NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|564362234|ref|XP_006242554|]
View 

transcriptional coactivator YAP1 isoform X6 [Rattus norvegicus]

Protein Classification

transcriptional coactivator YAP1( domain architecture ID 10078884)

transcriptional coactivator YAP1 can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943|7641887
SCOP:  3001621

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 213-245 6.52e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


:

Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.84  E-value: 6.52e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564362234   213 PLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 156-185 1.01e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


:

Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.01e-10
                         10        20        30
                 ....*....|....*....|....*....|
gi 564362234 156 PAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 213-245 6.52e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.84  E-value: 6.52e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564362234   213 PLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 214-243 9.20e-11

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 56.36  E-value: 9.20e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 564362234  214 LPDGWEQAMTQDGEVYYINHKNKTTSWLDP 243
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 156-185 1.01e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.01e-10
                         10        20        30
                 ....*....|....*....|....*....|
gi 564362234 156 PAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 215-245 1.04e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.04e-10
                         10        20        30
                 ....*....|....*....|....*....|.
gi 564362234 215 PDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 154-185 1.57e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 55.68  E-value: 1.57e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564362234   154 PLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 155-184 1.85e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 1.85e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 564362234  155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDP 184
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
155-250 7.46e-07

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 51.69  E-value: 7.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362234 155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRkamlSQLNVPTSASPAVPQTLMN----SASGPLPDGWEQAMTQDGEVYY 230
Cdd:COG5021  388 KPTGWSSSIEDLGQFLFSDFLTSSSTYEDLR----REQLGRESDESFYVASNVQqqraSREGPLLSGWKTRLNNLYRFYF 463

                         90       100
                 ....*....|....*....|
gi 564362234 231 INHKNKTTSWLDPRLDPRFG 250
Cdd:COG5021  464 VEHRKKTLTKNDSRLGSFIS 483
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 213-245 6.52e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.84  E-value: 6.52e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 564362234   213 PLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 214-243 9.20e-11

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 56.36  E-value: 9.20e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 564362234  214 LPDGWEQAMTQDGEVYYINHKNKTTSWLDP 243
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 156-185 1.01e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.01e-10
                         10        20        30
                 ....*....|....*....|....*....|
gi 564362234 156 PAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 215-245 1.04e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.04e-10
                         10        20        30
                 ....*....|....*....|....*....|.
gi 564362234 215 PDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 154-185 1.57e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 55.68  E-value: 1.57e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 564362234   154 PLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 155-184 1.85e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 1.85e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 564362234  155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDP 184
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
155-250 7.46e-07

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 51.69  E-value: 7.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362234 155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRkamlSQLNVPTSASPAVPQTLMN----SASGPLPDGWEQAMTQDGEVYY 230
Cdd:COG5021  388 KPTGWSSSIEDLGQFLFSDFLTSSSTYEDLR----REQLGRESDESFYVASNVQqqraSREGPLLSGWKTRLNNLYRFYF 463

                         90       100
                 ....*....|....*....|
gi 564362234 231 INHKNKTTSWLDPRLDPRFG 250
Cdd:COG5021  464 VEHRKKTLTKNDSRLGSFIS 483
PRP40 COG5104
Splicing factor [RNA processing and modification];
159-243 1.13e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.69  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564362234 159 WEMAKTSSGQRYFLNHNDQTTTWQDPRKamlsqlnvptsaspavpqtLMNSASGPLP-DGWEQAMTQDGEVYYINHKNKT 237
Cdd:COG5104   17 WEELKAPDGRIYYYNKRTGKSSWEKPKE-------------------LLKGSEEDLDvDPWKECRTADGKVYYYNSITRE 77


                 ....*.
gi 564362234 238 TSWLDP 243
Cdd:COG5104   78 SRWKIP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH