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Conserved domains on  [gi|564383567|ref|XP_006250987|]
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protein furry homolog-like isoform X11 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2335-3063 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1008.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2335 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2414
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2415 SVLSLCGPESGLPKNPSVIFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDSSSEQQFGVFKDFDFLDVELEDAEGESM 2494
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2495 DNFNWGVRRRSLDSIDKGDTPSLQECPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVPDDlmPDHQD 2574
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2575 -LLQSQDSASSntTEDVLqiRDETPSLEAcldnascQLPEDTSSVlkeehvtafedegpyliqdqqdplvcrgildleet 2653
Cdd:pfam19421  236 sLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR----------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2654 dmpeplapesypesvceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAYEDE 2733
Cdd:pfam19421  270 --------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2734 EEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITNEAVGFLGKSLQRIGTKFKSSLEVMMTCSECPTVFVDA 2813
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2814 ETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIDRINTNAHQMgilAELELCRRLYRLHFQ 2891
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKLHFQ 456

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2892 LLLLFQAYCKLINQVNAIKNEAEVINMSEELTQLEGILKE-----AEAASENEETDISKAAQTTIETAIHSLIETLKNKE 2966
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2967 FVSAVAQVKAFRTLWPSDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANCKLMELNLEIRESLRMVQSH 3046
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616

                          730
                   ....*....|....*..
gi 564383567  3047 PLLAQAKPVGKTASAGF 3063
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 168-700 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 624.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   168 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 247
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   248 KKFVTELKELRQKEQSPHVVQSIISLIMGMKFFRVMMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 327
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   328 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 407
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   408 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 485
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   486 KSAKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 563
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   564 RALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 629
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   630 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 700
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2052-2305 3.51e-72

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 242.77  E-value: 3.51e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2052 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIESVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVYL 2130
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2131 LSQLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDNP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2208
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2209 RDCANWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLASMQQSLLQIIYSLLSHVDLSAAPAKQFNLEITKTIGKYVQS 2287
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 564383567  2288 PYWKEALNILKLVVSRSA 2305
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 738-1910 6.26e-36

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 150.56  E-value: 6.26e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   738 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDEELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 817
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   818 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 897
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   898 nakKVSTTTSSDSYVGLWRNYLILCCSaaaspspsapagsvrCsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 977
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACS---------------C-PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   978 RSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1051
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1052 ASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1131
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1132 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1184
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1185 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1227
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1228 RCYTGSRRVAAGCFRAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1306
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1307 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVdvrplpsgrrqdee 1385
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFL-------------- 652

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1386 dgSLKDrelmvtsrrwlrgEGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--ICG 1463
Cdd:pfam14228  653 --KLWE-------------SGW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIED 710

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1464 VNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYRI 1518
Cdd:pfam14228  711 CDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPVQ 790

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1519 TSGCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESfvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSDS 1598
Cdd:pfam14228  791 VAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNMS 865

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1599 MPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCSIAVILLTDliIDHSVK 1664
Cdd:pfam14228  866 GPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEND 941

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1665 VEWGSYLHLLLHAVFIGFDHCHPEVYEHCKRLLLHLLIvmgpnsnirtvasvllrnkefneprvltvkptahsdytftag 1744
Cdd:pfam14228  942 EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLY------------------------------------------ 979

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1745 indftpdyqpspmtdsglsssstsssislgnnSAAISHLQatlLGEVDLS-VEQDGKVKTLMEFITSRKRGPLWNHEDVS 1823
Cdd:pfam14228  980 --------------------------------SLAGRHLE---LYDVEHGdGEYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1824 SKNPSIKSADQLTTFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSANTLSDVLSR 1902
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 564383567  1903 LVETVGDP 1910
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2335-3063 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1008.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2335 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2414
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2415 SVLSLCGPESGLPKNPSVIFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDSSSEQQFGVFKDFDFLDVELEDAEGESM 2494
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2495 DNFNWGVRRRSLDSIDKGDTPSLQECPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVPDDlmPDHQD 2574
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2575 -LLQSQDSASSntTEDVLqiRDETPSLEAcldnascQLPEDTSSVlkeehvtafedegpyliqdqqdplvcrgildleet 2653
Cdd:pfam19421  236 sLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR----------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2654 dmpeplapesypesvceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAYEDE 2733
Cdd:pfam19421  270 --------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2734 EEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITNEAVGFLGKSLQRIGTKFKSSLEVMMTCSECPTVFVDA 2813
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2814 ETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIDRINTNAHQMgilAELELCRRLYRLHFQ 2891
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKLHFQ 456

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2892 LLLLFQAYCKLINQVNAIKNEAEVINMSEELTQLEGILKE-----AEAASENEETDISKAAQTTIETAIHSLIETLKNKE 2966
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2967 FVSAVAQVKAFRTLWPSDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANCKLMELNLEIRESLRMVQSH 3046
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616

                          730
                   ....*....|....*..
gi 564383567  3047 PLLAQAKPVGKTASAGF 3063
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 168-700 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 624.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   168 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 247
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   248 KKFVTELKELRQKEQSPHVVQSIISLIMGMKFFRVMMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 327
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   328 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 407
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   408 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 485
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   486 KSAKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 563
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   564 RALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 629
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   630 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 700
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2052-2305 3.51e-72

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 242.77  E-value: 3.51e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2052 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIESVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVYL 2130
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2131 LSQLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDNP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2208
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2209 RDCANWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLASMQQSLLQIIYSLLSHVDLSAAPAKQFNLEITKTIGKYVQS 2287
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 564383567  2288 PYWKEALNILKLVVSRSA 2305
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 738-1910 6.26e-36

