NCBI Conserved Domain Search

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 207.99 E-value: 1.79e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  263 GTVTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHV 342
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  343 LYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCV 392
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 145.29 E-value: 4.57e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  513 GHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPK 592
Cdd:cd20409     1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80


                  ..
gi 569008102  593 LL 594
Cdd:cd20409    81 LL 82

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 126.31 E-value: 5.88e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102   490 DEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHvIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVL 569
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYAS-KPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 569008102   570 VGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 607
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 124.77 E-value: 2.24e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102   716 CMMYSPGEFYCHFLKDDalEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDY 795
Cdd:pfam00567    8 SHIESPSTFYIQPKSDS--KKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFIDY 85

                           90       100       110
                   ....*....|....*....|....*....|
gi 569008102   796 GNVEEVTTDQLQAILPQFLLLPFQGMQCWL 825
Cdd:pfam00567   86 GNTETVPLSDLRPLPPELESLPPQAIKCQL 115

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 121.29 E-value: 7.01e-33

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  756 FKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFL 814
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 114.08 E-value: 1.24e-29

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  914 RVQDDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 973
Cdd:cd20411    57 RFTGDKNWYRAVVLETSDSEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 111.29 E-value: 1.15e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102   259 MEIKGTVTEFKHPSNFYIQlySSEVLENMNQLSTSLKETYANVVPEdGYLPVKGEVCVAKYTVDQTWNRAIVQaVDVLQR 338
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPE-SLPPAVGDGCVAAFSEDGKWYRAKIT-ESLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 569008102   339 KAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSG 379
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 102.14 E-value: 1.87e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  515 KLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 594
Cdd:cd20411    25 KLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLE-TSDSEVKVLYADYGNTETLPLSRILPITKSHL 103

                          90
                  ....*....|...
gi 569008102  595 DLPMQALNCVLAG 607
Cdd:cd20411   104 ELPFQIIRCSLAG 116

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 96.28 E-value: 3.10e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  494 GVVAHIQTPEDFF--CQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAY-ASEESVLV 570
Cdd:cd20408     1 GTVTEFKNPGEFYiqIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVdVQQKKAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  571 GYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAV 620
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 93.67 E-value: 1.52e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYC-HFLKDDALEKLDDLNQSLADYC-AQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSgNVKVHFVDYGN 797
Cdd:cd20411     8 SPDLFYAlPKTGQVNVEKLKALMTELAEYCsKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDS-EVKVLYADYGN 86

                          90       100
                  ....*....|....*....|....*...
gi 569008102  798 VEEVTTDQLQAILPQFLLLPFQGMQCWL 825
Cdd:cd20411    87 TETLPLSRILPITKSHLELPFQIIRCSL 114

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 92.82 E-value: 5.63e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  719 YSPGEFYCHFLKDDALEKLDDLNQSLAD-YCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGN-VKVHFVDYG 796
Cdd:cd20408     7 KNPGEFYIQIYTLEVLESLVKLTSQLKKtYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKkAGVFYIDYG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 569008102  797 NVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEA 839
Cdd:cd20408    87 NEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEEC 129

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 92.55 E-value: 5.72e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  482 KVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHvipRSDFYPTIGDVCCAQFSEDDQWYRASVLA 561
Cdd:cd20439     2 KEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLI---HNDPYKHGQIACVAKYSKDGKWYRAAVLK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 569008102  562 YASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGV 608
Cdd:cd20439    79 QVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 90.99 E-value: 1.30e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  272 SNFYIQLYSSEVLEN-MNQL-STSLKETyanVVPEDGYLPVKGEVCVAKYTVDQTWNRAIV-----QAVDVLQRKAHVLY 344
Cdd:cd20443     2 GRFYVQVVSDQRLSSiQQQLeGLSLKDK---ANPPGGFNPKKGELVLAQFSADNSWNRAMVvnaprQGTQSPKDEYEVFY 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 569008102  345 IDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIP 382
Cdd:cd20443    79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 85.63 E-value: 2.24e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  494 GVVAHIQTPEDFFCQQlqSGHKLAELQESLSEYCGHVIPRSDFYPTI--GDVCCAQFSEDDQWYRASVLAYASEEsVLVG 571
Cdd:cd20426     3 AYATAVDSPEYFWCQF--ATEKIQCLAVKVQEAGEQVADRGNFIPSIyvGDPCIVKYSEDNHWYRALVTKINDNL-VSVR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 569008102  572 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAV 620
Cdd:cd20426    80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEAN 128

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 77.89 E-value: 5.67e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  506 FCQQLQSGHKLAELQESLSEYC--GHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVL------AYASEESVLVGYVDYGN 577
Cdd:cd20443     4 FYVQVVSDQRLSSIQQQLEGLSlkDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVnaprqgTQSPKDEYEVFYIDYGN 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 569008102  578 FEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 610
Cdd:cd20443    84 QETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 75.85 E-value: 3.13e-16

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569008102   914 RVQDDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 973
Cdd:pfam00567   57 AFSEDGKWYRAKITESLDDGlVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 74.26 E-value: 4.60e-16

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  284 LEN-MNQLSTslkETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVlQRKAHVLYIDYGNEEMIPIDSVHPL 361
Cdd:cd20433     5 LEKlMEKLRF---EIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEG-DKKVHVLYIDYGNREVLPSTRLAAL 79

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 74.26 E-value: 4.73e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  736 KLDDLNQSLADYCAQKPPNG--FKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQF 813
Cdd:cd20433     4 QLEKLMEKLRFEIASNPPLPgsYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 73.87 E-value: 7.50e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  736 KLDDLNQSLADYCAQKPPNGFKAEI--GRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQF 813
Cdd:cd20412     5 QLDKLVQEMTQYYESEENRHTLLTVqvGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDF 84

