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Conserved domains on  [gi|1958670618|ref|XP_006249349|]
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zinc finger protein 11 isoform X1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
17-76 2.02e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.02e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618   17 LSFKDVSVDFSPEEWECLDPARWNLYRNVMLENYRNLVSLGLAVCKPSLVTLLEQIQEPW 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-546 3.50e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 169 RPYKCKECGKAFKRSRNLAQHQVTHKREKPHKCEECGRA--FTTLSVLTQHRVTHTGEKPY-QCKECGRAFKYNSTLTQH 245
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 246 EVIHTEAKPYRCQECGKAFKRSHTLSQ--HQVTHKGEKPHK---------------------CEECGKAFSKHSSLTQHQ 302
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 303 VIHTGEKPYQCRECGKAFKYQSTLTrHQIVHTGTKPYKCPECGKAFNNSSTLSRHQIIHTGEKPYKCQECGRAFYCSSFL 382
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 383 IQHMKIHFEE-------MPYRCKECGKPFRLSSQLIRHQR--IHTGE--EPYICKE--CGKTFKYQSNLTRHQILHTGAK 449
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 450 PYKCP--ECGKAFNNSSTLSRHQII--HTGEKPYKCQEC---------GRAFYCSSYLIQHMKihFEEIPYRCKECGKPF 516
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnscirnfKRDSNLSLHIITHLS--FRPYNCKNPPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|
gi 1958670618 517 KCSSQLIRHQRIHSGEKPYICKECGKAFNC 546
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
606-630 4.88e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.88e-04
                          10        20
                  ....*....|....*....|....*
gi 1958670618 606 LNRHQRIHTGEKPYVCQECGKAFNC 630
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
549-574 1.35e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958670618 549 YLTKHQRTHTGEKPYVCQECGKAFNC 574
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PriA super family cl43353
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 646-709 1.61e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1198:

Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 42.03  E-value: 1.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958670618 646 PYV-CKECGKAF---NCSSYLTkhqrVHTGDRSYKCRECGkayyfssqltrhqrtHTREKPYRCKECG 709
Cdd:COG1198   431 PFLlCRDCGWVAkcpNCDVSLT----YHRSRRRLRCHYCG---------------YEEPVPKQCPECG 479
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
17-76 2.02e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.02e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618   17 LSFKDVSVDFSPEEWECLDPARWNLYRNVMLENYRNLVSLGLAVCKPSLVTLLEQIQEPW 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 16-57 4.53e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.15  E-value: 4.53e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958670618  16 LLSFKDVSVDFSPEEWECLDPARWNLYRNVMLENYRNLVSLG 57
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 17-56 1.53e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.21  E-value: 1.53e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958670618  17 LSFKDVSVDFSPEEWECLDPARWNLYRNVMLENYRNLVSL 56
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-546 3.50e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 169 RPYKCKECGKAFKRSRNLAQHQVTHKREKPHKCEECGRA--FTTLSVLTQHRVTHTGEKPY-QCKECGRAFKYNSTLTQH 245
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 246 EVIHTEAKPYRCQECGKAFKRSHTLSQ--HQVTHKGEKPHK---------------------CEECGKAFSKHSSLTQHQ 302
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 303 VIHTGEKPYQCRECGKAFKYQSTLTrHQIVHTGTKPYKCPECGKAFNNSSTLSRHQIIHTGEKPYKCQECGRAFYCSSFL 382
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 383 IQHMKIHFEE-------MPYRCKECGKPFRLSSQLIRHQR--IHTGE--EPYICKE--CGKTFKYQSNLTRHQILHTGAK 449
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 450 PYKCP--ECGKAFNNSSTLSRHQII--HTGEKPYKCQEC---------GRAFYCSSYLIQHMKihFEEIPYRCKECGKPF 516
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnscirnfKRDSNLSLHIITHLS--FRPYNCKNPPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|
gi 1958670618 517 KCSSQLIRHQRIHSGEKPYICKECGKAFNC 546
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
606-630 4.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.88e-04
                          10        20
                  ....*....|....*....|....*
gi 1958670618 606 LNRHQRIHTGEKPYVCQECGKAFNC 630
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
549-574 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958670618 549 YLTKHQRTHTGEKPYVCQECGKAFNC 574
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PriA COG1198
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 646-709 1.61e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 42.03  E-value: 1.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958670618 646 PYV-CKECGKAF---NCSSYLTkhqrVHTGDRSYKCRECGkayyfssqltrhqrtHTREKPYRCKECG 709
Cdd:COG1198   431 PFLlCRDCGWVAkcpNCDVSLT----YHRSRRRLRCHYCG---------------YEEPVPKQCPECG 479
zf-H2C2_2 pfam13465
Zinc-finger double domain;
690-714 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1958670618 690 LTRHQRTHTREKPYRCKECGKAFIT 714
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-350 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1958670618 326 LTRHQIVHTGTKPYKCPECGKAFNN 350
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 646-709 4.15e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 40.53  E-value: 4.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958670618 646 PYV-CKECGKAF---NCSSYLTKHQRvhtgDRSYKCRECGkayyfssqltrhqrtHTREKPYRCKECG 709
Cdd:PRK05580  380 PFLlCRDCGWVAecpHCDASLTLHRF----QRRLRCHHCG---------------YQEPIPKACPECG 428
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
17-76 2.02e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.02e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618   17 LSFKDVSVDFSPEEWECLDPARWNLYRNVMLENYRNLVSLGLAVCKPSLVTLLEQIQEPW 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 16-57 4.53e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.15  E-value: 4.53e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958670618  16 LLSFKDVSVDFSPEEWECLDPARWNLYRNVMLENYRNLVSLG 57
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 17-56 1.53e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.21  E-value: 1.53e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958670618  17 LSFKDVSVDFSPEEWECLDPARWNLYRNVMLENYRNLVSL 56
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-546 3.50e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 169 RPYKCKECGKAFKRSRNLAQHQVTHKREKPHKCEECGRA--FTTLSVLTQHRVTHTGEKPY-QCKECGRAFKYNSTLTQH 245
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 246 EVIHTEAKPYRCQECGKAFKRSHTLSQ--HQVTHKGEKPHK---------------------CEECGKAFSKHSSLTQHQ 302
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 303 VIHTGEKPYQCRECGKAFKYQSTLTrHQIVHTGTKPYKCPECGKAFNNSSTLSRHQIIHTGEKPYKCQECGRAFYCSSFL 382
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 383 IQHMKIHFEE-------MPYRCKECGKPFRLSSQLIRHQR--IHTGE--EPYICKE--CGKTFKYQSNLTRHQILHTGAK 449
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 450 PYKCP--ECGKAFNNSSTLSRHQII--HTGEKPYKCQEC---------GRAFYCSSYLIQHMKihFEEIPYRCKECGKPF 516
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnscirnfKRDSNLSLHIITHLS--FRPYNCKNPPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|
gi 1958670618 517 KCSSQLIRHQRIHSGEKPYICKECGKAFNC 546
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-661 2.74e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 267 SHTLSQHQVTHKGE----KPHKCEECGKAFSKHSSLTQHQVIHTGEKPYQCR--ECGKAFKYQSTLTRHQIVHT------ 334
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHnnpsdl 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 335 -----GTKPYKCPEC---GKAFNNSSTL----------SRHQIIHTGEKPYKCQECgRAFYCSSFLIQHMKIHFEEMPYR 396
Cdd:COG5048    94 nskslPLSNSKASSSslsSSSSNSNDNNllsshslppsSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLHPPLP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 397 CKECGKPFRLSSQLIRHQRIHTGEEPYICKECGKTFKYQSNLTRHQILHTGAKPYKCPECGKAFNNSSTLSRHQIIHTGE 476
Cdd:COG5048   173 ANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 477 KPYKCQECGRAFYCSSYLIQHMKIHFEE-------IPYRCKECGKPFKCSSQLIRHQR--IHSGE--KPYICKE--CGKA 543
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 544 FNCTSYLTKHQRTHTGEKPYVC--QECGKAFN-----------CSSYLSKHQRIHLGDRLYKCKECGKAYYFSSQLNRHQ 610
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnneppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHL 412

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958670618 611 RIHTGEKPyvCQECGKAFNCSSYLQKHQRIHIVEKPYVCKECGKAFNCSSY 661
Cdd:COG5048   413 SFRPYNCK--NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-721 1.13e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 1.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 253 KPYRCQECGKAFKRSHTLSQHQVTHKGEKPHKC--EECGKAFSKHSSLTQHQVIHTGEKPYqcRECGKAFKYQSTLTRHQ 330
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 331 IVHTGTKP-YKCPECGKAFNNSStlsRHQIIHTGEKPYKCQECgRAFYCSSFLIQHMKIHFEEMPYRCKECGKPFRLSSQ 409
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSS---RDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 410 LIRHQRIHTGEEPYICKECGKTFKYQSNLTRHQILHTGAKPYKCPECGKAFNNSSTLSRHQIIHTGEKPYKCQECGRAFY 489
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 490 CSSYLIQHMKIHFEE-------IPYRCKECGKPFKCSSQLIRHQR--IHSGE--KPYICKECGkafnctsyltkhqrtht 558
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSL----------------- 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 559 gekpyvcqeCGKAFNCSSYLSKHQRIHLGDRLYKCKecgkayyfssqLNRHQRIHTGEKPYvcqecgkafNCSSYLQKHQ 638
Cdd:COG5048   329 ---------CGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSPLLNN---------EPPQSLQQYK 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 639 RIHiVEKPYVC--KECGKAFNCSSYLTKHQRVHTGDRSYKCR--ECGKAYYFSSQLTRHQRTHTREKPYRCkECGKAFIT 714
Cdd:COG5048   380 DLK-NDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRR 457


