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Conserved domains on  [gi|564351983|ref|XP_006238569|]
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enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X3 [Rattus norvegicus]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-191 6.25e-77

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 230.46  E-value: 6.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PLN02600  65 MSPSEVQKFVNSLRSTFSSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQNEegdaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PLN02600 145 GRSRAKELIFTGRRIGAREAASMGLVNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIE 220

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564351983 161 HMCYAQNIPTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PLN02600 221 EECYEQVLKTKDRLEGLAAFAEKRKPVYTGK 251
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 1-191 6.25e-77

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 230.46  E-value: 6.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PLN02600  65 MSPSEVQKFVNSLRSTFSSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQNEegdaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PLN02600 145 GRSRAKELIFTGRRIGAREAASMGLVNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIE 220

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564351983 161 HMCYAQNIPTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PLN02600 221 EECYEQVLKTKDRLEGLAAFAEKRKPVYTGK 251
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-185 1.19e-59

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 186.53  E-value: 1.19e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:COG1024   69 ADPEEARAFARGLQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQneegDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:COG1024  149 GLARAKELLLTGRRIDAEEALELGLVNRVVPD----DELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELE 224

                        170       180
                 ....*....|....*....|....*
gi 564351983 161 HMCYAQNIPTQDRLEGMAAFREKRP 185
Cdd:COG1024  225 AEAFAELFASEDAREGIAAFLEKRK 249
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 2-130 7.80e-41

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 136.54  E-value: 7.80e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   2 SAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLG 81
Cdd:cd06558   71 AGEEARAFIRELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVG 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564351983  82 VALAKELIFTGRRLNGVQAHELGLVNHAVaqneEGDAAYHRALALAQEI 130
Cdd:cd06558  151 PARARELLLTGRRISAEEALELGLVDEVV----PDEELLAAALELARRL 195
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 16-191 1.10e-38

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 132.87  E-value: 1.10e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:pfam00378  80 LWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   96 NGVQAHELGLVNHAVAQneegDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLE 175
Cdd:pfam00378 160 SAQEALKWGLVDKVVPE----DQLLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIE 235

                         170
                  ....*....|....*.
gi 564351983  176 GMAAFREKRPPKFVGK 191
Cdd:pfam00378 236 GLQAFLEKRKPPWEDQ 251
menB TIGR01929
naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, ...
 10-188 2.60e-24

naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 200143 [Multi-domain]  Cd Length: 259  Bit Score: 95.69  E-value: 2.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   10 VQRLrglmseIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:TIGR01929  89 VQRQ------IRTCPKPVIAMVNGYAIGGGHVLHMMCDLTIAAENARFGQTGPKVGSFDGGYGSSYMARIVGQKKAREIW 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   90 FTGRRLNGVQAHELGLVNhAVAQNEEGDAAyhrALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGMAiEHMCYAQNIP 169
Cdd:TIGR01929 163 FLCRQYDAKQALDMGLVN-TVVPLADLEKE---TVRWCREILQKSPMAIRMLKAALN--ADCDGQAGLQ-ELAGNATMLF 235

                         170       180
                  ....*....|....*....|.
gi 564351983  170 --TQDRLEGMAAFREKRPPKF 188
Cdd:TIGR01929 236 ymTEEGQEGRNAFLEKRQPDF 256
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 1-191 6.25e-77

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 230.46  E-value: 6.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PLN02600  65 MSPSEVQKFVNSLRSTFSSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQNEegdaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PLN02600 145 GRSRAKELIFTGRRIGAREAASMGLVNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIE 220

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564351983 161 HMCYAQNIPTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PLN02600 221 EECYEQVLKTKDRLEGLAAFAEKRKPVYTGK 251
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 1-191 1.26e-74

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 225.00  E-value: 1.26e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PRK07657  74 MNEEQVRHAVSLIRTTMEMVEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQNEEGDaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:PRK07657 154 GVGRAKELIYTGRRISAQEAKEIGLVEFVVPAHLLEE----KAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIE 229

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564351983 161 HMCYAQNIPTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK07657 230 KQAYEGTIPTKDRLEGLQAFKEKRKPMYKGE 260
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-185 1.19e-59

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 186.53  E-value: 1.19e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:COG1024   69 ADPEEARAFARGLQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQneegDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE 160
Cdd:COG1024  149 GLARAKELLLTGRRIDAEEALELGLVNRVVPD----DELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELE 224

                        170       180
                 ....*....|....*....|....*
gi 564351983 161 HMCYAQNIPTQDRLEGMAAFREKRP 185
Cdd:COG1024  225 AEAFAELFASEDAREGIAAFLEKRK 249
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
26-191 8.91e-54

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 171.85  E-value: 8.91e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK05809  99 PVIAAINGFALGGGCELSMACDIRIASEKAKFGQPEVGLGITPGFGGTQRLARIVGPGKAKELIYTGDMINAEEALRIGL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQNEEGDAAYhralALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAAFREKRP 185
Cdd:PRK05809 179 VNKVVEPEKLMEEAK----ALANKIAANAPIAVKLCKDAINRGMQVDIDTAVAIEAEDFGECFSTEDQTEGMTAFVEKRE 254


                 ....*.
gi 564351983 186 PKFVGK 191
Cdd:PRK05809 255 KNFKNK 260
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 6-191 3.17e-47

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 154.92  E-value: 3.17e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   6 VGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALA 85
Cdd:PRK09674  74 AATLNDPRPQLWQRLQAFNKPLIAAVNGYALGAGCELALLCDIVIAGENARFGLPEITLGIMPGAGGTQRLIRSVGKSLA 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  86 KELIFTGRRLNGVQAHELGLVNHaVAQNEegdAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYA 165
Cdd:PRK09674 154 SQMVLTGESITAQQAQQAGLVSE-VFPPE---LTLERALQLASKIARHSPLALRAAKQALRQSQEVDLQAGLAQERQLFT 229

                        170       180
                 ....*....|....*....|....*.
gi 564351983 166 QNIPTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK09674 230 LLAATEDRHEGISAFLEKRTPDFKGR 255
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 16-191 1.09e-43

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 145.93  E-value: 1.09e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK07658  86 TFERVEKFSKPVIAAIHGAALGGGLELAMSCHIRFATESAKLGLPELNLGLIPGFAGTQRLPRYVGKAKALEMMLTSEPI 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  96 NGVQAHELGLVNHAVAQNEegdaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLE 175
Cdd:PRK07658 166 TGAEALKWGLVNGVFPEET----LLDDAKKLAKKIAGKSPATTRAVLELLQTTKSSSYYEGVKREAKIFGEVFTSEDAKE 241

                        170
                 ....*....|....*.
gi 564351983 176 GMAAFREKRPPKFVGK 191
Cdd:PRK07658 242 GVQAFLEKRKPSFSGK 257
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 26-191 2.68e-43

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 145.18  E-value: 2.68e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK06494  96 PIIAAVNGVAMGGGFELALACDLIVAAENATFALPEPRVGLAALAGGLHRLPRQIGLKRAMGMILTGRRVTAREGLELGF 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQnEEGDAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAiEHMCY---AQNIPTQDRLEGMAAFRE 182
Cdd:PRK06494 176 VNEVVPA-GELLAA---AERWADDILACSPLSIRASKQAVYRGLEVSLEEAIT-AQRDYpavEARRASQDYIEGPKAFAE 250


