemnprr 475
Cdd:pfam00617  77 AEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSKKYKKTLEELEKLMSPSRNFKNYREALSSASP------------ 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 564339895  476 tqrrqketgviqGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRR 522
Cdd:pfam00617 145 ------------PCIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKRR 179
RA_RalGDS cd17209
Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) ...
 724-809 5.04e-59

Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins; RalGDS, also termed Ral guanine nucleotide exchange factor (RalGEF), is a guanine exchange factor (GEF) for the Ral family of small GTPases. It is the prototype of RalGDS family proteins that are involved in Ras and Ral signaling pathways as downstream effector proteins. RalGDS stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. It interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Moreover, RalGDS functions as a novel interacting partner for Rab7-interacting lysosomal protein (RILP), a key regulator for late endosomal/lysosomal trafficking. RILP suppresses invasion of breast cancer cells by inhibiting the GEF activity for RalA of RalGDS. RalGDS also plays a vital role in the regulation of Ral-dependent Weibel-Palade bodies (WPB) exocytosis from endothelial cells. In addition, RalGDS couples growth factor signaling to Akt activation by promoting PDK1-induced Akt phosphorylation. Members in this family have similar domain structure: a central CDC25 homology domain with an upstream Ras Exchange motif (REM), and a C-terminal Ras-associating (RA) domain. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340729  Cd Length: 86  Bit Score: 195.17  E-value: 5.04e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 724 DCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYD 803
Cdd:cd17209    1 DCCIIRVSLDVDNGNMYKSILVTSQDKTPVVIRKAMAKHNLDEEEPEDYELLQILSEDRELKIPDNANVFYAMNSTANYD 80


                 ....*.
gi 564339895 804 FILKKR 809
Cdd:cd17209   81 FVLKKR 86
RA_RGL cd17210
Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 ...
 724-809 2.41e-44

Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins; RalGDS-like 1 (RGL) is a Ral-specific guanine nucleotide exchange factor that belongs to RalGDS family, whose members are involved in Ras and Ral signaling pathways as downstream effector proteins. RGL has been identified as a possible effector protein of Ras. It also regulates c-fos promoter and the GDP/GTP exchange of Ral. Members in this family have similar structure: a central CDC25 homology domain with an upstream Ras Exchange motif (REM), and a C-terminal Ras-associating (RA) domain. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340730  Cd Length: 87  Bit Score: 154.37  E-value: 2.41e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 724 DCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYD 803
Cdd:cd17210    2 DTCIIRVSVEDNNGNMYKSIMLTSQDKTPAVIQRAMSKHNLESDPAEDYELVQVISEDRELVIPDNANVFYAMNSSVNFD 81


                 ....*.
gi 564339895 804 FILKKR 809
Cdd:cd17210   82 FILRKK 87
RA_RalGDS_like cd00153
Ras-associating (RA) domain of RalGDS family; The RalGDS family RA domains can interact with ...
 724-809 2.63e-43

Ras-associating (RA) domain of RalGDS family; The RalGDS family RA domains can interact with activated Ras and may function as effectors for other Ras family. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub); Ub is a protein modifier in eukaryotes and is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. The RalGDS family includes RalGDS, RGL, RGL2/Rlf and RGL3. All family members have similar domain structure: a central CDC25 homology domain with an upstream Ras Exchange motif (REM), and a C-terminal RA domain. The RA domain mediates the GTP-dependent interaction with Ras and Ras-related proteins.


Pssm-ID: 340449  Cd Length: 88  Bit Score: 151.57  E-value: 2.63e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 724 DCCIIRVSLD--VDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAAN 801
Cdd:cd00153    1 DSRIIRVSLEdgSEDGNLYKSILLTNQDRTPSVIRRALEKHNLEDEDPDDFSLVQILPDDKELVIPDNANVFYAMNSSAN 80


                 ....*...
gi 564339895 802 YDFILKKR 809
Cdd:cd00153   81 LNFILRKK 88
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 57-181 1.27e-37

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 136.70  E-value: 1.27e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895    57 KVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYS-SEDGGPQDQLKNAISSILG 135
Cdd:smart00229   1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESwVEEKVNPRRVKNRVLNILR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 564339895   136 TWLDQYSEDFCQPP-DFPCLKQLvAYVQLNMPGSDLERRAHLLLAQL 181
Cdd:smart00229  81 TWVENYWEDFEDDPkLISFLLEF-LELVDDEKYPGLVTSLLNLLRRL 126
RA_RGL3 cd17212
Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 ...
 727-809 5.80e-34

Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) and similar proteins; RalGDS-like 3 (RGL3), also termed Ras pathway modulator (RPM), interacts in a GTP- and effector loop-dependent manner with Rit and Ras. As a novel potential effector of both p21 Ras and M-Ras, RGL3 negatively regulates Elk-1-dependent gene induction downstream of p21 Ras or mitogen activated protein/extracellular signal regulated kinase Kinase 1 (MEKK1). It also functions as a potential binding partner for Rap-family small G-proteins and profilin II. RGL3 belongs to RalGDS family, whose members are involved in Ras and Ral signaling pathways as downstream effector proteins. Members in this family have similar domain structure: a central CDC25 homology domain with an upstream Ras Exchange motif (REM), and a C-terminal Ras-associating (RA) domain. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340732  Cd Length: 87  Bit Score: 125.05  E-value: 5.80e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 727 IIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFIL 806
Cdd:cd17212    5 VIRVSIDNDHGNLYRSILLTSQDKAPSVVQRALQKHNVPQPWARDYQLFQVLPGDRELLIPDNANVFYAMSPAAPGDFML 84


                 ...
gi 564339895 807 KKR 809
Cdd:cd17212   85 RRK 87
RA_RGL2 cd17211
Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 ...
 724-809 2.40e-30

Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins; RalGDS-like 2 (RGL2), also termed RalGDS-like factor (RLF), or Ras-associated protein RAB2L, is a novel Ras and Rap 1A-associating protein that belongs to RalGDS family, whose members are involved in Ras and Ral signaling pathways as downstream effector proteins. RGL2 exhibits guanine nucleotide exchange activity towards the small GTPase Ral. Members in this family have similar domain structure: a central CDC25 homology domain with an upstream Ras Exchange motif (REM), and a C-terminal Ras-associating (RA) domain. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. The RA domain of RGL2 is phosphorylated by protein kinase A and the phosphorylation affects the ability of RGL2 to bind both Ras and Rap1.


