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Conserved domains on  [gi|568910984|ref|XP_006496969|]
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tenascin-N isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
1239-1451 7.88e-114

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


:

Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 356.94  E-value: 7.88e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1239 PHPSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGL 1318
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1319 DKLHNLTTgtTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSN 1397
Cdd:cd00087    80 EKIHLLTS--QGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568910984 1398 CALTHHGGWWYKNCHLANPNGKYGETKH----SEGVNWEPWKGHEFSIPYVELKIRPF 1451
Cdd:cd00087   158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
264-332 3.66e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.06  E-value: 3.66e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568910984   264 APQGLQLLKSTENSLLVSWEP----SSEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
884-961 2.83e-13

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.67  E-value: 2.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   884 DSPKNLAIDQVTETTLSVSWDP---VQADIDRYVVRYTSADGES--KEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 958
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984   959 ESK 961
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
532-608 6.55e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 6.55e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    532 DSPENLVTDRVTENSLSVSWDPVEAD-----IDRYVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    607 ES 608
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
972-1048 2.97e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    972 DSPKNLVTNQVTENTATISWDPVQAD-----IDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1046
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1047 ES 1048
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1060-1136 4.52e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 4.52e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1060 DSPKNLVTNRVTENTATISWDPVRAN-----IDRYMVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1134
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1135 ES 1136
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
620-696 1.61e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.61e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    620 DSPKNLVTDQVTENTLSVSWDPVQAN-----IDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    695 ES 696
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
798-869 3.21e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 3.21e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   798 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 869
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
710-781 3.21e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 3.21e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   710 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 781
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
359-434 1.21e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 1.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   359 VNEETETSLDVEWENPLT---EVDYYKLRYGPLTGQEV-TEVTVPKSrdpKSRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
444-529 7.83e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  444 DGPTNVVTNQVTEDTASVSWDPVRAD---IDKYVVRYIAPDGETKEKAVPKDQSST--VLTGLKPGEAYKVFVWAERGNQ 518
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984  519 GSKKADTKALT 529
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1148-1221 5.71e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 5.71e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  1148 DPPRNLRPFGVTHSGGVLTWLPP---SAQIDGYILTYQFPNGT--VKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGN 1221
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
171-198 1.30e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 46.14  E-value: 1.30e-06
                           10        20
                   ....*....|....*....|....*...
gi 568910984   171 CPGACNGHGRCVDGQCVCDAPYVGVDCA 198
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
C_rich_MXAN6577 super family cl49352
MXAN_6577-like cysteine-rich domain;
171-237 4.36e-05

MXAN_6577-like cysteine-rich domain;


The actual alignment was detected with superfamily member NF041328:

Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 45.13  E-value: 4.36e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  171 CPGACNGHGRCVDGQCVCDAPYV--GVDCAY--------AACPQDCSGHGVCVQGVCqchedftAEDCSE--QRCPGDC 237
Cdd:NF041328   45 CGVACGAGQTCVAGACGCGPGTVacGGACVDtasdpahcGACGAACAPGQVCEGGAC-------REACSEglTRCGGAC 116
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
236-259 7.93e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 7.93e-05
                           10        20
                   ....*....|....*....|....*.
gi 568910984   236 DCSGNGFCD--TGECYCEMGFTGPDC 259
Cdd:pfam07974    1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
142-166 3.32e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 3.32e-04
                           10        20
                   ....*....|....*....|....*
gi 568910984   142 CSGHGTFLPETCSCHCDQGWEGADC 166
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
1239-1451 7.88e-114

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 356.94  E-value: 7.88e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1239 PHPSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGL 1318
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1319 DKLHNLTTgtTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSN 1397
Cdd:cd00087    80 EKIHLLTS--QGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568910984 1398 CALTHHGGWWYKNCHLANPNGKYGETKH----SEGVNWEPWKGHEFSIPYVELKIRPF 1451
Cdd:cd00087   158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
1240-1451 2.08e-102

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 325.39  E-value: 2.08e-102
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1240 HPSDCSQVQQNTNAASGLYTIYLNGdASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLD 1319
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1320 KLHNLTtgTTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDA-LTYHNGWKFTTFDRDNDIALSN 1397
Cdd:smart00186   80 NIHLLT--SQGKYELRIDLEDWeGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDAsLTYHNGMQFSTYDRDNDKYSGN 157
                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568910984   1398 CALTHHGGWWYKNCHLANPNGKYG-ETKHSEGVNWEPWKGHEFSIPYVELKIRPF 1451
Cdd:smart00186  158 CAEEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1241-1450 6.56e-85

