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Conserved domains on  [gi|564354201|ref|XP_006239503|]
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arginine-glutamic acid dipeptide repeats protein isoform X5 [Rattus norvegicus]

Protein Classification

SANT_MTA3_like and Atrophin-1 domain-containing protein( domain architecture ID 12020273)

protein containing domains ELM2, SANT_MTA3_like, ZnF_GATA, and Atrophin-1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 300-1299 0e+00

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 1149.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   300 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNT 379
Cdd:pfam03154    1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   380 KRQREKVASDTEDTDRATSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 459
Cdd:pfam03154   81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   460 SAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPaaHTLIQQTPTLH 539
Cdd:pfam03154  161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   540 PPRLPSPHPPLQPMT--APPSQNSAQPHPQPSLHGQGPPGPHSLQTGP-LLQHPGPPQPFGLTPQSSQGQGPLGPSPAAA 616
Cdd:pfam03154  239 PQRLPSPHPPLQPMTqpPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAP 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   617 HP-HSTIQLPASQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKP 695
Cdd:pfam03154  319 GQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKP 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   696 LSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASHPTTGGLHQVPSQSPFPQHPFVPGGPPPITPP 775
Cdd:pfam03154  399 LSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPP 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   776 SCPPTSTPPAGPSSSSQPPcsAAVSSGGNVPGAPSCPLPAVQIKEEALDEAEEPESPPPPPRSPSPEPTVVDTPSHASQS 855
Cdd:pfam03154  479 SGPPTSTSSAMPGIQPPSS--ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHASQS 556

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   856 ARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAqKAS 935
Cdd:pfam03154  557 ARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAERAA-KAS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   936 SSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHM 1015
Cdd:pfam03154  636 SSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPLLAYHM 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1016 PGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHPFASFHP 1095
Cdd:pfam03154  716 PGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPFASFHP 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1096 GLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSA 1175
Cdd:pfam03154  796 GLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSG 875

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1176 GPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFaepvlrlaGTPYPRDLPGAIPPPMSAAHQLQAMH 1255
Cdd:pfam03154  876 GPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVF--------GTPYPRDLPGGLPPPMSAAHQLQAMH 947

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 564354201  1256 AQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1299
Cdd:pfam03154  948 AQSAELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 127-172 3.60e-23

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


:

Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 93.45  E-value: 3.60e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564354201  127 CWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKK 172
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
235-284 2.25e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


:

Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 71.30  E-value: 2.25e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 564354201    235 KGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL-PPIEKPVDPP 284
Cdd:smart00401    2 SGRSCSNCGTTETPLWRRGPSGNKTLCNACGLYYKKHGGLkRPLSLKKDGI 52
BAH super family cl02608
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). ...
 9-39 4.02e-13

BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions.


The actual alignment was detected with superfamily member cd04709:

Pssm-ID: 470629  Cd Length: 164  Bit Score: 68.57  E-value: 4.02e-13
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564354201    9 RRLNSTQGEIRVGPSHQAKLPDLQPFPSPDG 39
Cdd:cd04709   134 KTLLADQGEIRVGPSYQAKLPDLQPFPSPDG 164
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 18-68 1.15e-12

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


:

Pssm-ID: 460214  Cd Length: 53  Bit Score: 63.79  E-value: 1.15e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564354201    18 IRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMP--GVSDCDLLMYLRAARS 68
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPnhNLPDRKLDEYLVVARS 53
 
Name Accession Description Interval E-value
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 300-1299 0e+00

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 1149.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   300 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNT 379
Cdd:pfam03154    1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   380 KRQREKVASDTEDTDRATSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 459
Cdd:pfam03154   81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   460 SAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPaaHTLIQQTPTLH 539
Cdd:pfam03154  161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   540 PPRLPSPHPPLQPMT--APPSQNSAQPHPQPSLHGQGPPGPHSLQTGP-LLQHPGPPQPFGLTPQSSQGQGPLGPSPAAA 616
Cdd:pfam03154  239 PQRLPSPHPPLQPMTqpPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAP 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   617 HP-HSTIQLPASQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKP 695
Cdd:pfam03154  319 GQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKP 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   696 LSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASHPTTGGLHQVPSQSPFPQHPFVPGGPPPITPP 775
Cdd:pfam03154  399 LSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPP 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   776 SCPPTSTPPAGPSSSSQPPcsAAVSSGGNVPGAPSCPLPAVQIKEEALDEAEEPESPPPPPRSPSPEPTVVDTPSHASQS 855
Cdd:pfam03154  479 SGPPTSTSSAMPGIQPPSS--ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHASQS 556

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   856 ARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAqKAS 935
Cdd:pfam03154  557 ARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAERAA-KAS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   936 SSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHM 1015
Cdd:pfam03154  636 SSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPLLAYHM 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1016 PGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHPFASFHP 1095
Cdd:pfam03154  716 PGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPFASFHP 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1096 GLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSA 1175
Cdd:pfam03154  796 GLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSG 875

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1176 GPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFaepvlrlaGTPYPRDLPGAIPPPMSAAHQLQAMH 1255
Cdd:pfam03154  876 GPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVF--------GTPYPRDLPGGLPPPMSAAHQLQAMH 947

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 564354201  1256 AQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1299
Cdd:pfam03154  948 AQSAELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 127-172 3.60e-23