Pssm-ID: 340731  Cd Length: 86  Bit Score: 114.54  E-value: 2.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 724 DCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAAnYD 803
Cdd:cd17211    2 DCRIIRVRMELHDGSVYKSILVTSQDKTPAVISRALEKHNQSSQAASPYELVQLLPEGKELTIPPTANVFYAMSSAS-LD 80


                 ....*.
gi 564339895 804 FILKKR 809
Cdd:cd17211   81 FILRPR 86
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
 65-184 7.26e-29

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 111.74  E-value: 7.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  65 TLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRY----GCILPYSSEDGGPQDQLKNAISSILGTWLDQ 140
Cdd:cd06224    1 TLEALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYeiapPENLEYNDWDKKKSKPIRLRVLNVLRTWVEN 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564339895 141 YSEDFCqpPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDL 184
Cdd:cd06224   81 YPYDFF--DDEELLELLEEFLNRLVQEGALLQELKKLLRKLLKL 122
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
 60-158 2.33e-26

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 103.92  E-value: 2.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   60 TVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPY-----SSEDGGPQDQLKNAISSIL 134
Cdd:pfam00618   1 QVKAGTLEKLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLdlssdSYWISKKTLPIRIRVLSVL 80

                          90       100
                  ....*....|....*....|....
gi 564339895  135 GTWLDQYSEDFCQPPdfPCLKQLV 158
Cdd:pfam00618  81 RHWVENYFSDFNDDP--VLLSRLE 102
RA smart00314
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
 724-809 4.38e-19

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Kalhammer et al. have shown that not all RA domains bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase. Predicted RA domains in PLC210 and nore1 found to bind RasGTP. Included outliers (Grb7, Grb14, adenylyl cyclases etc.)


Pssm-ID: 214612  Cd Length: 90  Bit Score: 82.73  E-value: 4.38e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895   724 DCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDeDEPEDYELLQIISEDHKLKIPENANVFYAMN----SA 799
Cdd:smart00314   1 DTFVLRVYVDDLPGGTYKTLRVSSRTTARDVIQQLLEKFHLT-DDPEEYVLVEVLPDGKERVLPDDENPLQLQKlwprRG 79

                           90
                   ....*....|
gi 564339895   800 ANYDFILKKR 809
Cdd:smart00314  80 PNLRFVLRKR 89
RA pfam00788
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
 724-809 9.36e-15

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.


Pssm-ID: 425871  Cd Length: 93  Bit Score: 70.44  E-value: 9.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  724 DCCIIRVSLDVDN-GNMYKSILVTSQDKAPTVIRKAMDKHNLDEDePEDYELL-QIISEDHKLKIPENANVFYAMN---- 797
Cdd:pfam00788   1 DDGVLKVYTEDGKpGTTYKTILVSSSTTAEEVIEALLEKFGLEDD-PRDYVLVeVLERGGGERRLPDDECPLQIQLqwpr 79

                          90
                  ....*....|..
gi 564339895  798 SAANYDFILKKR 809
Cdd:pfam00788  80 DASDSRFLLRKR 91
RA cd17043
Ras-associating (RA) domain, structurally similar to a beta-grasp ubiquitin-like fold; RA ...
 727-808 9.87e-09

Ras-associating (RA) domain, structurally similar to a beta-grasp ubiquitin-like fold; RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in various functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub); Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. RA-containing proteins include RalGDS, AF6, RIN, RASSF1, SNX27, CYR1, STE50, and phospholipase C epsilon.


Pssm-ID: 340563  Cd Length: 87  Bit Score: 53.09  E-value: 9.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 727 IIRVSLDVDNGN-MYKSILVTSQDKAPTVIRKAMDKHNLDEDePEDYELLQII-SEDHKLKIPENANVFYAMNSAANYD- 803
Cdd:cd17043    1 VLKVYDDDLAPGsAYKSILVSSTTTAREVVQLLLEKYGLEED-PEDYSLYEVSeKQETERVLHDDECPLLIQLEWGPQGt 79


                 ....*...
gi 564339895 804 ---FILKK 808
Cdd:cd17043   80 efrFVLKR 87
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
186-293 1.43e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 58.71  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPA 265
Cdd:PRK07003 402 VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                         90       100
                 ....*....|....*....|....*...
gi 564339895 266 PELDPTVSqslhLEPAPVPAPALEPSWP 293
Cdd:PRK07003 482 SDAPPDAA----FEPAPRAAAPSAATPA 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 200-298 3.82e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 57.03  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 200 LSLKPASQLE-PAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELD------PTV 272
Cdd:PRK14951 362 LAFKPAAAAEaAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAapaaapAAA 441