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 150.56  E-value: 6.26e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   738 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDEELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 817
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   818 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 897
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   898 nakKVSTTTSSDSYVGLWRNYLILCCSaaaspspsapagsvrCsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 977
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACS---------------C-PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   978 RSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1051
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1052 ASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1131
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1132 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1184
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1185 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1227
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1228 RCYTGSRRVAAGCFRAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1306
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1307 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVdvrplpsgrrqdee 1385
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFL-------------- 652

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1386 dgSLKDrelmvtsrrwlrgEGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--ICG 1463
Cdd:pfam14228  653 --KLWE-------------SGW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIED 710

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1464 VNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYRI 1518
Cdd:pfam14228  711 CDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPVQ 790

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1519 TSGCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESfvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSDS 1598
Cdd:pfam14228  791 VAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNMS 865

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1599 MPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCSIAVILLTDliIDHSVK 1664
Cdd:pfam14228  866 GPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEND 941

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1665 VEWGSYLHLLLHAVFIGFDHCHPEVYEHCKRLLLHLLIvmgpnsnirtvasvllrnkefneprvltvkptahsdytftag 1744
Cdd:pfam14228  942 EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLY------------------------------------------ 979

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1745 indftpdyqpspmtdsglsssstsssislgnnSAAISHLQatlLGEVDLS-VEQDGKVKTLMEFITSRKRGPLWNHEDVS 1823
Cdd:pfam14228  980 --------------------------------SLAGRHLE---LYDVEHGdGEYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1824 SKNPSIKSADQLTTFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSANTLSDVLSR 1902
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 564383567  1903 LVETVGDP 1910
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2335-3063 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1008.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2335 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2414
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2415 SVLSLCGPESGLPKNPSVIFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDSSSEQQFGVFKDFDFLDVELEDAEGESM 2494
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2495 DNFNWGVRRRSLDSIDKGDTPSLQECPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVPDDlmPDHQD 2574
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2575 -LLQSQDSASSntTEDVLqiRDETPSLEAcldnascQLPEDTSSVlkeehvtafedegpyliqdqqdplvcrgildleet 2653
Cdd:pfam19421  236 sLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR----------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2654 dmpeplapesypesvceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAYEDE 2733
Cdd:pfam19421  270 --------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2734 EEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITNEAVGFLGKSLQRIGTKFKSSLEVMMTCSECPTVFVDA 2813
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2814 ETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIDRINTNAHQMgilAELELCRRLYRLHFQ 2891
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKLHFQ 456

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2892 LLLLFQAYCKLINQVNAIKNEAEVINMSEELTQLEGILKE-----AEAASENEETDISKAAQTTIETAIHSLIETLKNKE 2966
Cdd:pfam19421  457 LLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLRNKE 536

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2967 FVSAVAQVKAFRTLWPSDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANCKLMELNLEIRESLRMVQSH 3046
Cdd:pfam19421  537 FSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGY 616

                          730
                   ....*....|....*..
gi 564383567  3047 PLLAQAKPVGKTASAGF 3063
Cdd:pfam19421  617 RALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 168-700 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 624.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   168 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 247
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   248 KKFVTELKELRQKEQSPHVVQSIISLIMGMKFFRVMMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 327
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   328 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 407
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   408 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 485
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   486 KSAKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 563
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   564 RALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 629
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   630 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 700
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2052-2305 3.51e-72

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 242.77  E-value: 3.51e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2052 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIESVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVYL 2130
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2131 LSQLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDNP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2208
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  2209 RDCANWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLASMQQSLLQIIYSLLSHVDLSAAPAKQFNLEITKTIGKYVQS 2287
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 564383567  2288 PYWKEALNILKLVVSRSA 2305
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 738-1910 6.26e-36

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 150.56  E-value: 6.26e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   738 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDEELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 817
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   818 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 897
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   898 nakKVSTTTSSDSYVGLWRNYLILCCSaaaspspsapagsvrCsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 977
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACS---------------C-PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567   978 RSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1051
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1052 ASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1131
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1132 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1184
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1185 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1227
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1228 RCYTGSRRVAAGCFRAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1306
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1307 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVdvrplpsgrrqdee 1385
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFL-------------- 652

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1386 dgSLKDrelmvtsrrwlrgEGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--ICG 1463
Cdd:pfam14228  653 --KLWE-------------SGW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIED 710

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1464 VNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYRI 1518
Cdd:pfam14228  711 CDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPVQ 790

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1519 TSGCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESfvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSDS 1598
Cdd:pfam14228  791 VAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNMS 865

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1599 MPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCSIAVILLTDliIDHSVK 1664
Cdd:pfam14228  866 GPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEND 941

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1665 VEWGSYLHLLLHAVFIGFDHCHPEVYEHCKRLLLHLLIvmgpnsnirtvasvllrnkefneprvltvkptahsdytftag 1744
Cdd:pfam14228  942 EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLY------------------------------------------ 979

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1745 indftpdyqpspmtdsglsssstsssislgnnSAAISHLQatlLGEVDLS-VEQDGKVKTLMEFITSRKRGPLWNHEDVS 1823
Cdd:pfam14228  980 --------------------------------SLAGRHLE---LYDVEHGdGEYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564383567  1824 SKNPSIKSADQLTTFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSANTLSDVLSR 1902
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 564383567  1903 LVETVGDP 1910
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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