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Conserved domains on  [gi|578798931|ref|XP_006710635|]
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adenylate kinase isoenzyme 5 isoform X2 [Homo sapiens]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 17817814)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 348-535 4.24e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 363.75  E-value: 4.24e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  348 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 427
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  428 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 507
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 578798931  508 TKTQLHKINAEGTPEDVFLQLCTAIDSI 535
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 108-281 1.94e-53

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 1.94e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 108 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 187
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTEL--GKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 188 GIVIDGFPRDVAQALSFEDQIC---TPDLVVFLACANQRLKERLLKR-------------------AEQQGRPDDNVKAT 245
Cdd:cd01428   79 GFILDGFPRTVDQAEALDELLDegiKPDKVIELDVPDEVLIERILGRricpvsgrvyhlgkddvtgEPLSQRSDDNEETI 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 578798931 246 QRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 281
Cdd:cd01428  159 KKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
DD_R_PKA_DPY30-like super family cl02594
dimerization/docking (D/D) domains found in the cAMP-dependent protein kinase regulatory ...
 1-20 7.64e-05

dimerization/docking (D/D) domains found in the cAMP-dependent protein kinase regulatory subunit (PRKAR) and the DPY30/SDC1-like family; This hierarchy includes the dimerization/docking (D/D) domains of type I and type II cAMP-dependent protein kinase (PKA) regulatory (R) subunits, DPY30 from animals and its homologs, SDC1 from yeasts, and similar domains. PKA is a serine/threonine kinase (STK), catalyzing the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of R subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. There are two classes of R subunits, RI and RII; each exists as two isoforms (alpha and beta) from distinct genes. These functionally non-redundant R isoforms allow for specificity in PKA signaling. The R subunit contains an N-terminal D/D domain, a linker with an inhibitory sequence (IS), and two c-AMP binding domains. The D/D domain dimerizes to form a four-helix bundle that serves as a docking site for A-kinase-anchoring proteins (AKAPs), which facilitates the localization of PKA to specific sites in the cell. DPY30, also called dumpy-30, was initially discovered in Caenorhabditis elegans as a key player in X chromosome dosage compensation. Human DPY30 plays a dual function in moderately regulating the methyltransferase activity of SET1/COMPASS (COMplex of Proteins ASsociated with Set1) enzymes and contributing to the recruitment of the complex to chromatin. Yeast SDC1 (suppressor of CDC25 protein 1) is the smallest subunit of COMPASS (COMplex of Proteins ASsociated with Set1) and interacts exclusively with Bre2 at the distal end of the catalytic module. It positively regulates the COMPASS catalytic module by stabilizing the non-canonical Bre2 SPRY domain. DPY30/SDC1 contains a C-terminal helical bundle domain that directly interacts with Ash2L (in human)/Bre2 (in yeast) COMPASS through the DPY30-binding motif (DBM). The DPY30/SDC1 helical bundle domain, also called D/D domain, is formed of two alpha-helices that may be analogous to the D/D domain found in regulatory subunit of PKA.


The actual alignment was detected with superfamily member cd22978:

Pssm-ID: 445844  Cd Length: 44  Bit Score: 40.21  E-value: 7.64e-05
                         10        20
                 ....*....|....*....|
gi 578798931   1 MCSKPEDPVEYLESCLQKVK 20
Cdd:cd22978   25 MYNRPDDPIEFLEDCLEKIR 44
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 348-535 4.24e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 363.75  E-value: 4.24e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  348 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 427
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  428 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 507
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 578798931  508 TKTQLHKINAEGTPEDVFLQLCTAIDSI 535
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 352-524 9.33e-61

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 198.61  E-value: 9.33e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRG 431
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 432 FLIDGYPREVKQGEEFGRRI---GDPQLVICMDCSADTMTNRLLQRSRSSLP-------------------VDDTTKTIA 489
Cdd:cd01428   80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICPVSgrvyhlgkddvtgeplsqrSDDNEETIK 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 578798931 490 KRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 524
Cdd:cd01428  160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 108-281 1.94e-53

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 1.94e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 108 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 187
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTEL--GKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 188 GIVIDGFPRDVAQALSFEDQIC---TPDLVVFLACANQRLKERLLKR-------------------AEQQGRPDDNVKAT 245
Cdd:cd01428   79 GFILDGFPRTVDQAEALDELLDegiKPDKVIELDVPDEVLIERILGRricpvsgrvyhlgkddvtgEPLSQRSDDNEETI 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 578798931 246 QRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 281
Cdd:cd01428  159 KKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 107-290 9.41e-50

