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Conserved domains on  [gi|564364087|ref|XP_006243278|]
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transducin-like enhancer protein 3 isoform X8 [Rattus norvegicus]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10511324)

WD40 domain-containing protein similar to Drosophila melanogaster protein groucho and Homo sapiens transducin-like enhancer proteins; also contains a Groucho/TLE N-terminal Q-rich domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 18-133 7.28e-91

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 280.08  E-value: 7.28e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087   18 FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLS 97
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 564364087   98 QEHQQQVAQAVERAKQVTMTELNAIIGQ-QQLQAQHL 133
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGQqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
485-770 3.49e-43

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 3.49e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 485 HGEVVCAVTISNPTRHVYTGGK-GCVKIWDISQPGSKSPISqldclNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLAS 563
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLT-----GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 564 PTPRikAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVR 643
Cdd:COG2319  194 GKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 644 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKD 721
Cdd:COG2319  272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564364087 722 NLLNAWRTPYGASIFQSKE-SSSVLSCDISADDKYIVTGSGDKKATVYEV 770
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 251-472 1.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  251 DVSNEDPA-----TPRVSPAHSPPENGLD-KARGLKKDAPTSPASVASSSSTPSSKTKDlghNDKSSTPGLKSNTPTPRN 324
Cdd:pfam05109 472 DVTSPTPAgttsgASPVTPSPSPRDNGTEsKAPDMTSPTSAVTTPTPNATSPTPAVTTP---TPNATSPTLGKTSPTSAV 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  325 DAPTP-GTSTTPGLrSMPGKPPGMDPIGIMA--SALRTP----ISLTSSYAAPFAMMSHHEMNGSLTSP----------- 386
Cdd:pfam05109 549 TTPTPnATSPTPAV-TTPTPNATIPTLGKTSptSAVTTPtpnaTSPTVGETSPQANTTNHTLGGTSSTPvvtsppknats 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  387 SAYAGLHNIPSQMSAAAAAAAAAYGR--SPMVSFGAVGfdpHPPMRATGLPSSLASIPGGKPA-YSFHVSADGQMQPVPF 463
Cdd:pfam05109 628 AVTTGQHNITSSSTSSMSLRPSSISEtlSPSTSDNSTS---HMPLLTSAHPTGGENITQVTPAsTSTHHVSTSSPAPRPG 704


                  ....*....
gi 564364087  464 PHDALAGPG 472
Cdd:pfam05109 705 TTSQASGPG 713
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 18-133 7.28e-91

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 280.08  E-value: 7.28e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087   18 FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLS 97
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 564364087   98 QEHQQQVAQAVERAKQVTMTELNAIIGQ-QQLQAQHL 133
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGQqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
485-770 3.49e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 3.49e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 485 HGEVVCAVTISNPTRHVYTGGK-GCVKIWDISQPGSKSPISqldclNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLAS 563
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLT-----GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 564 PTPRikAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVR 643
Cdd:COG2319  194 GKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 644 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKD 721
Cdd:COG2319  272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564364087 722 NLLNAWRTPYGASIFQSKE-SSSVLSCDISADDKYIVTGSGDKKATVYEV 770
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-769 5.93e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 5.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 484 SHGEVVCAVTISNPTRHVYTGGK-GCVKIWDISqpgSKSPISQLdCLNRDNyIRSCKLLPDGRTLIVGGEASTLTIWDLa 562
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 563 sPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTV 642
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 643 RSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGK 720
Cdd:cd00200  160 KLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564364087 721 DNLLNAWRTPYGASIFQ-SKESSSVLSCDISADDKYIVTGSGDKKATVYE 769
Cdd:cd00200  240 DGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 607-646 2.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564364087   607 NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWD 646
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 506-768 2.07e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 506 KGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPtprIKAELTSSAPACYALAIS 585
Cdd:PLN00181 457 EGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRS 533

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 586 PDAKVCF---------SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISH-DGTKLWTGGLDNTVRSWDLREGRQLQQ 655
Cdd:PLN00181 534 KLSGICWnsyiksqvaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGT 613