                         90       100
                 ....*....|....*....|....*.
gi 564339895 273 SQSLHLEPAPVPAPALEPSWPLPETT 298
Cdd:PRK14951 442 PAAVALAPAPPAQAAPETVAIPVRVA 467
PHA03247 PHA03247
large tegument protein UL36; Provisional
 178-301 6.34e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 6.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  178 LAQLEDLEPSEVEPE----ALSPAPVLSLKPASQLEPAPALLLTP------------------------SRAVASTPVRE 229
Cdd:PHA03247 2695 LTSLADPPPPPPTPEpaphALVSATPLPPGPAAARQASPALPAAPappavpagpatpggparparppttAGPPAPAPPAA 2774

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564339895  230 PA-PVPVLASSPVVAPASELEPALEPPLDPE----PTLAPAPELDPTVSQSLHLEPAPVPAPA--LEPSWPLPETTENG 301
Cdd:PHA03247 2775 PAaGPPRRLTRPAVASLSESRESLPSPWDPAdppaAVLAPAAALPPAASPAGPLPPPTSAQPTapPPPPGPPPPSLPLG 2853
PHA03379 PHA03379
EBNA-3A; Provisional
 181-295 8.30e-08

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 56.22  E-value: 8.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 181 LEDLEPSEV-EPEALSPAPVlslkpaSQLEPAPALLLTPSR---AVASTPVREPAPVPVLASsPVVAPaselepaLEPPL 256
Cdd:PHA03379 448 VHDLEPGPLhDQHSMAPCPV------AQLPPGPLQDLEPGDqlpGVVQDGRPACAPVPAPAG-PIVRP-------WEASL 513

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564339895 257 DPEPTLAPAPELdptvSQSLHLEPAPVPAPALE-PSWPLP 295
Cdd:PHA03379 514 SQVPGVAFAPVM----PQPMPVEPVPVPTVALErPVCPAP 549
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 165-301 1.02e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 55.76  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 165 MPGSDLERRAhlLLAQLEDLE-------PSEVEPEALSPAPVLSLKPAS-QLEPAPALLLTPSRAVASTPVREPAPVPVl 236
Cdd:PRK07764 364 LPSASDDERG--LLARLERLErrlgvagGAGAPAAAAPSAAAAAPAAAPaPAAAAPAAAAAPAPAAAPQPAPAPAPAPA- 440

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564339895 237 ASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENG 301
Cdd:PRK07764 441 PPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
PHA03247 PHA03247
large tegument protein UL36; Provisional
 185-317 2.52e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  185 EPSEVEPEALSPAPVLSLKPASQLEPAP-ALLLTPSRAVA-------STPVREPAPVPVLASSPVV------APASELEP 250
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGPpPPSLPLGGSVApggdvrrRPPSRSPAAKPAAPARPPVrrlarpAVSRSTES 2897

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564339895  251 ALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPA--PALEPSWPLPETTENGLCAKPHLLLFPPDLVA 317
Cdd:PHA03247 2898 FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGA 2966
PRK04654 PRK04654
sec-independent translocase; Provisional
 195-290 1.24e-06

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 50.20  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 195 SPAPVlslkpASQLEPAPALLLTPSR---AVASTPVREPAPVPVLASSPVVAPASELEPAleppldPEPTLAPAPE--LD 269
Cdd:PRK04654 104 SATPV-----ATPLELAHADLSASAQvdaAAGAEPGAGQAHTPVPAPAPVIAQAQPIAPA------PHQTLVPAPHdtIV 172

                         90       100
                 ....*....|....*....|.
gi 564339895 270 PTvSQSLHLEPAPVPAPALEP 290
Cdd:PRK04654 173 PA-PHAAHLPSAPATPVSVAP 192
PHA03247 PHA03247
large tegument protein UL36; Provisional
 166-302 1.56e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  166 PGSDLERRAHLLLAQLEDLEPSEVEPEALsPAPVLSLKPASQLEPAPAllltPSRAVASTPVREPAPVPVLASSPVVAPA 245
Cdd:PHA03247 2858 PGGDVRRRPPSRSPAAKPAAPARPPVRRL-ARPAVSRSTESFALPPDQ----PERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564339895  246 SELEPALEPPLDPEPTLAPAPELDPTV--SQSLHLEPAPVPAPALE-----PSWPLPETTENGL 302
Cdd:PHA03247 2933 PPPPPRPQPPLAPTTDPAGAGEPSGAVpqPWLGALVPGRVAVPRFRvpqpaPSREAPASSTPPL 2996
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 189-301 1.61e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 51.64  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 189 VEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPEL 268
Cdd:PRK14951 382 ARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVA 461

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564339895 269 DPTVSQSLHLEPAPVPAPALEPSWPLPETTENG 301
Cdd:PRK14951 462 IPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PHA03378 PHA03378
EBNA-3B; Provisional
 204-295 2.36e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 51.61  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 204 PASQLEP--APALLLTPSRAvaSTPVREPAPVPVLASSPVVAPASELEPALEP----PLDPEPTLAPAPELDPTVSQSLH 277
Cdd:PHA03378 681 ANTMLPIqwAPGTMQPPPRA--PTPMRPPAAPPGRAQRPAAATGRARPPAAAPgrarPPAAAPGRARPPAAAPGRARPPA 758

                         90
                 ....*....|....*...
gi 564339895 278 LEPAPVPAPALEPSWPLP 295
Cdd:PHA03378 759 AAPGRARPPAAAPGAPTP 776
RA2_Afadin cd01781
Ras-associating (RA) domain 2 found in Afadin; Afadin, also termed ALL1-fused gene from ...
 740-777 2.68e-06

Ras-associating (RA) domain 2 found in Afadin; Afadin, also termed ALL1-fused gene from chromosome 6 protein (AF-6), or canoe, is involved in many fundamental signaling cascades in cells. In addition, it is involved in oncogenesis and metastasis. Afadin has multiple domains: from the N-terminus to the C-terminus it has two Ras-associated (RA) domains, a forkhead-associated domain, a dilute domain, a PDZ domain, three proline-rich domains, and an F-actin binding domain. RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in several different functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has a beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub). Ub is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes. Afadin is abundant at cadherin-based adherens junctions in epithelial cells, endothelial cells, and fibroblasts. This family corresponds to the second RA domain of afadin.