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 169.61  E-value: 9.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  107 KIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQ-IPD 185
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGK--QLQAIMESGDLVPLDTVLDLLKDAMVAaLGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  186 EEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQE 265
Cdd:TIGR01360  82 SKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYET 161

                         170       180
                  ....*....|....*....|....*
gi 578798931  266 KGLIMTFDADRDEDEVFYDISMAVD 290
Cdd:TIGR01360 162 KGKLRKINAEGTVDDVFLQVCTAID 186
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 351-532 1.21e-48

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 167.23  E-value: 1.21e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 351 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTR 430
Cdd:COG0563    2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 431 GFLIDGYPREVKQGE-------EFGRRIgdpQLVICMDCSADTMTNRLLQR-----------SRSSLPV----------- 481
Cdd:COG0563   80 GFILDGFPRTVAQAEaldellaELGIKL---DAVIELDVDDEELVERLSGRrvcpncgatyhVKFNPPKvegvcdkcgge 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578798931 482 -----DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAI 532
Cdd:COG0563  157 lvqraDDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
355-509 2.31e-48

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 165.56  E-value: 2.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  355 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVAsLGDTRGFLI 434
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ-NDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  435 DGYPREVKQGEEFGR---RIGDPQLVICMDCSADTMTNRLLQR---------------------------SRSSLPVDDT 484
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRrihpnsgrsyhlefnppkvpgkddvtgEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 578798931  485 TKTIAKRLEAYYRASIPVIAYYETK 509
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
PLN02200 PLN02200
adenylate kinase family protein
 352-528 3.47e-48

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.99  E-value: 3.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTRG 431
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESS--DNNK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 432 FLIDGYPREVKQGEEFGRRIG-DPQLVICMDCSADTMTNRLLQRSRSSlpVDDTTKTIAKRLEAYYRASIPVIAYYETKT 510
Cdd:PLN02200 123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVLNRNQGR--VDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                        170
                 ....*....|....*...
gi 578798931 511 QLHKINAEGTPEDVFLQL 528
Cdd:PLN02200 201 KLYTINAVGTVDEIFEQV 218
PLN02200 PLN02200
adenylate kinase family protein
 87-282 1.07e-38

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 141.57  E-value: 1.07e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  87 SETAELIEEYEVFDPTRPR-PKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGE 165
Cdd:PLN02200  23 SFSTEIITLEERGSSSKEKtPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEH--GAMILNTIKEGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 166 LAPQETTITEIKQKlMQIPDEEGIVIDGFPRDVAQALSFEDQI-CTPDLVVFLACANQRLKERLLKRaeQQGRPDDNVKA 244
Cdd:PLN02200 101 IVPSEVTVKLIQKE-MESSDNNKFLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNR--NQGRVDDNIDT 177

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578798931 245 TQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVF 282
Cdd:PLN02200 178 IKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIF 215
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 107-285 1.51e-37

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 137.57  E-value: 1.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 107 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLMQIPD 185
Cdd:COG0563    2 RIIL-LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAV---KAGTELGKKAKeYMDAGELVPDEIVIGLVKERLAQPDC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 186 EEGIVIDGFPRDVAQALSFEDQIC----TPDLVVFLACANQRLKERLLKRA---------------------------EQ 234
Cdd:COG0563   78 ANGFILDGFPRTVAQAEALDELLAelgiKLDAVIELDVDDEELVERLSGRRvcpncgatyhvkfnppkvegvcdkcggEL 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578798931 235 QGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDI 285
Cdd:COG0563  158 VQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADI 208
ADK pfam00406
Adenylate kinase;
111-266 7.97e-36

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 132.05  E-value: 7.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  111 VIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIV 190
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGK--EAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  191 IDGFPRDVAQALSFED---QICTPDLVVFLACANQRLKERLLKRAEQQ---------------------------GRPDD 240
Cdd:pfam00406  79 LDGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHPnsgrsyhlefnppkvpgkddvtgeplvQRSDD 158

                         170       180
                  ....*....|....*....|....*.
gi 578798931  241 NVKATQRRLMNFKQNAAPLVKYFQEK 266
Cdd:pfam00406 159 NEETVKKRLETYHKQTKPLIDYYKKK 184
DD_AK5 cd22978
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar ...
 1-20 7.64e-05