                 ....*....
gi 564351983 183 KRPPKFVGK 191
Cdd:PRK06494 251 KRPPRWKGR 259
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 20-186 3.67e-41

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 139.28  E-value: 3.67e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  20 IAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQ 99
Cdd:PRK09076  91 LSAFRGVSIAAINGYAMGGGLECALACDIRIAEEQAQMALPEASVGLLPCAGGTQNLPWLVGEGWAKRMILCGERVDAAT 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 100 AHELGLVNHAVAQNEegdaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAA 179
Cdd:PRK09076 171 ALRIGLVEEVVEKGE----AREAALALAQKVANQSPSAVAACKTLIQAARNGPRAAALALERELFVDLFDTEDQREGVNA 246


                 ....*..
gi 564351983 180 FREKRPP 186
Cdd:PRK09076 247 FLEKRAP 253
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 2-130 7.80e-41

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 136.54  E-value: 7.80e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   2 SAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLG 81
Cdd:cd06558   71 AGEEARAFIRELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVG 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564351983  82 VALAKELIFTGRRLNGVQAHELGLVNHAVaqneEGDAAYHRALALAQEI 130
Cdd:cd06558  151 PARARELLLTGRRISAEEALELGLVDEVV----PDEELLAAALELARRL 195
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 19-188 2.16e-39

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 134.78  E-value: 2.16e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  19 EIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGV 98
Cdd:PRK05862  89 KVARIRKPVIAAVAGYALGGGCELAMMCDIIIAADTAKFGQPEIKLGVLPGMGGSQRLTRAVGKAKAMDLCLTGRMMDAA 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  99 QAHELGLVNHAVAQNEEGDAAYHRALALAQEILPqapiAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMA 178
Cdd:PRK05862 169 EAERAGLVSRVVPADKLLDEALAAATTIASFSLP----AVMMAKEAVNRAYETTLAEGLLFERRLFHSLFATEDQKEGMA 244

                        170
                 ....*....|
gi 564351983 179 AFREKRPPKF 188
Cdd:PRK05862 245 AFVEKRKPVF 254
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 20-191 3.43e-39

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 134.23  E-value: 3.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  20 IAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQ 99
Cdd:PRK06688  92 IAALPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDAGGSALLPRLIGRARAAEMLLLGEPLSAEE 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 100 AHELGLVNHAVAqNEEGDAAyhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAA 179
Cdd:PRK06688 172 ALRIGLVNRVVP-AAELDAE---ADAQAAKLAAGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPDFREGATA 247

                        170
                 ....*....|..
gi 564351983 180 FREKRPPKFVGK 191
Cdd:PRK06688 248 FIEKRKPDFTGF 259
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 20-191 6.24e-39

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 134.02  E-value: 6.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  20 IAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQ 99
Cdd:PRK08138  94 IAQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQPEIKVGLMPGAGGTQRLVRAVGKFKAMRMALTGCMVPAPE 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 100 AHELGLVNHAVaqneEGDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAA 179
Cdd:PRK08138 174 ALAIGLVSEVV----EDEQTLPRALELAREIARMPPLALAQIKEVVLAGADAPLDAALALERKAFQLLFDSEDQKEGMDA 249

                        170
                 ....*....|..
gi 564351983 180 FREKRPPKFVGK 191
Cdd:PRK08138 250 FLEKRKPAYKGK 261
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 16-191 1.10e-38

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 132.87  E-value: 1.10e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:pfam00378  80 LWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   96 NGVQAHELGLVNHAVAQneegDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLE 175
Cdd:pfam00378 160 SAQEALKWGLVDKVVPE----DQLLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIE 235

                         170
                  ....*....|....*.
gi 564351983  176 GMAAFREKRPPKFVGK 191
Cdd:pfam00378 236 GLQAFLEKRKPPWEDQ 251
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
26-191 1.19e-35

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 125.10  E-value: 1.19e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK08252  93 PLIAAVEGYALAGGFELALACDLIVAARDAKFGLPEVKRGLVAAGGGLLRLPRRIPYHIAMELALTGDMLTAERAHELGL 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQNEEGDAayhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAAFREKRP 185
Cdd:PRK08252 173 VNRLTEPGQALDA----ALELAERIAANGPLAVAASKRIVVESGDWSEDEMFARQRELIAPVFTSADAKEGATAFAEKRA 248


                 ....*.
gi 564351983 186 PKFVGK 191
Cdd:PRK08252 249 PVWTGK 254
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 3-191 2.74e-33

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 119.42  E-value: 2.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   3 AAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGV 82
Cdd:PRK06127  85 AEAVAAYEQAVEAAQAALADYAKPTIACIRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGLGYGYDGVKNLVDLVGP 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  83 ALAKELIFTGRRLNGVQAHELGLVNHAVAQNEEGDAAYHRALALAQeilpQAPIAVRLGKVAIDR----GMEVDIASGMA 158
Cdd:PRK06127 165 SAAKDLFYTARRFDAAEALRIGLVHRVTAADDLETALADYAATIAG----NAPLTLRAAKRAIAEllkdEPERDMAACQA 240

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564351983 159 IEHMCYAqnipTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK06127 241 LVAACFD----SEDYREGRAAFMEKRKPVFKGR 269
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
17-191 1.46e-32

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 117.49  E-value: 1.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  17 MSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLN 96
Cdd:PRK03580  87 LTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCADNASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMD 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  97 GVQAHELGLVNHAVAQNEEGDaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGM------AIEHmcYAQNIPT 170
Cdd:PRK03580 167 AEEALRWGIVNRVVPQAELMD----RARELAQQLVNSAPLAIAALKEIYRETSEMPVEEAYryirsgVLKH--YPSVLHS 240

                        170       180
                 ....*....|....*....|.
gi 564351983 171 QDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK03580 241 EDALEGPRAFAEKRDPVWKGR 261
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
9-188 1.60e-32

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 117.17  E-value: 1.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   9 FVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKEL 88
Cdd:PRK05980  85 FVRRGQAMTARLEAFPKPVIAAVNGLAFGGGCEITEAVHLAIASERALFAKPEIRLGMPPTFGGTQRLPRLAGRKRALEL 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  89 IFTGRRLNGVQAHELGLVNHAVAQNEEGDAayhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNI 168
Cdd:PRK05980 165 LLTGDAFSAERALEIGLVNAVVPHEELLPA----ARALARRIIRHSPVAVAAILTAVTRGLNLSIAEGLLIESEQFARMA 240

                        170       180
                 ....*....|....*....|
gi 564351983 169 PTQDRLEGMAAFREKRPPKF 188
Cdd:PRK05980 241 GSADLREGLAAWIERRRPAY 260
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
2-125 7.54e-32

