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Conserved domains on  [gi|564342364|ref|XP_006234818|]
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protein dispatched homolog 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
448-604 1.63e-11

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 69.12  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  448 LLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAFFLyhvafrMAYF--PFvNLASLLLLS---GVCVNYTLIFFDlwR 522
Cdd:COG1033   612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGL------MGLLgiPL-NIATAVVASialGIGVDYTIHFLS--R 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  523 LSRGQVPSGGLAHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVLHERY 602
Cdd:COG1033   683 YREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762


                  ..
gi 564342364  603 LA 604
Cdd:COG1033   763 IA 764
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
448-604 1.63e-11

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 69.12  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  448 LLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAFFLyhvafrMAYF--PFvNLASLLLLS---GVCVNYTLIFFDlwR 522
Cdd:COG1033   612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGL------MGLLgiPL-NIATAVVASialGIGVDYTIHFLS--R 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  523 LSRGQVPSGGLAHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVLHERY 602
Cdd:COG1033   683 YREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762


                  ..
gi 564342364  603 LA 604
Cdd:COG1033   763 IA 764
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 448-598 3.42e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 53.83  E-value: 3.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   448 LLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAF-----FLYHVAFRMAYFPfVNLASLLLLsGVCVNYTLIFFDLWR 522
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQglvaiLAHILGIGLSTFA-LNLLVVLLI-AVGTDYALFLVSRYR 226

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564342364   523 LSRGQVPSGGLAhrVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVL 598
Cdd:pfam03176  227 EELRAGEDREEA--VIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 448-601 1.93e-06

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 52.60  E-value: 1.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   448 LLSLVIIFFGMSLYL------RSLFITFMSLLGVLGSLMVAFflyHVAFRMAYFPFVNLASLLLLS----------GVCV 511
Cdd:TIGR00917  578 AISYLVMFAYISLTLgdsprlKSLYVTSKVLLGLSGILIVML---SVLGSVGVFSAVGLKSTLIIMevipflvlavGVDN 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   512 NYTLI--FFDLWRLsRGQVPSGG-----LAHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVH 584
Cdd:TIGR00917  655 IFILVffYFYLEYF-YRQVGVDNeqeltLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLD 733

                          170
                   ....*....|....*..
gi 564342364   585 MGLTLLWLPATVVLHER 601
Cdd:TIGR00917  734 FLLQITAFVALLVLDFK 750
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 377-526 2.40e-04

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 44.09  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  377 SPQTADYQVPSLKFALLFLPIIktsslLDIYLDGLGDPIKVSDN------YTSISGMDLGLkprLLKYYLAEDTMYPLLS 450
Cdd:cd10432    30 TPALLLIAGSPLMWVLLIAELA-----LVFGLSFRINKMSVATAlplffaFAALTGLTLSP---ILLVYTGASIAQAFFT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  451 LVIIFFGMSLY-------LRSL-FITFMSLLGVLGSLMVAFFLYHVAFRMAyfpfVNLASLLLLSGvcvnytLIFFDLWR 522
Cdd:cd10432   102 TAATFGGLSLYgyttkkdLSFLgSFLFMGLIGLIIASLVNIFLQSSALQFA----ISAIGVLIFSG------LIAYDTQR 171


                  ....
gi 564342364  523 LSRG 526
Cdd:cd10432   172 IKRM 175
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
448-604 1.63e-11

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 69.12  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  448 LLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAFFLyhvafrMAYF--PFvNLASLLLLS---GVCVNYTLIFFDlwR 522
Cdd:COG1033   612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGL------MGLLgiPL-NIATAVVASialGIGVDYTIHFLS--R 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  523 LSRGQVPSGGLAHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVLHERY 602
Cdd:COG1033   683 YREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762


                  ..
gi 564342364  603 LA 604
Cdd:COG1033   763 IA 764
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
439-778 9.36e-11

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 66.42  E-value: 9.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  439 YLAEDTM-YPLLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAF-FLYHVAFRMaYFPFVNLASLLLlsGVCVNYTLI 516
Cdd:COG1033   215 AIQSDLAiFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMGLLGIPL-SPLTILVPPLLL--AIGIDYGIH 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  517 FFDLWRLSRGQVPSGGLAhrVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATV 596
Cdd:COG1033   292 LLNRYREERRKGLDKREA--LREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALL 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  597 VLherylahgcvaqaqgqrggSDPLRLLLALHRRIRILRKIFSILSRLlfqrllpcgVIKFRY-IWICWFAALAAGGAYI 675
Cdd:COG1033   370 SL-------------------LPRPKPKTRRLKKPPELGRLLAKLARF---------VLRRPKvILVVALVLAVVSLYGI 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  676 GGVSPRLRLPillplggQFFRSSHPFERFDAEYRQQFlfedlppneGGNLPVVLVwgilpVDTsdpldprtnssvvsDPD 755
Cdd:COG1033   422 SRLKVEYDFE-------DYLPEDSPIRQDLDFIEENF---------GGSDPLEVV-----VDT--------------GEP 466

                         330       340
                  ....*....|....*....|...
gi 564342364  756 FSPSSPEAQEWLQALCQGAQNQS 778
Cdd:COG1033   467 DGLKDPEVLKEIDRLQDYLESLP 489
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 448-598 3.42e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 53.83  E-value: 3.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   448 LLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAF-----FLYHVAFRMAYFPfVNLASLLLLsGVCVNYTLIFFDLWR 522
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQglvaiLAHILGIGLSTFA-LNLLVVLLI-AVGTDYALFLVSRYR 226