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 276.71  E-value: 6.56e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  1241 PSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMK-EFWLGLD 1319
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGA-TKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPgEFWLGND 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  1320 KLHNLTTgtTTRYEVRADLQTFN-ESAYAVYDFFQVASSKERYKLSVGKYRGTAGDAL-------TYHNGWKFTTFDRDN 1391
Cdd:pfam00147   81 KIHLLTK--QGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtagrsmTYHNGMQFSTWDRDN 158
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568910984  1392 DIALSNCALTHHGGWWYKNCHLANPNGKY--GETKHSE-GVNWEPWKGHEFSIPYVELKIRP 1450
Cdd:pfam00147  159 DSPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRP 220
fn3 pfam00041
Fibronectin type III domain;
264-332 3.66e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.06  E-value: 3.66e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568910984   264 APQGLQLLKSTENSLLVSWEP----SSEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
884-961 2.83e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.67  E-value: 2.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   884 DSPKNLAIDQVTETTLSVSWDP---VQADIDRYVVRYTSADGES--KEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 958
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984   959 ESK 961
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
532-608 6.55e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 6.55e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    532 DSPENLVTDRVTENSLSVSWDPVEAD-----IDRYVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    607 ES 608
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
532-609 2.72e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 2.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   532 DSPENLVTDRVTENSLSVSWDPVE---ADIDRYVVSYTSVDGET--KQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984   607 ESK 609
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
972-1048 2.97e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    972 DSPKNLVTNQVTENTATISWDPVQAD-----IDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1046
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1047 ES 1048
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1060-1136 4.52e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 4.52e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1060 DSPKNLVTNRVTENTATISWDPVRAN-----IDRYMVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1134
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1135 ES 1136
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
789-1283 6.04e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 6.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  789 TKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKG 868
Cdd:COG3401    47 TTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTAT 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  869 AQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIGKEQRSTVLTGLRPGVEYK 948
Cdd:COG3401   127 TATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYY 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  949 VEVWAQKGARESKKANTEGHTDI----DSPKNLVTNQVTENTATISWDPVQA-DIDRYMV-RYTSADGETREIPVRKEKS 1022
Cdd:COG3401   207 YRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTEsDATGYRVyRSNSGDGPFTKVATVTTTS 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1023 STVlTGLRPGVEYTVQVWAQKGA----RESKKAKTKAPTEI-DSPKNLVTNRVTENTATISWDPVR-ANIDRYMV-RYTS 1095
Cdd:COG3401   287 YTD-TGLTNGTTYYYRVTAVDAAgnesAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSdADVTGYNVyRSTS 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1096 ADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQ-KGARESKKADTKALTEIDPPRNL---RPFGVTHSGGVLTWLPPS 1171
Cdd:COG3401   366 GGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGEsltASVDAVPLTDVAGATAAA 445
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1172 AQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVaFKGNQRSRTVSTTLSTVDARFPHPSDCSQVQQNT 1251
Cdd:COG3401   446 SAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS-VTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAP 524
                         490       500       510
                  ....*....|....*....|....*....|..
gi 568910984 1252 NAASGLYTIYLNGDASRPMQVYCDMDTDGGGW 1283
Cdd:COG3401   525 DGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
fn3 pfam00041
Fibronectin type III domain;
1060-1137 6.54e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 6.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  1060 DSPKNLVTNRVTENTATISWDP---VRANIDRYMVRYTSADGET--KEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1134
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984  1135 ESK 1137
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
884-960 1.02e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.02e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    884 DSPKNLAIDQVTETTLSVSWDPVQAD-----IDRYVVRYTSADGESKEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 958
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    959 ES 960
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
972-1049 1.15e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   972 DSPKNLVTNQVTENTATISWDP---VQADIDRYMVRYTSADGET--REIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1046
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984  1047 ESK 1049
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
620-696 1.61e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.61e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    620 DSPKNLVTDQVTENTLSVSWDPVQAN-----IDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    695 ES 696
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
532-617 1.68e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  532 DSPENLVTDRVTENSLSVSWDPVEAD---IDRYVVSYTSVDGET-KQVPVKK-DQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984  607 ESKKANTKAPT 617
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
798-869 3.21e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 3.21e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   798 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 869
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
710-781 3.21e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 3.21e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   710 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 781
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
708-784 3.65e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 3.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    708 DGPKNLVTDQVTETTLSVSWDPVEAD-----IDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    783 DS 784
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
796-872 3.65e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 3.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    796 DGPKNLVTDQVTETTLSVSWDPVEAD-----IDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ 870
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    871 DS 872
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
972-1057 3.96e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  972 DSPKNLVTNQVTENTATISWDPVQAD---IDRYMVRYTSADGET-REIPVRKEKS-STVLTGLRPGVEYTVQVWAQKGAR 1046
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984 1047 ESKKAKTKAPT 1057
Cdd:cd00063    82 ESPPSESVTVT 92
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
1244-1283 5.25e-11