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar proteins; AK5 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 5, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It is active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. It also displays broad nucleoside diphosphate kinase activity. AK5 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438547  Cd Length: 44  Bit Score: 40.21  E-value: 7.64e-05
                         10        20
                 ....*....|....*....|
gi 578798931   1 MCSKPEDPVEYLESCLQKVK 20
Cdd:cd22978   25 MYNRPDDPIEFLEDCLEKIR 44
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 107-161 5.08e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 37.47  E-value: 5.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578798931 107 KIILVIGGPGSGKgTQSL-KIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKII 161
Cdd:NF033453  17 KLILLVGPPGSGK-TALLrELAAKRGAPVINVNLELSRRLLELPEKQRALRAPRLL 71
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 348-535 4.24e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 363.75  E-value: 4.24e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  348 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 427
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  428 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 507
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 578798931  508 TKTQLHKINAEGTPEDVFLQLCTAIDSI 535
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 352-524 9.33e-61

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 198.61  E-value: 9.33e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRG 431
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 432 FLIDGYPREVKQGEEFGRRI---GDPQLVICMDCSADTMTNRLLQRSRSSLP-------------------VDDTTKTIA 489
Cdd:cd01428   80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICPVSgrvyhlgkddvtgeplsqrSDDNEETIK 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 578798931 490 KRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 524
Cdd:cd01428  160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 352-525 7.19e-58

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 190.66  E-value: 7.19e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASE-SERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 430
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAIQED-GSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  431 GFLIDGYPREVKQGEEFGRRIG---DPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 507
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDnkvNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170
                  ....*....|....*...
gi 578798931  508 TKTQLHKINAEGTPEDVF 525
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVF 177
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 108-281 1.94e-53

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 1.94e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 108 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 187
Cdd:cd01428    1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTEL--GKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 188 GIVIDGFPRDVAQALSFEDQIC---TPDLVVFLACANQRLKERLLKR-------------------AEQQGRPDDNVKAT 245
Cdd:cd01428   79 GFILDGFPRTVDQAEALDELLDegiKPDKVIELDVPDEVLIERILGRricpvsgrvyhlgkddvtgEPLSQRSDDNEETI 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 578798931 246 QRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 281
Cdd:cd01428  159 KKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 107-290 9.41e-50

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 169.61  E-value: 9.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  107 KIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQ-IPD 185
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGK--QLQAIMESGDLVPLDTVLDLLKDAMVAaLGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  186 EEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQE 265
Cdd:TIGR01360  82 SKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYET 161

                         170       180
                  ....*....|....*....|....*
gi 578798931  266 KGLIMTFDADRDEDEVFYDISMAVD 290
Cdd:TIGR01360 162 KGKLRKINAEGTVDDVFLQVCTAID 186
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 351-532 1.21e-48

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 167.23  E-value: 1.21e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 351 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTR 430
Cdd:COG0563    2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 431 GFLIDGYPREVKQGE-------EFGRRIgdpQLVICMDCSADTMTNRLLQR-----------SRSSLPV----------- 481
Cdd:COG0563   80 GFILDGFPRTVAQAEaldellaELGIKL---DAVIELDVDDEELVERLSGRrvcpncgatyhVKFNPPKvegvcdkcgge 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578798931 482 -----DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAI 532
Cdd:COG0563  157 lvqraDDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
355-509 2.31e-48

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 165.56  E-value: 2.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  355 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVAsLGDTRGFLI 434
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ-NDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  435 DGYPREVKQGEEFGR---RIGDPQLVICMDCSADTMTNRLLQR---------------------------SRSSLPVDDT 484
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRrihpnsgrsyhlefnppkvpgkddvtgEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 578798931  485 TKTIAKRLEAYYRASIPVIAYYETK 509
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
PLN02200 PLN02200
adenylate kinase family protein
 352-528 3.47e-48

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.99  E-value: 3.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTRG 431
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESS--DNNK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 432 FLIDGYPREVKQGEEFGRRIG-DPQLVICMDCSADTMTNRLLQRSRSSlpVDDTTKTIAKRLEAYYRASIPVIAYYETKT 510
Cdd:PLN02200 123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVLNRNQGR--VDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                        170
                 ....*....|....*...
gi 578798931 511 QLHKINAEGTPEDVFLQL 528
Cdd:PLN02200 201 KLYTINAVGTVDEIFEQV 218
adk PRK00279
adenylate kinase; Reviewed
 353-535 5.94e-45

