|
Name |
Accession |
Description |
Interval |
E-value |
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
14-371 |
5.51e-171 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 484.00 E-value: 5.51e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 14 IGSWSS-RRMGAFRAA----LEGVAI-ADNVIYVADTENHLIRKIDLEAEKVTTVAGVGIQGTDTEGGEEGDKQPISSPW 87
Cdd:cd14951 1 IGSGERgLKDGSFAEAsfnePQGLALlPGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 88 DVALGTSgsevqrNDILWIAMAGTHQIWALLLDSGTlpkksdlkkgtCIRFAGSGNEENRNNAYPHKAGFAQPSGLALAs 167
Cdd:cd14951 81 DVAWGPE------DDILYIAMAGTHQIWAYDLDTGT-----------CRVFAGSGNEGNRNGPYPHEAWFAQPSGLSLA- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 168 eePWSCLFVADSESSTVRTVSLRDGAVKHLVGGERDPMNLFAFGDVDGAGINAKLQHPLGVAWDEERQVlYVADSYNHKI 247
Cdd:cd14951 143 --GWGELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPDGSV-YVADTYNHKI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 248 KVVDPKTKGCTTLAGTGDASDASssfAESAFNEPGGLCIGESGRlLYVADTNNHQIKVMDLEARTVSVLPVcksDSAVVD 327
Cdd:cd14951 220 KRVDPATGEVSTLAGTGKAGYKD---LEAQFSEPSGLVVDGDGR-LYVADTNNHRIRRLDLPTEALEVLTL---AHRTLR 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 569007656 328 GSFPREKQKTVPKVPKSAAHIGLPPVTvhPGQALQLRLKLQLPP 371
Cdd:cd14951 293 PATPPAPGPLRLRVRFTAPAGQKLDDR--WGPSTRLKLSISPPE 334
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
21-472 |
6.07e-86 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 284.82 E-value: 6.07e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 21 RMGAFRAAL----EGVA--IADNVIYVADTENHLIRKIDLEAEKVTTVAGVGIQGTDTEGGEEGDKQPISSPWDVALGTS 94
Cdd:PLN02919 614 RDGSFEDATfnrpQGLAynAKKNLLYVADTENHALREIDFVNETVRTLAGNGTKGSDYQGGKKGTSQVLNSPWDVCFEPV 693
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 95 gsevqrNDILWIAMAGTHQIWallldsgtlpkKSDLKKGTCIRFAGSGNEENRNNAYPHKAGFAQPSGLALASEepWSCL 174
Cdd:PLN02919 694 ------NEKVYIAMAGQHQIW-----------EYNISDGVTRVFSGDGYERNLNGSSGTSTSFAQPSGISLSPD--LKEL 754
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 175 FVADSESSTVRTVSLRDGAVKHLVGGerDPM---NLFAFGDVDGAGINAKLQHPLGVAWDEERQVlYVADSYNHKIKVVD 251
Cdd:PLN02919 755 YIADSESSSIRALDLKTGGSRLLAGG--DPTfsdNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQI-YVADSYNHKIKKLD 831
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 252 PKTKGCTTLAGTGDASDASSSFAESAFNEPGGLCIGESGRlLYVADTNNHQIKVMDLEARTVSVLPVCKsdsavVDGSFP 331
Cdd:PLN02919 832 PATKRVTTLAGTGKAGFKDGKALKAQLSEPAGLALGENGR-LFVADTNNSLIRYLDLNKGEAAEILTLE-----LKGVQP 905
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 332 REKQKTVPKVPKSAAHIGLPPVTVHPGQALQ--LRLKLQLPPGAKLTEGAPSCWFLEAEGNEWLLQEqtPSGDIENISNQ 409
Cdd:PLN02919 906 PRPKSKSLKRLRRRSSADTQVIKVDGVTSLEgdLQLKISLPPGYHFSKEARSKFEVEVEPENAVDID--PDEGTLSPDGR 983
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007656 410 PAISLQIPTHCLSLEAVVSVVvflYYCSADsSACMMKGVVFRQPLQiTSTQPACAAPVELAYA 472
Cdd:PLN02919 984 ASLHFKRSSASASTGRISCKV---YYCKED-EVCLYQSLVFEVPFE-EENGGESSSSITLKYT 1041
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
30-303 |
1.74e-38 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 142.28 E-value: 1.74e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 30 EGVAI-ADNVIYVADTENHLIRKIDLEAEkVTTVAGVGIQGTDtegGEEGDKQPISSPWDVALGTSGSevqrndiLWIAM 108
Cdd:cd14953 26 SGVAVdAAGNLYVADRGNHRIRKITPDGV-VTTVAGTGTAGFA---DGGGAAAQFNTPSGVAVDAAGN-------LYVAD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 109 AGTHQIwallldsgtlpKKSDLkKGTCIRFAGSGNEENRNNAYPHKAGFAQPSGLALaseEPWSCLFVADSESSTVRTVS 188
Cdd:cd14953 95 TGNHRI-----------RKITP-DGVVSTLAGTGTAGFSDDGGATAAQFNYPTGVAV---DAAGNLYVADTGNHRIRKIT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 189 lRDGAVKHLVGGERdpmnlfAFGDVDGAGINAKLQHPLGVAWDEErQVLYVADSYNHKIKVVDPKTKGcTTLAGTGDASD 268
Cdd:cd14953 160 -PDGVVTTVAGTGG------AGYAGDGPATAAQFNNPTGVAVDAA-GNLYVADRGNHRIRKITPDGVV-TTVAGTGTAGF 230
|
250 260 270
....*....|....*....|....*....|....*.