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 120.77  E-value: 7.54e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   2 SAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSA--VMGLIETTRGLLPGAGGTQRLPRC 79
Cdd:PRK11154  79 TAQEAEALARQGQQLFAEIEALPIPVVAAIHGACLGGGLELALACHYRVCTDDPktVLGLPEVQLGLLPGSGGTQRLPRL 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564351983  80 LGVALAKELIFTGRRLNGVQAHELGLVNHAVAQNEEGDAAYHRALA 125
Cdd:PRK11154 159 IGVSTALDMILTGKQLRAKQALKLGLVDDVVPHSILLEVAVELAKK 204
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 13-190 3.92e-30

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 110.86  E-value: 3.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  13 LRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTG 92
Cdd:PRK07511  87 LHDWIRAIRAFPKPVIAAVEGAAAGAGFSLALACDLLVAARDAKFVMAYVKVGLTPDGGGSWFLARALPRQLATELLLEG 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  93 RRLNGVQAHELGLVNHAVaqneEGDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQD 172
Cdd:PRK07511 167 KPISAERLHALGVVNRLA----EPGQALAEALALADQLAAGSPNALARIKSLIADAPEATLAAQLEAERDHFVASLHHAD 242

                        170
                 ....*....|....*...
gi 564351983 173 RLEGMAAFREKRPPKFVG 190
Cdd:PRK07511 243 ALEGIAAFLEKRAPDYKR 260
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
26-191 1.30e-29

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 109.68  E-value: 1.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK09245 105 PVIAAVNGPAIGAGCDLACMCDIRIASETARFAESFVKLGLIPGDGGAWLLPRIIGMARAAEMAFTGDAIDAATALEWGL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQNEEGDAayhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAAFREKRP 185
Cdd:PRK09245 185 VSRVVPADQLLPA----ARALAERIAANPPHALRLTKRLLREGQHASLDTLLELSAAYQALAHHTADHREAVDAFLEKRP 260


                 ....*.
gi 564351983 186 PKFVGK 191
Cdd:PRK09245 261 PVFTGR 266
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
24-189 4.74e-29

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 108.04  E-value: 4.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  24 PAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHEL 103
Cdd:PRK07509 102 PVPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVPDMAGTVSLRGLVRKDVARELTYTARVFSAEEALEL 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 104 GLVNHAVaqneegDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAAFREK 183
Cdd:PRK07509 182 GLVTHVS------DDPLAAALALAREIAQRSPDAIAAAKRLINRSWTASVRALLARESVEQIRLLLGKNQKIAVKAQMKK 255


                 ....*.
gi 564351983 184 RPPKFV 189
Cdd:PRK07509 256 RAPKFL 261
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 12-191 1.46e-27

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 104.30  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  12 RLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGL-IETTRGLLPGAGGTQRLPRCLGVALAKELIF 90
Cdd:PRK06144  90 RIDRVLGALEQLRVPTIAAIAGACVGGGAAIAAACDLRIATPSARFGFpIARTLGNCLSMSNLARLVALLGAARVKDMLF 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  91 TGRRLNGVQAHELGLVNHAVAqneegDAAYH-RALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAqnip 169
Cdd:PRK06144 170 TARLLEAEEALAAGLVNEVVE-----DAALDaRADALAELLAAHAPLTLRATKEALRRLRREGLPDGDDLIRMCYM---- 240

                        170       180
                 ....*....|....*....|..
gi 564351983 170 TQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK06144 241 SEDFREGVEAFLEKRPPKWKGR 262
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
10-190 1.56e-27

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 104.29  E-value: 1.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  10 VQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:PRK06142  95 ILRLQAAINAVADCRKPVIAAVQGWCIGGGVDLISACDMRYASADAKFSVREVDLGMVADVGSLQRLPRIIGDGHLRELA 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  90 FTGRRLNGVQAHELGLVNHAVaqnEEGDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIP 169
Cdd:PRK06142 175 LTGRDIDAAEAEKIGLVNRVY---DDADALLAAAHATAREIAAKSPLAVRGTKEVLDYMRDHRVADGLRYVATWNAAMLP 251

                        170       180
                 ....*....|....*....|.
gi 564351983 170 TQDRLEGMAAFREKRPPKFVG 190
Cdd:PRK06142 252 SKDLTEAIAAHMEKRPPEFTG 272
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 12-182 3.19e-27

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 103.52  E-value: 3.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  12 RLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFT 91
Cdd:PRK06190  82 ALPNPSPAWPAMRKPVIGAINGAAVTGGLELALACDILIASERARFADTHARVGILPGWGLSVRLPQKVGIGRARRMSLT 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  92 GRRLNGVQAHELGLVNHAVAQNEEGDaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHmCYAQNIPTQ 171
Cdd:PRK06190 162 GDFLDAADALRAGLVTEVVPHDELLP----RARRLAASIAGNNPAAVRALKASYDDGAAAQTGDALALEA-EAARAHNRS 236

                        170
                 ....*....|.
gi 564351983 172 DRLEGMAAFRE 182
Cdd:PRK06190 237 VSPDGIAARRE 247
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
1-157 2.29e-26

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 104.94  E-value: 2.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PRK11730  79 APEEELSQWLHFANSIFNRLEDLPVPTVAAINGYALGGGCECVLATDYRVASPDARIGLPETKLGIMPGFGGTVRLPRLI 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQNEEGDAAYHRA-LALAQEILPQAPIAVRLGKV---AIDRGMEVDIASG 156
Cdd:PRK11730 159 GADNALEWIAAGKDVRAEDALKVGAVDAVVAPEKLQEAALALLkQAIAGKLDWKARRQPKLEPLklsKIEAMMSFTTAKG 238


                 .
gi 564351983 157 M 157
Cdd:PRK11730 239 M 239
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 13-191 3.10e-26

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 100.87  E-value: 3.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  13 LRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTG 92
Cdd:PRK11423  85 LRQILRMIQKFPKPVIAMVEGSVWGGAFELIMSCDLIIAASTSTFAMTPANLGVPYNLSGILNFTNDAGFHIVKEMFFTA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  93 RRLNGVQAHELGLVNHaVAQNEEGDAAyhrALALAQEILPQAPIAVRLGKvaidrgMEVDI---ASGMAIEHMCYAQNI- 168
Cdd:PRK11423 165 SPITAQRALAVGILNH-VVEVEELEDF---TLQMAHHISEKAPLAIAVIK------EQLRVlgeAHPMNPDEFERIQGLr 234

                        170       180
                 ....*....|....*....|....*..
gi 564351983 169 ----PTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK11423 235 ravyDSEDYQEGMNAFLEKRKPVFVGH 261
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
26-191 8.07e-26

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 99.79  E-value: 8.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK07799 102 PLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFPMGGSAVRLVRQIPYTVACDLLLTGRHITAAEAKEIGL 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQneegDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAAFREKRP 185
Cdd:PRK07799 182 IGHVVPD----GQALDKALELAELINANGPLAVQAILRTIRETEGMHENEAFKIDTKIGIPVFLSEDAKEGPRAFAEKRA 257


                 ....*.
gi 564351983 186 PKFVGK 191
Cdd:PRK07799 258 PNFQGR 263
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
26-191 2.01e-25