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 93.45  E-value: 3.60e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564354201  127 CWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKK 172
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
235-284 2.25e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 71.30  E-value: 2.25e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 564354201    235 KGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL-PPIEKPVDPP 284
Cdd:smart00401    2 SGRSCSNCGTTETPLWRRGPSGNKTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 238-292 2.72e-15

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 71.25  E-value: 2.72e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 564354201  238 ACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPvDPPPFMFKPVK 292
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPSGGSTLCNACGLYWKKHGVMRPLSKR-KKDQIKRRNRK 54
BAH_MTA cd04709
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The ...
 9-39 4.02e-13

BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240060  Cd Length: 164  Bit Score: 68.57  E-value: 4.02e-13
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564354201    9 RRLNSTQGEIRVGPSHQAKLPDLQPFPSPDG 39
Cdd:cd04709   134 KTLLADQGEIRVGPSYQAKLPDLQPFPSPDG 164
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 18-68 1.15e-12

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 63.79  E-value: 1.15e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564354201    18 IRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMP--GVSDCDLLMYLRAARS 68
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPnhNLPDRKLDEYLVVARS 53
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 239-274 1.04e-11

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.41  E-value: 1.04e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564354201   239 CRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL 274
Cdd:pfam00320    1 CSNCGTTKTPLWRRGPNGNRTLCNACGLYYKKKGLK 36
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 277-461 3.44e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 3.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  277 IEKPVDPP----PFMFKPVKEEDDGL----SGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSA 348
Cdd:NF033609  539 IDKPVVPEqpdePGEIEPIPEDSDSDpgsdSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDS 618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  349 ASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE-DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVN 426
Cdd:NF033609  619 ASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDS 698

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 564354201  427 DEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  699 DSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 732
PHA03247 PHA03247
large tegument protein UL36; Provisional
 272-761 3.74e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  272 GELPPIEKPVDPPPFMFKPVKEeddglsgkhSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNE--DVRSSGRNSPSAA 349
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVPP---------PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPP 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  350 STSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTEDTDRATSKKTKTqeiSRPNSPSEGEGESSDSRSVNDEG 429
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA---AQASSPPQRPRRRAARPTVGSLT 2696

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  430 SS-----DPKDIDQDNRSTSPSIPSPqdnesdsdsSAQQQMLQTQPPALQAPSGAASAPSTAPPGTtqlPTPGPTPSATT 504
Cdd:PHA03247 2697 SLadpppPPPTPEPAPHALVSATPLP---------PGPAAARQASPALPAAPAPPAVPAGPATPGG---PARPARPPTTA 2764

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  505 VPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPslhgqgPPGPHSLQTG 584
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL------PPPTSAQPTA 2838

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  585 PllqhPGPPQPFGLTPQSSQGQGPLGPSPAAAHPHSTIQLPASQSalqpqqppreqplppaplampHIKPPPTTPIPQLP 664
Cdd:PHA03247 2839 P----PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPA---------------------RPPVRRLARPAVSR 2893

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  665 APQAHKHPPHLSGPSPfsmnanlppppalkPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASH 744
Cdd:PHA03247 2894 STESFALPPDQPERPP--------------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                         490
                  ....*....|....*..
gi 564354201  745 PTTGGLHQVPSQSPFPQ 761
Cdd:PHA03247 2960 PQPWLGALVPGRVAVPR 2976
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-461 2.68e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  618 SASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 697

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564354201  392 -DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  698 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 768
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
128-173 3.23e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.60  E-value: 3.23e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 564354201    128 WTEDEVKRFVKGLRQYG-KNFFRIRKElLPNKETGELITFYYYWKKT 173
Cdd:smart00717    4 WTEEEDELLIELVKKYGkNNWEKIAKE-LPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 128-171 8.62e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.95  E-value: 8.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564354201   128 WTEDEVKRFVKGLRQYGKNFFRIrKELLPNKETGELITFYYYWK 171
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-511 4.03e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.90  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  684 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 763

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  392 -DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSpsipspqDNESDSDSSAQQQMLQTQ 469
Cdd:NF033609  764 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDS-------DSDSDSDSDSDSDSDSDS 836

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 564354201  470 PPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSP 511
Cdd:NF033609  837 DSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSP 878
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-517 6.05e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.13  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTe 391
Cdd:NF033609  690 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS- 768

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  392 DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPS-IPSPQDNESDSDSSAQQQMLQTQ 469
Cdd:NF033609  769 DSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDS 848

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 564354201  470 PPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPP 517
Cdd:NF033609  849 DSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEP 896
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-461 8.21e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.74  E-value: 8.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564354201  392 -----DTDRATSKKTKTQEISRPNSPSEGEGES---SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  710 sdsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 786
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-461 1.01e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.74  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  648 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564354201  392 -----DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  728 sdsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 802
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 376-525 1.54e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 42.57  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   376 LKNTKRQREKVASDTEDTDRATSKKTKtQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDN---------RSTSPS 446
Cdd:TIGR00601    5 FKTLQQQKFKIDMEPDETVKELKEKIE-AEQGKDAYPVAQQKLIYSGKILSDDKTVKEYKIKEKDfvvvmvskpKTGTGK 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564354201   447 IPSPqdnESDSDSSAQqqmlqtqpPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVA 525
Cdd:TIGR00601   84 VAPP---AATPTSAPT--------PTPSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGSDAASTLV 151
COG5644 COG5644
U3 small nucleolar RNA-associated protein 14 [Function unknown];
375-480 5.82e-03