gi 569007656 269 ASSSFAESA-FNEPGGLCIGESGRlLYVADTNNHQI 303
Cdd:cd14953 231 SGDGGATAAqLNNPTGVAVDAAGN-LYVADSGNHRI 265
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
31-303 |
1.03e-36 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 137.66 E-value: 1.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAI--ADNvIYVADTENHLIRKIDLeAEKVTTVAGVGIQGTDTEGGeeGDKQPISSPWDVALGTSGsevqrndILWIAM 108
Cdd:cd14953 81 GVAVdaAGN-LYVADTGNHRIRKITP-DGVVSTLAGTGTAGFSDDGG--ATAAQFNYPTGVAVDAAG-------NLYVAD 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 109 AGTHQIwallldsgtlpKKSDlKKGTCIRFAGSGNEENRNNAYPHKAGFAQPSGLALASEEpwsCLFVADSESSTVRTVS 188
Cdd:cd14953 150 TGNHRI-----------RKIT-PDGVVTTVAGTGGAGYAGDGPATAAQFNNPTGVAVDAAG---NLYVADRGNHRIRKIT 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 189 LrDGAVKHLVGgerdpmNLFAFGDVDGAGINAKLQHPLGVAWDEeRQVLYVADSYNHKIKVVDPKTKGcTTLAG-----T 263
Cdd:cd14953 215 P-DGVVTTVAG------TGTAGFSGDGGATAAQLNNPTGVAVDA-AGNLYVADSGNHRIRKITPAGVV-TTVAGggagfS 285
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 569007656 264 GDASDASSsfaeSAFNEPGGLCIGESGRlLYVADTNNHQI 303
Cdd:cd14953 286 GDGGPATS----AQFNNPTGVAVDAAGN-LYVADTGNNRI 320
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
31-313 |
1.59e-35 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 132.83 E-value: 1.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAIA-DNVIYVADTENHLIRKIDLEAEKVTTVAGVGiqgtdteggeEGDKQpISSPWDVALGTSGSevqrndiLWIAMA 109
Cdd:cd05819 12 GIAVDsSGNIYVADTGNNRIQVFDPDGNFITSFGSFG----------SGDGQ-FNEPAGVAVDSDGN-------LYVADT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 110 GTHQIwallldsgtlpKKSDLKKGTCIRFAGSGNEENrnnayphkaGFAQPSGLALASEepwSCLFVADSESSTVRTVSl 189
Cdd:cd05819 74 GNHRI-----------QKFDPDGNFLASFGGSGDGDG---------EFNGPRGIAVDSS---GNIYVADTGNHRIQKFD- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 190 RDGAVKHLVGGErdpmnlfafgdvdGAGiNAKLQHPLGVAWDEERQVlYVADSYNHKIKVVDPKTkgcTTLAGTGdasda 269
Cdd:cd05819 130 PDGEFLTTFGSG-------------GSG-PGQFNGPTGVAVDSDGNI-YVADTGNHRIQVFDPDG---NFLTTFG----- 186
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 569007656 270 SSSFAESAFNEPGGLCIGESGRlLYVADTNNHQIKVMDLEARTV 313
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGN-IYVADSGNNRVQVFDPDGAGF 229
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
31-305 |
6.41e-29 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 114.72 E-value: 6.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAI-ADNVIYVADTENHLIRKIDLEAEKVTTVAGVGIQGTDteggeegdkqpISSPWDVALGTSGSevqrndiLWIAMA 109
Cdd:cd05819 59 GVAVdSDGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGE-----------FNGPRGIAVDSSGN-------IYVADT 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 110 GTHQIWAllLDSGtlpkksdlkkGTCIRFAGSGNEENrnnayphkAGFAQPSGLALASEEPwscLFVADSESSTVRTVSL 189
Cdd:cd05819 121 GNHRIQK--FDPD----------GEFLTTFGSGGSGP--------GQFNGPTGVAVDSDGN---IYVADTGNHRIQVFDP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 190 RDGAVkhlvggerdpmnlFAFGDvDGAGiNAKLQHPLGVAWDEERqVLYVADSYNHKIKVVDPktkGCTTLAGTGDASDA 269
Cdd:cd05819 178 DGNFL-------------TTFGS-TGTG-PGQFNYPTGIAVDSDG-NIYVADSGNNRVQVFDP---DGAGFGGNGNFLGS 238
|
250 260 270
....*....|....*....|....*....|....*.
gi 569007656 270 SSSfaesaFNEPGGLCIGESGRlLYVADTNNHQIKV 305
Cdd:cd05819 239 DGQ-----FNRPSGLAVDSDGN-LYVADTGNNRIQV 268
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
155-307 |
4.19e-24 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 102.61 E-value: 4.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 155 AGFAQPSGLALASEepwSCLFVADSESSTVRTVSlRDGAVKHLVGGErdpmnlfAFGDVDGAGINAKLQHPLGVAWDEER 234
Cdd:cd14953 20 ARFNSPSGVAVDAA---GNLYVADRGNHRIRKIT-PDGVVTTVAGTG-------TAGFADGGGAAAQFNTPSGVAVDAAG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007656 235 QvLYVADSYNHKIKVVDPKTkGCTTLAGTGDASDASSSFAESA-FNEPGGLCIGESGRLlYVADTNNHQIKVMD 307
Cdd:cd14953 89 N-LYVADTGNHRIRKITPDG-VVSTLAGTGTAGFSDDGGATAAqFNYPTGVAVDAAGNL-YVADTGNHRIRKIT 159
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
157-317 |
6.09e-21 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 92.38 E-value: 6.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 157 FAQPSGLALASEepwSCLFVADSESSTVRTVSlRDGAVKHLVGGerdpmnlfaFGDVDGaginaKLQHPLGVAWDEERQv 236
Cdd:cd05819 7 LNNPQGIAVDSS---GNIYVADTGNNRIQVFD-PDGNFITSFGS---------FGSGDG-----QFNEPAGVAVDSDGN- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 237 LYVADSYNHKIKVVDPKTKGCTTLAGTGDasdasssfAESAFNEPGGLCIGESGRlLYVADTNNHQIKVMDLEARTVSVL 316
Cdd:cd05819 68 LYVADTGNHRIQKFDPDGNFLASFGGSGD--------GDGEFNGPRGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLTTF 138
|
.