                          90
                  ....*....|
gi 569008102  814 LLLPFQGMQC 823
Cdd:cd20412    85 LSLPFQAIEC 94

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 72.16 E-value: 8.55e-16

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  760 IGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAI 809
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 74.82 E-value: 1.29e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  757 KAEIGRPCCAFFSGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWT 836
Cdd:cd20438    54 KPEPGLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWT 132


                  ....*...
gi 569008102  837 KEATARFQ 844
Cdd:cd20438   133 KNANDFFK 140

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 72.72 E-value: 1.36e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  512 SGHKLAELQESLSEYCG-HVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPII 590
Cdd:cd20433     1 TGPQLEKLMEKLRFEIAsNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80


                  .
gi 569008102  591 P 591
Cdd:cd20433    81 P 81

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 71.60 E-value: 1.99e-15

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  536 FYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 594
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 72.87 E-value: 3.93e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  718 MYSPGEFYCHFLKDDalEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGN 797
Cdd:cd20440    19 VYSPAKFYCQLDRNT--EILEALMEKIAEISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDYGN 96

                          90       100       110
                  ....*....|....*....|....*....|.
gi 569008102  798 VEEVTTDQLQAILPQF---LLLPFQGMQCWL 825
Cdd:cd20440    97 KQIVEKNEVLPIPDTAvdlLLTPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 70.97 E-value: 4.98e-15

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569008102  543 VCCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLG 613
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDnVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 72.53 E-value: 7.26e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYCHFlkddALEKLDDLNQSLADYCAQKPPNGFKA---EIGRPCCAFFSGDGNWYRALVKEIlPSGNVKVHFVDYG 796
Cdd:cd20426    10 SPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKI-NDNLVSVRFVDYG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 569008102  797 NVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEATARF 843
Cdd:cd20426    85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 71.32 E-value: 1.08e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  265 VTEFKHPSNFYI-QLYSSEVLENMNQLSTSLKEtYANVVPE-DGYLPVKGEVCVAKYTVDQTWNRAIVqaVDVLQRKAHV 342
Cdd:cd20411     3 VLEVISPDLFYAlPKTGQVNVEKLKALMTELAE-YCSKQSVpQQFRPRIGDACCARFTGDKNWYRAVV--LETSDSEVKV 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 569008102  343 LYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSG 379
Cdd:cd20411    80 LYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 68.70 E-value: 1.38e-14

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  540 IGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPI 589
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 71.00 E-value: 2.33e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  757 KAEIGRPCCAFFSGDGnWYRALVKEILPSGnVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWT 836
Cdd:cd20422    49 KPQPGQLCCAKWKEDR-YYRAIVTAVKGKM-VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWS 126


                  ....*...
gi 569008102  837 KEATARFQ 844
Cdd:cd20422   127 PEAISAFK 134

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 70.60 E-value: 2.56e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  719 YSPGEFYCHFLKDdaLEKLDDLNQSLADYCAQKPPNGFKAEIGrpCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNV 798
Cdd:cd20439    20 NSPGDFWCQLQTK--SSELKSLMKQIQSYYLIHNDPYKHGQIA--CVAKYSKDGKWYRAAVLKQVSAKEVDVIFVDYGNQ 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 569008102  799 EEVTTDQLQAILPQFLLLPFQGMQCWLVDI 828
Cdd:cd20439    96 ERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 69.02 E-value: 2.73e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  735 EKLDDLNQSLADYCAQKPPN-GFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQF 813
Cdd:cd20409     2 RQLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81


                  .
gi 569008102  814 L 814
Cdd:cd20409    82 L 82

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 69.05 E-value: 2.85e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569008102  762 RPCCAFFSGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPN 832
Cdd:cd20423     7 PVCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPS 78

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 69.02 E-value: 6.41e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYCHFLKDDAL-----EKLDDLNQSlADYCAQKPPNgfkaeIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVD 794
Cdd:cd20425    11 SPSDFYVQLAQDEDElsmisEKLNASKAN-DEEVECESLQ-----LGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFID 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 569008102  795 YGNVEEVTTDQLQAILPQFLLLPFQGMQCWL 825
Cdd:cd20425    85 YGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 69.37 E-value: 6.64e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYCHFLKDDalEKLDDLNQSLADYCAQKppngfKAEIGRPC------CAFFSGDGNWYRALVKEILPSGNVKVHFV 793
Cdd:cd20437    14 SPSKFYCQLLSWE--PELSKLTTQMTLHYESV-----SKELNPSCenfgllCAAKGKDGQWHRGFLQQLLPPSQVKVWFI 86

                          90       100       110
                  ....*....|....*....|....*....|..
gi 569008102  794 DYGNVEEVTTDQLQAILPQFLLLPFQGMQCWL 825
Cdd:cd20437    87 DYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 68.25 E-value: 2.05e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  496 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYcGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 575
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEI-SKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDY 94

                          90       100       110
                  ....*....|....*....|....*....|...
gi 569008102  576 GNFEILSLKRLCPI---IPKLLDLPMQALNCVL 605
Cdd:cd20440    95 GNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 65.19 E-value: 6.47e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569008102  314 VCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAG 385
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 65.12 E-value: 1.33e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  534 SDFYPtiGDVCCAQFSeDDQWYRASVLAYASEESV--LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPS 611
Cdd:cd20418     2 TDFRP--EMPCLAEYS-DGKWYRAKLLSILEFNPVkiLVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPP 78

                          90       100
                  ....*....|....*....|...
gi 569008102  612 LGI-----------WTPEAVCVM 623
Cdd:cd20418    79 LNDseteripycpeWSMKALWAM 101

MYND finger;