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 98.49  E-value: 2.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK06563  94 PLVVAVQGYCLTLGIELMLAADIVVAADNTRFAQLEVQRGILPFGGATLRFPQAAGWGNAMRYLLTGDEFDAQEALRLGL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQNEEgdaaYHRALALAQEILPQAPIAVRL----GKVAIDRGMEVDIASGMAIEHMCYAqnipTQDRLEGMAAFR 181
Cdd:PRK06563 174 VQEVVPPGEQ----LERAIELAERIARAAPLGVQAtlasARAAVREGEAAAAAQLPPELRPLFT----SEDAKEGVQAFL 245

                        170
                 ....*....|
gi 564351983 182 EKRPPKFVGK 191
Cdd:PRK06563 246 ERRPARFKGR 255
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 1-146 6.64e-25

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 96.45  E-value: 6.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PRK05869  76 LSAQEADTAARVRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLAPSGDGMARLTRAA 155

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564351983  81 GVALAKELIFTGRRLNGVQAHELGLVNHAVAQneegDAAYHRALALAQEILPQAPIAVRLGKVAID 146
Cdd:PRK05869 156 GPSRAKELVFSGRFFDAEEALALGLIDEMVAP----DDVYDAAAAWARRFLDGPPHALAAAKAGIS 217
PLN02888 PLN02888
enoyl-CoA hydratase
 26-187 1.98e-24

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 96.36  E-value: 1.98e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PLN02888 101 PIIGAINGFAITAGFEIALACDILVASRGAKFIDTHAKFGIFPSWGLSQKLSRIIGANRAREVSLTAMPLTAETAERWGL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQNEegdaAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIE----HMCYAQNipTQDRLEGMAAF- 180
Cdd:PLN02888 181 VNHVVEESE----LLKKAREVAEAIIKNNQGMVLRYKSVINDGLKLDLGHALQLEkeraHDYYNGM--TKEQFQKMQEFi 254

                        170
                 ....*....|
gi 564351983 181 ---REKRPPK 187
Cdd:PLN02888 255 agrSSKKPSK 264
menB TIGR01929
naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, ...
 10-188 2.60e-24

naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 200143 [Multi-domain]  Cd Length: 259  Bit Score: 95.69  E-value: 2.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   10 VQRLrglmseIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:TIGR01929  89 VQRQ------IRTCPKPVIAMVNGYAIGGGHVLHMMCDLTIAAENARFGQTGPKVGSFDGGYGSSYMARIVGQKKAREIW 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   90 FTGRRLNGVQAHELGLVNhAVAQNEEGDAAyhrALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGMAiEHMCYAQNIP 169
Cdd:TIGR01929 163 FLCRQYDAKQALDMGLVN-TVVPLADLEKE---TVRWCREILQKSPMAIRMLKAALN--ADCDGQAGLQ-ELAGNATMLF 235

                         170       180
                  ....*....|....*....|.
gi 564351983  170 --TQDRLEGMAAFREKRPPKF 188
Cdd:TIGR01929 236 ymTEEGQEGRNAFLEKRQPDF 256
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
26-191 6.75e-24

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 94.76  E-value: 6.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLlpgAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK06495  99 PVIAAVNGPALGAGLGLVASCDIIVASENAVFGLPEIDVGL---AGGGKHAMRLFGHSLTRRMMLTGYRVPAAELYRRGV 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAqneeGDAAYHRALALAQEILPQAPIAVRLGKVAIDrgmevdiasgmAIEHMC------YAQNIP-----TQDRL 174
Cdd:PRK06495 176 IEACLP----PEELMPEAMEIAREIASKSPLATRLAKDALN-----------TIENMSlrdgyrYEQDITaklakTEDAK 240

                        170
                 ....*....|....*..
gi 564351983 175 EGMAAFREKRPPKFVGK 191
Cdd:PRK06495 241 EAQRAFLEKRPPVFKGR 257
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 22-191 8.98e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 94.77  E-value: 8.98e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  22 AFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAH 101
Cdd:PRK06210 106 ALRKPVIAAINGACAGIGLTHALMCDVRFAADGAKFTTAFARRGLIAEHGISWILPRLVGHANALDLLLSARTFYAEEAL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 102 ELGLVNHAVAQNEEGDAAYHRALALAQEILPqAPIAVRLGKVAIDRGMEVDIASGMAIEHMcyAQNIPTQDRLEGMAAFR 181
Cdd:PRK06210 186 RLGLVNRVVPPDELMERTLAYAEDLARNVSP-ASMAVIKRQLYEDAFQTLAEATARANREM--HESLQRPDFIEGVASFL 262

                        170
                 ....*....|
gi 564351983 182 EKRPPKFVGK 191
Cdd:PRK06210 263 EKRPPRFPGL 272
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 9-142 1.19e-23

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 93.95  E-value: 1.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   9 FVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGlLPGAGGTQRLPRCLGVALAKEL 88
Cdd:PRK06143  85 FISRLRDLCDAVRHFPVPVIARIPGWCLGGGLELAAACDLRIAAHDAQFGMPEVRVG-IPSVIHAALLPRLIGWARTRWL 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564351983  89 IFTGRRLNGVQAHELGLVnHAVAQNEEGDAAYHRalaLAQEILPQAPIAVRLGK 142
Cdd:PRK06143 164 LLTGETIDAAQALAWGLV-DRVVPLAELDAAVER---LAASLAGCGPQALRQQK 213
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 11-152 7.21e-23

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 92.38  E-value: 7.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  11 QRLRglmseiaAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIF 90
Cdd:PRK09120  98 RRLR-------WYQKPTIAMVNGWCFGGGFSPLVACDLAIAADEAQFGLSEINWGIPPGGGVSKAMADTVGHRDALYYIM 170

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564351983  91 TGRRLNGVQAHELGLVNHAV--AQNEEgdaayhRALALAQEILPQAPIAVRLGKVAIDRGMEVD 152
Cdd:PRK09120 171 TGETFTGRKAAEMGLVNESVplAQLRA------RTRELAAKLLEKNPVVLRAAKDGFKRVRELT 228
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 16-191 7.91e-23

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 91.90  E-value: 7.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK08140  91 LVRRLRALPLPVIAAVNGVAAGAGANLALACDIVLAARSASFIQAFVKIGLVPDSGGTWFLPRLVGMARALGLALLGEKL 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  96 NGVQAHELGLVNHAVAqneegDAAYH-RALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRL 174
Cdd:PRK08140 171 SAEQAEQWGLIWRVVD-----DAALAdEAQQLAAHLATQPTRGLALIKQAMNASATNTLDAQLDLERDLQREAGRSADYA 245

                        170
                 ....*....|....*..
gi 564351983 175 EGMAAFREKRPPKFVGK 191
Cdd:PRK08140 246 EGVSAFLEKRAPRFTGR 262
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 2-110 1.34e-22

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 94.13  E-value: 1.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983    2 SAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAA--SSAVMGLIETTRGLLPGAGGTQRLPRC 79
Cdd:TIGR02441  86 TAQEVTQLSQEGQEMFERIEKSQKPIVAAISGSCLGGGLELALACHYRIATkdRKTLLGLPEVMLGLLPGAGGTQRLPKL 165

                          90       100       110
                  ....*....|....*....|....*....|.
gi 564351983   80 LGVALAKELIFTGRRLNGVQAHELGLVNHAV 110
Cdd:TIGR02441 166 TGVPAALDMMLTGKKIRADRAKKMGIVDQLV 196
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 26-191 8.78e-22