gi 569007656 317 P 317
Cdd:cd05819 139 G 139
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
31-317 |
1.57e-18 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 85.46 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAI-ADNVIYVADTENHLIRKIDLEAEKVTTVAGVGiqgtdteggeegdkqPISSPWDVALGTSGSevqrndiLWIAMA 109
Cdd:COG4257 63 GIAVdPDGNLWFTDNGNNRIGRIDPKTGEITTFALPG---------------GGSNPHGIAFDPDGN-------LWFTDQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 110 GTHQIWALLLDSGTLpkksdlkkgtcirfagsgneenrnNAYPHKAGFAQPSGLALASE-EPWsclfVADSESSTVRTVS 188
Cdd:COG4257 121 GGNRIGRLDPATGEV------------------------TEFPLPTGGAGPYGIAVDPDgNLW----VTDFGANAIGRID 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 189 LRDGAVKHLVGgerdpmnlfafgdvdgagiNAKLQHPLGVAWDEErQVLYVADSYNHKIKVVDPKTKGCTTLAGTGDASd 268
Cdd:COG4257 173 PDTGTLTEYAL-------------------PTPGAGPRGLAVDPD-GNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGA- 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 569007656 269 asssfaesafnEPGGLCIGESGRlLYVADTNNHQIKVMDLEAR-TVSVLP 317
Cdd:COG4257 232 -----------RPYGVAVDGDGR-VWFAESGANRIVRFDPDTElTEYVLP 269
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
209-316 |
1.77e-17 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 82.96 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 209 AFGDVDGAGINAKLQHPLGVAWDEErQVLYVADSYNHKIKVVDPKTKgCTTLAGTGDASDASSSFAESAFNEPGGLCIGE 288
Cdd:cd14953 9 TAGFSGGGGTAARFNSPSGVAVDAA-GNLYVADRGNHRIRKITPDGV-VTTVAGTGTAGFADGGGAAAQFNTPSGVAVDA 86
|
90 100
....*....|....*....|....*...
gi 569007656 289 SGRlLYVADTNNHQIKVMDLeARTVSVL 316
Cdd:cd14953 87 AGN-LYVADTGNHRIRKITP-DGVVSTL 112
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
29-305 |
1.62e-16 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 79.63 E-value: 1.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 29 LEGVAIA-DNVIYVADTENHLIRKIDLEAEKVTTvagvgiqgtdteGGEEGDKQP-ISSPWDVALGTSGSevqrndiLWI 106
Cdd:cd14956 62 PRGLAVDkDGWLYVADYWGDRIQVFTLTGELQTI------------GGSSGSGPGqFNAPRGVAVDADGN-------LYV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 107 AMAGTHQIWALLLDsgtlpkksdlkkGTCIRFAGSgneenrnnaYPHKAG-FAQPSGLALAseePWSCLFVADSESSTVR 185
Cdd:cd14956 123 ADFGNQRIQKFDPD------------GSFLRQWGG---------TGIEPGsFNYPRGVAVD---PDGTLYVADTYNDRIQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 186 TVSlRDGAVKHLVGGErdpmnlfafgdvdGAGiNAKLQHPLGVAWDEERQVlYVADSYNHKIKVVdpkTKGCTTLAGTGD 265
Cdd:cd14956 179 VFD-NDGAFLRKWGGR-------------GTG-PGQFNYPYGIAIDPDGNV-FVADFGNNRIQKF---TADGTFLTSWGS 239
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 569007656 266 ASDASSsfaesAFNEPGGLCIGESGRLlYVADTNNHQIKV 305
Cdd:cd14956 240 PGTGPG-----QFKNPWGVVVDADGTV-YVADSNNNRVQR 273
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
31-307 |
1.52e-14 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 73.48 E-value: 1.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAIADNVIYVADTENHLIRKIDLEAEKVTTVagvgiqgtdteGGEEGDKQPISSPWDVALGTSGSevqrndiLWIAMAG 110
Cdd:cd14963 14 GVAVSDGRIYVADTNNHRVQVFDYEGKFKKSF-----------GGPGTGPGEFKYPYGIAVDSDGN-------IYVADLY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 111 THQIWalLLDSgtlpkksdlkKGTCIRFAGSGneENRNNAyphkagfAQPSGLALASEEpwscLFVADSESSTVrTVSLR 190
Cdd:cd14963 76 NGRIQ--VFDP----------DGKFLKYFPEK--KDRVKL-------ISPAGLAIDDGK----LYVSDVKKHKV-IVFDL 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 191 DGAVKHLVGGErdpmnlfafGDVDGaginaKLQHPLGVAWDEERQvLYVADSYNHKIKVVDPKTKGCTTLAGTGDASdas 270
Cdd:cd14963 130 EGKLLLEFGKP---------GSEPG-----ELSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGKFIKELNGSPDGK--- 191
|
250 260 270
....*....|....*....|....*....|....*..