                  ....*..
gi 1958670618 715 SSSLKRH 721
Cdd:COG5048   458 DLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
336-732 3.69e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 336 TKPYKCPECGKAFNNSSTLSRHQIIHTGEKPYKCQECGRAFYCS--SFLIQHMKIHFEEMPYRCKECGKP---FRLSSQL 410
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLsnsKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 411 IRHqrIHTGEEPYICKECGKTFKYQSNLTRHQILHTGAKPYKCPEC-GKAFNNSSTLSRHQIIHTGEKPYKCQECGRAFY 489
Cdd:COG5048   111 SSS--SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 490 CSSyliqhmkIHFEEIPYRCKECGKPFKCSSQLIRHQRIHSGEKPYICKECGKAFNCTSYLTKHQRTHTGEKPYVCQECG 569
Cdd:COG5048   189 SSN-------VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 570 KAFNC--SSYLSKHQRIHLGDR-----LYKCKECGKAYYFSSQLNRHQR--IHTGE--KPYVC--QECGKAFNCSSYLQK 636
Cdd:COG5048   262 RSSLPtaSSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 637 HQRIHIVEKPYVCK-------------ECGKAFNCSSYLTKHQRVHTGDRSYKCRECGKAYYFSSQLTRHQRThtREKPY 703
Cdd:COG5048   342 HILLHTSISPAKEKllnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNC 419

                         410       420
                  ....*....|....*....|....*....
gi 1958670618 704 RCKECGKAFITSSSLKRHQETHTLLKPSH 732
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
zf-H2C2_2 pfam13465
Zinc-finger double domain;
606-630 4.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.88e-04
                          10        20
                  ....*....|....*....|....*
gi 1958670618 606 LNRHQRIHTGEKPYVCQECGKAFNC 630
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 278-357 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 278 KGEKPHKCE--ECGKAFS-----KHSSLTQHQVIHTGEKPYQcrecgkafkyqstlTRHQIVHTGTKPYKCPECGKAFNN 350
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKnqnglKYHMLHGHQNQKLHENPSP--------------EKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*..
gi 1958670618 351 SSTLSRH 357
Cdd:COG5189   411 LNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
549-574 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958670618 549 YLTKHQRTHTGEKPYVCQECGKAFNC 574
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PriA COG1198
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 646-709 1.61e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 42.03  E-value: 1.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958670618 646 PYV-CKECGKAF---NCSSYLTkhqrVHTGDRSYKCRECGkayyfssqltrhqrtHTREKPYRCKECG 709
Cdd:COG1198   431 PFLlCRDCGWVAkcpNCDVSLT----YHRSRRRLRCHYCG---------------YEEPVPKQCPECG 479
zf-H2C2_2 pfam13465
Zinc-finger double domain;
690-714 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1958670618 690 LTRHQRTHTREKPYRCKECGKAFIT 714
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
633-658 2.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958670618 633 YLQKHQRIHIVEKPYVCKECGKAFNC 658
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-350 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1958670618 326 LTRHQIVHTGTKPYKCPECGKAFNN 350
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 3.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958670618 297 SLTQHQVIHTGEKPYQCRECGKAFKY 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-269 3.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 147 DCGKAFKYRSVLYQHHISHTAARPYKCKECGKAFKRSRNL-------AQHQVTHKREKPHKCE--ECGRAFTTLSVLTQH 217
Cdd:COG5048   328 LCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLH 407

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958670618 218 RVTHTGEKPYQCK--ECGRAFKYNSTLTQHEVIHTEAKPYRCQECGKAFKRSHT 269
Cdd:COG5048   408 IITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 646-709 4.15e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 40.53  E-value: 4.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958670618 646 PYV-CKECGKAF---NCSSYLTKHQRvhtgDRSYKCRECGkayyfssqltrhqrtHTREKPYRCKECG 709
Cdd:PRK05580  380 PFLlCRDCGWVAecpHCDASLTLHRF----QRRLRCHHCG---------------YQEPIPKACPECG 428
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 4.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.86e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958670618 437 NLTRHQILHTGAKPYKCPECGKAFNN 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-378 6.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.58e-03
                          10        20
                  ....*....|....*....|....*
gi 1958670618 354 LSRHQIIHTGEKPYKCQECGRAFYC 378
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
466-490 6.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.58e-03
                          10        20
                  ....*....|....*....|....*
gi 1958670618 466 LSRHQIIHTGEKPYKCQECGRAFYC 490
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 194-273 6.66e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670618 194 KREKPHKCE--ECGRAFTTLSVLTQHRVThtgekpyqcKECGRAFKYNSTLTQHEVIHTEAKPYRCQECGKAFKRSHTLS 271
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 1958670618 272 QH 273
Cdd:COG5189   416 YH 417
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 367-416 9.02e-03

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 39.40  E-value: 9.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958670618 367 YKCQECGRAFYcssflIQHMKIHFEEmPYRCKECGK--PFRL---SSQLIRHQRI 416
Cdd:COG1241   129 FECPRCGTETY-----VPQTGEKLQE-PHECPGCGRqgPFKLlpeKSEFIDAQKI 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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