U3 small nucleolar RNA-associated protein 14 [Function unknown];


Pssm-ID: 227931 [Multi-domain]  Cd Length: 869  Bit Score: 41.23  E-value: 5.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  375 PLKNTKRQREKVASDTEDTDRATSKKTKTQeiSRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSP--SIPSPQD 452
Cdd:COG5644   126 DLDTLLDNDQPEKNESGNNDHATDKENLLE--SDASSSNDSESEESDSESEIESSDSDHDDENSDSKLDNLrnYIVSLKK 203

                          90       100       110
                  ....*....|....*....|....*....|....
gi 564354201  453 NESDS------DSSAQQQMLQTQPPALQAPSGAA 480
Cdd:COG5644   204 DEADAesvlssDDNDSIEEIKYDPHETNKESGSS 237
 
Name Accession Description Interval E-value
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 300-1299 0e+00

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 1149.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   300 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNT 379
Cdd:pfam03154    1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   380 KRQREKVASDTEDTDRATSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 459
Cdd:pfam03154   81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   460 SAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPaaHTLIQQTPTLH 539
Cdd:pfam03154  161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   540 PPRLPSPHPPLQPMT--APPSQNSAQPHPQPSLHGQGPPGPHSLQTGP-LLQHPGPPQPFGLTPQSSQGQGPLGPSPAAA 616
Cdd:pfam03154  239 PQRLPSPHPPLQPMTqpPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAP 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   617 HP-HSTIQLPASQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKP 695
Cdd:pfam03154  319 GQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKP 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   696 LSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASHPTTGGLHQVPSQSPFPQHPFVPGGPPPITPP 775
Cdd:pfam03154  399 LSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPP 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   776 SCPPTSTPPAGPSSSSQPPcsAAVSSGGNVPGAPSCPLPAVQIKEEALDEAEEPESPPPPPRSPSPEPTVVDTPSHASQS 855
Cdd:pfam03154  479 SGPPTSTSSAMPGIQPPSS--ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHASQS 556

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   856 ARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAqKAS 935
Cdd:pfam03154  557 ARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAERAA-KAS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   936 SSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHM 1015
Cdd:pfam03154  636 SSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPLLAYHM 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1016 PGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHPFASFHP 1095
Cdd:pfam03154  716 PGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPFASFHP 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1096 GLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSA 1175
Cdd:pfam03154  796 GLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSG 875

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  1176 GPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFaepvlrlaGTPYPRDLPGAIPPPMSAAHQLQAMH 1255
Cdd:pfam03154  876 GPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVF--------GTPYPRDLPGGLPPPMSAAHQLQAMH 947

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 564354201  1256 AQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1299
Cdd:pfam03154  948 AQSAELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 127-172 3.60e-23

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 93.45  E-value: 3.60e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564354201  127 CWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKK 172
Cdd:cd11661     1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
235-284 2.25e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 71.30  E-value: 2.25e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 564354201    235 KGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL-PPIEKPVDPP 284
Cdd:smart00401    2 SGRSCSNCGTTETPLWRRGPSGNKTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 238-292 2.72e-15

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 71.25  E-value: 2.72e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 564354201  238 ACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPvDPPPFMFKPVK 292
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPSGGSTLCNACGLYWKKHGVMRPLSKR-KKDQIKRRNRK 54
BAH_MTA cd04709
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The ...
 9-39 4.02e-13

BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240060  Cd Length: 164  Bit Score: 68.57  E-value: 4.02e-13
                          10        20        30
                  ....*....|....*....|....*....|.
gi 564354201    9 RRLNSTQGEIRVGPSHQAKLPDLQPFPSPDG 39
Cdd:cd04709   134 KTLLADQGEIRVGPSYQAKLPDLQPFPSPDG 164
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 18-68 1.15e-12

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 63.79  E-value: 1.15e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564354201    18 IRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMP--GVSDCDLLMYLRAARS 68
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPnhNLPDRKLDEYLVVARS 53
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 239-274 1.04e-11

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.41  E-value: 1.04e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564354201   239 CRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL 274
Cdd:pfam00320    1 CSNCGTTKTPLWRRGPNGNRTLCNACGLYYKKKGLK 36
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 277-461 3.44e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 3.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  277 IEKPVDPP----PFMFKPVKEEDDGL----SGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSA 348
Cdd:NF033609  539 IDKPVVPEqpdePGEIEPIPEDSDSDpgsdSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDS 618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  349 ASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE-DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVN 426
Cdd:NF033609  619 ASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDS 698

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 564354201  427 DEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  699 DSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 732
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 464-630 4.77e-08

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 57.74  E-value: 4.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   464 QM-LQTQPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPatsQPPNQTQSTVAPAAhtlIQQTPtlhppr 542
Cdd:pfam09770  202 AMrAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQP---QQPQQHPGQGHPVT---ILQRP------ 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   543 lpsphpplQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSLQtgpLLQHP---------------GPPQPFGLTPQSSQGQG 607
Cdd:pfam09770  270 --------QSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ---ILQNPnrlsaarvgypqnpqPGVQPAPAHQAHRQQGS 338