gi 569007656 271 ssfaeSAFNEPGGLCIGESGRlLYVADTNNHQIKVMD 307
Cdd:cd14963 192 -----SGFVNPRGIAVDPDGN-LYVVDNLSHRVYVFD 222
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
31-187 |
1.24e-13 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 71.79 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAI-ADNVIYVADTENHLIRKIDLeAEKVTTVAGVGIQGTDTEGGeeGDKQPISSPWDVALGTSGSevqrndiLWIAMA 109
Cdd:cd14953 191 GVAVdAAGNLYVADRGNHRIRKITP-DGVVTTVAGTGTAGFSGDGG--ATAAQLNNPTGVAVDAAGN-------LYVADS 260
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007656 110 GTHQIwaLLLDSGtlpkksdlkkGTCIRFAGSGNEENRNNAYPHKAGFAQPSGLALASEepwSCLFVADSESSTVRTV 187
Cdd:cd14953 261 GNHRI--RKITPA----------GVVTTVAGGGAGFSGDGGPATSAQFNNPTGVAVDAA---GNLYVADTGNNRIRKI 323
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
13-305 |
7.21e-13 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 68.83 E-value: 7.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 13 TIGSWSSRRmGAFRAAlEGVAIADN-VIYVADTENHLIRkidleaekVTTVAGV---GIQGTDTEGGeegdkqPISSPWD 88
Cdd:cd14957 53 SIGSGGTGS-GQFNSP-YGIAVDSNgNIYVADTDNNRIQ--------VFNSSGVyqySIGTGGSGDG------QFNGPYG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 89 VALGTSGSevqrndiLWIAMAGTH--QIWAllldsgtlpkksdlKKGTCIRFAGSGNEENRNnayphkagFAQPSGLALA 166
Cdd:cd14957 117 IAVDSNGN-------IYVADTGNHriQVFT--------------SSGTFSYSIGSGGTGPGQ--------FNGPQGIAVD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 167 SEepwSCLFVADSESSTVRTVSlRDGAVKHLVGGErdpmnlfafgdvdGAGiNAKLQHPLGVAWDEERQVlYVADSYNHK 246
Cdd:cd14957 168 SD---GNIYVADTGNHRIQVFT-SSGTFQYTFGSS-------------GSG-PGQFSDPYGIAVDSDGNI-YVADTGNHR 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 569007656 247 IKVVDPktkgcttlAGTGDASDASSSFAESAFNEPGGLCIGESGRLlYVADTNNHQIKV 305
Cdd:cd14957 229 IQVFTS--------SGAYQYSIGTSGSGNGQFNYPYGIAVDNDGKI-YVADSNNNRIQV 278
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
75-311 |
7.25e-12 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 65.69 E-value: 7.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 75 GEEGDKQPISSPWDVAlgtsgseVQRNDILWIAMAGTHQIWALlldsgtlpkksDLKKGtciRFAGSGNEENRNnayphk 154
Cdd:cd14962 3 GEERPKEALTRPYGVA-------ADGRGRIYVADTGRGAVFVF-----------DLPNG---KVFVIGNAGPNR------ 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 155 agFAQPSGLALASEEPwscLFVADSESstvrtvslrdGAVKHLVGGERdPMNLFafgdvdGAGinAKLQHPLGVAWDEER 234
Cdd:cd14962 56 --FVSPIGVAIDANGN---LYVSDAEL----------GKVFVFDRDGK-FLRAI------GAG--ALFKRPTGIAVDPAG 111
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569007656 235 QVLYVADSYNHKIKVVDPKTKGCTTLAGTGDasdasssfAESAFNEPGGLCIGESGRlLYVADTNNHQIKVMDLEAR 311
Cdd:cd14962 112 KRLYVVDTLAHKVKVFDLDGRLLFDIGKRGS--------GPGEFNLPTDLAVDRDGN-LYVTDTMNFRVQIFDADGK 179
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
16-312 |
1.16e-11 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 65.00 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 16 SWSSR--RMGAFRAaLEGVAI-ADNVIYVADTENHLIRKIDLEAEKVTTVagvGIQGTDTEGGEEGdkqpisspwdvalg 92
Cdd:cd14956 1 SWGGRgsGPGQFKD-PRGIAVdADDNVYVADARNGRIQVFDKDGTFLRRF---GTTGDGPGQFGRP-------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 93 tSGSEVQRNDILWIAMAGTHQIwallldsgtlpKKSDLKkGTCIRFAGSgneenrnnaYPHKAG-FAQPSGLALASEepw 171
Cdd:cd14956 63 -RGLAVDKDGWLYVADYWGDRI-----------QVFTLT-GELQTIGGS---------SGSGPGqFNAPRGVAVDAD--- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 172 SCLFVADSESStvRTVSLR-DGAVkhlvggerdpmnLFAFGDVDGAGInaKLQHPLGVAWDEErQVLYVADSYNHKIKVV 250
Cdd:cd14956 118 GNLYVADFGNQ--RIQKFDpDGSF------------LRQWGGTGIEPG--SFNYPRGVAVDPD-GTLYVADTYNDRIQVF 180
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007656 251 DPKTKGCTTLAGTGDasdasssfAESAFNEPGGLCIGESGRlLYVADTNNHQIKVMDLEART 312
Cdd:cd14956 181 DNDGAFLRKWGGRGT--------GPGQFNYPYGIAIDPDGN-VFVADFGNNRIQKFTADGTF 233
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
31-307 |
3.00e-11 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 63.82 E-value: 3.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAI-ADNVIYVADTENHLIrkidleaeKVTTVAGV--GIQGTDTEGGEEGDkqpisSPWDVALGTSGSevqrndiLWIA 107
Cdd:cd14957 22 GIAVdSAGNIYVADTGNNRI--------QVFTSSGVysYSIGSGGTGSGQFN-----SPYGIAVDSNGN-------IYVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 108 MAGTH--QIWalllDSgtlpkksdlkKGTCIRFAGSGNEENrnnayphkAGFAQPSGLALASEepwSCLFVADSESSTVR 185
Cdd:cd14957 82 DTDNNriQVF----NS----------SGVYQYSIGTGGSGD--------GQFNGPYGIAVDSN---GNIYVADTGNHRIQ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 186 tVSLRDGAvkhlvggerdpmNLFAFGDvDGAGiNAKLQHPLGVAWDEERQVlYVADSYNHKIKVVDPktkgcttlAGTGD 265
Cdd:cd14957 137 -VFTSSGT------------FSYSIGS-GGTG-PGQFNGPQGIAVDSDGNI-YVADTGNHRIQVFTS--------SGTFQ 192
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 569007656 266 ASDASSSFAESAFNEPGGLCIGESGrLLYVADTNNHQIKVMD 307
Cdd:cd14957 193 YTFGSSGSGPGQFSDPYGIAVDSDG-NIYVADTGNHRIQVFT 233
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
30-303 |
3.66e-11 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 63.75 E-value: 3.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 30 EGVAI--ADNViYVADTENHLIRKIDLEAEKVTTVagvGIQGTdteggeeGDKQpISSPWDVAlgtsgseVQRNDILWIA 107
Cdd:cd14955 66 TGIAVdsDGNV-YVADTGNHRIQKFDSTGTFLTKW---GSSGS-------GDGQ-FNSPSGIA-------VDSAGNVYVT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 108 MAGTHQIwaLLLDS-GTLpkksDLKKGTcirfAGSGNEEnrnnayphkagFAQPSGLALASEepwSCLFVADSESSTVRT 186
Cdd:cd14955 127 DSGNNRI--QKFDSsGTF----ITKWGS----FGSGDGQ-----------FNSPTGIAVDSA---GNVYVADTGNNRIQK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 187 VSlRDGAVkhlvggerdpmnLFAFGdVDGAGiNAKLQHPLGVAWDEERQVlYVADSYNHKIKVVDPktkgcttlAGTGDA 266
Cdd:cd14955 183 FT-STGTF------------LTKWG-SEGSG-DGQFNAPYGIAVDSAGNV-YVADTGNNRIQKFDS--------SGTFIT 238
|
250 260 270
....*....|....*....|....*....|....*..