Pssm-ID: 340479  Cd Length: 102  Bit Score: 46.50  E-value: 2.68e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 564339895 740 YKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQI 777
Cdd:cd01781   17 YKTLLLSTNDTADFVVREALEKYGLEKENPKDYCLVQV 54
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
186-299 2.70e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 51.00  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVLSLKPA--SQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPA----LEPPLDPE 259
Cdd:PRK07003 420 ATRAEAPPAAPAPPATADRGddAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDaafePAPRAAAP 499

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564339895 260 PTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTE 299
Cdd:PRK07003 500 SAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAA 539
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
185-292 4.86e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 50.26  E-value: 4.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 185 EPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVAST---PVREPAPVPVLASSPVVAPASELEPALEPPLDPEPT 261
Cdd:PRK12323 396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAArqaSARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAA 475

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564339895 262 LAPAPELDptvsqslhlEPAPVPAPALE--PSW 292
Cdd:PRK12323 476 AAAAPARA---------APAAAPAPADDdpPPW 499
PHA03378 PHA03378
EBNA-3B; Provisional
 191-291 4.87e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.45  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 191 PEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPA----- 265
Cdd:PHA03378 698 PRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGaptpq 777

                         90       100
                 ....*....|....*....|....*...
gi 564339895 266 --PELDPTVSQSLHLEPAPVPAPALEPS 291
Cdd:PHA03378 778 ppPQAPPAPQQRPRGAPTPQPPPQAGPT 805
PRK11633 PRK11633
cell division protein DedD; Provisional
 190-290 8.48e-06

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 47.69  E-value: 8.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 190 EPEALSPA--PVLSLKP-----ASQLEPAPALLLTPSRAVASTPVREPAPVPVlaSSPVVAPASELEPALEPPLDPEPTL 262
Cdd:PRK11633  52 EPDMMPAAtqALPTQPPegaaeAVRAGDAAAPSLDPATVAPPNTPVEPEPAPV--EPPKPKPVEKPKPKPKPQQKVEAPP 129

                         90       100
                 ....*....|....*....|....*...
gi 564339895 263 APAPEldptvsqslhlePAPVPAPALEP 290
Cdd:PRK11633 130 APKPE------------PKPVVEEKAAP 145
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 185-293 1.40e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 185 EPSEVEPEALSPAPVlslKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAP 264
Cdd:PRK07764 424 APAAAPQPAPAPAPA---PAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAP 500

                         90       100
                 ....*....|....*....|....*....
gi 564339895 265 APeldptvsqslhlEPAPVPAPALEPSWP 293
Cdd:PRK07764 501 AA------------PAGADDAATLRERWP 517
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 186-282 1.47e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.56  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVlslkPASQLEPAPAlllTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPA 265
Cdd:PRK14951 403 PAAAPAAAASAPAA----PPAAAPPAPV---AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASA 475

                         90
                 ....*....|....*..
gi 564339895 266 PELDPTVSQSLHLEPAP 282
Cdd:PRK14951 476 APAPAAAPAAARLTPTE 492
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 189-306 1.64e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 48.32  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 189 VEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELE--PALEPPLDPEPTLAPAP 266
Cdd:PRK07994 370 VPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQraQGATKAKKSEPAAASRA 449

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564339895 267 ELDPTVSQSLH--------LEPAPVPAPALEPSWPLPETTENGLCAKP 306
Cdd:PRK07994 450 RPVNSALERLAsvrpapsaLEKAPAKKEAYRWKATNPVEVKKEPVATP 497
Cuticle_3 pfam11018
Pupal cuticle protein C1; Insect cuticles are composite structures whose mechanical properties ...
 191-293 2.44e-05

Pupal cuticle protein C1; Insect cuticles are composite structures whose mechanical properties are optimized for biological function. The major components are the chitin filament system and the cuticular proteins, and the cuticle's properties are determined largely by the interactions between these two sets of molecules. The proteins can be ordered by species.


Pssm-ID: 431611 [Multi-domain]  Cd Length: 182  Bit Score: 45.91  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  191 PEALSPAPVLSLKPASQLEPAPALLLT----PSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAP 266
Cdd:pfam11018  48 PKTLYSAPAPVVTKSAYAAPAPVVTTYahaaPAPVVAKTVYAAPAVVVYAAPAPVVAKTVTYAAPAVHYAAPAPVVAKTV 127

                          90       100
                  ....*....|....*....|....*..
gi 564339895  267 ELDPTVsQSLHlEPAPVPAPALEPSWP 293
Cdd:pfam11018 128 YAAPAV-QHYA-APAPVEAAAHAAPVV 152
RA2_DAGK-theta cd01783
Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar ...
 740-778 3.23e-05

Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins; DAGK phosphorylates the second messenger diacylglycerol to phosphatidic acid as part of a protein kinase C pathway. DAGK-theta is characterized as a type V DAGK that has three cysteine-rich domains (all other isoforms have two), a proline/glycine-rich domain at its N-terminal, and a proposed Ras-associating (RA) domain. RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in several different functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has a beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub). Ub is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes. There are ten mammalian isoforms of DAGK have been identified to date, these are organized into five categories based on the domain architecture. DAGK-theta also contains a pleckstrin homology (PH) domain. The subcellular localization and the activity of DAGK-theta are regulated in a complex (stimulation- and cell type-dependent) manner. This family corresponds to the second RA domain of DAGK-theta.


