|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
103-486 |
6.97e-105 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 318.78 E-value: 6.97e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 103 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQI 182
Cdd:COG2319 65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 183 LLWDPSTGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-L 261
Cdd:COG2319 145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 262 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQ 341
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 342 gpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 421
Cdd:COG2319 260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564373454 422 IAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
108-486 |
1.40e-89 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 275.37 E-value: 1.40e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 108 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDP 187
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 188 STGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 266
Cdd:cd00200 81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 267 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgperl 346
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 347 vsgsddftlflwspaedkkplarmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 426
Cdd:cd00200 185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 427 DSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| NLE |
pfam08154 |
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ... |
19-79 |
1.15e-15 |
|
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.
Pssm-ID: 462380 Cd Length: 66 Bit Score: 71.40 E-value: 1.15e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564373454 19 LLVQFQDEGGQL--LGSPFDVPVDITPDQLQLVCNALLAQDE---PLPLAFYVHDAEIVSSLGKTL 79
Cdd:pfam08154 1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
107-144 |
1.24e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.47 E-value: 1.24e-09
10 20 30
....*....|....*....|....*....|....*...
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
161-445 |
1.83e-09 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 60.10 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 161 VLSISWSPDGKKLASGCKNGQILLWDPSTGTQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 233
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 234 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 307
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 308 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 380
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564373454 381 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 445
Cdd:PLN00181 715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
107-144 |
2.66e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 52.35 E-value: 2.66e-09
10 20 30
....*....|....*....|....*....|....*...
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| propeller_TolB |
TIGR02800 |
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ... |
116-211 |
2.28e-03 |
|
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]
Pssm-ID: 274305 [Multi-domain] Cd Length: 417 Bit Score: 40.33 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 116 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGKKLA---SGCKNGQI 182
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLAvslSKDGNPDI 260
|
90 100
....*....|....*....|....*....
gi 564373454 183 LLWDPSTGTQvgRTLTGHSKWITGLSWEP 211
Cdd:TIGR02800 261 YVMDLDGKQL--TRLTNGPGIDTEPSWSP 287
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
103-486 |
6.97e-105 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 318.78 E-value: 6.97e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 103 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQI 182
Cdd:COG2319 65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 183 LLWDPSTGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-L 261
Cdd:COG2319 145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 262 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQ 341
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 342 gpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 421
Cdd:COG2319 260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564373454 422 IAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
106-446 |
9.38e-93 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 287.58 E-value: 9.38e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 106 TRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLW 185
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 186 DPSTGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYS 264
Cdd:COG2319 190 DLATGKLL-RTLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLAS 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 265 ASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpe 344
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD---------------------------------------GK--- 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 345 RLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW 424
Cdd:COG2319 302 LLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
|
330 340
....*....|....*....|..
gi 564373454 425 SADSRLLVSGSSDSTLKVWDVK 446
Cdd:COG2319 381 SPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
98-487 |
2.58e-91 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 283.73 E-value: 2.58e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 98 AVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGC 177
Cdd:COG2319 18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 178 KNGQILLWDPSTGtQVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWG 257
Cdd:COG2319 98 ADGTVRLWDLATG-LLLRTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 258 GDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassryn 336
Cdd:COG2319 172 PDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD------------------------------------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 337 lvrGQgpeRLVSGSDDFTLFLWSpAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHV 416
Cdd:COG2319 216 ---GK---LLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564373454 417 AAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 487
Cdd:COG2319 289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
108-486 |
1.40e-89 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 275.37 E-value: 1.40e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 108 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDP 187
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 188 STGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 266
Cdd:cd00200 81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 267 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgperl 346
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 347 vsgsddftlflwspaedkkplarmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 426
Cdd:cd00200 185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 427 DSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
123-485 |
4.58e-75 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 241.74 E-value: 4.58e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 123 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGTQVgRTLTGHSK 202
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 203 WITGLSWEPLHmnpecRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVL 281
Cdd:COG2319 80 AVLSVAFSPDG-----RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 282 CRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkerassrynlvrGQgpeRLVSGSDDFTLFLWSpA 361
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-L 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 362 EDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 441
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 564373454 442 VWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 485
Cdd:COG2319 272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
107-301 |
2.45e-56 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 189.08 E-value: 2.45e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 187 PSTGtQVGRTLTGHSKWITGLSWEPlhmnPECRYVASSSkDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 265
Cdd:cd00200 164 LRTG-KCVATLTGHTGEVNSVAFSP----DGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASG 237
|
170 180 190
....*....|....*....|....*....|....*.