                          170       180
                   ....*....|....*....|...
gi 564354201   608 PLGPSPAAAHPHSTIQLPASQSA 630
Cdd:pfam09770  339 FGRQAPIITHPQQLAQLSEEEKA 361
PHA03247 PHA03247
large tegument protein UL36; Provisional
 272-761 3.74e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  272 GELPPIEKPVDPPPFMFKPVKEeddglsgkhSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNE--DVRSSGRNSPSAA 349
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVPP---------PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPP 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  350 STSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTEDTDRATSKKTKTqeiSRPNSPSEGEGESSDSRSVNDEG 429
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA---AQASSPPQRPRRRAARPTVGSLT 2696

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  430 SS-----DPKDIDQDNRSTSPSIPSPqdnesdsdsSAQQQMLQTQPPALQAPSGAASAPSTAPPGTtqlPTPGPTPSATT 504
Cdd:PHA03247 2697 SLadpppPPPTPEPAPHALVSATPLP---------PGPAAARQASPALPAAPAPPAVPAGPATPGG---PARPARPPTTA 2764

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  505 VPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPslhgqgPPGPHSLQTG 584
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL------PPPTSAQPTA 2838

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  585 PllqhPGPPQPFGLTPQSSQGQGPLGPSPAAAHPHSTIQLPASQSalqpqqppreqplppaplampHIKPPPTTPIPQLP 664
Cdd:PHA03247 2839 P----PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPA---------------------RPPVRRLARPAVSR 2893

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  665 APQAHKHPPHLSGPSPfsmnanlppppalkPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASH 744
Cdd:PHA03247 2894 STESFALPPDQPERPP--------------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                         490
                  ....*....|....*..
gi 564354201  745 PTTGGLHQVPSQSPFPQ 761
Cdd:PHA03247 2960 PQPWLGALVPGRVAVPR 2976
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 433-679 1.10e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.12  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   433 PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQT------QP---PALQAPSGAASAPSTAPPGTTQLPTPGPTPSAT 503
Cdd:pfam09770  107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTgyekykEPepiPDLQVDASLWGVAPKKAAAPAPAPQPAAQPASL 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   504 TVPP---------------QGSPATSQPPNQTQSTvaPAAHTLIQQTPtlhpprlpspHPPLQPMTAPPSQNSAQPHPQP 568
Cdd:pfam09770  187 PAPSrkmmsleeveaamraQAKKPAQQPAPAPAQP--PAAPPAQQAQQ----------QQQFPPQIQQQQQPQQQPQQPQ 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   569 SLHGQGPPgPHSLQtGPLLQHPGPPQPFGLTPQSSQGQGPlgpSPAAAHPHSTIQLPASQSAlqpqQPPREQPLPPAPLA 648
Cdd:pfam09770  255 QHPGQGHP-VTILQ-RPQSPQPDPAQPSIQPQAQQFHQQP---PPVPVQPTQILQNPNRLSA----ARVGYPQNPQPGVQ 325

                          250       260       270
                   ....*....|....*....|....*....|.
gi 564354201   649 MPHIKPPPTTPIPQLPAPQAHKHPPHLSGPS 679
Cdd:pfam09770  326 PAPAHQAHRQQGSFGRQAPIITHPQQLAQLS 356
PHA03247 PHA03247
large tegument protein UL36; Provisional
 440-774 1.48e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  440 NRSTSPSIPSPQDNESDSDSSAQQQMLQTQPPALQAPSG------AASAPSTAPPGTTQLPTPGPTPS-ATTVPPQGSPA 512
Cdd:PHA03247 2565 DRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDdrgdprGPAPPSPLPPDTHAPDPPPPSPSpAANEPDPHPPP 2644

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  513 TSQPPNQTQSTVAPAAHTLIQQT-----PTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSlhgQGPPGPHSLQTGPLL 587
Cdd:PHA03247 2645 TVPPPERPRDDPAPGRVSRPRRArrlgrAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP---TPEPAPHALVSATPL 2721

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  588 QhPGPPQPFGLTPQSSQGQGPLGPSPAAAHPHSTIQL---PASQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLP 664
Cdd:PHA03247 2722 P-PGPAAARQASPALPAAPAPPAVPAGPATPGGPARParpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  665 APQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASH 744
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPAR 2880

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 564354201  745 PTTGGLHQ---VPSQSPFPQHPFVPGGP---PPITP 774
Cdd:PHA03247 2881 PPVRRLARpavSRSTESFALPPDQPERPpqpQAPPP 2916
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-461 2.68e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  618 SASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 697

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564354201  392 -DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  698 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 768
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
128-173 3.23e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.60  E-value: 3.23e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 564354201    128 WTEDEVKRFVKGLRQYG-KNFFRIRKElLPNKETGELITFYYYWKKT 173
Cdd:smart00717    4 WTEEEDELLIELVKKYGkNNWEKIAKE-LPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 128-171 3.27e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 42.18  E-value: 3.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 564354201  128 WTEDEVKRFVKGLRQYG-KNFFRIRKElLPNKETGELITFYYYWK 171
Cdd:cd00167     2 WTEEEDELLLEAVKKYGkNNWEKIAKE-LPGRTPKQCRERWRNLL 45
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 448-618 4.52e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 4.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  448 PSPQDNESDSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGttqlPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPA 527
Cdd:PRK07764  601 PAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAA----PAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  528 AHTLIQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSLH------GQGPPGPHSLQTGPLLQHPG-PPQPFGLTP 600
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQppqaaqGASAPSPAADDPVPLPPEPDdPPDPAGAPA 756