Pssm-ID: 340481  Cd Length: 95  Bit Score: 43.37  E-value: 3.23e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 564339895 740 YKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQII 778
Cdd:cd01783   16 YKSIPVTKETTVEEVIKEALPKFGLQDEDPEDFRLVEVL 54
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
191-317 8.37e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 8.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 191 PEALSPAPVLS-LKPASQLEPAPALLLTPSRAVAsTPVREPAPVPVLASSPVV--APASELEPALE--PPLDPEPTLAPA 265
Cdd:PRK12323 430 PEALAAARQASaRGPGGAPAPAPAPAAAPAAAAR-PAAAGPRPVAAAAAAAPAraAPAAAPAPADDdpPPWEELPPEFAS 508

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564339895 266 PELDPTVSQSLHLE----------PAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVA 317
Cdd:PRK12323 509 PAPAQPDAAPAGWVaesipdpataDPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASA 570
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 202-299 8.56e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.62  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  202 LKPASQLEP----APALLLTPSRAVASTPVREPAPVPVlASSPVVAPASELEPAlEPPLDPEPTLAPAPELDPTVSQ--- 274
Cdd:PRK10263  311 LNGAPITEPvavaAAATTATQSWAAPVEPVTQTPPVAS-VDVPPAQPTVAWQPV-PGPQTGEPVIAPAPEGYPQQSQyaq 388

                          90       100
                  ....*....|....*....|....*..
gi 564339895  275 --SLHLEPAPVPAPALEPSWPLPETTE 299
Cdd:PRK10263  389 paVQYNEPLQQPVQPQQPYYAPAAEQP 415
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
191-300 8.90e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 8.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 191 PEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVpvLASSPVVAPASELEPALEPPldPEPTLAPAPELDP 270
Cdd:PRK07003 385 ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP--AAPAPPATADRGDDAADGDA--PVPAKANARASAD 460

                         90       100       110
                 ....*....|....*....|....*....|
gi 564339895 271 TVSQSLHLEPAPVPAPALEPSWPLPETTEN 300
Cdd:PRK07003 461 SRCDERDAQPPADSGSASAPASDAPPDAAF 490
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
180-306 9.04e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 9.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 180 QLEDLEPSEVEPEALSPAPVlslkPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASEL--EPALEPPLD 257
Cdd:PRK12323 438 QASARGPGGAPAPAPAPAAA----PAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELppEFASPAPAQ 513

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564339895 258 PEPTLAP---APELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKP 306
Cdd:PRK12323 514 PDAAPAGwvaESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP 565
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
186-296 1.13e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVA-PASELEPALEPPLDPEPTLAP 264
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAlAAARQASARGPGGAPAPAPAP 454

                         90       100       110
                 ....*....|....*....|....*....|..
gi 564339895 265 APELDPTVSQSLhlePAPVPAPALEPSWPLPE 296
Cdd:PRK12323 455 AAAPAAAARPAA---AGPRPVAAAAAAAPARA 483
PHA03379 PHA03379
EBNA-3A; Provisional
 161-295 1.17e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 45.82  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 161 VQLNMPGSdLERRAHLLLAQLEDLEPS---EVEPEALSPAPVLSLKPASQLEPAPA----------LLLTPSRAVAstPV 227
Cdd:PHA03379 448 VHDLEPGP-LHDQHSMAPCPVAQLPPGplqDLEPGDQLPGVVQDGRPACAPVPAPAgpivrpweasLSQVPGVAFA--PV 524

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564339895 228 RePAPVPVlasSPVVAPASelepALEPPLDPEPTLA----PApELDPTVSQSLHLEPAP-VPAPALEPSwPLP 295
Cdd:PHA03379 525 M-PQPMPV---EPVPVPTV----ALERPVCPAPPLIamqgPG-ETSGIVRVRERWRPAPwTPNPPRSPS-QMS 587
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 190-311 1.54e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.46  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  190 EPEALSPAPVLSLKPASQLEP------------APALLLTPSR----AVASTPVREPAPVPVlASSPVVAPASELEPAlE 253
Cdd:PRK10263  376 APEGYPQQSQYAQPAVQYNEPlqqpvqpqqpyyAPAAEQPAQQpyyaPAPEQPAQQPYYAPA-PEQPVAGNAWQAEEQ-Q 453

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564339895  254 PPLDPEPTLAP-APELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENglcAKPHLLLF 311
Cdd:PRK10263  454 STFAPQSTYQTeQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKP---ARPPLYYF 509
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 153-303 1.75e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.10  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 153 CLKQLVAYVQLNMPGSDLERRAHlllAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALllTPSRAVASTPvrEPAP 232
Cdd:PHA03269  14 CINLIIANLNTNIPIPELHTSAA---TQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQ--APTPAASEKF--DPAP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564339895 233 VPVLASS----PVVAPASELEPALEPPLdpEPTLAPAPELDPTVSQSLHLEPAPVPAPALE---PSWPLPETTENGLC 303
Cdd:PHA03269  87 APHQAASrapdPAVAPQLAAAPKPDAAE--AFTSAAQAHEAPADAGTSAASKKPDPAAHTQhspPPFAYTRSMEHIAC 162
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 122-306 1.94e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  122 PQDQLKNAISSILGTWLDQysedfcQPPDFPCLKQLVAYVQLNMPGSdlerrahlllAQLEDLEPSEVEPEALS-PAPVL 200
Cdd:pfam03154 151 PQDNESDSDSSAQQQILQT------QPPVLQAQSGAASPPSPPPPGT----------TQAATAGPTPSAPSVPPqGSPAT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  201 SLKPASQLEPAPALLLTPSrAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPeldptvsQSLHLEP 280
Cdd:pfam03154 215 SQPPNQTQSTAAPHTLIQQ-TPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP-------HSLQTGP 286