Pssm-ID: 460312 Cd Length: 39 Bit Score: 62.44 E-value: 1.71e-12

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569008102   163 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSSHSTIC 199
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 62.15 E-value: 2.66e-12

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569008102  311 KGEVCVAKYTVDQTWNRAIVQAVDvLQRKAHVLYIDYGNEEMIPIDSVHPL 361
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 64.84 E-value: 2.95e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  262 KGTVTEFKHPSNFYIQLYSSEVleNMNQLSTSLKETYANVVPEDGYL--PVKGEVCVAKYTvDQTWNRAIVQAVDvlQRK 339
Cdd:cd20422     3 DAQVEFVKDPSEFWIRLGEHAV--PFSKLMRSMTAFYSQASKLDGVVlkPQPGQLCCAKWK-EDRYYRAIVTAVK--GKM 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  340 AHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVK 396
Cdd:cd20422    78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 64.45 E-value: 4.22e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  492 FC-GVVAHIQTPEDFFCQQLQSGHKLAELQESLSeycghviprsDFY------------PTIGDVCCAQFsEDDQWYRAS 558
Cdd:cd20422     1 FYdAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMT----------AFYsqaskldgvvlkPQPGQLCCAKW-KEDRYYRAI 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569008102  559 VLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAVCVMK 624
Cdd:cd20422    70 VTA-VKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 63.22 E-value: 4.89e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  516 LAELQEslsEYCGHVIPRSDFY-PTIGDVCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 594
Cdd:cd20415     5 TKKIQE---FYKEGDDGGLEILcPVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                          90
                  ....*....|....*.
gi 569008102  595 DLPMQALNCVLAGVKP 610
Cdd:cd20415    81 SLPEKARECRLAFIEP 96

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 63.63 E-value: 5.02e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  496 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 575
Cdd:cd20425     6 VSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFIDY 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 569008102  576 GNFEILSLKRLCPIIPKLLDLPMQALNCVL 605
Cdd:cd20425    86 GNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 62.31 E-value: 5.40e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  519 LQESLSEYC--GHVIPRSdfyPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 593
Cdd:cd20430     1 LSDELAEVCptAPPLFGT---PDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 63.08 E-value: 5.40e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  515 KLAELQESLSEY--CGHVIPRSDfYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPK 592
Cdd:cd20412     5 QLDKLVQEMTQYyeSEENRHTLL-TVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83

                          90
                  ....*....|.
gi 569008102  593 LLDLPMQALNC 603
Cdd:cd20412    84 FLSLPFQAIEC 94

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 62.06 E-value: 1.59e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  502 PEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEIL 581
Cdd:cd20441     2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVV 81

                          90       100
                  ....*....|....*....|....*..
gi 569008102  582 SLKRLCPIIPKLLDLPMQALNCVLAGV 608
Cdd:cd20441    82 DKSNIYTLQEKFLSLPRLSIPCSLSGV 108

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 62.88 E-value: 1.88e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  494 GVVAHIQTPEDFFCQQLQSGHKLAELQESLSEY---CG---HVIPRsdfyPTIGDVCCAQFSEDDQWYRAsVLAYASEES 567
Cdd:cd20438     9 AFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIynlCGndeELLKK----PEPGLLCCARYSKDRHYYRA-VITEVLDLK 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569008102  568 VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEA 619
Cdd:cd20438    84 VSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNA 135

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 62.13 E-value: 3.10e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  261 IKGTVTEFKHPSNFYIQLYSSEV--LENMNQLSTSLKETYANVVPEdgylPVKGEVCVAKYTVDQTWNRAIVQAVDvlQR 338
Cdd:cd20426     1 IEAYATAVDSPEYFWCQFATEKIqcLAVKVQEAGEQVADRGNFIPS----IYVGDPCIVKYSEDNHWYRALVTKIN--DN 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569008102  339 KAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQ 402
Cdd:cd20426    75 LVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTED 138

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 61.75 E-value: 4.07e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  914 RVQDDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQ 983
Cdd:cd20426    56 KYSEDNHWYRALVTKINDNLVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSD 125

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 59.78 E-value: 4.53e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  285 ENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVdVLQRKAHVLYIDYGNEEMIPIDSVHPLSRG 364
Cdd:cd20409     2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80


                  .
gi 569008102  365 L 365
Cdd:cd20409    81 L 81

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 60.98 E-value: 6.00e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  486 LNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIP-RSDFYPtiGDVCCAQFSeDDQWYRASVLayAS 564
Cdd:cd20424     8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIII--TN 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 569008102  565 EESVLVGYVDYGNFEILSLKRLCPI---IPKLLDLPMQALNCVL 605
Cdd:cd20424    83 KNSTEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 60.14 E-value: 6.52e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYCHFLKDDAL-----EKLDDLNQSLADYCAQKPpngfkaEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVD 794
Cdd:cd20441     1 SPSRFFIQLSEDEKVilqlaEELNETSEKSRENAAVKL------KVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFID 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 569008102  795 YGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDI 828
Cdd:cd20441    75 YGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 60.21 E-value: 1.02e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYCHFLKDDalEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSgDGNWYRALVKEILPsgNVKVHFVDYGNVE 799
Cdd:cd20424    23 DPWTFYCQLARNA--GVLDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKN--STEVFFVDYGNTE 97

                          90       100       110
                  ....*....|....*....|....*....|..
gi 569008102  800 EVTTDQLqaiLP------QFLLLPFQGMQCWL 825
Cdd:cd20424    98 KVEKEDM---LPipsdayELLLLPMQAIKCSL 126

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 58.37 E-value: 1.10e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569008102  759 EIGRPCCAffSGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20407     6 EVGVICAA--PVMNAWYRAQVVGVFEETDeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 58.59 E-value: 1.87e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  535 DFYPTIGDVCCAQF----------SEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCV 604
Cdd:cd20427     9 EFYSKSSTAMCLRSpsvgqlvavkAEEDAWLRAQVIE-VEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCK 87