gi 569007656 267 SDASSSFAESAFNEPGGLCIGESGRLlYVADTNNHQI 303
Cdd:cd14955 239 KWGSEGSGDGQFNSPSGIAVDSAGNV-YVADSGNNRI 274
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
75-309 |
8.50e-11 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 62.31 E-value: 8.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 75 GEEGDkqPISSPWDVAlgtsgseVQRNDIlWIAMAGTHQIwaLLLDSGTLPKKSdlkkgtcirFAGSGNEENRnnayphk 154
Cdd:cd14963 3 GPFGD--PLNKPMGVA-------VSDGRI-YVADTNNHRV--QVFDYEGKFKKS---------FGGPGTGPGE------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 155 agFAQPSGLALASEEPwscLFVADSESSTVRTVSlRDGAVKHLVGGERDpmnlfafgdvdgagiNAKLQHPLGVAWDEER 234
Cdd:cd14963 55 --FKYPYGIAVDSDGN---IYVADLYNGRIQVFD-PDGKFLKYFPEKKD---------------RVKLISPAGLAIDDGK 113
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007656 235 qvLYVADSYNHKIKVVDPKTKGCTTLAGTGDAsdasssfaESAFNEPGGLCIGESGRLlYVADTNNHQIKVMDLE 309
Cdd:cd14963 114 --LYVSDVKKHKVIVFDLEGKLLLEFGKPGSE--------PGELSYPNGIAVDEDGNI-YVADSGNGRIQVFDKN 177
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
207-316 |
1.06e-10 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 62.18 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 207 LFAFGDvDGAGiNAKLQHPLGVAWDEERQVlYVADSYNHKIKVVDPKTKGCTTLAGTGDAsdasssfaESAFNEPGGLCI 286
Cdd:cd14954 104 LLKFGE-RGTK-NGQFNYPWGVAVDSEGRI-YVSDTRNHRVQVFDSDGQFIRKFGFEGAG--------PGQLDSPRGVAV 172
|
90 100 110
....*....|....*....|....*....|
gi 569007656 287 GESGRLlYVADTNNHQIKVMDLEARTVSVL 316
Cdd:cd14954 173 NPDGNI-VVSDFNNHRLQVFDPDGQFLRFF 201
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
174-313 |
2.75e-10 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 60.48 E-value: 2.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 174 LFVADSESSTVRTVSLRDGAVKHLVGGERDPMnlfafgdvdgaginaklqhplGVAWDEERQVLYVADSYNHKIKVVDPK 253
Cdd:COG3391 82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPR---------------------GLAVDPDGGRLYVADSGNGRVSVIDTA 140
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007656 254 TKGCTTLAGTGdasdasssfaesafNEPGGLCIGESGRLLYVADTNNHQI----KVMDLEARTV 313
Cdd:COG3391 141 TGKVVATIPVG--------------AGPHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATGKV 190
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
19-305 |
5.05e-10 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 60.29 E-value: 5.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 19 SRRMGAFRAALEGVAIADNVIYVADTENHLIRKIDLEAEKVTTVagvgiqgtdtegGEEGDKQpISSPWDVALGtsgsev 98
Cdd:cd14962 5 ERPKEALTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKVFVI------------GNAGPNR-FVSPIGVAID------ 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 99 qRNDILWIAMAGTHQIwaLLLDsgtlpkksdlKKGTCIRFAGSGNEENRnnayphkagfaqPSGLALASEEPWscLFVAD 178
Cdd:cd14962 66 -ANGNLYVSDAELGKV--FVFD----------RDGKFLRAIGAGALFKR------------PTGIAVDPAGKR--LYVVD 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 179 SESSTVRtVSLRDGAVKHLVG------GE-----------------RDPMN------------LFAFGDV-DGAGinaKL 222
Cdd:cd14962 119 TLAHKVK-VFDLDGRLLFDIGkrgsgpGEfnlptdlavdrdgnlyvTDTMNfrvqifdadgkfLRSFGERgDGPG---SF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 223 QHPLGVAWDEERQVlYVADSYNHKIKVVDPKTKGCTTLAGTGDASDasssfaesAFNEPGGLCIGESGRlLYVADTNNHQ 302
Cdd:cd14962 195 ARPKGIAVDSEGNI-YVVDAAFDNVQIFNPEGELLLTVGGPGSGPG--------EFYLPSGIAIDKDDR-IYVVDQFNRR 264
|
...