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 58.73  E-value: 5.25e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568910984 1244 CSQV-QQNTNAASGLYTIYLNGD-ASRPMQVYCDMDTDGGGW 1283
Cdd:NF040941    2 CWEIlQAGPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1060-1145 5.91e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 5.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1060 DSPKNLVTNRVTENTATISWDPVR---ANIDRYMVRYTSADGET-KEIPVSK-DQSSTILTGLKPGMEYTIHVWAQKGAR 1134
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984 1135 ESKKADTKALT 1145
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
620-692 6.73e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 6.73e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910984   620 DSPKNLVTDQVTENTLSVSWDP---VQANIDRYMVSYTSADGET--REVPVPKEKSSTVLTGLRPGVEYKVHVWAQKG 692
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
884-966 8.48e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 8.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  884 DSPKNLAIDQVTETTLSVSWDPVQAD---IDRYVVRYTSADGESKEFLIGK--EQRSTVLTGLRPGVEYKVEVWAQKGAR 958
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ....*...
gi 568910984  959 ESKKANTE 966
Cdd:cd00063    82 ESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
264-342 8.48e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 8.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  264 APQGLQLLKSTENSLLVSWEPS----SEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDIS 339
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                  ...
gi 568910984  340 SSP 342
Cdd:cd00063    83 SPP 85
fn3 pfam00041
Fibronectin type III domain;
359-434 1.21e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 1.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   359 VNEETETSLDVEWENPLT---EVDYYKLRYGPLTGQEV-TEVTVPKSrdpKSRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
620-696 5.40e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  620 DSPKNLVTDQVTENTLSVSWDPVQ---ANIDRYMVSYTSADGET-REVPVPKEKS-STVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984  695 ES 696
Cdd:cd00063    82 ES 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
444-529 7.83e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  444 DGPTNVVTNQVTEDTASVSWDPVRAD---IDKYVVRYIAPDGETKEKAVPKDQSST--VLTGLKPGEAYKVFVWAERGNQ 518
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984  519 GSKKADTKALT 529
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
446-517 9.76e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 9.76e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   446 PTNVVTNQVTEDTASVSWDP---VRADIDKYVVRYIAPDGET--KEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGN 517
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
359-434 9.79e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 9.79e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  359 VNEETETSLDVEWENPL---TEVDYYKLRYGPLTGQEVTEVTVPKSRDPksRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:cd00063     9 VTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRAVNGGGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
796-872 2.00e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  796 DGPKNLVTDQVTETTLSVSWDPVEAD---IDRYMVRYTSPDGET-KEVPVSK-DKSSTVLRGLRPGVEYKVDVWAQKGAQ 870
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984  871 DS 872
Cdd:cd00063    82 ES 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
708-784 2.00e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  708 DGPKNLVTDQVTETTLSVSWDPVEAD---IDRYMVRYTSPDGET-KEVPVSK-DKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984  783 DS 784
Cdd:cd00063    82 ES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
264-332 2.47e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 2.47e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568910984    264 APQGLQLLKSTENSLLVSWEPSSE--VDYYLLSYYPLGKEQAT--KQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1148-1221 5.71e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 5.71e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  1148 DPPRNLRPFGVTHSGGVLTWLPP---SAQIDGYILTYQFPNGT--VKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGN 1221
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
444-520 7.32e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 7.32e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    444 DGPTNVVTNQVTEDTASVSWDPVRAD-----IDKYVVRYIAPDGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQ 518
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    519 GS 520
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
359-432 4.99e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 4.99e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910984    359 VNEETETSLDVEWENPLTE-VDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEG 432
Cdd:smart00060    9 VTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
171-198 1.30e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.14  E-value: 1.30e-06
                           10        20
                   ....*....|....*....|....*...
gi 568910984   171 CPGACNGHGRCVDGQCVCDAPYVGVDCA 198
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1148-1224 1.20e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 1.20e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1148 DPPRNLRPFGVTHSGGVLTWLPPSAQ-----IDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQ 1222
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1223 RS 1224
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1148-1224 1.31e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1148 DPPRNLRPFGVTHSGGVLTWLPPS---AQIDGYILTYQ-FPNGTVKEVELPRGQQ-RFELQDLEQGVTYPVSLVAFKGNQ 1222
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984 1223 RS 1224
Cdd:cd00063    82 ES 83
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
171-237 4.36e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 45.13  E-value: 4.36e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  171 CPGACNGHGRCVDGQCVCDAPYV--GVDCAY--------AACPQDCSGHGVCVQGVCqchedftAEDCSE--QRCPGDC 237
Cdd:NF041328   45 CGVACGAGQTCVAGACGCGPGTVacGGACVDtasdpahcGACGAACAPGQVCEGGAC-------REACSEglTRCGGAC 116
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
236-259 7.93e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 7.93e-05
                           10        20
                   ....*....|....*....|....*.
gi 568910984   236 DCSGNGFCD--TGECYCEMGFTGPDC 259
Cdd:pfam07974    1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
202-229 1.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 1.17e-04
                           10        20
                   ....*....|....*....|....*...
gi 568910984   202 CPQDCSGHGVCVQGVCQCHEDFTAEDCS 229
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
142-166 3.32e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 3.32e-04
                           10        20
                   ....*....|....*....|....*
gi 568910984   142 CSGHGTFLPETCSCHCDQGWEGADC 166
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
181-260 3.04e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 39.74  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  181 CVDGQCVCDAPYVGVDCAYA---ACPQDCSGHGVCVQGVCQCHEDftAEDCSEQrC------PGDCSGNGF-CDTGECyC 250
Cdd:NF041328   21 CPEGLSVCGGACVDLRSDPSncgACGVACGAGQTCVAGACGCGPG--TVACGGA-CvdtasdPAHCGACGAaCAPGQV-C 96
                          90
                  ....*....|
gi 568910984  251 EMGFTGPDCS 260
Cdd:NF041328   97 EGGACREACS 106
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
1239-1451 7.88e-114