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 89.68  E-value: 8.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PRK08260 115 PVIAAVNGPAVGVGATMTLAMDIRLASTAARFGFVFGRRGIVPEAASSWFLPRLVGLQTALEWVYSGRVFDAQEALDGGL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQNEEGDAAYhralALAQEILPQ-APIAVRLGKVAIDRG------MEVDIASGMAIehmcYAQNIpTQDRLEGMA 178
Cdd:PRK08260 195 VRSVHPPDELLPAAR----ALAREIADNtSPVSVALTRQMMWRMagadhpMEAHRVDSRAI----YSRGR-SGDGKEGVS 265

                        170
                 ....*....|...
gi 564351983 179 AFREKRPPKFVGK 191
Cdd:PRK08260 266 SFLEKRPAVFPGK 278
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 26-188 1.34e-21

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 88.81  E-value: 1.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHELGL 105
Cdd:PLN02664 113 PVIAAIHGACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAITADLGTLQRLPSIVGYGNAMELALTGRRFSGSEAKELGL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 106 VNHAVAQNEEGDAAYHralALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAAFREKRP 185
Cdd:PLN02664 193 VSRVFGSKEDLDEGVR---LIAEGIAAKSPLAVTGTKAVLLRSRELSVEQGLDYVATWNSAMLVSDDLNEAVSAQIQKRK 269


                 ...
gi 564351983 186 PKF 188
Cdd:PLN02664 270 PVF 272
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 1-191 2.10e-21

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 88.06  E-value: 2.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgaggTQRLP--- 77
Cdd:PRK05995  76 YSDDENRADARRLADMLRAIYRCPKPVIARVHGDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIP----ATISPyvi 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  78 RCLGVALAKELIFTGRRLNGVQAHELGLVNHAVAQnEEGDAAYHralALAQEILPQAPIAVRLGKVAID--RGMEVD--- 152
Cdd:PRK05995 152 RAMGERAARRYFLTAERFDAAEALRLGLVHEVVPA-EALDAKVD---ELLAALVANSPQAVRAGKRLVRdvAGRPIDaal 227

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 564351983 153 ---IASGMAIEHMcyaqnipTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK05995 228 iadTASRIALIRA-------TEEAREGVAAFLEKRKPAWRGR 262
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
26-134 5.66e-21

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 86.87  E-value: 5.66e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMG---------LIEttrgllpgaGGTQRLPRCLGVALAKELIFTGRRLN 96
Cdd:PRK08259  95 PVIAAVSGYAVAGGLELALWCDLRVAEEDAVFGvfcrrwgvpLID---------GGTVRLPRLIGHSRAMDLILTGRPVD 165

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564351983  97 GVQAHELGLVNHAVAQNEegdaAYHRALALAQEI--LPQA 134
Cdd:PRK08259 166 ADEALAIGLANRVVPKGQ----ARAAAEELAAELaaFPQT 201
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
24-137 7.31e-21

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 86.61  E-value: 7.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  24 PAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHEL 103
Cdd:PRK08150  92 RVPVIAALHGAVVGGGLELASAAHIRVADESTYFALPEGQRGIFVGGGGSVRVPRLIGVARMTDMMLTGRVYDAQEGERL 171

                         90       100       110
                 ....*....|....*....|....*....|....
gi 564351983 104 GLVNHAVAQNEegdaAYHRALALAQEILPQAPIA 137
Cdd:PRK08150 172 GLAQYLVPAGE----ALDKAMELARRIAQNAPLT 201
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
1-190 1.70e-19

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 83.09  E-value: 1.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   1 MSAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGlLPGA--GGTQRLPR 78
Cdd:PRK08258  90 MDMPELLAFTRMTGDLVKAMRACPQPIIAAVDGVCAGAGAILAMASDLRLGTPSAKTAFLFTRVG-LAGAdmGACALLPR 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  79 CLGVALAKELIFTGRRLNGVQAHELGLVNHAVaqneEGDAAYHRALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGMA 158
Cdd:PRK08258 169 IIGQGRASELLYTGRSMSAEEGERWGFFNRLV----EPEELLAEAQALARRLAAGPTFAHGMTKTMLH--QEWDMGLEEA 242

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564351983 159 IEHMCYAQNI--PTQDRLEGMAAFREKRPPKFVG 190
Cdd:PRK08258 243 IEAEAQAQAIcmQTEDFRRAYEAFVAKRKPVFEG 276
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 16-186 3.29e-19

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 82.30  E-value: 3.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLL---PGAGgtqrLPRCLGVALAKELIFTG 92
Cdd:PRK08139  96 VMQAIVALPQPVIARVHGIATAAGCQLVASCDLAVAADTARFAVPGVNIGLFcstPMVA----LSRNVPRKQAMEMLLTG 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  93 RRLNGVQAHELGLVNHAVAQNEEGDAayhrALALAQEILPQAPIAVRLGKVAIDR--GMEVDIASGMAIEHMcyAQNIPT 170
Cdd:PRK08139 172 EFIDAATAREWGLVNRVVPADALDAA----VARLAAVIAAKSPAAVRIGKEAFYRqaEMPLADAYAYAGDVM--AENMMA 245

                        170
                 ....*....|....*.
gi 564351983 171 QDRLEGMAAFREKRPP 186
Cdd:PRK08139 246 EDAEEGIDAFLEKRPP 261
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
 23-187 5.36e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 81.93  E-value: 5.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  23 FPAPTIAAMDGFALGGGLELALACDLRIAASSAV-------MGliettrgllpgAGGTQRL--PRCLGVALAKELIFTGR 93
Cdd:PRK08290 117 LPKPTIAQVQGACIAGGLMLAWVCDLIVASDDAFfsdpvvrMG-----------IPGVEYFahPWELGPRKAKELLFTGD 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  94 RLNGVQAHELGLVNHAVAQNEEGDAayhrALALAQEILPQAPIAVRLGKVAIDR-----GMEVDIASGMAIEHMCYAQNI 168
Cdd:PRK08290 186 RLTADEAHRLGMVNRVVPRDELEAE----TLELARRIAAMPPFGLRLTKRAVNQtldaqGFRAALDAVFDLHQLGHAHNA 261

                        170       180
                 ....*....|....*....|....*
gi 564351983 169 PTQD------RLEGMAAFREKRPPK 187
Cdd:PRK08290 262 EVGGdrlggaDARGMADARKAAAAK 286
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
16-191 7.07e-19

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 81.32  E-value: 7.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK05981  95 FLRRLRNLPCPIVTAVNGPAAGVGMSFALMGDLILCARSAYFLQAFRRIGLVPDGGSTWLLPRLVGKARAMELSLLGEKL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  96 NGVQAHELGLVNHAVAQNEEGDAayhrALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEhmCYAQNIP--TQDR 173
Cdd:PRK05981 175 PAETALQWGLVNRVVDDAELMAE----AMKLAHELANGPTVALGLIRKLYWDSPENDFEEQLNLE--REAQRIAgkTEDF 248