gi 564373454 266 SQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 301
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
107-275 |
6.08e-52 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 177.53 E-value: 6.08e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 187 PSTGTQVGrTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 265
Cdd:cd00200 206 LSTGKCLG-TLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASG 279
|
170
....*....|
gi 564373454 266 SQDRTIKVWR 275
Cdd:cd00200 280 SADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
107-278 |
3.59e-49 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 173.56 E-value: 3.59e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 187 PSTGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 265
Cdd:COG2319 317 LATGKLL-RTLTGHTGAVRSVAF-----SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASG 390
|
170
....*....|...
gi 564373454 266 SQDRTIKVWRAHD 278
Cdd:COG2319 391 SADGTVRLWDLAT 403
|
|
| NLE |
pfam08154 |
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ... |
19-79 |
1.15e-15 |
|
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.
Pssm-ID: 462380 Cd Length: 66 Bit Score: 71.40 E-value: 1.15e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564373454 19 LLVQFQDEGGQL--LGSPFDVPVDITPDQLQLVCNALLAQDE---PLPLAFYVHDAEIVSSLGKTL 79
Cdd:pfam08154 1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
381-486 |
4.94e-10 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 61.47 E-value: 4.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 381 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADE 460
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100
....*....|....*....|....*.
gi 564373454 461 VYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWD 106
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
107-144 |
1.24e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.47 E-value: 1.24e-09
10 20 30
....*....|....*....|....*....|....*...
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
405-444 |
1.32e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 53.47 E-value: 1.32e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564373454 405 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 444
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
161-445 |
1.83e-09 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 60.10 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 161 VLSISWSPDGKKLASGCKNGQILLWDPSTGTQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 233
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 234 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 307
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 308 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 380
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564373454 381 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 445
Cdd:PLN00181 715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
107-144 |
2.66e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 52.35 E-value: 2.66e-09
10 20 30
....*....|....*....|....*....|....*...
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
147-186 |
3.25e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 52.31 E-value: 3.25e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564373454 147 TETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
343-458 |
4.90e-09 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 58.37 E-value: 4.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 343 PERLVSGSDDFTLFLWS-PAEDKK-----PLARMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGH 415
Cdd:PTZ00421 88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 564373454 416 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHA 458
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
98-278 |
1.71e-08 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 56.82 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 98 AVFRVRAVTRCTSS---LEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTE-------TPHFTCKGHRHWVLSISW 166
Cdd:PTZ00421 54 AVLKHTDYGKLASNppiLLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSF 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 167 SPDGKK-LASGCKNGQILLWDPSTGTqVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILT 245
Cdd:PTZ00421 134 HPSAMNvLASAGADMVVNVWDVERGK-AVEVIKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE 207
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 564373454 246 GH--TQSVTCLrWGGDGLL-----YSASQDRTIKVWRAHD 278
Cdd:PTZ00421 208 AHasAKSQRCL-WAKRKDLiitlgCSKSQQRQIMLWDTRK 246
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
406-444 |
2.10e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.04 E-value: 2.10e-08
10 20 30
....*....|....*....|....*....|....*....
gi 564373454 406 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 444
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
363-402 |
4.49e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 49.23 E-value: 4.49e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564373454 363 DKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 402
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
161-288 |
5.03e-08 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 55.28 E-value: 5.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 161 VLSISWSP-DGKKLASGCKNGQILLWD-PSTGTQVGRT-----LTGHSKWITGLSWEPLHMNpecrYVASSSKDGSVRVW 233
Cdd:PTZ00421 78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 564373454 234 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 288
Cdd:PTZ00421 154 DVERGKAVEVIKCHSDQITSLEWNLDGsLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
449-485 |
5.73e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 48.85 E-value: 5.73e-08
10 20 30
....*....|....*....|....*....|....*..