gi 569007656 303 IKV 305
Cdd:cd14962 265 IQV 267
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
12-305 |
6.95e-10 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 59.87 E-value: 6.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 12 GTIGSwssrRMGAF-RAAleGVAI-ADNVIYVADTENHLIRKIDLEaekvttvaGVGIQGTDTEGGEEGDKQpisSPWDV 89
Cdd:cd14954 61 GSYGS----RDGQFdRPA--GVAVnSRGRIIVADKDNHRIQVFDLN--------GRFLLKFGERGTKNGQFN---YPWGV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 90 AlgtsgseVQRNDILWIAMAGTHQIWALLLDsgtlpkksdlkkGTCIR-FAGSGNEEnrnnayphkAGFAQPSGLALASE 168
Cdd:cd14954 124 A-------VDSEGRIYVSDTRNHRVQVFDSD------------GQFIRkFGFEGAGP---------GQLDSPRGVAVNPD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 169 EPwscLFVADSESSTVRTVSlRDGAVKHLVGGErdpmnlfafGDVDGaginaKLQHPLGVAWDEERQVLyVADSYNHKIK 248
Cdd:cd14954 176 GN---IVVSDFNNHRLQVFD-PDGQFLRFFGSE---------GSGNG-----QFKRPRGVAVDDEGNII-VADSGNHRVQ 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 569007656 249 VVDPKTKGCTTLAGTGDasdasssfAESAFNEPGGLCIGESGRLLyVADTNNHQIKV 305
Cdd:cd14954 237 VFSPDGEFLCSFGTEGN--------GEGQFDRPSGVAVTPDGRIV-VVDRGNHRIQV 284
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
157-307 |
6.65e-09 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 56.79 E-value: 6.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 157 FAQPSGLALASEepwSCLFVADSESSTVRTVSLrDGAvkhlvggerdPMNLFAFgdvDGAGInAKLQHPLGVAWDEERQV 236
Cdd:cd14954 117 FNYPWGVAVDSE---GRIYVSDTRNHRVQVFDS-DGQ----------FIRKFGF---EGAGP-GQLDSPRGVAVNPDGNI 178
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007656 237 lYVADSYNHKIKVVDPKtkgCTTLAGTGdasdaSSSFAESAFNEPGGLCIGESGRLLyVADTNNHQIKVMD 307
Cdd:cd14954 179 -VVSDFNNHRLQVFDPD---GQFLRFFG-----SEGSGNGQFKRPRGVAVDDEGNII-VADSGNHRVQVFS 239
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
222-316 |
7.30e-09 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 58.32 E-value: 7.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 222 LQHPLGVAWDEERQVLYVADSYNHKIKVVDPKTKGCTTLAGTGDASDASSSFAESAFNEPGGLCIGESGRLLYVADTNNH 301
Cdd:PLN02919 567 LKFPGKLAIDLLNNRLFISDSNHNRIVVTDLDGNFIVQIGSTGEEGLRDGSFEDATFNRPQGLAYNAKKNLLYVADTENH 646
|
90
....*....|....*
gi 569007656 302 QIKVMDLEARTVSVL 316
Cdd:PLN02919 647 ALREIDFVNETVRTL 661
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
208-307 |
8.81e-09 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 56.51 E-value: 8.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 208 FAFGDVdGAGINAkLQHPLGVAWDEERQvLYVADSYNHKIKVVDPKTKGCTTLaGTGDASDasssfaeSAFNEPGGLCIG 287
Cdd:cd14957 5 YAFGSN-GSGNGQ-FNTPRGIAVDSAGN-IYVADTGNNRIQVFTSSGVYSYSI-GSGGTGS-------GQFNSPYGIAVD 73
|
90 100
....*....|....*....|
gi 569007656 288 ESGRlLYVADTNNHQIKVMD 307
Cdd:cd14957 74 SNGN-IYVADTDNNRIQVFN 92
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
153-311 |
3.02e-08 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 54.86 E-value: 3.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 153 HKAG-FAQPSGLALASEEPwscLFVADSESSTVRtVSLRDGAVKHLVGGErdpmnlfafGDVDGaginaKLQHPLGVAWD 231
Cdd:cd14954 18 SKDGeLCRPWGVAVDKDGR---IIVADRSNNRVQ-VFDPDGKFLRKFGSY---------GSRDG-----QFDRPAGVAVN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 232 EERQVlYVADSYNHKIKVVDPktKGCTTLA----GTGDASdasssfaesaFNEPGGLCIGESGRlLYVADTNNHQIKVMD 307
Cdd:cd14954 80 SRGRI-IVADKDNHRIQVFDL--NGRFLLKfgerGTKNGQ----------FNYPWGVAVDSEGR-IYVSDTRNHRVQVFD 145
|
....
gi 569007656 308 LEAR 311
Cdd:cd14954 146 SDGQ 149
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
215-307 |
1.19e-07 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 52.96 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 215 GAGiNAKLQHPLGVAWDEERQVlYVADSYNHKIKVVDpktkgcttlaGTGD--ASDASSSFAESAFNEPGGLCIGESGRL 292
Cdd:cd14955 56 GSG-DGQFYSPTGIAVDSDGNV-YVADTGNHRIQKFD----------STGTflTKWGSSGSGDGQFNSPSGIAVDSAGNV 123
|
90
....*....|....*
gi 569007656 293 lYVADTNNHQIKVMD 307
Cdd:cd14955 124 -YVTDSGNNRIQKFD 137
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
33-254 |
1.74e-07 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 52.00 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 33 AIADNVIYVADTENHLIRKIDLEAEKVTTVAGVGiqgtdteggeegdkqpiSSPWDVALGTSGSEvqrndiLWIAMAGTH 112
Cdd:COG3391 76 GADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-----------------GGPRGLAVDPDGGR------LYVADSGNG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 113 QIWALlldsgtlpkksDLKKGTCIRFAGSGNeenrnnayphkagfaQPSGLALASEEPWscLFVADSESSTVRTV----S 188
Cdd:COG3391 133 RVSVI-----------DTATGKVVATIPVGA---------------GPHGIAVDPDGKR--LYVANSGSNTVSVIvsviD 184
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007656 189 LRDGAVKHLVggerdpmnlfAFGdvdgaginaklQHPLGVAWDEERQVLYVADSYN-------HKIKVVDPKT 254
Cdd:COG3391 185 TATGKVVATI----------PVG-----------GGPVGVAVSPDGRRLYVANRGSntsnggsNTVSVIDLAT 236
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
174-321 |
1.90e-07 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 52.00 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 174 LFVADSESSTVRTVSLRDGAVKHLVGGERDPMNLFAFGDVDGAGINAKLQHPLGVAWDEERQVLYVADSYNHKIKVVDPK 253
Cdd:COG3391 19 AALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLA 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007656 254 TKgctTLAGTGDASDasssfaesafnEPGGLCIGESGRLLYVADTNNHQIKVMDLEARTV-SVLPVCKS 321
Cdd:COG3391 99 TG---KVVATIPVGG-----------GPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVvATIPVGAG 153
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
7-303 |
3.33e-07 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 51.81 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 7 WWqtqGTIGSWSsrrmGAFrAALEGVAI-ADNVIYVADTENHLIRKIDLEAEKVTTVagvGIQGTdteggeeGDKQpISS 85
Cdd:cd14955 4 QW---GSYGSGD----GQF-NSPSGIAVdSAGNVYVADTGNNRIQKFDSTGTFLTKW---GSSGS-------GDGQ-FYS 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 86 PWDVALGTSGSevqrndiLWIAMAGTHQIWALllDS-GTLPKKSdlkkGTCirfaGSGNEEnrnnayphkagFAQPSGLA 164
Cdd:cd14955 65 PTGIAVDSDGN-------VYVADTGNHRIQKF--DStGTFLTKW----GSS----GSGDGQ-----------FNSPSGIA 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 165 LASEepwSCLFVADSESSTVRTVSlRDGAVKHLVGGerdpmnlfaFGDVDGAginakLQHPLGVAWDEERQVlYVADSYN 244
Cdd:cd14955 117 VDSA---GNVYVTDSGNNRIQKFD-SSGTFITKWGS---------FGSGDGQ-----FNSPTGIAVDSAGNV-YVADTGN 177
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007656 245 HKIKVVDPKTKGCTT--LAGTGDasdasssfaeSAFNEPGGLCIGESGRlLYVADTNNHQI 303
Cdd:cd14955 178 NRIQKFTSTGTFLTKwgSEGSGD----------GQFNAPYGIAVDSAGN-VYVADTGNNRI 227
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
219-317 |
7.54e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 50.37 E-value: 7.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 219 NAKLQHPLGVAWDEERqvLYVADSYNHKIKVVDPKTKGCTTLAGTGDAsdasssfaESAFNEPGGLCIGESGRLlYVADT 298
Cdd:cd14963 6 GDPLNKPMGVAVSDGR--IYVADTNNHRVQVFDYEGKFKKSFGGPGTG--------PGEFKYPYGIAVDSDGNI-YVADL 74
|
90
....*....|....*....