                        170
                 ....*....|....*...
gi 564351983 174 LEGMAAFREKRPPKFVGK 191
Cdd:PRK05981 249 KEGVGAFLQKRPAQFKGR 266
MenB COG0447
1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1, ...
 10-188 2.49e-18

1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1,4-Dihydroxy-2-naphthoyl-CoA synthase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440216  Cd Length: 281  Bit Score: 80.25  E-value: 2.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  10 VQRLrglmseIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:COG0447  109 VQRL------IRFMPKPVIAMVAGWAIGGGHVLHVVCDLTIASENARFGQTGPDVGSFDAGYGSAYLARQVGQKKAREIW 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  90 FTGRRLNGVQAHELGLVNHAV--AQNEEgdaayhRALALAQEILPQAPIAVRLGKVAIDrgMEVDiasGMA--------I 159
Cdd:COG0447  183 FLCRQYSAQEALEMGLVNKVVphAELEE------EAVEWAREILEKSPTAIRMLKAAFN--ADDD---GLAgqqefageA 251

                        170       180
                 ....*....|....*....|....*....
gi 564351983 160 EHMCYAqnipTQDRLEGMAAFREKRPPKF 188
Cdd:COG0447  252 TRLAYM----TDEAQEGRDAFLEKRKPDF 276
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 9-191 3.49e-18

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 79.30  E-value: 3.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   9 FVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKEL 88
Cdd:PRK07854  71 FPDALIEMLHAIDAAPVPVIAAINGPAIGAGLQLAMACDLRVVAPEAYFQFPVAKYGIALDNWTIRRLSSLVGGGRARAM 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  89 IFTGRRLNGVQAHELGLVnhavaqNEEGDAAyhRALALAQEILPQAPIAVRLGKVAI--DRGMEVDIASGMAIEHMCYAq 166
Cdd:PRK07854 151 LLGAEKLTAEQALATGMA------NRIGTLA--DAQAWAAEIAGLAPLALQHAKRVLndDGAIEEAWPAHKELFDKAWA- 221

                        170       180
                 ....*....|....*....|....*
gi 564351983 167 nipTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK07854 222 ---SQDAIEAQVARIEKRPPKFQGA 243
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
 10-188 4.27e-18

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 79.55  E-value: 4.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  10 VQRLrglmseIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:PRK07396  99 LQRL------IRTCPKPVIAMVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGYGASYLARIVGQKKAREIW 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  90 FTGRRLNGVQAHELGLVNHAV--AQNEEgdaayhRALALAQEILPQAPIAVRLGKVAIDrgMEVDIASGMA-----IEHM 162
Cdd:PRK07396 173 FLCRQYDAQEALDMGLVNTVVplADLEK------ETVRWCREMLQNSPMALRCLKAALN--ADCDGQAGLQelagnATML 244

                        170       180
                 ....*....|....*....|....*.
gi 564351983 163 CYAqnipTQDRLEGMAAFREKRPPKF 188
Cdd:PRK07396 245 FYM----TEEAQEGRNAFNEKRQPDF 266
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 11-191 2.17e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 74.68  E-value: 2.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  11 QRLRGLMSEIA----AFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAK 86
Cdd:PRK07659  81 DGVMNTISEIVvtlyTMPKLTISAIHGPAAGLGLSIALTADYVIADISAKLAMNFIGIGLIPDGGGHFFLQKRVGENKAK 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  87 ELIFTGRRLNGVQAHELGLVNhAVAQNEEGDAAYHRALALAQEILpQAPIAVRLGKVAIDRGmevDIASGMAIEHMCYAQ 166
Cdd:PRK07659 161 QIIWEGKKLSATEALDLGLID-EVIGGDFQTAAKQKISEWLQKPL-KAMIETKQIYCELNRS---QLEQVLQLEKRAQYA 235

                        170       180
                 ....*....|....*....|....*
gi 564351983 167 NIPTQDRLEGMAAFREKRPPKFVGK 191
Cdd:PRK07659 236 MRQTADHKEGIRAFLEKRLPVFKGE 260
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
14-188 3.15e-16

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 74.29  E-value: 3.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  14 RGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGR 93
Cdd:PRK07327  96 RDLVYNVINCDKPIVSAIHGPAVGAGLVAALLADISIAAKDARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYYLLLCE 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  94 RLNGVQAHELGLVNHAVaqneEGDAAYHRALALAQEILPQAPIAVRLGKVAID---RGMEVDIASGMAIEHMCYAqnipT 170
Cdd:PRK07327 176 PVSGEEAERIGLVSLAV----DDDELLPKALEVAERLAAGSQTAIRWTKYALNnwlRMAGPTFDTSLALEFMGFS----G 247

                        170
                 ....*....|....*...
gi 564351983 171 QDRLEGMAAFREKRPPKF 188
Cdd:PRK07327 248 PDVREGLASLREKRAPDF 265
PRK08321 PRK08321
1,4-dihydroxy-2-naphthoyl-CoA synthase;
10-188 9.44e-16

1,4-dihydroxy-2-naphthoyl-CoA synthase;


Pssm-ID: 181386  Cd Length: 302  Bit Score: 73.52  E-value: 9.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  10 VQRLrglmseIAAFPAPTIAAMDGFALGGGLELALACDLRIAASS-AVMGLIETTRGLLPGAGGTQRLPRCLGVALAKEL 88
Cdd:PRK08321 127 VQRL------IRFMPKVVIAVVPGWAAGGGHSLHVVCDLTLASREhARFKQTDADVGSFDGGYGSAYLARQVGQKFAREI 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  89 IFTGRRLNGVQAHELGLVNHAVAQNEEGDAayhrALALAQEILPQAPIAVRLGKVA---IDRGM-EVDIASGMAIEhMCY 164
Cdd:PRK08321 201 FFLGRTYSAEEAHDMGAVNAVVPHAELETE----ALEWAREINGKSPTAMRMLKYAfnlTDDGLvGQQLFAGEATR-LAY 275

                        170       180
                 ....*....|....*....|....
gi 564351983 165 AqnipTQDRLEGMAAFREKRPPKF 188
Cdd:PRK08321 276 M----TDEAQEGRDAFLEKRDPDW 295
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
24-191 1.66e-15

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 72.40  E-value: 1.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  24 PAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRcLGVALAKELIFTGRRLNGVQAHEL 103
Cdd:PRK07468 100 PKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIPATISPYVVAR-MGEANARRVFMSARLFDAEEAVRL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 104 GLVNHAVAQnEEGDAAYHRALAlaqEILPQAPIAV-RLGKVAIDRGMEVDIAS-GMAIEHMcyAQNIPTQDRLEGMAAFR 181
Cdd:PRK07468 179 GLLSRVVPA-ERLDAAVEAEVT---PYLSCAPGAVaAAKALVRALGAPIDEAViDATIEAL--ADTWETEEAREGIAAFF 252

                        170
                 ....*....|
gi 564351983 182 EKRPPKFVGK 191
Cdd:PRK07468 253 DKRAPAWRGG 262
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 16-147 1.90e-15