gi 564373454 449 KLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 485
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
364-402 |
1.60e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 47.34 E-value: 1.60e-07
10 20 30
....*....|....*....|....*....|....*....
gi 564373454 364 KKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 402
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
372-484 |
1.82e-07 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 53.36 E-value: 1.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 372 GHQALINQVLFSP-DSRIVASASFDKSIKLWD-------GRTGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKV 442
Cdd:PTZ00421 73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 564373454 443 WDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRI 484
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
449-485 |
1.87e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 47.34 E-value: 1.87e-07
10 20 30
....*....|....*....|....*....|....*..
gi 564373454 449 KLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 485
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
238-274 |
2.22e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 2.22e-07
10 20 30
....*....|....*....|....*....|....*...
gi 564373454 238 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 274
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
195-234 |
4.76e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.15 E-value: 4.76e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564373454 195 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 234
Cdd:smart00320 6 KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
149-186 |
5.28e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 46.18 E-value: 5.28e-07
10 20 30
....*....|....*....|....*....|....*...
gi 564373454 149 TPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
131-274 |
6.77e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.01 E-value: 6.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 131 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP-DGKKLASGCKNGQILLWDPSTGTQVGRTLTGHSKWITGLSW 209
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564373454 210 EplhmnpECRYVASSSKDGSVRVWDTTAGR---CERIltGHTQSVTCLRWGGDGLLYSASQDRTIKVW 274
Cdd:PLN00181 628 E------SGRSLAFGSADHKVYYYDLRNPKlplCTMI--GHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
238-274 |
7.36e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.41 E-value: 7.36e-07
10 20 30
....*....|....*....|....*....|....*...
gi 564373454 238 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 274
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
195-234 |
1.14e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.03 E-value: 1.14e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 564373454 195 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 234
Cdd:pfam00400 5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
161-209 |
2.10e-06 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 45.73 E-value: 2.10e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 564373454 161 VLSISWSPDGKKLASGCKNGQILLWDPSTGTQVgRTLTGHSKWITGLSW 209
Cdd:pfam12894 41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDLITCLGW 88
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
376-485 |
3.94e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 49.70 E-value: 3.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 376 LINQVLFSPDSRIVASASFDKSIKLW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWDVKA 447
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564
|
90 100 110
....*....|....*....|....*....|....*....
gi 564373454 448 QKLTTDLPGHADEVYAVDW-SPDGQRVASGGKDKCLRIW 485
Cdd:PLN00181 565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
380-474 |
2.03e-05 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 47.34 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 380 VLFSPDSRIVASASfDKSiklwdGRTGKYLASLRGHVAA----------VYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 449
Cdd:COG4946 348 PAWSPDGKSIAYFS-DAS-----GEYELYIAPADGSGEPkqltlgdlgrVFNPVWSPDGKKIAFTDNRGRLWVVDLASGK 421
|
90 100
....*....|....*....|....*.