                  ....*.
gi 569008102  605 LAGVKP 610
Cdd:cd20427    88 LAGLEP 93

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 57.60 E-value: 2.57e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569008102  540 IGDVCCAQFseDDQWYRASVLAYASE-ESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 610
Cdd:cd20407     7 VGVICAAPV--MNAWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.51 E-value: 3.14e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 569008102    538 PTIGDVCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 593
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 57.11 E-value: 5.03e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569008102  771 DGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGM 821
Cdd:cd20429    41 ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.13 E-value: 5.59e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 569008102    761 GRPCCAFFSgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAI 809
Cdd:smart00333    6 GDKVAARWE-DGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQL 53

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 57.46 E-value: 7.71e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  717 MMYSPGEFYCHFLKDDALEKLDDLNQSLADYCAQKP-------PNGFKAEiGRPCCAFFSGDGNWYRALVKEILPSGNVK 789
Cdd:cd20419     4 YIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHvseryvmPEAFIQP-GQVCCVRIPEDVWWYRVIIHQVLNKQEVE 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 569008102  790 VHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWL 825
Cdd:cd20419    83 VFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 57.82 E-value: 9.10e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  495 VVAHIQTPEDFFCQQLQSGHKLAELQESLSE-YCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVL-AYASEESVLVGY 572
Cdd:cd20421    16 VVTEVTDPHRIFCQLRSLSQELKRLSESMHQyYEGRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQqVFSANRVVEVLH 95

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 569008102  573 VDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 607
Cdd:cd20421    96 VDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 55.95 E-value: 1.21e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008102  917 DDDFWYRAIVLETSES--DVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNG 979
Cdd:cd20423    15 EDGKWCRALIDNVYEPveMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 56.71 E-value: 1.29e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569008102  918 DDFWYRAIVLE-------TSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 973
Cdd:cd20443    51 DNSWNRAMVVNaprqgtqSPKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAH 113

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 55.92 E-value: 2.57e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  496 VAHIQTPEDF---FCQQLQSgHKLAELQESLSEYCG--HVIPRS---DFYPTIGDVCCAQFSEDDQWYRASVLAYASEES 567
Cdd:cd20419     2 VEYIESPSQFyvrFYSKDTS-EMLEDMMIEMRRCYSneHVSERYvmpEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 569008102  568 VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVL 605
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 55.55 E-value: 3.83e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  726 CHFLKDDALEKLDDLNQSLADYCAQK---PPNGFKAEIGRPCCAFFSGDGNWYRALVKE------ILPSGNVKVHFVDYG 796
Cdd:cd20443     3 RFYVQVVSDQRLSSIQQQLEGLSLKDkanPPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDYG 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 569008102  797 NVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPP 831
Cdd:cd20443    83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKVP 117

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 54.36 E-value: 5.35e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  761 GRPCCAFFSgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20415    28 GQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 53.45 E-value: 5.95e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  743 SLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEV 801
Cdd:cd20430     4 ELAEVCPTAPPLFGTPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETV 62

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 55.53 E-value: 6.50e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYCHfLKDDALEKLDDLNQSLADY--CAQKPPNGFkaeIGRPCCA---FFSGDGNWYRALVKEILPSGNVKVHFVD 794
Cdd:cd20428    11 SDGTLYCQ-VPSKGLSKLNEILDKIEYYfhSRQMTSEYF---VSLPFCGkicLARYKGKWARVEITNVHSSRALDVHFLD 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 569008102  795 YGNVEEVTTDQLQAILPQFL----LLPFQGMQCWLVDIQPPNKHWTKEA 839
Cdd:cd20428    87 TGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDA 135

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 54.22 E-value: 6.97e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569008102  916 QDDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCS 970
Cdd:cd20412    40 RHDGSWYRARVLGFLENGnLDLYFVDYGDSGYVPLEDLRALRSDFLSLPFQAIECS 95

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 53.61 E-value: 7.63e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569008102  917 DDDFWYRAIVLE-TSESDVKVLYADYGNIETLPLSRVQPIPASHL 960
Cdd:cd20409    38 EDNQWYRASVLAySSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 52.52 E-value: 7.78e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 569008102  917 DDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPI 955
Cdd:cd20379    11 EDGKWYRARVLEVLSNDkVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 54.38 E-value: 9.15e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  891 RCGSPQDSLMSRPAN----QHKQIDSHRVQDDDFWYRAIVLET-SESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQ 965
Cdd:cd20419    33 RCYSNEHVSERYVMPeafiQPGQVCCVRIPEDVWWYRVIIHQVlNKQEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQ 112


                  ....*.
gi 569008102  966 IIRCSL 971
Cdd:cd20419   113 AIPASL 118

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 53.95 E-value: 9.46e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008102  760 IGRPCCAFFSgDGNWYRALVKEILPSGNVK--VHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPN 832
Cdd:cd20418     6 PEMPCLAEYS-DGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPL 79

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 54.95 E-value: 9.63e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  765 CAFFSGDGNWYRALVKEILPSG------NVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNK--HW 835
Cdd:cd20435    56 CAVEDENNLYHRVKVLEITEKDdktkprEVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPVDNdtEW 134

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 53.07 E-value: 1.26e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 569008102  917 DDDFWYRAIVlETSESD--VKVLYADYGNIETLPLSRVQPIPAS 958
Cdd:cd20433    40 EDGEWYRAKV-EKVEGDkkVHVLYIDYGNREVLPSTRLAALPPA 82

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 51.89 E-value: 1.53e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 569008102    309 PVKGEVCVAKYTvDQTWNRAIVQAVDVLQrKAHVLYIDYGNEEMIPIDSVHPL 361
Cdd:smart00333    3 FKVGDKVAARWE-DGEWYRARIVKVDGEQ-LYEVFFIDYGNEEVVPPSDLRQL 53

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 54.37 E-value: 1.84e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  506 FCQQLQSG-HKLAELQESLSEYCGHVIPRSDFY---PTIGDVCCAQFSedDQWYRASVLAYASEESVLVGYVDYG---NF 578
Cdd:cd20428    16 YCQVPSKGlSKLNEILDKIEYYFHSRQMTSEYFvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLDTGtvaSV 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 569008102  579 EILSLKRLCPIIPK-LLDLPMQALNCVLAGVKPSLGIWTPEAV 620
Cdd:cd20428    94 KVSELREIPPPFLReLISIPPQALKCCLADLPLNIGMWTPDAV 136

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 51.48 E-value: 1.85e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  312 GEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPL 361
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410503 Cd Length: 139 Bit Score: 53.97 E-value: 2.50e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  247 FSDLRSLQLkkTMEIKGT----VTE-FKHPSNFYIQLYSSEVLENMNQLSTSLketyANVVPEDGYLP----VKGEVCVA 317
Cdd:cd20432     6 FGDLSWLAS--IMKVHGEvgllVTDtFPHTPYFWAILLTEESQQNMQQLFSTL----AEVESQQPFLAkedvHRGRRCLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 569008102  318 KYTVDQ---TWNRAIVqaVDVLQRKAHVLYIDYGNEEMIPIDSVHPLS 362
Cdd:cd20432    80 ECPLGEeggAWNRCWV--LDVVEDFAVVFFVDFGSTANIPLPSLRSLD 125

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 53.19 E-value: 2.74e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  493 CGVVAHIQ-----TPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDfyPTIG--DVCCAQFSEDDQWYRASVLAYASE 565
Cdd:cd20437     1 VGTTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELN--PSCEnfGLLCAAKGKDGQWHRGFLQQLLPP 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 569008102  566 ESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLA 606
Cdd:cd20437    79 SQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 52.82 E-value: 2.76e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  271 PSNFYIQLYSSE-----VLENMNQLSTSLKETYANVvpedgylPVKGEVCVAKYTVDQTWNRAIVQAVDVlQRKAHVLYI 345
Cdd:cd20441     2 PSRFFIQLSEDEkvilqLAEELNETSEKSRENAAVK-------LKVGDLVAAEYDEDLALYRAVITAVLP-GKSFKVEFI 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 569008102  346 DYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGV 380
Cdd:cd20441    74 DYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 54.27 E-value: 2.83e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  262 KGTVTEFKHPSNFYIQLY-SSEVLENMNQLSTSLKETYANVVPEDgylPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKA 340
Cdd:cd20442     5 KGTLLSVSKNGTFYVRLLrNSEQLTDLESLIAKEAKKCKFVPVED---IKEGLECLAKSKKNLKWYRAVVEHLYPETEKM 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 569008102  341 HVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKC 375
Cdd:cd20442    82 LVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 53.58 E-value: 2.84e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  264 TVTEFKHPSNFYIQLYSseVLENMNQLSTSLKETY-ANVVPEDGYLPVK-GEVCVAKyTVDQTWNRAIVQAVDVLQRKAH 341
Cdd:cd20421    16 VVTEVTDPHRIFCQLRS--LSQELKRLSESMHQYYeGRVGSGYETRPEKlGSPCAAR-GSDGRWYRAVLQQVFSANRVVE 92

                          90       100
                  ....*....|....*....|.
gi 569008102  342 VLYIDYGNEEMIPIDSVHPLS 362
Cdd:cd20421    93 VLHVDYGRKEVVSVSNLRYLA 113

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 53.23 E-value: 3.06e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  265 VTEFKHPSNFYIQLYSSEvlENMNQLSTSLKEtYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRkAHVLY 344
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNT--EILEALMEKIAE-ISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSH-LSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 569008102  345 IDYGNEEMIPIDSVHPLSR---GLDLFPPSAIKCC 376
Cdd:cd20440    92 VDYGNKQIVEKNEVLPIPDtavDLLLTPMQAIKCC 126

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 52.04 E-value: 6.31e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  263 GTVTEFK-----HPSNFYIQLYSSEV-LENMNQLSTSLKETYAN--VVPEDGYlpvkGEVCVAKYTvDQTWNRAIVQAVd 334
Cdd:cd20437     2 GTTEKVKitaavSPSKFYCQLLSWEPeLSKLTTQMTLHYESVSKelNPSCENF----GLLCAAKGK-DGQWHRGFLQQL- 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 569008102  335 VLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVS 378
Cdd:cd20437    76 LPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 52.25 E-value: 7.67e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  538 PTIGDVCCAQfSEDDQWYRASVLAYASEES------VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 610
Cdd:cd20435    50 VKVGDLCAVE-DENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 52.12 E-value: 8.22e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  265 VTEFKHPSNFYIQL-YSSEVLE----NMNQLSTSLKETYANVVPedgylpvkGEVCVAKYTvDQTWNRAIVQAvdvLQRK 339
Cdd:cd20424    18 ITYVNDPWTFYCQLaRNAGVLDqlasAISRLSSEIRKLELSVNP--------GTLCLAKYS-DQHWYRGIIIT---NKNS 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 569008102  340 AHVLYIDYGNEEMIPIDSVHPL---SRGLDLFPPSAIKC 375
Cdd:cd20424    86 TEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKC 124

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 51.26 E-value: 9.97e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  917 DDDFWYRAIVLETSE-SDVKVL--YADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 973
Cdd:cd20418    15 SDGKWYRAKLLSILEfNPVKILvrHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAG 74