                         170       180
                  ....*....|....*....|....*.
gi 564339895  281 APVPAPAlePSWPLPETTENGLCAKP 306
Cdd:pfam03154 287 SHMQHPV--PPQPFPLTPQSSQSQVP 310
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
186-287 2.29e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVLSLKPASQlePAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPA 265
Cdd:PRK12323 467 AGPRPVAAAAAAAPARAAPAAA--PAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPA 544

                         90       100
                 ....*....|....*....|..
gi 564339895 266 PELDPTVSQSLHLEPAPVPAPA 287
Cdd:PRK12323 545 PAAAPAPRAAAATEPVVAPRPP 566
PHA03247 PHA03247
large tegument protein UL36; Provisional
 186-295 2.76e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  186 PSEVEPEALSPAPVLSLkPASQLEPAPALLLTPSRA----VASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPT 261
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSV-PPPRPAPRPSEPAVTSRArrpdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110
                  ....*....|....*....|....*....|....
gi 564339895  262 LAPAPeldptvSQSLHLEPAPVPAPALEPSWPLP 295
Cdd:PHA03247 2631 PSPAA------NEPDPHPPPTVPPPERPRDDPAP 2658
PRK11633 PRK11633
cell division protein DedD; Provisional
 186-283 3.97e-04

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 42.68  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEAL--SPAPVLSLKPaSQLEPAPallltpsravaSTPVREPAPVPVlassPVVAPASELEPALEPPLDPEPTLA 263
Cdd:PRK11633  67 PPEGAAEAVraGDAAAPSLDP-ATVAPPN-----------TPVEPEPAPVEP----PKPKPVEKPKPKPKPQQKVEAPPA 130

                         90       100
                 ....*....|....*....|
gi 564339895 264 PAPELDPTVSQslhlEPAPV 283
Cdd:PRK11633 131 PKPEPKPVVEE----KAAPT 146
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 181-290 4.28e-04

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 41.26  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  181 LEDLEPSEVEPEALSPAPVLSLKPASQLEPAPAllltpsravastPVREPAPVPVLASSPVVAPASELEPALEPPLDPEP 260
Cdd:pfam05104  50 LPESEQADESEEEPREFKTPDEAPSAALEPEPV------------PTPVPAPVEPEPAPPSESPAPSPKEKKKKEKKSAK 117

                          90       100       110
                  ....*....|....*....|....*....|
gi 564339895  261 tLAPAPEldPTVSQslhlePAPVPAPALEP 290
Cdd:pfam05104 118 -VEPAET--PEAVQ-----PKPALEKEEPP 139
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
176-296 4.36e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 43.88  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 176 LLLAQLEDLEPSEV---EPEALSPAPVLSLKPASQLEPApallLTPSRAVASTPVR-EPAPV-PVLASSPVVAPASELEP 250
Cdd:PRK14960 353 LRLLAFRPLAPNEIlvsEPVQQNGQAEVGLNSQAQTAQE----ITPVSAVQPVEVIsQPAMVePEPEPEPEPEPEPEPEP 428

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564339895 251 ALEPPLDPEPTLAPAPE-----LDPTVSQSLHLEPAPVP---APALEPSWPLPE 296
Cdd:PRK14960 429 EPEPEPEPEPEPEPQPNqdlmvFDPNHHELIGLESAVVQetvSVLEEDFIPVPE 482
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 203-286 4.42e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 43.78  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 203 KPASQLEPAPallltpsraVASTPVREPAPVPVLASSPV-VAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPA 281
Cdd:PRK14954 375 RNDGGVAPSP---------AGSPDVKKKAPEPDLPQPDRhPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPS 445


                 ....*
gi 564339895 282 PVPAP 286
Cdd:PRK14954 446 PQASA 450
PHA01929 PHA01929
putative scaffolding protein
 196-308 4.58e-04

putative scaffolding protein


Pssm-ID: 177328  Cd Length: 306  Bit Score: 43.12  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 196 PAPVLSLKPASQLEPAPALLLTPSRAV----------ASTPVREPAPVPVLASSPVVAPaselepalEPPLDPEPTLAPA 265
Cdd:PHA01929  13 AGLVANVPPAAAPTPQPNPVIQPQAPVqpgqpgapqqLAIPTQQPQPVPTSAMTPHVVQ--------QAPAQPAPAAPPA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 564339895 266 PelDPTVSQSLHlepaPVPAPALEPSWPLPETTENGLCAKPHL 308
Cdd:PHA01929  85 A--GAALPEALE----VPPPPAFTPNGEIVGTLAGNLEGDPQL 121
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 185-296 5.09e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 5.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 185 EPSEVEPEALSPAPVLSLKPASQLEPAPallltPSRAVASTPVREPAPVPVLASSPV-VAPASELEPALEPPLDPEPTla 263
Cdd:PRK14951 394 VAQAAAAPAPAAAPAAAASAPAAPPAAA-----PPAPVAAPAAAAPAAAPAAAPAAVaLAPAPPAQAAPETVAIPVRV-- 466

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564339895 264 pAPELDPTVSQslhlePAPVPAPALEPSWPLPE 296
Cdd:PRK14951 467 -APEPAVASAA-----PAPAAAPAAARLTPTEE 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
 186-314 6.22e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  186 PSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPvREPA--PVPVLASSPVVAPASELEPALEPPLDPEPTLA 263
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP-WDPAdpPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564339895  264 PAPE--LDPTVSQSLHLEP-----------APVPAPALEPSWPLPETTENGLCAKPHLLLFPPD 314
Cdd:PHA03247 2840 PPPPgpPPPSLPLGGSVAPggdvrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPD 2903
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
195-297 7.02e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 7.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 195 SPAPVLSlKPASQLEPAPAllltPSRAVASTPVREPAPVPVLASSPVVAPASELEPA-LEPPLDPEPTLAPAPELDPTVS 273
Cdd:PRK12323 373 GPATAAA-APVAQPAPAAA----APAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPArRSPAPEALAAARQASARGPGGA 447