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 656 HDFTSQIFSLGY-CPTGEWLAVGMESSNVEV--LHHTKPDKYQLHLHESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYG 732
Cdd:PLN00181 614 IKTKANICCVQFpSESGRSLAFGSADHKVYYydLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMS 692

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564364087 733 ASIFQSKESSSVLS-------CDISADDKYIVTGSGDKKATVY 768
Cdd:PLN00181 693 ISGINETPLHSFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
609-646 3.97e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 3.97e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564364087  609 TLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWD 646
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 251-472 1.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  251 DVSNEDPA-----TPRVSPAHSPPENGLD-KARGLKKDAPTSPASVASSSSTPSSKTKDlghNDKSSTPGLKSNTPTPRN 324
Cdd:pfam05109 472 DVTSPTPAgttsgASPVTPSPSPRDNGTEsKAPDMTSPTSAVTTPTPNATSPTPAVTTP---TPNATSPTLGKTSPTSAV 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  325 DAPTP-GTSTTPGLrSMPGKPPGMDPIGIMA--SALRTP----ISLTSSYAAPFAMMSHHEMNGSLTSP----------- 386
Cdd:pfam05109 549 TTPTPnATSPTPAV-TTPTPNATIPTLGKTSptSAVTTPtpnaTSPTVGETSPQANTTNHTLGGTSSTPvvtsppknats 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  387 SAYAGLHNIPSQMSAAAAAAAAAYGR--SPMVSFGAVGfdpHPPMRATGLPSSLASIPGGKPA-YSFHVSADGQMQPVPF 463
Cdd:pfam05109 628 AVTTGQHNITSSSTSSMSLRPSSISEtlSPSTSDNSTS---HMPLLTSAHPTGGENITQVTPAsTSTHHVSTSSPAPRPG 704


                  ....*....
gi 564364087  464 PHDALAGPG 472
Cdd:pfam05109 705 TTSQASGPG 713
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 18-133 7.28e-91

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 280.08  E-value: 7.28e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087   18 FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLS 97
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 564364087   98 QEHQQQVAQAVERAKQVTMTELNAIIGQ-QQLQAQHL 133
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGQqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
485-770 3.49e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 3.49e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 485 HGEVVCAVTISNPTRHVYTGGK-GCVKIWDISQPGSKSPISqldclNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLAS 563
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLT-----GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 564 PTPRikAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVR 643
Cdd:COG2319  194 GKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 644 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKD 721
Cdd:COG2319  272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564364087 722 NLLNAWRTPYGASIFQSKE-SSSVLSCDISADDKYIVTGSGDKKATVYEV 770
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-769 5.93e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 5.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 484 SHGEVVCAVTISNPTRHVYTGGK-GCVKIWDISqpgSKSPISQLdCLNRDNyIRSCKLLPDGRTLIVGGEASTLTIWDLa 562
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 563 sPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTV 642
Cdd:cd00200   81 -ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 643 RSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGK 720
Cdd:cd00200  160 KLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 564364087 721 DNLLNAWRTPYGASIFQ-SKESSSVLSCDISADDKYIVTGSGDKKATVYE 769
Cdd:cd00200  240 DGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
452-770 7.93e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 7.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 452 VSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLdclnR 531
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG----H 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 532 DNYIRSCKLLPDGRTLIVGGEASTLTIWDLAspTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLV 611
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 612 RQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ---HdfTSQIFSLGYCPTGEWLAVGMESSNVEVLH- 687
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltgH--TGAVRSVAFSPDGKLLASGSADGTVRLWDl 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 688 HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISADDKYIVTGSGDKKAT 766
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313