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 51.30 E-value: 1.10e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  265 VTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYAN-------VVPEDGYLPvkGEVCVAKYTVDQTWNRAIVQAVdVLQ 337
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNehvseryVMPEAFIQP--GQVCCVRIPEDVWWYRVIIHQV-LNK 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 569008102  338 RKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKC 375
Cdd:cd20419    79 QEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPA 116

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 51.66 E-value: 1.28e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  760 IGRPCCAFfSGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLQAILPQFLLLP 817
Cdd:cd20421    63 LGSPCAAR-GSDGRWYRAVLQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMP 120

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 51.71 E-value: 1.52e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  271 PSNFYIQL--YSSEVLENMNQLStslkETYANVVPEDGYL--PVKGEVCVAKYTVDQTWNRAIVqaVDVLQRKAHVLYID 346
Cdd:cd20438    17 PSNFWIRTdeYNNEFQALMKNIA----DIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRAVI--TEVLDLKVSVYFLD 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 569008102  347 YGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSE 389
Cdd:cd20438    91 FGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTK 133

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 48.84 E-value: 1.74e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 569008102  760 IGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQ 807
Cdd:cd20399     3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLK 50

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 48.81 E-value: 1.75e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 569008102  540 IGDVCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPIIPK 592
Cdd:cd20398     3 VGDKCRAVYSEDGIIYEATIVSiDAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 48.35 E-value: 2.27e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 569008102  761 GRPCCAFFSGDGNWYRALVKEILPSGNVKVHFvDYGNVEEVTTDQLQ 807
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIR 46

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 50.83 E-value: 2.33e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  918 DDFWYRAIVLETSESD--VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCS 982
Cdd:cd20408    60 DQNWYRALVQTVDVQQkkAGVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWS 126

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 51.58 E-value: 2.36e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  493 CGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEycghVIPRSDFYPTI----GDVCCAQFSEDDQWYRASVL-AYASEES 567
Cdd:cd20442     5 KGTLLSVSKNGTFYVRLLRNSEQLTDLESLIAK----EAKKCKFVPVEdikeGLECLAKSKKNLKWYRAVVEhLYPETEK 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 569008102  568 VLVGYVDYGNFEILSL---KRLCpiiPKLLDLPMQALNC 603
Cdd:cd20442    81 MLVFFVDHGITEVVSMgniKQLS---NDLLQIPRQAVLC 116

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 49.74 E-value: 2.80e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  916 QDDDFWYRA-IVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 971
Cdd:cd20415    35 FEDGAWYRArIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRL 91

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 48.02 E-value: 3.17e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  541 GDVCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPI 589
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEiTEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 49.31 E-value: 4.48e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  720 SPGEFYCHFLKDDALEKLDDLN-----QSLADYCAQKPPNGFkaeigrpCCAFFS-GDGN-WYRALVKEILPSgNVKVHF 792
Cdd:cd20431     5 EVGHFWGYRIDENSSEILQQLTaeinqRQLVPLTTKPVPNLL-------CLAPFTdADMKkYYRAKILYVSGS-SAEVFF 76

                          90       100
                  ....*....|....*....|....*
gi 569008102  793 VDYGNVEEVTTDQLQAILPQFLLLP 817
Cdd:cd20431    77 VDYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 48.06 E-value: 5.73e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008102  290 LSTSLKET--YANVVPEDgylPVKGEVCVAKYTVDQTWNRAIVQAVDVlQRKAHVLYIDYGNEEMIPIDSVHPLS 362
Cdd:cd20430     1 LSDELAEVcpTAPPLFGT---PDPNKIYGGKFSEDNCWYRCKVKSILS-DEKCTVQYIDYGNTETVSRSSIVELP 71

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 47.34 E-value: 5.82e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  307 YLPVKGEVCVAKYTVDQTWNRAIVQavDVLQR-KAHVLYIDYGNEEMIPIDSVHPLS 362
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVK--EILPGgAVKVHFVDYGNVEEVTLDKLRKIT 55

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 49.38 E-value: 5.98e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  271 PSNFYIQLYSSEVLENMnqLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIV---QAVDVLqrkaHVLYIDY 347
Cdd:cd20425    12 PSDFYVQLAQDEDELSM--ISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVkekIPNNLV----SVQFIDY 85

                          90       100
                  ....*....|....*....|....*...
gi 569008102  348 GNEEMIPIDSVHPLSRGLDLFPPSAIKC 375
Cdd:cd20425    86 GNTSVVQPSKIHRLPKELLSIPALSIHC 113

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 46.48 E-value: 9.23e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  761 GRPCCAFFSGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLQAI 809
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEITEESDtATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 48.15 E-value: 1.05e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  510 LQSGHKLAELQESLSEYCGhVIPRSDFYPTigDVCCAQFSEDDQ--WYRASVLaYASEESVLVGYVDYGNFEILSLKRLC 587
Cdd:cd20431    16 ENSSEILQQLTAEINQRQL-VPLTTKPVPN--LLCLAPFTDADMkkYYRAKIL-YVSGSSAEVFFVDYGNTSQVPSSLLR 91

                          90
                  ....*....|
gi 569008102  588 PIIPKLLDLP 597
Cdd:cd20431    92 EIPETLLTLP 101

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 48.65 E-value: 1.32e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  918 DDFWYRAIVLETSESdVKVLYADYGNIETLPLSRVQPIPASHLE---LPFQIIRCSL 971
Cdd:cd20424    71 DQHWYRGIIITNKNS-TEVFFVDYGNTEKVEKEDMLPIPSDAYElllLPMQAIKCSL 126

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 45.76 E-value: 2.19e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  309 PVKGEVCVAKYtvDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGL 365
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKILVRFVDFGNVEVMKLENLYECPEYL 55