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 356.94  E-value: 7.88e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1239 PHPSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGL 1318
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1319 DKLHNLTTgtTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSN 1397
Cdd:cd00087    80 EKIHLLTS--QGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568910984 1398 CALTHHGGWWYKNCHLANPNGKYGETKH----SEGVNWEPWKGHEFSIPYVELKIRPF 1451
Cdd:cd00087   158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
1240-1451 2.08e-102

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 325.39  E-value: 2.08e-102
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1240 HPSDCSQVQQNTNAASGLYTIYLNGdASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLD 1319
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1320 KLHNLTtgTTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDA-LTYHNGWKFTTFDRDNDIALSN 1397
Cdd:smart00186   80 NIHLLT--SQGKYELRIDLEDWeGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDAsLTYHNGMQFSTYDRDNDKYSGN 157
                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568910984   1398 CALTHHGGWWYKNCHLANPNGKYG-ETKHSEGVNWEPWKGHEFSIPYVELKIRPF 1451
Cdd:smart00186  158 CAEEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1241-1450 6.56e-85

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 276.71  E-value: 6.56e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  1241 PSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMK-EFWLGLD 1319
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGA-TKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPgEFWLGND 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  1320 KLHNLTTgtTTRYEVRADLQTFN-ESAYAVYDFFQVASSKERYKLSVGKYRGTAGDAL-------TYHNGWKFTTFDRDN 1391
Cdd:pfam00147   81 KIHLLTK--QGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtagrsmTYHNGMQFSTWDRDN 158
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568910984  1392 DIALSNCALTHHGGWWYKNCHLANPNGKY--GETKHSE-GVNWEPWKGHEFSIPYVELKIRP 1450
Cdd:pfam00147  159 DSPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRP 220
fn3 pfam00041
Fibronectin type III domain;
264-332 3.66e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.06  E-value: 3.66e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568910984   264 APQGLQLLKSTENSLLVSWEP----SSEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
884-961 2.83e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.67  E-value: 2.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   884 DSPKNLAIDQVTETTLSVSWDP---VQADIDRYVVRYTSADGES--KEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 958
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984   959 ESK 961
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
532-608 6.55e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 6.55e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    532 DSPENLVTDRVTENSLSVSWDPVEAD-----IDRYVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    607 ES 608
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
532-609 2.72e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 2.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   532 DSPENLVTDRVTENSLSVSWDPVE---ADIDRYVVSYTSVDGET--KQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984   607 ESK 609
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
972-1048 2.97e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    972 DSPKNLVTNQVTENTATISWDPVQAD-----IDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1046
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1047 ES 1048
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1060-1136 4.52e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 4.52e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1060 DSPKNLVTNRVTENTATISWDPVRAN-----IDRYMVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1134
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1135 ES 1136
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
789-1283 6.04e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 6.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  789 TKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKG 868
Cdd:COG3401    47 TTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTAT 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  869 AQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIGKEQRSTVLTGLRPGVEYK 948
Cdd:COG3401   127 TATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYY 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  949 VEVWAQKGARESKKANTEGHTDI----DSPKNLVTNQVTENTATISWDPVQA-DIDRYMV-RYTSADGETREIPVRKEKS 1022
Cdd:COG3401   207 YRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTEsDATGYRVyRSNSGDGPFTKVATVTTTS 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1023 STVlTGLRPGVEYTVQVWAQKGA----RESKKAKTKAPTEI-DSPKNLVTNRVTENTATISWDPVR-ANIDRYMV-RYTS 1095
Cdd:COG3401   287 YTD-TGLTNGTTYYYRVTAVDAAgnesAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSdADVTGYNVyRSTS 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1096 ADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQ-KGARESKKADTKALTEIDPPRNL---RPFGVTHSGGVLTWLPPS 1171
Cdd:COG3401   366 GGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGEsltASVDAVPLTDVAGATAAA 445
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1172 AQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVaFKGNQRSRTVSTTLSTVDARFPHPSDCSQVQQNT 1251
Cdd:COG3401   446 SAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS-VTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAP 524
                         490       500       510
                  ....*....|....*....|....*....|..
gi 568910984 1252 NAASGLYTIYLNGDASRPMQVYCDMDTDGGGW 1283
Cdd:COG3401   525 DGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
fn3 pfam00041
Fibronectin type III domain;
1060-1137 6.54e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 6.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  1060 DSPKNLVTNRVTENTATISWDP---VRANIDRYMVRYTSADGET--KEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1134
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984  1135 ESK 1137
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
884-960 1.02e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.02e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    884 DSPKNLAIDQVTETTLSVSWDPVQAD-----IDRYVVRYTSADGESKEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 958
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    959 ES 960
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
972-1049 1.15e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   972 DSPKNLVTNQVTENTATISWDP---VQADIDRYMVRYTSADGET--REIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1046
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80

                   ...
gi 568910984  1047 ESK 1049
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
620-696 1.61e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.61e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    620 DSPKNLVTDQVTENTLSVSWDPVQAN-----IDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    695 ES 696
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
532-617 1.68e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  532 DSPENLVTDRVTENSLSVSWDPVEAD---IDRYVVSYTSVDGET-KQVPVKK-DQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984  607 ESKKANTKAPT 617
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
798-869 3.21e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 3.21e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   798 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 869
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
710-781 3.21e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 3.21e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   710 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 781
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
708-784 3.65e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 3.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    708 DGPKNLVTDQVTETTLSVSWDPVEAD-----IDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    783 DS 784
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
796-872 3.65e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 3.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    796 DGPKNLVTDQVTETTLSVSWDPVEAD-----IDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ 870
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    871 DS 872
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
972-1057 3.96e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  972 DSPKNLVTNQVTENTATISWDPVQAD---IDRYMVRYTSADGET-REIPVRKEKS-STVLTGLRPGVEYTVQVWAQKGAR 1046
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984 1047 ESKKAKTKAPT 1057
Cdd:cd00063    82 ESPPSESVTVT 92
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
1244-1283 5.25e-11

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 58.73  E-value: 5.25e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568910984 1244 CSQV-QQNTNAASGLYTIYLNGD-ASRPMQVYCDMDTDGGGW 1283
Cdd:NF040941    2 CWEIlQAGPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1060-1145 5.91e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 5.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1060 DSPKNLVTNRVTENTATISWDPVR---ANIDRYMVRYTSADGET-KEIPVSK-DQSSTILTGLKPGMEYTIHVWAQKGAR 1134
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984 1135 ESKKADTKALT 1145
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
620-692 6.73e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 6.73e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910984   620 DSPKNLVTDQVTENTLSVSWDP---VQANIDRYMVSYTSADGET--REVPVPKEKSSTVLTGLRPGVEYKVHVWAQKG 692
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
884-966 8.48e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 8.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  884 DSPKNLAIDQVTETTLSVSWDPVQAD---IDRYVVRYTSADGESKEFLIGK--EQRSTVLTGLRPGVEYKVEVWAQKGAR 958
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ....*...
gi 568910984  959 ESKKANTE 966
Cdd:cd00063    82 ESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
264-342 8.48e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 8.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  264 APQGLQLLKSTENSLLVSWEPS----SEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDIS 339
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                  ...
gi 568910984  340 SSP 342
Cdd:cd00063    83 SPP 85
fn3 pfam00041
Fibronectin type III domain;
359-434 1.21e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 1.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   359 VNEETETSLDVEWENPLT---EVDYYKLRYGPLTGQEV-TEVTVPKSrdpKSRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
620-696 5.40e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  620 DSPKNLVTDQVTENTLSVSWDPVQ---ANIDRYMVSYTSADGET-REVPVPKEKS-STVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984  695 ES 696
Cdd:cd00063    82 ES 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
327-683 6.29e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.87  E-value: 6.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  327 YIVTLRNVKKDISSSPQHLLATTDLAVVGTAWVNEETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKS 406
Cdd:COG3401    24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSV 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  407 RYDI-TGLQPGTEYKITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDKYVVRYIAPDGETK 485
Cdd:COG3401   104 GGATnTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  486 EKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQGSKKAD----TKALTEIDSPENLVTDRVTENSLSVSWDPV-EADIDR 560
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVtESDATG 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  561 YVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGD-RESKKANT-KAPTDI---DSPKNLVTDQVTENTL 635
Cdd:COG3401   264 YRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVvSVTTDLtppAAPSGLTATAVGSSSI 343
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 568910984  636 SVSWDPV-QANIDRYMVSY-TSADGETREVPVPKEKSSTVLTGLRPGVEY 683
Cdd:COG3401   344 TLSWTASsDADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTY 393
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
444-529 7.83e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  444 DGPTNVVTNQVTEDTASVSWDPVRAD---IDKYVVRYIAPDGETKEKAVPKDQSST--VLTGLKPGEAYKVFVWAERGNQ 518
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
                          90
                  ....*....|.
gi 568910984  519 GSKKADTKALT 529
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
446-517 9.76e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 9.76e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910984   446 PTNVVTNQVTEDTASVSWDP---VRADIDKYVVRYIAPDGET--KEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGN 517
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
359-434 9.79e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 9.79e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  359 VNEETETSLDVEWENPL---TEVDYYKLRYGPLTGQEVTEVTVPKSRDPksRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:cd00063     9 VTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRAVNGGGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
796-872 2.00e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  796 DGPKNLVTDQVTETTLSVSWDPVEAD---IDRYMVRYTSPDGET-KEVPVSK-DKSSTVLRGLRPGVEYKVDVWAQKGAQ 870
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984  871 DS 872
Cdd:cd00063    82 ES 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
708-784 2.00e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  708 DGPKNLVTDQVTETTLSVSWDPVEAD---IDRYMVRYTSPDGET-KEVPVSK-DKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984  783 DS 784
Cdd:cd00063    82 ES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
264-332 2.47e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 2.47e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568910984    264 APQGLQLLKSTENSLLVSWEPSSE--VDYYLLSYYPLGKEQAT--KQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1148-1221 5.71e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 5.71e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  1148 DPPRNLRPFGVTHSGGVLTWLPP---SAQIDGYILTYQFPNGT--VKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGN 1221
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
444-520 7.32e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 7.32e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984    444 DGPTNVVTNQVTEDTASVSWDPVRAD-----IDKYVVRYIAPDGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQ 518
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984    519 GS 520
Cdd:smart00060   82 EG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
714-1116 4.29e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 58.03  E-value: 4.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  714 VTDQVTETTLSVSWDPVEADIdRYMVRYTSPDGETKEVPVSkDKSSTVLRGLRPGvEYKVDVWAqKGAQDSRKANTKAP- 792
Cdd:COG4733   545 VAQGTAVTTLTVSWDAPAGAV-AYEVEWRRDDGNWVSVPRT-SGTSFEVPGIYAG-DYEVRVRA-INALGVSSAWAASSe 620
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  793 TDIDG-------PKNL-VTDQVTETTLsvSWD-PVEADIDRYMVRY-TSPDGETKEVPVSKDKSST-VLRGLRPGVEYK- 860
Cdd:COG4733   621 TTVTGktapppaPTGLtATGGLGGITL--SWSfPVDADTLRTEIRYsTTGDWASATVAQALYPGNTyTLAGLKAGQTYYy 698
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  861 ----VDVWAQKGAQDsrkANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQ--ADIDRYVVRYTSADGESKEFLIGKEQR 934
Cdd:COG4733   699 raraVDRSGNVSAWW---VSGQASADAAGILDAITGQILETELGQELDAIIqnATVAEVVAATVTDVTAQIDTAVLFAGV 775
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  935 STVL-TGLRPGVEYKVEVWAQKGARESkkANTEGHTDIDSPKNLVTNQVTENTATISWDPVQADIDRYMVRYTSADGETR 1013
Cdd:COG4733   776 ATAAaIGAEARVAATVAESATAAAATG--TAADAAGDASGGVTAGTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIIE 853
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1014 eipvrkekssTVLTGLRPGVEYTVQVWAQKGARESKKAKTKAPTEIDSPKNLVTN----RVTENTATISWDPVRANIDRY 1089
Cdd:COG4733   854 ----------SGNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADSTAASLTaiviAATTIIDAIGDGTTREPAGDI 923
                         410       420
                  ....*....|....*....|....*..
gi 568910984 1090 MVRYTSAdGETKEIPVSKDQSSTILTG 1116
Cdd:COG4733   924 GASGGAQ-GFAVTIVGSFDGAGAVATV 949
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
359-432 4.99e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 4.99e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910984    359 VNEETETSLDVEWENPLTE-VDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEG 432
Cdd:smart00060    9 VTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
171-198 1.30e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.14  E-value: 1.30e-06
                           10        20
                   ....*....|....*....|....*...
gi 568910984   171 CPGACNGHGRCVDGQCVCDAPYVGVDCA 198
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
301-575 1.56e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 53.03  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  301 EQATKQVRV----PKEQHTYDITGLL--PGtKYIVTLRNVKKDISssPQHLLATTDLAVVGTAWVNEETETSLDVEWENP 374
Cdd:COG4733   485 ELETQLFRVvsieENEDGTYTITAVQhaPE-KYAAIDAGAFDDVP--PQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAP 561
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  375 lTEVDYYKLRYGPLTGqevTEVTVPksRDPKSRYDITGLQPGTeYKITVVPI-RGDLEGKP-----ILLNGRteIDGPTN 448
Cdd:COG4733   562 -AGAVAYEVEWRRDDG---NWVSVP--RTSGTSFEVPGIYAGD-YEVRVRAInALGVSSAWaasseTTVTGK--TAPPPA 632
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  449 VVTNQVTEDT--ASVSWD-PVRADIDKYVVRYI-APDGETKEKAVPKDQSST-VLTGLKPGEAYKVFVWAE--RGNQGSK 521
Cdd:COG4733   633 PTGLTATGGLggITLSWSfPVDADTLRTEIRYStTGDWASATVAQALYPGNTyTLAGLKAGQTYYYRARAVdrSGNVSAW 712
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568910984  522 KADTKALTEIDSPENLVTDRVTENSLSVSWDPVEADIDRYVVSYTSVDGETKQV 575
Cdd:COG4733   713 WVSGQASADAAGILDAITGQILETELGQELDAIIQNATVAEVVAATVTDVTAQI 766
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
264-559 1.08e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  264 APQGLQLLKSTENSLLVSWEPSSEVDyylLSYYPL--GKEQATKQVRVPKEQHT-YDITGLLPGTK--YIVTLRNVKKDI 338
Cdd:COG3401   235 APTGLTATADTPGSVTLSWDPVTESD---ATGYRVyrSNSGDGPFTKVATVTTTsYTDTGLTNGTTyyYRVTAVDAAGNE 311
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  339 SSSPQHLLATTDL----AVVGTAwVNEETETSLDVEWENPLTE-VDYYKLRYGPLTGQEVTEVTVPKSrdpKSRYDITGL 413
Cdd:COG3401   312 SAPSNVVSVTTDLtppaAPSGLT-ATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGGTYTKIAETVT---TTSYTDTGL 387
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  414 QPGTEYKITVVPIRGDLEGKPillngrteidgPTNVVTnqVTEDTASVSWDPVRADIDKYVVRYIAPDGETKEKAVPKDQ 493
Cdd:COG3401   388 TPGTTYYYKVTAVDAAGNESA-----------PSEEVS--ATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVS 454
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568910984  494 SSTVLTGLKPGEAYKvfVWAERGNQGSKKADTKALTEIDSPENLVTDRVTENSLSVSWDPVEADID 559
Cdd:COG3401   455 AAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1148-1224 1.20e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 1.20e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   1148 DPPRNLRPFGVTHSGGVLTWLPPSAQ-----IDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQ 1222
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 568910984   1223 RS 1224
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1148-1224 1.31e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984 1148 DPPRNLRPFGVTHSGGVLTWLPPS---AQIDGYILTYQ-FPNGTVKEVELPRGQQ-RFELQDLEQGVTYPVSLVAFKGNQ 1222
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81

                  ..
gi 568910984 1223 RS 1224
Cdd:cd00063    82 ES 83
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
171-237 4.36e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 45.13  E-value: 4.36e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568910984  171 CPGACNGHGRCVDGQCVCDAPYV--GVDCAY--------AACPQDCSGHGVCVQGVCqchedftAEDCSE--QRCPGDC 237
Cdd:NF041328   45 CGVACGAGQTCVAGACGCGPGTVacGGACVDtasdpahcGACGAACAPGQVCEGGAC-------REACSEglTRCGGAC 116
DUF4998 pfam16389
Domain of unknown function; This family around 200 residues locates in the N-terminal of some ...
985-1124 5.49e-05

Domain of unknown function; This family around 200 residues locates in the N-terminal of some uncharacterized proteins in various Bacteroides and Parabacteroides species. The function of this family remains unknown.


Pssm-ID: 435316 [Multi-domain]  Cd Length: 199  Bit Score: 45.77  E-value: 5.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984   985 NTATISW----DPVQADIDRYmvrytsADGETREIPVRKeksstvltgLRPGVeYTVQVWAqkgarESKKAKTKAPTEI- 1059
Cdd:pfam16389   48 VKAKIFWnnglDSLEVPITRT------AGVDTISVIIDN---------LPEGS-YTFSIRT-----YDKKGNSSVPSEVt 106
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910984  1060 -----DSPKNLVTNRV-------TENTATISWDPVRANIDRY-MVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYT 1124
Cdd:pfam16389  107 gtvygDSYQASLTNRSlksveitAGSNLTINWSPVLASALVGtEVTYTNNDGKVKTVRIKNGETQTVLPDFKPGTSFK 184
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
236-259 7.93e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 7.93e-05
                           10        20
                   ....*....|....*....|....*.
gi 568910984   236 DCSGNGFCD--TGECYCEMGFTGPDC 259
Cdd:pfam07974    1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
202-229 1.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 1.17e-04
                           10        20
                   ....*....|....*....|....*...
gi 568910984   202 CPQDCSGHGVCVQGVCQCHEDFTAEDCS 229
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
174-197 1.36e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 1.36e-04
                           10        20
                   ....*....|....*....|....*.
gi 568910984   174 ACNGHGRCVD--GQCVCDAPYVGVDC 197
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
142-166 3.32e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 3.32e-04
                           10        20
                   ....*....|....*....|....*
gi 568910984   142 CSGHGTFLPETCSCHCDQGWEGADC 166
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
264-465 7.00e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 7.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  264 APQGLQLLKSTENSLLVSWEPSSEVD--YYLLsYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDISSS 341
Cdd:COG3401   329 APSGLTATAVGSSSITLSWTASSDADvtGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNES 407
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  342 PQhllattDLAVVGTAWVNEETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLqPGTEYKI 421
Cdd:COG3401   408 AP------SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTT-SSTVTAT 480
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 568910984  422 TVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDP 465
Cdd:COG3401   481 TTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAP 524
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
181-233 1.79e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.79  E-value: 1.79e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568910984   181 CVDGQCVCDAPYvGVDCAYaacPQDCSGHGVCVQGVCQCHEDFTAEDcseQRC 233
Cdd:pfam01683    7 LVNGQCVPKVAP-GESCEA---DEQCPGGSVCVNGVCQCPPGFTPVN---GRC 52
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
233-260 1.96e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|....*...
gi 568910984   233 CPGDCSGNGFCDTGECYCEMGFTGPDCS 260
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
181-260 3.04e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 39.74  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  181 CVDGQCVCDAPYVGVDCAYA---ACPQDCSGHGVCVQGVCQCHEDftAEDCSEQrC------PGDCSGNGF-CDTGECyC 250
Cdd:NF041328   21 CPEGLSVCGGACVDLRSDPSncgACGVACGAGQTCVAGACGCGPG--TVACGGA-CvdtasdPAHCGACGAaCAPGQV-C 96
                          90
                  ....*....|
gi 568910984  251 EMGFTGPDCS 260
Cdd:NF041328   97 EGGACREACS 106
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
273-660 5.25e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.47  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  273 STENSLLVSWEPSSEVDYYLLSYYPLGKEQatkqVRVPKEQHT-YDITGLLPGTkYIVTLR-----NVKKDISSSPQHLL 346
Cdd:COG4733   549 TAVTTLTVSWDAPAGAVAYEVEWRRDDGNW----VSVPRTSGTsFEVPGIYAGD-YEVRVRainalGVSSAWAASSETTV 623
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  347 --------ATTDLAVVGTAWvneetetSLDVEWENPL-TEVDYYKLRYGplTGQEVTEVTVPKSRDPKSRYDITGLQPGT 417
Cdd:COG4733   624 tgktapppAPTGLTATGGLG-------GITLSWSFPVdADTLRTEIRYS--TTGDWASATVAQALYPGNTYTLAGLKAGQ 694
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  418 EYKITV--VPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDkyVVRYIAPDGETKEKAVPKDQSS 495
Cdd:COG4733   695 TYYYRAraVDRSGNVSAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT--VAEVVAATVTDVTAQIDTAVLF 772
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  496 TVLTGLKPGEAYKVFVWAERGNQGSKKADTKALTEIDSPENLVTDrvTENSLSVSWDPVEADIDRYVVSYTSVDGETKQV 575
Cdd:COG4733   773 AGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGVTA--GTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDA 850
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910984  576 pvkkdQRSTVLTGLSPGVEYKVYVWAEKGDRESkkantkaPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTS 655
Cdd:COG4733   851 -----IIESGNTGDIVATGDIASAAAGAVATTV-------SGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGTTRE 918

                  ....*
gi 568910984  656 ADGET 660
Cdd:COG4733   919 PAGDI 923
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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