gi 564373454 450 LTT-DLPGHADEVYAVDWSPDGQRVA 474
Cdd:COG4946 422 VRKvDTDGYGDGISDLAWSPDSKWLA 447
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
130-276 |
2.53e-05 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 44.28 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 130 YLASGSGDTTVRFWDLSTETPH-FTckGHRHWVLSISWSPDGKKLA---SGCKNGQILLWDPSTGTQvgRTLTGHSKWIT 205
Cdd:COG0823 3 FTLSRDGNSDIYVVDLDGGEPRrLT--NSPGIDTSPAWSPDGRRIAftsDRGGGPQIYVVDADGGEP--RRLTFGGGYNA 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564373454 206 GLSWeplhmNPECRYVA-SSSKDGSVRVW--DTTAGRcERILTGHTQSVTclrWGGDG--LLYSASQDRTIKVWRA 276
Cdd:COG0823 79 SPSW-----SPDGKRLAfVSRSDGRFDIYvlDLDGGA-PRRLTDGPGSPS---WSPDGrrIVFSSDRGGRPDLYVV 145
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
112-306 |
6.46e-05 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 45.33 E-value: 6.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 112 LEGHSEAVISVAFSPT-GKYLASGSGDTTVRFWdlstETPHftckgHRHWVLSISwspdgkklasgckngqillwDPSTg 190
Cdd:PTZ00420 70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVW----EIPH-----NDESVKEIK--------------------DPQC- 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 191 tqvgrTLTGHSKWITGLSWEPLHMNPECryvaSSSKDGSVRVWDT-TAGRCERILTghTQSVTCLRWGGDGLLYSAS-QD 268
Cdd:PTZ00420 120 -----ILKGHKKKISIIDWNPMNYYIMC----SSGFDSFVNIWDIeNEKRAFQINM--PKKLSSLKWNIKGNLLSGTcVG 188
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 564373454 269 RTIKVWRAHDGVLCRTLQGHGH-------WVNTMALSTDYALRTG 306
Cdd:PTZ00420 189 KHMHIIDPRKQEIASSFHIHDGgkntkniWIDGLGGDDNYILSTG 233
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
364-449 |
8.98e-05 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 44.94 E-value: 8.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 364 KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKY--------LASLRGHVAAVYQIAWSADSRLLVSG 434
Cdd:PTZ00420 64 KPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCS 143
|
90
....*....|....*.
gi 564373454 435 SS-DSTLKVWDVKAQK 449
Cdd:PTZ00420 144 SGfDSFVNIWDIENEK 159
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
344-402 |
1.28e-04 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 44.56 E-value: 1.28e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564373454 344 ERLVSGSDDFTLFLWS-PAED------KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 402
Cdd:PTZ00420 88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
109-167 |
6.61e-04 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 38.80 E-value: 6.61e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 564373454 109 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 167
Cdd:pfam12894 31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
118-268 |
1.31e-03 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 41.56 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 118 AVISVAFSPTGKYLA-----SGSgdttvrfWDL------STETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:COG4946 344 RERLPAWSPDGKSIAyfsdaSGE-------YELyiapadGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVD 416
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 187 PSTG--TQVGRTLTGHSkwITGLSWeplhmNPECRYVASSSKDGS----VRVWDTTAGRcERILTGHTQSVTCLRWGGDG 260
Cdd:COG4946 417 LASGkvRKVDTDGYGDG--ISDLAW-----SPDSKWLAYSKPGPNqlsqIFLYDVETGK-TVQLTDGRYDDGSPAFSPDG 488
|
170
....*....|
gi 564373454 261 --LLYSASQD 268
Cdd:COG4946 489 kyLYFLSSRD 498
|
|
| propeller_TolB |
TIGR02800 |
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ... |
116-211 |
2.28e-03 |
|
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]
Pssm-ID: 274305 [Multi-domain] Cd Length: 417 Bit Score: 40.33 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 116 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGKKLA---SGCKNGQI 182
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLAvslSKDGNPDI 260
|
90 100
....*....|....*....|....*....
gi 564373454 183 LLWDPSTGTQvgRTLTGHSKWITGLSWEP 211
Cdd:TIGR02800 261 YVMDLDGKQL--TRLTNGPGIDTEPSWSP 287
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
393-479 |
5.45e-03 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 38.90 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 393 SFdKSIKLWDGRTgkyLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV--------KAQKLTTDLP--------- 455
Cdd:pfam20426 105 SF-QVISLNDGRM---VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEFPrkdhviaet 180
|
90 100 110
....*....|....*....|....*....|
gi 564373454 456 ------GHADEVYAVDWSPDGQRVASGGKD 479
Cdd:pfam20426 181 pfhilcGHDDIITCLYVSVELDIVISGSKD 210
|
|
|