                         90       100
                 ....*....|....*....|....
gi 564339895 274 QSLHLEPAPVPAPALEPSWPLPET 297
Cdd:PRK12323 448 PAPAPAPAAAPAAAARPAAAGPRP 471
PHA03247 PHA03247
large tegument protein UL36; Provisional
 166-313 8.65e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 8.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  166 PGSDLERRAHLLLAQLEDLEPSEVEPeALSPAPVLSLKPASQLEPAPALLL-TPSRAVASTPVREPAPVP-VLASSPVVA 243
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDP-ADPPAAVLAPAAALPPAASPAGPLpPPTSAQPTAPPPPPGPPPpSLPLGGSVA 2857

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564339895  244 PASELE---PALEPPLDPE-PTLAPAPELD-PTVSQSLH--LEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPP 313
Cdd:PHA03247 2858 PGGDVRrrpPSRSPAAKPAaPARPPVRRLArPAVSRSTEsfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 185-302 1.21e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  185 EPSEVEPEALSPA--PVLSLKPASQLEPAPALLltPSRAVASTPVREPAPVPVLASSPVVAPASElEPALEPPLDPEPTL 262
Cdd:PHA03307  125 SPPPSPAPDLSEMlrPVGSPGPPPAASPPAAGA--SPAAVASDAASSRQAALPLSSPEETARAPS-SPPAEPPPSTPPAA 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 564339895  263 AP--APELDPTVSQSlhlEPAPVPAPALEPSWPLPETTENGL 302
Cdd:PHA03307  202 ASprPPRRSSPISAS---ASSPAPAPGRSAADDAGASSSDSS 240
PHA03247 PHA03247
large tegument protein UL36; Provisional
 185-312 1.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  185 EPSEVEPEALSPAPVLSLKPASQLEPAPAL-----LLTPSRAVASTPVREPAPvPVLASSPVVAPAselEPALEPPLDPE 259
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPerprdDPAPGRVSRPRRARRLGR-AAQASSPPQRPR---RRAARPTVGSL 2695

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 564339895  260 PTLA--PAPELDPtvsqslhlEPAPvpaPALEPSWPLPETTENGLCAKPHLLLFP 312
Cdd:PHA03247 2696 TSLAdpPPPPPTP--------EPAP---HALVSATPLPPGPAAARQASPALPAAP 2739
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 186-293 1.56e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.10  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEALSPAPVLSlKPASQLEPAPALLLTPSRAvasTPVREPAPVPVLASSPVVAPASELEPALEP------PLDPE 259
Cdd:PRK14950 366 PQPAKPTAAAPSPVRP-TPAPSTRPKAAAAANIPPK---EPVRETATPPPVPPRPVAPPVPHTPESAPKltraaiPVDEK 441

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564339895 260 PTLAPAPeldPTVSQSLHLEPAPVPAPALEPSWP 293
Cdd:PRK14950 442 PKYTPPA---PPKEEEKALIADGDVLEQLEAIWK 472
rne PRK10811
ribonuclease E; Reviewed
 185-299 1.77e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.95  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  185 EPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPAlepplDPEPTLAP 264
Cdd:PRK10811  849 RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETT-----HPEVIAAP 923

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 564339895  265 APELDPTVSQSL---------HLEPAPVPAPALEPSWPLPETTE 299
Cdd:PRK10811  924 VTEQPQVITESDvavaqevaeHAEPVVEPQDETADIEEAAETAE 967
PRK10819 PRK10819
transport protein TonB; Provisional
 185-286 1.82e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 40.82  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 185 EPSEVEPEALSPAPVLSLKPASQLEPAPAllltpsravastpvrEPAPvpvlasSPVVAPASELEPALEPPLdPEPTLAP 264
Cdd:PRK10819  36 HQVIELPAPAQPISVTMVAPADLEPPQAV---------------QPPP------EPVVEPEPEPEPIPEPPK-EAPVVIP 93

                         90       100
                 ....*....|....*....|..
gi 564339895 265 APELDPtvsqslhlEPAPVPAP 286
Cdd:PRK10819  94 KPEPKP--------KPKPKPKP 107
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 180-292 2.69e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.91  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 180 QLEDLEPSEVEPEALSPA--PVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSP---------VVAPASEL 248
Cdd:NF040712 208 EPADARPEEVEPAPAAEGapATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPdeatrdagePPAPGAAE 287

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564339895 249 EPALEPPLDPEPTlAPAPELDPTVSQSLHLEPAPVPAP------ALEPSW 292
Cdd:NF040712 288 TPEAAEPPAPAPA-APAAPAAPEAEEPARPEPPPAPKPkrrrrrASVPSW 336
PHA03247 PHA03247
large tegument protein UL36; Provisional
 185-291 2.78e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  185 EPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAV-ASTPVREPAPVpvlASSPVVAPASELEPALEPPLDPEP--- 260
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRR---AARPTVGSLTSLADPPPPPPTPEPaph 2713

                          90       100       110
                  ....*....|....*....|....*....|.
gi 564339895  261 TLAPAPELDPTVSQSLHLEPAPVPAPALEPS 291
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPAAPAPPAV 2744
rne PRK10811
ribonuclease E; Reviewed
 179-290 2.82e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.56  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  179 AQLEDLEPSEV--EPEALSPAPVLSLKPAsqlEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAP-ASELEPALEPP 255
Cdd:PRK10811  877 AAVEPVVSAPVveAVAEVVEEPVVVAEPQ---PEEVVVVETTHPEVIAAPVTEQPQVITESDVAVAQEvAEHAEPVVEPQ 953