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564342364   523 LSRGQVPSGGLAhrVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVL 598
Cdd:pfam03176  227 EELRAGEDREEA--VIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 448-601 1.93e-06

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 52.60  E-value: 1.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   448 LLSLVIIFFGMSLYL------RSLFITFMSLLGVLGSLMVAFflyHVAFRMAYFPFVNLASLLLLS----------GVCV 511
Cdd:TIGR00917  578 AISYLVMFAYISLTLgdsprlKSLYVTSKVLLGLSGILIVML---SVLGSVGVFSAVGLKSTLIIMevipflvlavGVDN 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   512 NYTLI--FFDLWRLsRGQVPSGG-----LAHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVH 584
Cdd:TIGR00917  655 IFILVffYFYLEYF-YRQVGVDNeqeltLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLD 733

                          170
                   ....*....|....*..
gi 564342364   585 MGLTLLWLPATVVLHER 601
Cdd:TIGR00917  734 FLLQITAFVALLVLDFK 750
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 451-598 4.62e-06

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 51.30  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  451 LVIIFfgmslylRSLFITFMSLLGVLGSLMVAF-FLYHVAFRMAYFPFV-NLASLLLLsGVCVNYTLIFFDLWR--LSRG 526
Cdd:COG2409   186 LLLVF-------RSLVAALLPLLTAGLAVGVALgLLALLAAFTDVSSFApNLLTMLGL-GVGIDYALFLVSRYReeLRAG 257

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564342364  527 QVPsgglAHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHM--GLTLlwLPATVVL 598
Cdd:COG2409   258 EDR----EEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVlaALTL--LPALLAL 325
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 468-598 5.94e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.52  E-value: 5.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   468 TFMSLLGVLGSLMVAFFLYHvAFRMAYFPFVNLAS-------LLLLSGVCVNYTLIFFDLWRLSRGQVPSGGLAHR---- 536
Cdd:TIGR00921  570 RRMTIAGAILVLMILLAVFR-NPIKAVFPLIAIGSgilwaigLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERyfee 648

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564342364   537 ---------VGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVL 598
Cdd:TIGR00921  649 rkehgpkeaITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 377-526 2.40e-04

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 44.09  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  377 SPQTADYQVPSLKFALLFLPIIktsslLDIYLDGLGDPIKVSDN------YTSISGMDLGLkprLLKYYLAEDTMYPLLS 450
Cdd:cd10432    30 TPALLLIAGSPLMWVLLIAELA-----LVFGLSFRINKMSVATAlplffaFAALTGLTLSP---ILLVYTGASIAQAFFT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  451 LVIIFFGMSLY-------LRSL-FITFMSLLGVLGSLMVAFFLYHVAFRMAyfpfVNLASLLLLSGvcvnytLIFFDLWR 522
Cdd:cd10432   102 TAATFGGLSLYgyttkkdLSFLgSFLFMGLIGLIIASLVNIFLQSSALQFA----ISAIGVLIFSG------LIAYDTQR 171


                  ....
gi 564342364  523 LSRG 526
Cdd:cd10432   172 IKRM 175
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 435-600 4.42e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.83  E-value: 4.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   435 LLKYYLAEDTMYPLLSLVIIFFGMSLYLrslfiTFMSLLGVlgslmvafflyhvafrmayfPF--VNLASLLLLSGVCVN 512
Cdd:TIGR00921  208 LVLLLDFKRWWRPLLPLVIILFGVAWVL-----GIMGWLGI--------------------PLyaTTLLAVPMLIGVGID 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364   513 YTLIFFDLWRLSR--GQVPSGGLAHRVGRTmhhfGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLL 590
Cdd:TIGR00921  263 YGIQTLNRYEEERdiGRAKGEAIVTAVRRT----GRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLL 338

                          170
                   ....*....|
gi 564342364   591 WLPATVVLHE 600
Cdd:TIGR00921  339 VLPALLQSID 348
COG4258 COG4258
Predicted exporter [General function prediction only];
448-594 5.76e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 5.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  448 LLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAfflyHVAFRMayfpfVNLASLLLLSGVCVNYTlIFFDLWRLSRGQ 527
Cdd:COG4258   653 LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLL----GIPLNL-----FHLIALLLVLGIGIDYA-LFFTEGLLDKGE 722

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564342364  528 VPsgglahrvgRTMHhfgyLLLVSGLTTSAAFyGSY-LSRLPTVRCFALFMGTAVLVHMGLTLLWLPA 594
Cdd:COG4258   723 LA---------RTLL----SILLAALTTLLGF-GLLaFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 529-601 1.56e-03

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 40.64  E-value: 1.56e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564342364   529 PSGGLAHRVGRTMHHFGYLLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPATVVLHER 601
Cdd:pfam12349   66 RSLDVSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIR 138
COG4258 COG4258
Predicted exporter [General function prediction only];
448-594 9.16e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 40.61  E-value: 9.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  448 LLSLVIIFFGMSLYLRSLFITFMSLLGVLGSLMVAFFLYHVAFRMayfpfVNLASLLL---LSGVCVNYTLIFFdLWRLS 524
Cdd:COG4258   256 LISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAVSLVFGS-----VHGITLGFgssLIGVAVDYSLHYL-THRRA 329

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564342364  525 RGQVPSGGLAHRVGRTmhhfgylLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLWLPA 594
Cdd:COG4258   330 AGEWDPRAALRRIWPT-------LLLGLLTTVLGYLALLFSPFPGLRQLGVFAAAGLLAAALTTLLWLPL 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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