                         170
                  ....*....|....*...
gi 564354201  601 QSSQGQGPLGPSPAAAHP 618
Cdd:PRK07764  757 QPPPPPAPAPAAAPAAAP 774
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
423-535 4.77e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 47.85  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  423 RSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESdSDSSAQQQMLQTQPPALQAPSgAASAPSTAPPGTTQLPTPGPTPSA 502
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAA-AAASPSPSQSSAAAQPSAPQS-ATQPAGTPPTVSVDPPAAVPVNPP 440

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 564354201  503 TTVPPQGSPATSQPPNQ----TQSTVAPAAHTLIQQT 535
Cdd:PRK14971  441 STAPQAVRPAQFKEEKKipvsKVSSLGPSTLRPIQEK 477
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
442-519 4.88e-05

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 46.93  E-value: 4.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  442 STSPSIPSPQDNESDSDSSAQQQMLQTQPPALQaPSGAASAPSTAPPGTTQLPTPGPTPSATTVP------PQgSPATSQ 515
Cdd:PRK13042   17 TTGVITTTTQAANATTPSSTKVEAPQSTPPSTK-VEAPQSKPNATTPPSTKVEAPQQTPNATTPSstkvetPQ-SPTTKQ 94


                  ....
gi 564354201  516 PPNQ 519
Cdd:PRK13042   95 VPTE 98
PRK10856 PRK10856
cytoskeleton protein RodZ;
418-524 6.15e-05

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 46.56  E-value: 6.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  418 ESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTPG 497
Cdd:PRK10856  149 QSSAELSQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAP 228

                          90       100
                  ....*....|....*....|....*..
gi 564354201  498 PTPSATTVPPQGSPATSQPPNQTQSTV 524
Cdd:PRK10856  229 ATPDGAAPLPTDQAGVSTPAADPNALV 255
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 128-171 8.62e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.95  E-value: 8.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 564354201   128 WTEDEVKRFVKGLRQYGKNFFRIrKELLPNKETGELITFYYYWK 171
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 457-613 9.37e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 9.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  457 SDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQQTP 536
Cdd:PRK07764  599 GPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564354201  537 TlhpprlpSPHPPLQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSlqtGPLLQHPGPPQPFGLTPQSSQGQGPLGPSP 613
Cdd:PRK07764  679 A-------APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD---DPAAQPPQAAQGASAPSPAADDPVPLPPEP 745
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 379-585 1.32e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   379 TKRQREKVASDTEDTDRATSKKTKTQEISRPNSPSEGEGESSDSRSVN--DEGSSDPKDIDQDNRSTSPSiPSPQDNESD 456
Cdd:pfam05109  422 SKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVStaDVTSPTPAGTTSGASPVTPS-PSPRDNGTE 500

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   457 SdssaqqqmlqtQPPALQAPSGAASAPS---TAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQ 533
Cdd:pfam05109  501 S-----------KAPDMTSPTSAVTTPTpnaTSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNA 569

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 564354201   534 QTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSLQTGP 585
Cdd:pfam05109  570 TIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSP 621
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 469-618 1.53e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  469 QPPALQAPSGAASAPSTAPPGTTQL-------PTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHPP 541
Cdd:PRK07764  583 QVEAVVGPAPGAAGGEGPPAPASSGppeeaarPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564354201  542 RLPSPHPPLQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSLQTGPLLQHPGP-PQPFGLTPQSSQGQGPLGPSPAAAHP 618
Cdd:PRK07764  663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQaDDPAAQPPQAAQGASAPSPAADDPVP 740
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 423-528 2.25e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.65  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  423 RSVNDEGSSDPK--DIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQlPTPGPTP 500
Cdd:PRK12270   17 QYLADPNSVDPSwrEFFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA-AAAAAAA 95

                          90       100       110
                  ....*....|....*....|....*....|.
gi 564354201  501 SATTVPPQGSPATSQPPNQTQSTV---APAA 528
Cdd:PRK12270   96 PAAPPAAAAAAAPAAAAVEDEVTPlrgAAAA 126
PHA03247 PHA03247
large tegument protein UL36; Provisional
 274-789 2.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  274 LPPIEKPVDPPPFMFKPVKEEDDG---LSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNEDVRSSGRnSPSAAS 350
Cdd:PHA03247 2617 LPPDTHAPDPPPPSPSPAANEPDPhppPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR-PTVGSL 2695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  351 TSSNDSKAEAVKKSAKKVKEEAASPL---KNTKRQREKVASDTEDTDRATSKKTKTQEISRPNSPSEGEGESSDSRSVND 427
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLppgPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  428 EGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQTQPPALQAPSGAASAPSTA---PPGTTQLPTPGPTPSATT 504
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAqptAPPPPPGPPPPSLPLGGS 2855

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  505 VPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSLHGQGPPGPHslqtg 584
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ----- 2930

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  585 PLLQHPGPPQPfGLTPQSsQGQGPLGPSPAAAHPHSTIQLPASQSAlqpqqppreqplppaplamphIKPPPTTPIPQLP 664
Cdd:PHA03247 2931 PPPPPPPRPQP-PLAPTT-DPAGAGEPSGAVPQPWLGALVPGRVAV---------------------PRFRVPQPAPSRE 2987