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 564339895  256 LDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEP 290
Cdd:PRK10811  954 DETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVA 988
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 186-300 3.45e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 186 PSEVEPEAlsPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPA 265
Cdd:PRK07994 361 PAAPLPEP--EVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKA 438

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564339895 266 PELDPTVSQSlhLEPAPVPAPALEPSWPLPETTEN 300
Cdd:PRK07994 439 KKSEPAAASR--ARPVNSALERLASVRPAPSALEK 471
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
169-266 4.39e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 40.75  E-value: 4.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 169 DLERRAHLLLAQLEDLEpSEVEPEALSPAPVLslkpasqlEPAPAlllTPSRAVASTPVREPAPVPVlASSPVVAPASEL 248
Cdd:COG5373   18 GLLGRVARLRRRVEELE-AELAEAAEAASAPA--------EPEPE---AAAAATAAAPEAAPAPVPE-APAAPPAAAEAP 84

                         90
                 ....*....|....*....
gi 564339895 249 EPA-LEPPLDPEPTLAPAP 266
Cdd:COG5373   85 APAaAAPPAEAEPAAAPAA 103
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
193-306 4.48e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 193 ALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPvlASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTV 272
Cdd:PRK07003 357 AFEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPA--VTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPA 434

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564339895 273 SQSLHLEPA--PVPAPALEPSWPLPETTENGLCAKP 306
Cdd:PRK07003 435 TADRGDDAAdgDAPVPAKANARASADSRCDERDAQP 470
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 174-299 4.58e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.22  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 174 AHLLLAQLEDLEPSEvepEALSPAPVLSLKPASQLEPapallLTPsrAVASTPVREPAPVPVLASSPVVAPASELEPAle 253
Cdd:COG3266  246 LLLLIIGSALKAPSQ---ASSASAPATTSLGEQQEVS-----LPP--AVAAQPAAAAAAQPSAVALPAAPAAAAAAAA-- 313

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564339895 254 ppldpePTLAPAPELDPTvsqslhlepAPVPAPALEPSWPLPETTE 299
Cdd:COG3266  314 ------PAEAAAPQPTAA---------KPVVTETAAPAAPAPEAAA 344
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 181-277 4.60e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.64  E-value: 4.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  181 LEDlePSEVEPE----------ALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASEleP 250
Cdd:PRK12270   19 LAD--PNSVDPSwreffadygpGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAA--A 94

                          90       100
                  ....*....|....*....|....*..
gi 564339895  251 ALEPPLDPEPTLAPAPELDPTVSQSLH 277
Cdd:PRK12270   95 APAAPPAAAAAAAPAAAAVEDEVTPLR 121
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 193-292 4.67e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 40.59  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 193 ALSPAPVLSLKPASQLEPAPAllltpsrAVASTPVREPAPVPVLASSPVVAPAselePALEPPLDPEPTLAPAPELDPTV 272
Cdd:PRK14963 341 ALGGAPSEGVAAVAPPAPAPA-------DLTQRLNRLEKEVRSLRSAPTAAAT----AAGAPLPDFDPRPRGPPAPEPAR 409

                         90       100
                 ....*....|....*....|.
gi 564339895 273 SQSLHLEPAPVPAPA-LEPSW 292
Cdd:PRK14963 410 SAEAPPLVAPAAAPAgLALRW 430
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
168-255 5.53e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 40.37  E-value: 5.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 168 SDLERRahllLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPallltPSRAVASTPVREPAPvpvlassPVVAPASE 247
Cdd:COG5373   31 EELEAE----LAEAAEAASAPAEPEPEAAAAATAAAPEAAPAPVP-----EAPAAPPAAAEAPAP-------AAAAPPAE 94


                 ....*...
gi 564339895 248 LEPALEPP 255
Cdd:COG5373   95 AEPAAAPA 102
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 98-306 6.47e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 39.83  E-value: 6.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895  98 TQQVLDLLFKRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLL 177
Cdd:COG3266  139 LLALLLDLPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALLLLLLASALGE 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 178 LAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPApvpVLASSPVVAPASELEPALEPPLD 257
Cdd:COG3266  219 AVAAAAELAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASSASAPATTSL---GEQQEVSLPPAVAAQPAAAAAAQ 295

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 564339895 258 PEPTLAPAPELDPTVsqslhlEPAPVPAPALEPSWPLPETTENGLCAKP 306
Cdd:COG3266  296 PSAVALPAAPAAAAA------AAAPAEAAAPQPTAAKPVVTETAAPAAP 338
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 205-299 6.63e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.99  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 205 ASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPA--SELEPALEPPLDP-EPTLAPAPELDPTVSQSLHLEPA 281
Cdd:NF041121  12 AAQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPepPAPEPAPLPAPYPgSLAPPPPPPPGPAGAAPGAALPV 91

                         90
                 ....*....|....*...
gi 564339895 282 PVPAPAlepswPLPETTE 299
Cdd:NF041121  92 RVPAPP-----ALPNPLE 104
PRK10819 PRK10819
transport protein TonB; Provisional
 185-275 6.68e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 39.28  E-value: 6.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564339895 185 EPsEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPvpvlassPVVAPASELEPAlePPLDPEPTLAP 264
Cdd:PRK10819  77 EP-EPIPEPPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKREVKP-------VEPRPASPFENT--APARPTSSTAT 146

                         90
                 ....*....|.
gi 564339895 265 APELDPTVSQS 275
Cdd:PRK10819 147 AAASKPVTSVS 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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