                 ....
gi 564364087 767 VYEV 770
Cdd:COG2319  314 LWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
478-730 4.42e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 4.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 478 RQINTLS-HGEVVCAVTISNPTRHVYTGGK-GCVKIWDISqpgSKSPISQLDclNRDNYIRSCKLLPDGRTLIVGGEAST 555
Cdd:COG2319  153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 556 LTIWDLAspTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWT 635
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 636 GGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLH-HTKPDKYQLHLHESCVLSLKFAYCGK 713
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 564364087 714 WFVSTGKDNLLNAWRTP 730
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 579-770 3.53e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 3.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 579 CYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ-HD 657
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTlTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 658 FTSQIFSLGYCPTGEWLAVGMESSNVEVLH-HTKPDKYQLHLHESCVLSLKFAyCGKWFVSTGK-DNLLNAWRTPYGASI 735
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFS-PDGTFVASSSqDGTIKLWDLRTGKCV 170

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 564364087 736 --FQSkESSSVLSCDISADDKYIVTGSGDKKATVYEV 770
Cdd:cd00200  171 atLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 610-770 1.33e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 610 LVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMESSNVEVL 686
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 687 H-HTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISADDKYIVTGSGDK 763
Cdd:cd00200   79 DlETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157


                 ....*..
gi 564364087 764 KATVYEV 770
Cdd:cd00200  158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
478-607 4.07e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 4.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 478 RQINTLS-HGEVVCAVTISNPTRHVYTGGKGC-VKIWDISqpgSKSPISQLDclNRDNYIRSCKLLPDGRTLIVGGEAST 555
Cdd:COG2319  279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564364087 556 LTIWDLAspTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHN 607
Cdd:COG2319  354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 607-646 2.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564364087   607 NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWD 646
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 506-768 2.07e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 506 KGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPtprIKAELTSSAPACYALAIS 585
Cdd:PLN00181 457 EGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRS 533

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 586 PDAKVCF---------SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISH-DGTKLWTGGLDNTVRSWDLREGRQLQQ 655
Cdd:PLN00181 534 KLSGICWnsyiksqvaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGT 613

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087 656 HDFTSQIFSLGY-CPTGEWLAVGMESSNVEV--LHHTKPDKYQLHLHESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYG 732
Cdd:PLN00181 614 IKTKANICCVQFpSESGRSLAFGSADHKVYYydLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMS 692

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 564364087 733 ASIFQSKESSSVLS-------CDISADDKYIVTGSGDKKATVY 768
Cdd:PLN00181 693 ISGINETPLHSFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
609-646 3.97e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 3.97e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564364087  609 TLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWD 646
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 251-472 1.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  251 DVSNEDPA-----TPRVSPAHSPPENGLD-KARGLKKDAPTSPASVASSSSTPSSKTKDlghNDKSSTPGLKSNTPTPRN 324
Cdd:pfam05109 472 DVTSPTPAgttsgASPVTPSPSPRDNGTEsKAPDMTSPTSAVTTPTPNATSPTPAVTTP---TPNATSPTLGKTSPTSAV 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  325 DAPTP-GTSTTPGLrSMPGKPPGMDPIGIMA--SALRTP----ISLTSSYAAPFAMMSHHEMNGSLTSP----------- 386
Cdd:pfam05109 549 TTPTPnATSPTPAV-TTPTPNATIPTLGKTSptSAVTTPtpnaTSPTVGETSPQANTTNHTLGGTSSTPvvtsppknats 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  387 SAYAGLHNIPSQMSAAAAAAAAAYGR--SPMVSFGAVGfdpHPPMRATGLPSSLASIPGGKPA-YSFHVSADGQMQPVPF 463
Cdd:pfam05109 628 AVTTGQHNITSSSTSSMSLRPSSISEtlSPSTSDNSTS---HMPLLTSAHPTGGENITQVTPAsTSTHHVSTSSPAPRPG 704


                  ....*....
gi 564364087  464 PHDALAGPG 472
Cdd:pfam05109 705 TTSQASGPG 713
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 565-604 2.38e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 2.38e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564364087   565 TPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWD 604
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 570-651 3.42e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.44  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564364087  570 AELTSSAPACYALAISPDAKVCFSCcsdGNiavWD-------LHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTV 642
Cdd:pfam20426  75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148


                  ....*....
gi 564364087  643 RSWDLREGR 651
Cdd:pfam20426 149 MVWEVLRGR 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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