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  665 APQAHKHPPHLSGPSPFSMNANLppppalkplsslsthhppsahpppLQLMPQSQPLPSSPAQ---PPGLTQSQSLPPPA 741
Cdd:PHA03247 2988 APASSTPPLTGHSLSRVSSWASS------------------------LALHEETDPPPVSLKQtlwPPDDTEDSDADSLF 3043

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 564354201  742 ASHPTTGGLHQVPSQSPFPQHPFvpggppPITPPSCPPTSTPPAGPSS 789
Cdd:PHA03247 3044 DSDSERSDLEALDPLPPEPHDPF------AHEPDPATPEAGARESPSS 3085
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
450-564 2.29e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.54  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  450 PQDNESDSDSSAQQQMLQ---TQPPALQAPSgAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQstvAP 526
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKpvfTQPAAAPQPS-AAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVP---VN 438

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 564354201  527 AAHTLIQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQP 564
Cdd:PRK14971  439 PPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQE 476
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 455-595 2.51e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  455 SDSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQQ 534
Cdd:PRK07764  367 ASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAG 446

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564354201  535 TPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSlhGQGPPGPHSLQTGPLLQHPGPPQP 595
Cdd:PRK07764  447 NAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPA--PAPPAAPAPAAAPAAPAAPAAPAG 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 471-601 3.04e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.09  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  471 PALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAhtliqqTPTLHPPRLPSPHPPL 550
Cdd:PRK14951  383 RPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAA------APAAVALAPAPPAQAA 456

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 564354201  551 QPMTAPPSQNSAQPHPQPslhgqgPPGPHSLQTGPLLQHPGPPQPF--GLTPQ 601
Cdd:PRK14951  457 PETVAIPVRVAPEPAVAS------AAPAPAAAPAAARLTPTEEGDVwhATVQQ 503
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 393-578 3.58e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  393 TDRATSKKTKTQEISRPnSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQTQPPA 472
Cdd:PRK07764  599 GPPAPASSGPPEEAARP-AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  473 LQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPPLQP 552
Cdd:PRK07764  678 PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQ 757

                         170       180
                  ....*....|....*....|....*.
gi 564354201  553 MTAPPSQNSAQPHPQPSLHGQGPPGP 578
Cdd:PRK07764  758 PPPPPAPAPAAAPAAAPPPSPPSEEE 783
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-511 4.03e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.90  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  684 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 763

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  392 -DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSpsipspqDNESDSDSSAQQQMLQTQ 469
Cdd:NF033609  764 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDS-------DSDSDSDSDSDSDSDSDS 836

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 564354201  470 PPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSP 511
Cdd:NF033609  837 DSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSP 878
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-517 6.05e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.13  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTe 391
Cdd:NF033609  690 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS- 768

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  392 DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPS-IPSPQDNESDSDSSAQQQMLQTQ 469
Cdd:NF033609  769 DSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDS 848

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 564354201  470 PPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPP 517
Cdd:NF033609  849 DSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEP 896
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-461 8.21e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.74  E-value: 8.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564354201  392 -----DTDRATSKKTKTQEISRPNSPSEGEGES---SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  710 sdsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 786
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 312-461 1.01e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.74  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  312 SMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSNDSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTE 391
Cdd:NF033609  648 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564354201  392 -----DTDRATSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 461
Cdd:NF033609  728 sdsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 802
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 470-641 1.22e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  470 PPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPP 549
Cdd:PRK07764  591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  550 LQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSLQTGPLLQHPGP-PQPFGLTPQSSQGQGPLGPSPAAAHPhstiqLPASQ 628
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQaDDPAAQPPQAAQGASAPSPAADDPVP-----LPPEP 745

                         170
                  ....*....|...
gi 564354201  629 SALQPQQPPREQP 641
Cdd:PRK07764  746 DDPPDPAGAPAQP 758
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
492-611 1.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.84  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  492 QLPTPGPTPSATTVPPQG-SPATSQPPNQTQSTVAPAAHTliQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSL 570
Cdd:PRK14971  361 QLTQKGDDASGGRGPKQHiKPVFTQPAAAPQPSAAAAASP--SPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVN 438

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 564354201  571 hgqgPPGPHSLQTGPllQHPGPPQPFGLTPQSSQGQGPLGP 611
Cdd:PRK14971  439 ----PPSTAPQAVRP--AQFKEEKKIPVSKVSSLGPSTLRP 473
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 376-525 1.54e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 42.57  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   376 LKNTKRQREKVASDTEDTDRATSKKTKtQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDN---------RSTSPS 446
Cdd:TIGR00601    5 FKTLQQQKFKIDMEPDETVKELKEKIE-AEQGKDAYPVAQQKLIYSGKILSDDKTVKEYKIKEKDfvvvmvskpKTGTGK 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564354201   447 IPSPqdnESDSDSSAQqqmlqtqpPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVA 525
Cdd:TIGR00601   84 VAPP---AATPTSAPT--------PTPSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGSDAASTLV 151
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 470-557 1.92e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.49  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  470 PPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATsqPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPP 549
Cdd:PRK14950  365 APQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETAT--PPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKP 442


