NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|564368025|ref|XP_006244853|]
View 

transforming growth factor-beta receptor-associated protein 1 isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
738-846 1.82e-41

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


:

Pssm-ID: 402126  Cd Length: 109  Bit Score: 147.02  E-value: 1.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  738 VDLLNHHAREFDATQVLQLLPDTWSVQLLCPFLTGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGSAIWLSEKKL 817
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80
                          90       100
                  ....*....|....*....|....*....
gi 564368025  818 CQLCQNPFGEPVFVRYPNGGLVHTHCAAS 846
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFRR 109
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
448-550 1.83e-33

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


:

Pssm-ID: 371008  Cd Length: 108  Bit Score: 124.28  E-value: 1.83e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  448 IDTALLKLYAEADHDSLLDLLVTENSCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIV---NGDIQDSTRSD 524
Cdd:pfam10366   1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELAdetTGDETDSTLKG 80
                          90       100
                  ....*....|....*....|....*...
gi 564368025  525 LYEYIVDFLTYC--LDQELVWTHADWLL 550
Cdd:pfam10366  81 PKETIIQYLQKLgpSDLDLILEYSDWVL 108
CNH super family cl02434
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
34-283 3.81e-11

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


The actual alignment was detected with superfamily member pfam00780:

Pssm-ID: 470577  Cd Length: 261  Bit Score: 64.57  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025   34 GRNLYVGTND-CFIYHflLEEKAMPTgtatfiatkqlhrHLGFKKPVNELCAASALNRLLVLC--DNSITLVNMLNLEPV 110
Cdd:pfam00780   2 GQNLLLGTEEgLYVLN--RSGPREPV-------------RIIDKKRVTQLAVLEEFNLLLLLSgkDKRLYVYPLSALDSR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  111 PSGAR----------IKGATTFAVNENpvngdpfCVEVCIISVKRRTVqmfLVYE------DRVQIVKEVSTTEQPLAVA 174
Cdd:pfam00780  67 EENDRkdaaknklpeTKGCHFFKVGRH-------SNGRFLVVAVKRTI---KLLEwyepllDKFRKFKEFYLPSPPVSIE 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  175 VDGYFLCLALTTQYIILN------YSTGFSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGgLGMFATVAG-ISQRAPVHWS 247
Cdd:pfam00780 137 LLKSKLCVGCAKGFEIVSldskatESLLTSLLFANRQENLKPLAVVRLDRSEFLLCYNE-FGVYVNLQGrRSRPWEIEWE 215
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 564368025  248 ENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLP 283
Cdd:pfam00780 216 GAPEAVAYLYPYLLAFHDNFIEIRDVETGELVQEIA 251
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
585-699 3.93e-06

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 47.25  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  585 KYPKALVKYLEHLVIDRRLQKEEYHTHLALLYLEevlrqraptggkdveaTETQAKLRRLLQKSDLYRVHLLKEKIQGAG 664
Cdd:pfam00637  21 GLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 564368025  665 LPMESAILHGKLGEHEKALHiLVHEMGDFSAAEDY 699
Cdd:pfam00637  85 LYEEAVILYKKIGNWKEAIS-LLKKLGDYKDAIEY 118
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
738-846 1.82e-41

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 147.02  E-value: 1.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  738 VDLLNHHAREFDATQVLQLLPDTWSVQLLCPFLTGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGSAIWLSEKKL 817
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80
                          90       100
                  ....*....|....*....|....*....
gi 564368025  818 CQLCQNPFGEPVFVRYPNGGLVHTHCAAS 846
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFRR 109
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
448-550 1.83e-33

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 124.28  E-value: 1.83e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  448 IDTALLKLYAEADHDSLLDLLVTENSCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIV---NGDIQDSTRSD 524
Cdd:pfam10366   1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELAdetTGDETDSTLKG 80
                          90       100
                  ....*....|....*....|....*...
gi 564368025  525 LYEYIVDFLTYC--LDQELVWTHADWLL 550
Cdd:pfam10366  81 PKETIIQYLQKLgpSDLDLILEYSDWVL 108
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
34-283 3.81e-11

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 64.57  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025   34 GRNLYVGTND-CFIYHflLEEKAMPTgtatfiatkqlhrHLGFKKPVNELCAASALNRLLVLC--DNSITLVNMLNLEPV 110
Cdd:pfam00780   2 GQNLLLGTEEgLYVLN--RSGPREPV-------------RIIDKKRVTQLAVLEEFNLLLLLSgkDKRLYVYPLSALDSR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  111 PSGAR----------IKGATTFAVNENpvngdpfCVEVCIISVKRRTVqmfLVYE------DRVQIVKEVSTTEQPLAVA 174
Cdd:pfam00780  67 EENDRkdaaknklpeTKGCHFFKVGRH-------SNGRFLVVAVKRTI---KLLEwyepllDKFRKFKEFYLPSPPVSIE 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  175 VDGYFLCLALTTQYIILN------YSTGFSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGgLGMFATVAG-ISQRAPVHWS 247
Cdd:pfam00780 137 LLKSKLCVGCAKGFEIVSldskatESLLTSLLFANRQENLKPLAVVRLDRSEFLLCYNE-FGVYVNLQGrRSRPWEIEWE 215
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 564368025  248 ENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLP 283
Cdd:pfam00780 216 GAPEAVAYLYPYLLAFHDNFIEIRDVETGELVQEIA 251
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
585-699 3.93e-06