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 72.89  E-value: 1.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRC---LGVALAkeliFTG 92
Cdd:pfam16113  80 LNYLIATYPKPYVALMDGIVMGGGVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLpgeLGLYLA----LTG 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564351983   93 RRLNGVQAHELGLVNHAV-------------AQNEEGDAAYHRALALAQEILPQAPIAVRLGKVAIDR 147
Cdd:pfam16113 156 ARLNGADALAAGLATHYVpsarlpaleealaALDWSDPADVDAVLAEFAEESDPPPSPLAAHREAIDR 223
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 26-189 2.51e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 71.79  E-value: 2.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  26 PTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGA-GGTQRLPRCLGVALAKELIFTGRRLNGVQAHELG 104
Cdd:PRK05864 111 PVIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTASElGLSYLLPRAIGSSRAFEIMLTGRDVDAEEAERIG 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 105 LVNHAVAQNEEGDAAYhralALAQEILPQAPIAVRLGKVAIDRGMevDIASGMAieHMcYAQNIP-------TQDRLEGM 177
Cdd:PRK05864 191 LVSRQVPDEQLLDTCY----AIAARMAGFSRPGIELTKRTLWSGL--DAASLEA--HM-QAEGLGqlfvrllTANFEEAV 261

                        170
                 ....*....|..
gi 564351983 178 AAFREKRPPKFV 189
Cdd:PRK05864 262 AARAEKRPPVFT 273
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 16-128 5.36e-15

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 70.77  E-value: 5.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  16 LMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 95
Cdd:PRK07110  86 LYSLALNCPIPVIAAMQGHAIGGGLVLGLYADIVVLSRESVYTANFMKYGFTPGMGATAILPEKLGLALGQEMLLTARYY 165

                         90       100       110
                 ....*....|....*....|....*....|...
gi 564351983  96 NGVQAHELGLVNHAVAQNEEGDAAYHRALALAQ 128
Cdd:PRK07110 166 RGAELKKRGVPFPVLPRAEVLEKALELARSLAE 198
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
 24-119 6.88e-15

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 70.71  E-value: 6.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  24 PAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHEL 103
Cdd:PRK08788 121 GAISIALVQGDALGGGFEAALSHHTIIAERGAKMGFPEILFNLFPGMGAYSFLARRVGPKLAEELILSGKLYTAEELHDM 200

                         90
                 ....*....|....*.
gi 564351983 104 GLVnHAVAQNEEGDAA 119
Cdd:PRK08788 201 GLV-DVLVEDGQGEAA 215
PLN02921 PLN02921
naphthoate synthase
 12-188 9.22e-15

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 70.97  E-value: 9.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  12 RLR--GLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 89
Cdd:PLN02921 147 RLNvlDLQIQIRRLPKPVIAMVAGYAVGGGHILHMVCDLTIAADNAVFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMW 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  90 FTGRRLNGVQAHELGLVNHAV--AQNEEGDAAYHRalalaqEILPQAPIAVRLGKVAIDRGMevDIASGmaIEHMcyAQN 167
Cdd:PLN02921 227 FLARFYTASEALKMGLVNTVVplDELEGETVKWCR------EILRNSPTAIRVLKSALNAAD--DGHAG--LQEL--GGN 294

                        170       180
                 ....*....|....*....|....*.
gi 564351983 168 IP-----TQDRLEGMAAFREKRPPKF 188
Cdd:PLN02921 295 ATllfygSEEGNEGRTAYLEGRAPDF 320
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
24-145 3.65e-14

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 68.46  E-value: 3.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  24 PAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLprcLGVALAKELIFTGRRLNGVQAHEL 103
Cdd:PRK07938  94 AVPVIAAVHGFCLGGGIGLVGNADVIVASDDATFGLPEVDRGALGAATHLQRL---VPQHLMRALFFTAATITAAELHHF 170

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564351983 104 GLVnHAVAQNEEGDAAyhrALALAQEILPQAPIAVRLGKVAI 145
Cdd:PRK07938 171 GSV-EEVVPRDQLDEA---ALEVARKIAAKDTRVIRAAKEAL 208
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 28-190 4.41e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 68.27  E-value: 4.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  28 IAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRcLGVALAKELIFTGRRLNGVQAHELGLVn 107
Cdd:PRK06072  93 ISAINGVTAGACIGIALSTDFKFASRDVKFVTAFQRLGLASDTGVAYFLLK-LTGQRFYEILVLGGEFTAEEAERWGLL- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 108 havaqnEEGDAAYHRALALAQEILPQAPIAVRLGKVAIDRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAAFREKRPPK 187
Cdd:PRK06072 171 ------KISEDPLSDAEEMANRISNGPFQSYIAAKRMINLVLYNDLEEFLEYESAIQGYLGKTEDFKEGISSFKEKREPK 244


                 ...
gi 564351983 188 FVG 190
Cdd:PRK06072 245 FKG 247
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 20-106 5.68e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 62.44  E-value: 5.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  20 IAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQ 99
Cdd:PRK05870  91 VASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKALFDARFQKLGLHPGGGATWMLQRAVGPQVARAALLFGMRFDAEA 170


                 ....*..
gi 564351983 100 AHELGLV 106
Cdd:PRK05870 171 AVRHGLA 177
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 11-186 2.46e-11

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 60.59  E-value: 2.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  11 QRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgAGGTQRLPRCLGVALAKELIF 90
Cdd:PRK05674  88 RELAELMYNLYRLKIPTLAVVQGAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAP-AVISPFVVKAIGERAARRYAL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  91 TGRRLNGVQAHELGLVNHAVAQNEegdaAYHRALALAQEILPQAPIAVRLGKvaiDRGMEVDiASGMAIEHMCYAQNIPT 170
Cdd:PRK05674 167 TAERFDGRRARELGLLAESYPAAE----LEAQVEAWIANLLLNSPQALRASK---DLLREVG-DGELSPALRRYCENAIA 238

                        170       180
                 ....*....|....*....|.
gi 564351983 171 QDRL-----EGMAAFREKRPP 186
Cdd:PRK05674 239 RIRVsaegqEGLRAFLEKRTP 259
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
14-130 2.50e-11

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 60.83  E-value: 2.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  14 RGLMSEIAAfPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIET-TRGLLPGAGGTQRlprcLGVALAKELIFTG 92
Cdd:PRK08272 118 RGFMSLWHA-HKPTVAKVHGYCVAGGTDIALHCDQVIAADDAKIGYPPTrVWGVPATGMWAYR----LGPQRAKRLLFTG 192

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564351983  93 RRLNGVQAHELGLVNHAVAQnEEGDAayhRALALAQEI 130
Cdd:PRK08272 193 DCITGAQAAEWGLAVEAVPP-EELDE---RTERLVERI 226
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 20-114 8.29e-11

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 59.83  E-value: 8.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  20 IAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKELIFTGRRLNGVQ 99
Cdd:PRK05617  96 IARYPKPYIALMDGIVMGGGVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRAPG-ALGTYLALTGARISAAD 174

                         90
                 ....*....|....*
gi 564351983 100 AHELGLVNHAVAQNE 114
Cdd:PRK05617 175 ALYAGLADHFVPSAD 189
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
12-190 1.23e-09

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 55.84  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  12 RLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIfT 91
Cdd:PRK07827  89 EMTALLRAIVELPKPVIAAIDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGVAPAIISLTLLPRLSPRAAARYYL-T 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  92 GRRLNGVQAHELGLVNHAVAQNEEGDAAYHRALALAQeilPQAPIAV-RLGKVAIDRGMEVDiASGMAIEHmcyAQNIPT 170
Cdd:PRK07827 168 GEKFGAAEAARIGLVTAAADDVDAAVAALLADLRRGS---PQGLAESkALTTAAVLAGFDRD-AEELTEES---ARLFVS 240

                        170       180
                 ....*....|....*....|
gi 564351983 171 QDRLEGMAAFREKRPPKFVG 190
Cdd:PRK07827 241 DEAREGMTAFLQKRPPRWAL 260
PLN02851 PLN02851
3-hydroxyisobutyryl-CoA hydrolase-like protein
 5-108 1.45e-09

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178443 [Multi-domain]  Cd Length: 407  Bit Score: 56.14  E-value: 1.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   5 EVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGT---QRLPRCLG 81
Cdd:PLN02851 119 ECKLFFENLYKFVYLQGTYLKPNVAIMDGITMGCGAGISIPGMFRVVTDKTVFAHPEVQMGFHPDAGASyylSRLPGYLG 198

                         90       100
                 ....*....|....*....|....*..
gi 564351983  82 VALAkeliFTGRRLNGVQAHELGLVNH 108
Cdd:PLN02851 199 EYLA----LTGQKLNGVEMIACGLATH 221
PRK12478 PRK12478
crotonase/enoyl-CoA hydratase family protein;
24-110 1.24e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 183548  Cd Length: 298  Bit Score: 53.42  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  24 PAPTIAAMDGFALGGGLELALACDLRIAASSAVMGlieTTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQAHEL 103
Cdd:PRK12478 112 SKPVIAQVHGWCVGGASDYALCADIVIASDDAVIG---TPYSRMWGAYLTGMWLYRLSLAKVKWHSLTGRPLTGVQAAEA 188


                 ....*..
gi 564351983 104 GLVNHAV 110
Cdd:PRK12478 189 ELINEAV 195
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
20-180 1.69e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 52.49  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  20 IAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGVQ 99
Cdd:PRK06023  93 LAEAEKPIVSGVDGLAIGIGTTIHLHCDLTFASPRSLFRTPFVDLALVPEAGSSLLAPRLMGHQRAFALLALGEGFSAEA 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983 100 AHELGLVNHAVAQneegDAAYHRALALAQEILPQAPIAVRLGKVAIdRGMEVDIASGMAIEHMCYAQNIPTQDRLEGMAA 179
Cdd:PRK06023 173 AQEAGLIWKIVDE----EAVEAETLKAAEELAAKPPQALQIARDLM-RGPREDILARIDEEAKHFAARLKSAEARAAFEA 247


                 .
gi 564351983 180 F 180
Cdd:PRK06023 248 F 248
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 8-139 1.53e-07

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 49.88  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   8 TFVQRLrgLMSEIAafpapTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGL-LPGAGGTQRLPRCLGVALAK 86
Cdd:PLN03214  98 TFLVRL--LRSRLA-----TVCAIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGIpVPKFWARLFMGRVIDRKVAE 170

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564351983  87 ELIFTGRRLNGVQAHELGLVNHAVaqneeGDAAYHRALALAQEILPQAPIAVR 139
Cdd:PLN03214 171 SLLLRGRLVRPAEAKQLGLIDEVV-----PAAALMEAAASAMERALKLPSAAR 218
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 19-106 1.11e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 47.43  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  19 EIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLNGV 98
Cdd:PRK07260  93 AIKQLPKPVIMCVDGAVAGAAANMAVAADFCIASTKTKFIQAFVGVGLAPDAGGLFLLTRAIGLNRATHLAMTGEALTAE 172


                 ....*...
gi 564351983  99 QAHELGLV 106
Cdd:PRK07260 173 KALEYGFV 180
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 20-110 3.15e-06

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 46.25  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  20 IAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVaLAKELIFTGRRLNGVQ 99
Cdd:PLN02988 101 MATYSKAQVSILNGIVMGGGAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGF-FGEYVGLTGARLDGAE 179

                         90
                 ....*....|.
gi 564351983 100 AHELGLVNHAV 110
Cdd:PLN02988 180 MLACGLATHFV 190
PLN02157 PLN02157
3-hydroxyisobutyryl-CoA hydrolase-like protein
 9-114 4.52e-06

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 177817 [Multi-domain]  Cd Length: 401  Bit Score: 45.83  E-value: 4.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   9 FVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKEL 88
Cdd:PLN02157 118 FFSSLYSFIYLLGTYLKPHVAILNGVTMGGGTGVSIPGTFRVATDRTIFATPETIIGFHPDAGASFNLSHLPG-RLGEYL 196

                         90       100
                 ....*....|....*....|....*.
gi 564351983  89 IFTGRRLNGVQAHELGLVNHAVAQNE 114
Cdd:PLN02157 197 GLTGLKLSGAEMLACGLATHYIRSEE 222
PRK07112 PRK07112
enoyl-CoA hydratase/isomerase;
13-114 2.53e-05

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235938  Cd Length: 255  Bit Score: 43.52  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  13 LRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPgAGGTQRLPRCLGVALAKELIFTG 92
Cdd:PRK07112  85 LYDLWHRLATGPYVTIAHVRGKVNAGGIGFVAASDIVIADETAPFSLSELLFGLIP-ACVLPFLIRRIGTQKAHYMTLMT 163

                         90       100
                 ....*....|....*....|..
gi 564351983  93 RRLNGVQAHELGLVNHAVAQNE 114
Cdd:PRK07112 164 QPVTAQQAFSWGLVDAYGANSD 185
PLN02267 PLN02267
enoyl-CoA hydratase/isomerase family protein
 2-131 2.13e-04

enoyl-CoA hydratase/isomerase family protein


Pssm-ID: 215151  Cd Length: 239  Bit Score: 40.47  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983   2 SAAEVGTFVQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIA-ASSAVMGLIETTRGLLPGAGGTQRLPRCL 80
Cdd:PLN02267  72 APSRLHLMVAKLRPLVADLISLPMPTIAAVTGHASAAGFILALSHDYVLMrKDRGVLYMSEVDIGLPLPDYFMALLRAKI 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564351983  81 GVALA-KELIFTGRRLNGVQAHELGLVnHAVAQNEEGDAAyhRALALAQEIL 131
Cdd:PLN02267 152 GSPAArRDVLLRAAKLTAEEAVEMGIV-DSAHDSAEETVE--AAVRLGEELA 200
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 10-110 2.15e-04

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 40.94  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564351983  10 VQRLRGLMSEIAAFPAPTIAAMDGFALGGGLELALACDLRIAASSAVMGLIETTRGLLPGAGGTQRLPRCLGvALAKELI 89
Cdd:PLN02874  91 VYRMYWLCYHIHTYKKTQVALVHGLVMGGGAGLMVPMKFRVVTEKTVFATPEASVGFHTDCGFSYILSRLPG-HLGEYLA 169

                         90       100
                 ....*....|....*....|.
gi 564351983  90 FTGRRLNGVQAHELGLVNHAV 110
Cdd:PLN02874 170 LTGARLNGKEMVACGLATHFV 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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