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 47.04 E-value: 2.46e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  307 YLPVKGEVCVAKYTvDQTWNRAIVQAVdVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKC 375
Cdd:cd20415    23 LCPVQGQACVALFE-DGAWYRARIIGL-PGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKAREC 89

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 47.49 E-value: 2.99e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  263 GTVTEFK-----HPSNFYIQLY--SSEVLENMNQLstslkETYANVvPEDGYLPvkGEV-CVAKYTVDQTWNRAIVQAVd 334
Cdd:cd20439     9 GSVVDVKcsyvnSPGDFWCQLQtkSSELKSLMKQI-----QSYYLI-HNDPYKH--GQIaCVAKYSKDGKWYRAAVLKQ- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 569008102  335 VLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGV 380
Cdd:cd20439    80 VSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 46.27 E-value: 4.57e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  917 DDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 973
Cdd:cd20427    34 EEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAG 90

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 44.64 E-value: 4.91e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  761 GRPCCAFFSGDGNWYRALVKEILPSGNVK-VHFVDYGNVEEVTTDQLQAI 809
Cdd:cd20413     4 GDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 44.25 E-value: 7.49e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569008102  311 KGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPL 361
Cdd:cd20413     3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 45.91 E-value: 1.04e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569008102  918 DDFWYRAIVLET-SESDVKVLYADYGNIETLPLSRVQPIPASHLEL---PFQIIRCSL 971
Cdd:cd20440    70 DGQWYRALAHPVeSSSHLSVYFVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 45.94 E-value: 1.18e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 569008102  921 WYRAIVL-ETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 973
Cdd:cd20439    71 WYRAAVLkQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNN 124

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 45.88 E-value: 1.21e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569008102  918 DDFWYRAIVLETSESD--VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 973
Cdd:cd20421    73 DGRWYRAVLQQVFSANrvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 46.26 E-value: 1.23e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  540 IGDVCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEA 619
Cdd:cd20436    49 VGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTA 127


                  .
gi 569008102  620 V 620
Cdd:cd20436   128 V 128

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 43.06 E-value: 2.00e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 569008102  538 PTIGDVCCAQFseDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRL--CP 588
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLrVLNPDLKILVRFVDFGNVEVMKLENLyeCP 52

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 44.37 E-value: 3.19e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569008102  917 DDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 971
Cdd:cd20425    60 EDGLWYRAVVKEKIPNNlVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 41.80 E-value: 3.74e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569008102  914 RVQDDDFWYRAIVLETSESD-VKVLYaDYGNIETLPLSRVQP 954
Cdd:cd04508     7 KWSDDGQWYPATVVAVNDDGkYTVLF-DDGNEEEVSEDDIRP 47

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 43.57 E-value: 4.18e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  771 DGNWYRALVKEIlPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP 830
Cdd:cd20427    35 EDAWLRAQVIEV-EEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 41.91 E-value: 4.50e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  539 TIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCP 588
Cdd:cd20399     2 KVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKP 51

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 42.58 E-value: 4.88e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569008102  921 WYRAIVLETSESD--VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 971
Cdd:cd20407    19 WYRAQVVGVFEETdeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYL 71

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 44.33 E-value: 5.03e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  270 HPSNFYIQL---YSS------EVLENMNQLSTSLKETYANvvpedgylpvkGEVCVAKYTVDQTWNRAIVQAVDVLQRka 340
Cdd:cd20436    10 HPKEVLVKFqgqYNSiceldyHILQNEIQNATKSKSSWGV-----------GEFCLVEDTTSGEWYRGRVLEKIDEKY-- 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569008102  341 HVLYIDYGNeeMIPIDSVHPLSRGLDLF--PPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFC 404
Cdd:cd20436    77 EVFLIDRGE--VLNVHATNMASASGELFqlPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQVK 140

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 42.42 E-value: 5.07e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569008102  918 DDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIpASHLELPFQIIRCSLEG 973
Cdd:cd20417    13 DTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPM-VLYPDIPQFCIPCQLYG 67

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 43.19 E-value: 6.57e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569008102  918 DDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGP 974
Cdd:cd20441    51 DLALYRAVITAVLPGKsFKVEFIDYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 41.11 E-value: 1.00e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569008102    917 DDDFWYRAIVLE-TSESDVKVLYADYGNIETLPLSRVQPIP 956
Cdd:smart00333   14 EDGEWYRARIVKvDGEQLYEVFFIDYGNEEVVPPSDLRQLP 54

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 42.79 E-value: 1.19e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569008102  916 QDDDFWYRAIVLET-SESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 971
Cdd:cd20437    62 GKDGQWHRGFLQQLlPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 43.23 E-value: 1.20e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569008102  914 RVQDDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 971
Cdd:cd20438    64 RYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 40.65 E-value: 1.24e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 569008102  541 GDVCCAQFSEDDQWYRASVLAYASEESVLVGYvDYGNFEILSLKRLCP 588
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 42.88 E-value: 1.30e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 569008102  918 DDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 971
Cdd:cd20422    62 EDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCL 115

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 41.12 E-value: 1.72e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 569008102  918 DDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPIP 956
Cdd:cd20430    32 DNCWYRCKVKSILSDEkCTVQYIDYGNTETVSRSSIVELP 71

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 40.29 E-value: 1.81e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569008102  759 EIGRPCCAFFSgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQlqaILP 811
Cdd:cd20384     6 KEGSRCLAKYD-DGLWYPATVTDIDEDGKYTVKFDSYGEVAVVELDD---ILP 54

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 39.93 E-value: 2.22e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 569008102  917 DDDFWYRAIVLE--TSESDVKVLYADYGNIETLPLSRVQPI 955
Cdd:cd21182    10 DDGKYYEATIEEitEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 41.60 E-value: 2.30e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 569008102  921 WYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELP 963
Cdd:cd20431    59 YYRAKILYVSGSSAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 40.02 E-value: 2.50e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  541 GDVCCAQFSEDDQWYRASVLAYASEESV-LVGYVDYGNFEILSLKRLCPI 589
Cdd:cd20413     4 GDECLAKYWEDNKFYRAEVTAVHPSGKTaVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 39.95 E-value: 2.89e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 569008102  759 EIGRPCCAFFSGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEV 801
Cdd:cd20398     2 KVGDKCRAVYSEDGIIYEATIVSIdAERGTCVVRYTGYGNEEEQ 45

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 39.60 E-value: 3.25e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569008102  771 DGNWYRALVKEIL-PSGNVKVHFVDYGNVEEVTTDQLQaILPQFL 814
Cdd:cd20444    12 DGNHYRAIVLRVLnPDLKILVRFVDFGNVEVMKLENLY-ECPEYL 55

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 38.56 E-value: 8.22e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569008102  313 EVCVAKYtvDQTWNRAI-VQAVDvlQRKAHVLYIDYGNEEMIPIDSVHPlsrgldlFPPSAIK 374
Cdd:cd20445     3 ELCIAKY--MDKWYRAVcLESVG--DGRPTVLFCDYGNILMARLTDIRP-------FPPTFAT 54

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 38.17 E-value: 9.53e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 569008102  919 DFWYRAIVLEtSESDVK--VLYADYGNIETLPLSRVQPIP 956
Cdd:cd20445    11 DKWYRAVCLE-SVGDGRptVLFCDYGNILMARLTDIRPFP 49

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 39.39 E-value: 1.04e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569008102  543 VCCAQFseDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQAL 601
Cdd:cd20429    35 VYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 38.02 E-value: 1.17e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569008102  312 GEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEmipidsVHPLSrglDLFPPSAI 373
Cdd:cd20398     4 GDKCRAVYSEDGIIYEATIVSIDAERGTCVVRYTGYGNEE------EQNLS---DLLPPSGE 56

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 40.31 E-value: 1.18e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569008102  917 DDDFWYRAIVLETSESD-------VKVLYADYGNIETLPLSRVQPIPASHLELPFQII 967
Cdd:cd20435    61 ENNLYHRVKVLEITEKDdktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 37.18 E-value: 1.62e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 569008102  312 GEVCVAKYTVDQTWNRAIVQAVDvLQRKAHVLYiDYGNEEMIPIDSV 358
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVN-DDGKYTVLF-DDGNEEEVSEDDI 45

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 37.80 E-value: 1.78e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  765 CAFFSGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLQAIL-----PQFlLLPFQ 819
Cdd:cd20417     7 CVVRGSDTLWYRGKVLEVI-GGMVRVQYVDQGYIEKIPQCHLYPMVlypdiPQF-CIPCQ 64

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 37.40 E-value: 1.98e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 569008102  772 GNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLP 817
Cdd:cd20445    11 DKWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410505 Cd Length: 164 Bit Score: 39.71 E-value: 2.67e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  721 PGEFYCHFLK--------DDALEKL-DDLNQSLADYCAQ----KPPNgfkAEIGRPCCAFFSGDGNWYRALVKEILPSGN 787
Cdd:cd20434     9 PGCFWGRILKgsgdlvvnPEEYENLqDEMNQFYHKGYKDveeiKPST---LEEGQVCVVFCEELKCWCRAVVESLMSSAD 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008102  788 ---VKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP---------------PNKHWTKEATARFQ 844
Cdd:cd20434    86 dylAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPvtlhvdlcedkakivPARKWDSAAIQYFQ 160

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 37.79 E-value: 4.24e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  289 QLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAivQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLF 368
Cdd:cd20427     2 QMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRA--QVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSL 79

                          90
                  ....*....|....
gi 569008102  369 PPSAIKCCVSGVIP 382
Cdd:cd20427    80 PFQATKCKLAGLEP 93

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410487 Cd Length: 82 Bit Score: 37.08 E-value: 4.45e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008102  290 LSTSLKETYANVVPEdgylPVKGEV---CVAKYTVDQTWNRAIVQAVdVLQRKAHVLYIDYGNEEMIPIDSVHPL 361
Cdd:cd20416     1 LQEKMIAEYENSKPE----PVKWENdmhCAVQIQDKKQWRRGQIIRV-VSDTLVEVFLYDFGNKEVVNIDCLRKL 70

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410491 Cd Length: 132 Bit Score: 38.18 E-value: 5.27e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  518 ELQES-LSEYCGHVIPRSDfyPTIGDVCCAQFseDDQWYRASVLAYASEESVlVGYVDYGNFEILSLKRLCPIIPKLLDL 596
Cdd:cd20420    44 EIQAAvKMRGCGAGDGGAE--PSVGDLCLVEV--GGLWHRCRVVSRQGDDYR-VFLLDEGRTVVARAKSLARGRKDFFSL 118

                          90
                  ....*....|....
gi 569008102  597 PMQALNCVLAGVKP 610
Cdd:cd20420   119 PPEVLGCVLANLVP 132

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 38.39 E-value: 5.29e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008102  270 HPSNFYIQL-----YSSEVLENMN----QLSTSLKETYA---NVVPEDgyLPVKGEVCVAKYTvDQTWNRAIVQAV---- 333
Cdd:cd20435     1 DATHYSARIlehrsSDGEVTKSMSstylKLSMKLNMYYSdpsNRILHG--KVKVGDLCAVEDE-NNLYHRVKVLEItekd 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 569008102  334 -DVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIP 382
Cdd:cd20435    78 dKTKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127