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 47.25  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  585 KYPKALVKYLEHLVIDRRLQKEEYHTHLALLYLEevlrqraptggkdveaTETQAKLRRLLQKSDLYRVHLLKEKIQGAG 664
Cdd:pfam00637  21 GLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 564368025  665 LPMESAILHGKLGEHEKALHiLVHEMGDFSAAEDY 699
Cdd:pfam00637  85 LYEEAVILYKKIGNWKEAIS-LLKKLGDYKDAIEY 118
CLH smart00299
Clathrin heavy chain repeat homology;
428-541 6.88e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 37.64  E-value: 6.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025   428 LMSYLNEIRSTEVANgykEDIDTALLKLYAEADHDSLLDLLVTENSCL-LTDSAAWLEKHKKYFALGLLYhynKQDASAV 506
Cdd:smart00299  26 LIPYLESALKLNSEN---PALQTKLIELYAKYDPQKEIERLDNKSNHYdIEKVGKLCEKAKLYEEAVELY---KKDGNFK 99
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 564368025   507 QLWVNIVNgdiqdstRSDLYEYIVDFLTYCLDQEL 541
Cdd:smart00299 100 DAIVTLIE-------HLGNYEKAIEYFVKQNNPEL 127
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
738-846 1.82e-41

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 147.02  E-value: 1.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  738 VDLLNHHAREFDATQVLQLLPDTWSVQLLCPFLTGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGSAIWLSEKKL 817
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80
                          90       100
                  ....*....|....*....|....*....
gi 564368025  818 CQLCQNPFGEPVFVRYPNGGLVHTHCAAS 846
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFRR 109
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
448-550 1.83e-33

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 124.28  E-value: 1.83e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  448 IDTALLKLYAEADHDSLLDLLVTENSCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIV---NGDIQDSTRSD 524
Cdd:pfam10366   1 IDTTLLKCYLYTNPSLVGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELAdetTGDETDSTLKG 80
                          90       100
                  ....*....|....*....|....*...
gi 564368025  525 LYEYIVDFLTYC--LDQELVWTHADWLL 550
Cdd:pfam10366  81 PKETIIQYLQKLgpSDLDLILEYSDWVL 108
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
34-283 3.81e-11

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 64.57  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025   34 GRNLYVGTND-CFIYHflLEEKAMPTgtatfiatkqlhrHLGFKKPVNELCAASALNRLLVLC--DNSITLVNMLNLEPV 110
Cdd:pfam00780   2 GQNLLLGTEEgLYVLN--RSGPREPV-------------RIIDKKRVTQLAVLEEFNLLLLLSgkDKRLYVYPLSALDSR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  111 PSGAR----------IKGATTFAVNENpvngdpfCVEVCIISVKRRTVqmfLVYE------DRVQIVKEVSTTEQPLAVA 174
Cdd:pfam00780  67 EENDRkdaaknklpeTKGCHFFKVGRH-------SNGRFLVVAVKRTI---KLLEwyepllDKFRKFKEFYLPSPPVSIE 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  175 VDGYFLCLALTTQYIILN------YSTGFSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGgLGMFATVAG-ISQRAPVHWS 247
Cdd:pfam00780 137 LLKSKLCVGCAKGFEIVSldskatESLLTSLLFANRQENLKPLAVVRLDRSEFLLCYNE-FGVYVNLQGrRSRPWEIEWE 215
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 564368025  248 ENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLP 283
Cdd:pfam00780 216 GAPEAVAYLYPYLLAFHDNFIEIRDVETGELVQEIA 251
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
585-699 3.93e-06

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 47.25  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025  585 KYPKALVKYLEHLVIDRRLQKEEYHTHLALLYLEevlrqraptggkdveaTETQAKLRRLLQKSDLYRVHLLKEKIQGAG 664
Cdd:pfam00637  21 GLLEELISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 564368025  665 LPMESAILHGKLGEHEKALHiLVHEMGDFSAAEDY 699
Cdd:pfam00637  85 LYEEAVILYKKIGNWKEAIS-LLKKLGDYKDAIEY 118
CLH smart00299
Clathrin heavy chain repeat homology;
428-541 6.88e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 37.64  E-value: 6.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368025   428 LMSYLNEIRSTEVANgykEDIDTALLKLYAEADHDSLLDLLVTENSCL-LTDSAAWLEKHKKYFALGLLYhynKQDASAV 506
Cdd:smart00299  26 LIPYLESALKLNSEN---PALQTKLIELYAKYDPQKEIERLDNKSNHYdIEKVGKLCEKAKLYEEAVELY---KKDGNFK 99
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 564368025   507 QLWVNIVNgdiqdstRSDLYEYIVDFLTYCLDQEL 541
Cdd:smart00299 100 DAIVTLIE-------HLGNYEKAIEYFVKQNNPEL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH