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Conserved domains on  [gi|568942593|ref|XP_006506535|]
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Krueppel-like factor 15 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF15_N cd21580
N-terminal domain of Kruppel-like factor 15; Kruppel-like factor 15 (KLF15; also known as ...
 108-425 1.77e-83

N-terminal domain of Kruppel-like factor 15; Kruppel-like factor 15 (KLF15; also known as Krueppel-like factor 15 or kidney-enriched Kruppel-like factor/KKLF) is a protein that in humans is encoded by the KLF15 gene. KLF15 plays a role in gluconeogenesis, adipogenesis, and may be a potential therapeutic target to reduce hepatitis B virus gene expression and viral replication, heart failure and aortic aneurysm formation, and endometrial, breast cancer, and other diseases related to estrogen. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF15.


:

Pssm-ID: 410206  Cd Length: 213  Bit Score: 256.53  E-value: 1.77e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 108 DHLLPVDETFSSPKCSVGYLGDRLASRQPYHMLPSPISED-DSDVSSPCSCASPDSQAFCSCYsagpgpeaqgsildfll 186
Cdd:cd21580    1 DHLLPVEETFLPYTCSVGYLSDMVSDRRSYQMLPSPLSEDlDSDSSSPRSCSSPDSQVLSSSL----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 187 sratlgsgggsggigdssgpvtwgswrrasvpvKEEHFCFPEFLSGDTDDVSRPFQPTLEEIEEFLEENMEAEVKEApen 266
Cdd:cd21580   64 ---------------------------------KEECFEFPVFLDDMEDPAAGPFQPTLEEIEEFLEENMEVVLKKG--- 107

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 267 gsrdletcsqlsagshrshlhpesagrerctpppggtsgggaqsagegpahdgpVPVLLQIQPVAVKQEAGTGPASPGQA 346
Cdd:cd21580  108 ------------------------------------------------------VPVILQIQPVQVKQEPGTSPVSPPQA 133

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 347 PESVKVAQLLVNIQGQTFALLPQVVPSSNLNLPSKFVRIAPVPIAAKPIGSGSLGPGPAGLLV-GQKFPKNPAAELLKMH 425
Cdd:cd21580  134 PSDIKIAQLLVNIQGQTFALVPQVVQSANLSLSSKFVRIAPVPIAAKPVGLGEGGGGQSGGLVgGQKFQKSPVADLIKMH 213
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-463 6.24e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.24e-03
                          10        20
                  ....*....|....*....|...
gi 568942593  441 HLKAHLRRHTGEKPFACtwPGCG 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECG 21
 
Name Accession Description Interval E-value
KLF15_N cd21580
N-terminal domain of Kruppel-like factor 15; Kruppel-like factor 15 (KLF15; also known as ...
 108-425 1.77e-83

N-terminal domain of Kruppel-like factor 15; Kruppel-like factor 15 (KLF15; also known as Krueppel-like factor 15 or kidney-enriched Kruppel-like factor/KKLF) is a protein that in humans is encoded by the KLF15 gene. KLF15 plays a role in gluconeogenesis, adipogenesis, and may be a potential therapeutic target to reduce hepatitis B virus gene expression and viral replication, heart failure and aortic aneurysm formation, and endometrial, breast cancer, and other diseases related to estrogen. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF15.


Pssm-ID: 410206  Cd Length: 213  Bit Score: 256.53  E-value: 1.77e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 108 DHLLPVDETFSSPKCSVGYLGDRLASRQPYHMLPSPISED-DSDVSSPCSCASPDSQAFCSCYsagpgpeaqgsildfll 186
Cdd:cd21580    1 DHLLPVEETFLPYTCSVGYLSDMVSDRRSYQMLPSPLSEDlDSDSSSPRSCSSPDSQVLSSSL----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 187 sratlgsgggsggigdssgpvtwgswrrasvpvKEEHFCFPEFLSGDTDDVSRPFQPTLEEIEEFLEENMEAEVKEApen 266
Cdd:cd21580   64 ---------------------------------KEECFEFPVFLDDMEDPAAGPFQPTLEEIEEFLEENMEVVLKKG--- 107

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 267 gsrdletcsqlsagshrshlhpesagrerctpppggtsgggaqsagegpahdgpVPVLLQIQPVAVKQEAGTGPASPGQA 346
Cdd:cd21580  108 ------------------------------------------------------VPVILQIQPVQVKQEPGTSPVSPPQA 133

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 347 PESVKVAQLLVNIQGQTFALLPQVVPSSNLNLPSKFVRIAPVPIAAKPIGSGSLGPGPAGLLV-GQKFPKNPAAELLKMH 425
Cdd:cd21580  134 PSDIKIAQLLVNIQGQTFALVPQVVQSANLSLSSKFVRIAPVPIAAKPVGLGEGGGGQSGGLVgGQKFQKSPVADLIKMH 213
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-463 6.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.24e-03
                          10        20
                  ....*....|....*....|...
gi 568942593  441 HLKAHLRRHTGEKPFACtwPGCG 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECG 21
 
Name Accession Description Interval E-value
KLF15_N cd21580
N-terminal domain of Kruppel-like factor 15; Kruppel-like factor 15 (KLF15; also known as ...
 108-425 1.77e-83

N-terminal domain of Kruppel-like factor 15; Kruppel-like factor 15 (KLF15; also known as Krueppel-like factor 15 or kidney-enriched Kruppel-like factor/KKLF) is a protein that in humans is encoded by the KLF15 gene. KLF15 plays a role in gluconeogenesis, adipogenesis, and may be a potential therapeutic target to reduce hepatitis B virus gene expression and viral replication, heart failure and aortic aneurysm formation, and endometrial, breast cancer, and other diseases related to estrogen. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF15.


Pssm-ID: 410206  Cd Length: 213  Bit Score: 256.53  E-value: 1.77e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 108 DHLLPVDETFSSPKCSVGYLGDRLASRQPYHMLPSPISED-DSDVSSPCSCASPDSQAFCSCYsagpgpeaqgsildfll 186
Cdd:cd21580    1 DHLLPVEETFLPYTCSVGYLSDMVSDRRSYQMLPSPLSEDlDSDSSSPRSCSSPDSQVLSSSL----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 187 sratlgsgggsggigdssgpvtwgswrrasvpvKEEHFCFPEFLSGDTDDVSRPFQPTLEEIEEFLEENMEAEVKEApen 266
Cdd:cd21580   64 ---------------------------------KEECFEFPVFLDDMEDPAAGPFQPTLEEIEEFLEENMEVVLKKG--- 107

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 267 gsrdletcsqlsagshrshlhpesagrerctpppggtsgggaqsagegpahdgpVPVLLQIQPVAVKQEAGTGPASPGQA 346
Cdd:cd21580  108 ------------------------------------------------------VPVILQIQPVQVKQEPGTSPVSPPQA 133

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942593 347 PESVKVAQLLVNIQGQTFALLPQVVPSSNLNLPSKFVRIAPVPIAAKPIGSGSLGPGPAGLLV-GQKFPKNPAAELLKMH 425
Cdd:cd21580  134 PSDIKIAQLLVNIQGQTFALVPQVVQSANLSLSSKFVRIAPVPIAAKPVGLGEGGGGQSGGLVgGQKFQKSPVADLIKMH 213
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-463 6.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.24e-03
                          10        20
                  ....*....|....*....|...
gi 568942593  441 HLKAHLRRHTGEKPFACtwPGCG 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECG 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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