                  ....*...
gi 564354201  550 LQPMTAPP 557
Cdd:PRK14950  443 KYTPPAPP 450
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 381-579 3.44e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  381 RQREKVASDTEDTDRATSKKTKTQEI----SRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIP-SPQDNES 455
Cdd:PTZ00449  595 KKPKRPRSAQRPTRPKSPKLPELLDIpkspKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPfDPKFKEK 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  456 --DSDSSAQQQMLQTQPPALQAPSGAASAPSTAP-----PGTTQLPTPG--PTPSATTVPPQGSPATSQPPNQTQSTVAP 526
Cdd:PTZ00449  675 fyDDYLDAAAKSKETKTTVVLDESFESILKETLPetpgtPFTTPRPLPPklPRDEEFPFEPIGDPDAEQPDDIEFFTPPE 754

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 564354201  527 AAHTLIQQTPTLHPPRLPSPHPPLQP----MTAPPSQNSAQPHpQPSLHGQGPPGPH 579
Cdd:PTZ00449  755 EERTFFHETPADTPLPDILAEEFKEEdihaETGEPDEAMKRPD-SPSEHEDKPPGDH 810
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 460-745 3.47e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 3.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   460 SAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTP-----------GPTP------SATTVPPQGSPATSQPPnqtqs 522
Cdd:pfam09770  103 NRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvrtgyekykepEPIPdlqvdaSLWGVAPKKAAAPAPAP----- 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   523 TVAPAAHTLIQQTPTLHPPrlpsphpplQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSLQTGPLLQHPGPPQPFGLTPQS 602
Cdd:pfam09770  178 QPAAQPASLPAPSRKMMSL---------EEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQ 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   603 SQGQGPlgPSPAAAHPHSTIQLPASQSAlqpqqppreqplppaplamphikPPPTTPIPQLPAPQAHKHPPHLSGPSPFS 682
Cdd:pfam09770  249 QPQQPQ--QHPGQGHPVTILQRPQSPQP-----------------------DPAQPSIQPQAQQFHQQPPPVPVQPTQIL 303

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564354201   683 MNANLPPPPALKPLSslsthhppsahppplQLMPQSQPLPSSPAQPPGltQSQSLPPPAASHP 745
Cdd:pfam09770  304 QNPNRLSAARVGYPQ---------------NPQPGVQPAPAHQAHRQQ--GSFGRQAPIITHP 349
PRK10856 PRK10856
cytoskeleton protein RodZ;
449-530 3.57e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.17  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  449 SPQDNES---DSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVA 525
Cdd:PRK10856  155 SQNSGQSvplDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGA 234


                  ....*
gi 564354201  526 PAAHT 530
Cdd:PRK10856  235 APLPT 239
PRK10856 PRK10856
cytoskeleton protein RodZ;
451-538 3.73e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.17  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  451 QDNESDSDSSAQQQMLQT--QPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQgSPATSQPPNQTQSTVAPAA 528
Cdd:PRK10856  149 QSSAELSQNSGQSVPLDTstTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNA-VVAPSQANVDTAATPAPAA 227

                          90
                  ....*....|
gi 564354201  529 HTLIQQTPTL 538
Cdd:PRK10856  228 PATPDGAAPL 237
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 490-618 4.38e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 41.25  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  490 TTQLPTPGPTPSATTvppqgsPATSQPPNQtqstvAPAAHTLIQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPS 569
Cdd:PHA03269   19 IANLNTNIPIPELHT------SAATQKPDP-----APAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPA 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564354201  570 LHGQG--PPGPHSLQTGPLLQHPGPPQPFGLTPQSSQGQGPLGPSPAAAHP 618
Cdd:PHA03269   88 PHQAAsrAPDPAVAPQLAAAPKPDAAEAFTSAAQAHEAPADAGTSAASKKP 138
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 475-625 4.53e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 41.41  E-value: 4.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201   475 APSGAASAPSTAPPGTTQLPTPGPTPSATtvPPQGSPatsqPPNQTQSTVapaahtliqQTPTLhppRLPSPHPPLQPMT 554
Cdd:pfam15324  966 EPPVAASVPGDLPTKETLLPTPVPTPQPT--PPCSPP----SPLKEPSPV---------KTPDS---SPCVSEHDFFPVK 1027

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564354201   555 APPSQNSAQPHPQPSLhgQGPPGPHSLQTGPLLQHPGPPqpfglTPQSSQGQGPLgPSPAAAHPHSTIQLP 625
Cdd:pfam15324 1028 EIPPEKGADTGPAVSL--VITPTVTPIATPPPAATPTPP-----LSENSIDKLKS-PSPELPKPWEDSDLP 1090
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 439-757 4.73e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  439 DNRSTSPSIPSPQDNESDSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGttqlPTPGPTPSATTVPPQGSPATSQPPN 518
Cdd:PHA03307   16 EGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFE----PPTGPPPGPGTEAPANESRSTPTWS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  519 QTQSTVAPAAHTLIQQTPTlhPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSlqtgpllqhpGPPQPFGL 598
Cdd:PHA03307   92 LSTLAPASPAREGSPTPPG--PSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAAS----------PPAAGASP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  599 TPQSSQGQGPLGPSPAAAHPHSTIQLPASQSAlqpqqppreqplppaplamphikpppttPIPQLPAPQAHKHPPHL--- 675
Cdd:PHA03307  160 AAVASDAASSRQAALPLSSPEETARAPSSPPA----------------------------EPPPSTPPAAASPRPPRrss 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  676 --------SGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQSLPPPAASHPTT 747
Cdd:PHA03307  212 pisasassPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP 291