gi 569007656 299 NNHQIKVMDLEARTVSVLP 317
Cdd:cd14963 75 YNGRIQVFDPDGKFLKYFP 93
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
128-318 |
1.61e-06 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 49.51 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 128 SDLKKGTCIRFAGSGNEENRnnaYPHKAGFaqPSGLALASEepwSCLFVADSESSTVRtVSLRDGAVKHLVGGERDPMNL 207
Cdd:COG3386 24 VDIPGGRIHRYDPDGGAVEV---FAEPSGR--PNGLAFDPD---GRLLVADHGRGLVR-FDPADGEVTVLADEYGKPLNR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 208 FAFGDVDGAG------------------INAKLQ-HPL--------GVAWDEERQVLYVADSYNHKIKVVDpktkgcttL 260
Cdd:COG3386 95 PNDGVVDPDGrlyftdmgeylptgalyrVDPDGSlRVLadgltfpnGIAFSPDGRTLYVADTGAGRIYRFD--------L 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 261 AGTGDASDAsSSFAESAFNE--PGGLCIGESGRlLYVADTNNHQIKVMDLEARTVSVLPV 318
Cdd:COG3386 167 DADGTLGNR-RVFADLPDGPggPDGLAVDADGN-LWVALWGGGGVVRFDPDGELLGRIEL 224
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
23-250 |
1.66e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 49.59 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 23 GAFRAALEGVAIADNVIYVADTENHLIRKIDLEAEKVTTvagvgIQGTDTEGGEegdkqpISSPWDVALGTSGSevqrnd 102
Cdd:cd14956 104 GQFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGSFLRQ-----WGGTGIEPGS------FNYPRGVAVDPDGT------ 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 103 iLWIAMAGTHQIwallldsGTLPKKSDLKK--GTciRFAGSGNeenrnnayphkagFAQPSGLALAseePWSCLFVADSE 180
Cdd:cd14956 167 -LYVADTYNDRI-------QVFDNDGAFLRkwGG--RGTGPGQ-------------FNYPYGIAID---PDGNVFVADFG 220
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 181 SSTVrTVSLRDGAVkhlvggerdpmnLFAFGDVDGAgiNAKLQHPLGVAWDEERQVlYVADSYNHKIKVV 250
Cdd:cd14956 221 NNRI-QKFTADGTF------------LTSWGSPGTG--PGQFKNPWGVVVDADGTV-YVADSNNNRVQRF 274
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
225-307 |
4.31e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 48.34 E-value: 4.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 225 PLGVAWDEERQVlYVADSYNHKIKVVDPK----TKGCTTlaGTGDAsdasssfaesAFNEPGGLCIGESGRLlYVADTNN 300
Cdd:cd14955 18 PSGIAVDSAGNV-YVADTGNNRIQKFDSTgtflTKWGSS--GSGDG----------QFYSPTGIAVDSDGNV-YVADTGN 83
|
....*..
gi 569007656 301 HQIKVMD 307
Cdd:cd14955 84 HRIQKFD 90
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
159-318 |
4.83e-06 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 47.77 E-value: 4.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 159 QPSGLALASEEpwSCLFVADSESSTVRTVSLRDGAVKHLVGGERDPMnlfafgdvdgaginaklqhplGVAWDEERQVLY 238
Cdd:COG3391 111 GPRGLAVDPDG--GRLYVADSGNGRVSVIDTATGKVVATIPVGAGPH---------------------GIAVDPDGKRLY 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 239 VADSYNHKI----KVVDPKTKGCTTLAGTGDAsdasssfaesafnePGGLCIGESGRLLYVADTNNHQIkvmDLEARTVS 314
Cdd:COG3391 168 VANSGSNTVsvivSVIDTATGKVVATIPVGGG--------------PVGVAVSPDGRRLYVANRGSNTS---NGGSNTVS 230
|
....