                         330
                  ....*....|
gi 564354201  748 GGLHQVPSQS 757
Cdd:PHA03307  292 RERSPSPSPS 301
COG5644 COG5644
U3 small nucleolar RNA-associated protein 14 [Function unknown];
375-480 5.82e-03

U3 small nucleolar RNA-associated protein 14 [Function unknown];


Pssm-ID: 227931 [Multi-domain]  Cd Length: 869  Bit Score: 41.23  E-value: 5.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  375 PLKNTKRQREKVASDTEDTDRATSKKTKTQeiSRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSP--SIPSPQD 452
Cdd:COG5644   126 DLDTLLDNDQPEKNESGNNDHATDKENLLE--SDASSSNDSESEESDSESEIESSDSDHDDENSDSKLDNLrnYIVSLKK 203

                          90       100       110
                  ....*....|....*....|....*....|....
gi 564354201  453 NESDS------DSSAQQQMLQTQPPALQAPSGAA 480
Cdd:COG5644   204 DEADAesvlssDDNDSIEEIKYDPHETNKESGSS 237
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
467-683 6.67e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 6.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  467 QTQPPALQAPSGAASAPSTAPPgTTQLPTPGPTPSATTVPPQgSPATSQPPNQTQSTVAPAAHTLiqqtptlhPPRLPSP 546
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAP-AAAAPAPAAPPAAPAAAPA-AAAAARAVAAAPARRSPAPEAL--------AAARQAS 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  547 HPPLQPMTAPPSQNSAQPHPQPSLHGQGPPGPHSLQTGPllqhPGPPQPFGLTPQSSQGQGP---LGPSPAAAHPHSTIQ 623
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAA----PARAAPAAAPAPADDDPPPweeLPPEFASPAPAQPDA 516

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  624 LPASQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSM 683
Cdd:PRK12323  517 APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 418-527 7.24e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  418 ESSDSRSVNDEGSSDP---KDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQLP 494
Cdd:PRK10263  728 EFSPMKALLDDGPHEPlftPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP 807

                          90       100       110
                  ....*....|....*....|....*....|...
gi 564354201  495 TPGPTPSATTVPPQGSPATSQPPNQTQSTVAPA 527
Cdd:PRK10263  808 QQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ 840
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 471-631 7.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.62  E-value: 7.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  471 PALQAPSGAASAPSTAPPGTTQ-LPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHpprlpsphpp 549
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQaTAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQ---------- 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  550 lqpmtaPPSQNSAQPHPQPSLHGQGPPGPHSLQtgPLLQHPGPPQPFGLTPQSSQGQGPLGPSPAAAHPHSTIQLPASQS 629
Cdd:PRK07994  431 ------RAQGATKAKKSEPAAASRARPVNSALE--RLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKK 502


                  ..
gi 564354201  630 AL 631
Cdd:PRK07994  503 AL 504
PRK12495 PRK12495
hypothetical protein; Provisional
 404-533 7.78e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 39.47  E-value: 7.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  404 QEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQmlQTQPPALQApsgAASAP 483
Cdd:PRK12495   66 QPVTEDGAAGDDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEA--ATDPPATAA---ARDGP 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 564354201  484 STAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQ 533
Cdd:PRK12495  141 TPDPTAQPATPDERRSPRQRPPVSGEPPTPSTPDAHVAGTLQAARESLVE 190
PRK10856 PRK10856
cytoskeleton protein RodZ;
461-577 8.17e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 40.01  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  461 AQQQMLQT---QPPALQAPSGAASAPSTAPPGTTQLPTPGPTPSATTVPPQGSPATSQPPNqtqstvAPAAHTliqqtpt 537
Cdd:PRK10856  138 AQQEEITTmadQSSAELSQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAP------APAVDP------- 204

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 564354201  538 lhpprlpsphppLQPMTAPPSQNSAQPHPQPSLHGQGPPG 577
Cdd:PRK10856  205 ------------QQNAVVAPSQANVDTAATPAPAAPATPD 232
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
443-612 9.14e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  443 TSPSIPSPQDNESDSDSSAQQQMLQTQPPALQAPSGAASAPSTAPPGTTQL-PTPGPTPSATTVPPQGSP---ATSQPPN 518
Cdd:PRK12323  400 AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPaPAPAAAPAAAARPAAAGPrpvAAAAAAA 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  519 QTQSTVAPAAHTLIQQTPTLHPPRLPSPHPPLQPMTAPPSQNSAQPHPQPSlhGQGPPGPHSLQTGPLLQHPGPPQPFGL 598
Cdd:PRK12323  480 PARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPA--TADPDDAFETLAPAPAAAPAPRAAAAT 557

                         170
                  ....*....|....
gi 564354201  599 TPQSSQGQGPLGPS 612
Cdd:PRK12323  558 EPVVAPRPPRASAS 571
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
477-594 9.42e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 9.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564354201  477 SGAASAPSTAPPGTTQlPTPGPTPSATTVPPQGSPATSQPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPPLQPMTAP 556
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQ-PAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVR 448

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 564354201  557 PSQNSAQPHPQPSLHGqgppgphslQTGPLLQHPGPPQ 594
Cdd:PRK14971  449 PAQFKEEKKIPVSKVS---------SLGPSTLRPIQEK 477
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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