gi 569007656 315 VLPV 318
Cdd:COG3391 231 VIDL 234
|
|
| NHL_brat_like |
cd14959 |
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ... |
275-332 |
1.52e-05 |
|
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271329 [Multi-domain] Cd Length: 274 Bit Score: 46.49 E-value: 1.52e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 275 ESAFNEPGGLCIGESGRLLyVADTNNHQIKVMDLEARTVSVLPVCKSDsavvDGS--FPR 332
Cdd:cd14959 18 EGQFNSPSGFCLGEDEDIL-VADTNNHRIQVFDKEGEFKFQFGIPGKR----DGQlwYPN 72
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
31-249 |
1.83e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 46.13 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAIADNVIYVADTENHLIRKIDLEAEKVTTVAGVGiqgtdTEGGEegdkqpISSPWDVAlgtsgseVQRNDILWIAMAG 110
Cdd:cd14963 106 GLAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPG-----SEPGE------LSYPNGIA-------VDEDGNIYVADSG 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 111 THQIwaLLLDsgtlpkksdlKKGTCIR-FAGSGNEENrnnayphkaGFAQPSGLALASEEPwscLFVADSESSTVRTVSl 189
Cdd:cd14963 168 NGRI--QVFD----------KNGKFIKeLNGSPDGKS---------GFVNPRGIAVDPDGN---LYVVDNLSHRVYVFD- 222
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 190 RDGAVKHLVGGerdpmnlfaFGDVDGAginakLQHPLGVAWDeERQVLYVADSYNHKIKV 249
Cdd:cd14963 223 EQGKELFTFGG---------RGKDDGQ-----FNLPNGLFID-DDGRLYVTDRENNRVAV 267
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
258-303 |
1.83e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 46.75 E-value: 1.83e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 569007656 258 TTLAGTGDASDASSSFAESAFNEPGGLCIGESGRlLYVADTNNHQI 303
Cdd:cd14953 2 STVAGSGTAGFSGGGGTAARFNSPSGVAVDAAGN-LYVADRGNHRI 46
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
30-184 |
2.60e-05 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 45.46 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 30 EGVAI--ADNVIYVADTENHLIRKIDLEAEKVTTVAGVGiqgtdteggeegdkqpiSSPWDVALGTSGSEvqrndiLWIA 107
Cdd:COG3391 113 RGLAVdpDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-----------------AGPHGIAVDPDGKR------LYVA 169
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569007656 108 MAGTHQIWALLLdsgtlpkKSDLKKGTCIRFAGSGNeenrnnayphkagfaQPSGLALASEEPWscLFVADSESSTV 184
Cdd:COG3391 170 NSGSNTVSVIVS-------VIDTATGKVVATIPVGG---------------GPVGVAVSPDGRR--LYVANRGSNTS 222
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
227-316 |
8.64e-05 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.11 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 227 GVAWDEErQVLYVADSYNHKIKVVDPKTKGCTTLAGTGdasdasssfaesafNEPGGLCIGESGRlLYVADTnNHQIKVM 306
Cdd:COG3386 12 GPVWDPD-GRLYWVDIPGGRIHRYDPDGGAVEVFAEPS--------------GRPNGLAFDPDGR-LLVADH-GRGLVRF 74
|
90
....*....|
gi 569007656 307 DLEARTVSVL 316
Cdd:COG3386 75 DPADGEVTVL 84
|
|
| NHL |
pfam01436 |
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ... |
278-305 |
1.28e-04 |
|
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.
Pssm-ID: 396153 [Multi-domain] Cd Length: 28 Bit Score: 38.92 E-value: 1.28e-04
10 20
....*....|....*....|....*...
gi 569007656 278 FNEPGGLCIGESGRLlYVADTNNHQIKV 305
Cdd:pfam01436 1 FNRPHGVAVDSNGDI-YVADSENHRVQV 27
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| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
31-317 |
3.49e-04 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.19 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 31 GVAI--ADNViYVADTENHLIRKIDLEAEKVTTVagvgiqgtdteggeegdkqPIS---SPWDVALGTSGSevqrndiLW 105
Cdd:cd14952 14 GVAVdaAGNV-YVADSGNNRVLKLAAGSTTQTVL-------------------PFTglyQPQGVAVDAAGT-------VY 66
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 106 IAMAGTHQIWALLLDSGT---LPkksdlkkgtcirFAGSGNeenrnnayphkagfaqPSGLALASEepwSCLFVADSESS 182
Cdd:cd14952 67 VTDFGNNRVLKLAAGSTTqtvLP------------FTGLND----------------PTGVAVDAA---GNVYVADTGNN 115
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 183 TVrtVSLRDGAVkhlvggerdpmnlfAFGDVDGAGinakLQHPLGVAWDEERQVlYVADSYNHKIKVVDPKTKGCTTLAG 262
Cdd:cd14952 116 RV--LKLAAGSN--------------TQTVLPFTG----LSNPDGVAVDGAGNV-YVTDTGNNRVLKLAAGSTTQTVLPF 174
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250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 569007656 263 TGDASdasssfaesafnePGGLCIGESGRLlYVADTNNHQIKVMDLEARTVSVLP 317
Cdd:cd14952 175 TGLNS-------------PSGVAVDTAGNV-YVTDHGNNRVLKLAAGSTTPTVLP 215
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| NHL_PAL_like |
cd14958 |
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ... |
224-311 |
1.44e-03 |
|
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271328 [Multi-domain] Cd Length: 300 Bit Score: 40.71 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 224 HPLGVAWDEERQVlYVADSY-NHKIKVVDPKTK-----GcttlagtgdasdaSSSFAESAFNEPGGLCIGESGRLlYVAD 297
Cdd:cd14958 129 KPTDVAVAPDGDI-FVADGYcNSRIVKFSPDGKllkswG-------------EPGSGPGQFNLPHSIALDEDGRV-YVAD 193
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90
....*....|....
gi 569007656 298 TNNHQIKVMDLEAR 311
Cdd:cd14958 194 RENGRIQVFDADGK 207
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| NHL_TRIM2_like |
cd14960 |
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ... |
137-305 |
6.87e-03 |
|
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271330 [Multi-domain] Cd Length: 274 Bit Score: 38.48 E-value: 6.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 137 RFAGSGNEENRnnayphkagFAQPSGLALASEEPwscLFVADSESSTVRtVSLRDGAVkhlvggerdpmnLFAFGdVDGA 216
Cdd:cd14960 141 RFGSRGNGDRQ---------FAGPHFAAVNNNNE---IIVTDFHNHSVK-VFNAEGEF------------LFKFG-SNGE 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007656 217 GiNAKLQHPLGVAWDEERQVLyVADSYNHKIKVvdpktkgcttlagtgdaSDASSSF------AESAFNEPGGLCIGESG 290
Cdd:cd14960 195 G-NGQFNAPTGVAVDSNGNII-VADWGNSRIQV-----------------FDSSGSFlsyintSADPLYGPQGLALTSDG 255
|
170
....*....|....*
gi 569007656 291 RLLyVADTNNHQIKV 305
Cdd:cd14960 256 HVV-VADSGNHCFKV 269
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