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 157.62  E-value: 5.94e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 353 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRGF 432
Cdd:PRK00279   3 LILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 433 LIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQRS--RSSLPV------------------------- 481
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMLKELGIkldaVIEIDVPDEELVERLSGRRicPACGRTyhvkfnppkvegkcdvcgeeliqra 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578798931 482 DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSI 535
Cdd:PRK00279 162 DDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 351-533 1.73e-42

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 150.85  E-value: 1.73e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  351 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTR 430
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  431 GFLIDGYPREVKQGEEF--------------------------GRRI------------GDPQLVICMDCSADtmtnRLL 472
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALdalleepidavieldvpdeelverlsGRRIcpscgrvyhlkfNPPKVPGCDDCTGE----LLV 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578798931  473 QRSrsslpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAID 533
Cdd:TIGR01351 156 QRE------DDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 108-285 6.88e-39

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 140.20  E-value: 6.88e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  108 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 187
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENG-SLIESYIKEGKIVPSEVTVELLKKAIQEDGSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  188 GIVIDGFPRDVAQALSFEDQICT---PDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQ 264
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDNkvnFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 578798931  265 EKGLIMTFDADRDEDEVFYDI 285
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
PLN02200 PLN02200
adenylate kinase family protein
 87-282 1.07e-38

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 141.57  E-value: 1.07e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  87 SETAELIEEYEVFDPTRPR-PKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGE 165
Cdd:PLN02200  23 SFSTEIITLEERGSSSKEKtPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEH--GAMILNTIKEGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 166 LAPQETTITEIKQKlMQIPDEEGIVIDGFPRDVAQALSFEDQI-CTPDLVVFLACANQRLKERLLKRaeQQGRPDDNVKA 244
Cdd:PLN02200 101 IVPSEVTVKLIQKE-MESSDNNKFLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNR--NQGRVDDNIDT 177

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578798931 245 TQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVF 282
Cdd:PLN02200 178 IKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIF 215
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 107-285 1.51e-37

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 137.57  E-value: 1.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 107 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLMQIPD 185
Cdd:COG0563    2 RIIL-LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAV---KAGTELGKKAKeYMDAGELVPDEIVIGLVKERLAQPDC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 186 EEGIVIDGFPRDVAQALSFEDQIC----TPDLVVFLACANQRLKERLLKRA---------------------------EQ 234
Cdd:COG0563   78 ANGFILDGFPRTVAQAEALDELLAelgiKLDAVIELDVDDEELVERLSGRRvcpncgatyhvkfnppkvegvcdkcggEL 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578798931 235 QGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDI 285
Cdd:COG0563  158 VQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADI 208
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 109-290 2.20e-36

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 134.28  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDEE- 187
Cdd:TIGR01351   2 LVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGK--KAKEYMEKGELVPDEIVNQLVKERLTQNDDNEn 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  188 GIVIDGFPRDVAQALSFEDQIC-TPDLVVFLACANQRLKERLLKR---------------------------AEQQGRPD 239
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLEePIDAVIELDVPDEELVERLSGRricpscgrvyhlkfnppkvpgcddctgELLVQRED 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578798931  240 DNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVD 290
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK pfam00406
Adenylate kinase;
111-266 7.97e-36

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 132.05  E-value: 7.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  111 VIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIV 190
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGK--EAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  191 IDGFPRDVAQALSFED---QICTPDLVVFLACANQRLKERLLKRAEQQ---------------------------GRPDD 240
Cdd:pfam00406  79 LDGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHPnsgrsyhlefnppkvpgkddvtgeplvQRSDD 158

                         170       180
                  ....*....|....*....|....*.
gi 578798931  241 NVKATQRRLMNFKQNAAPLVKYFQEK 266
Cdd:pfam00406 159 NEETVKKRLETYHKQTKPLIDYYKKK 184
adk PRK00279
adenylate kinase; Reviewed
 107-292 9.32e-35

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 129.88  E-value: 9.32e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 107 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDE 186
Cdd:PRK00279   2 RLIL-LGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGK--EAKSYMDAGELVPDEIVIGLVKERLAQPDCK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 187 EGIVIDGFPRDVAQALSFEDQIC----TPDLVVFLACANQRLKERLLKRA---------------------------EQQ 235
Cdd:PRK00279  79 NGFLLDGFPRTIPQAEALDEMLKelgiKLDAVIEIDVPDEELVERLSGRRicpacgrtyhvkfnppkvegkcdvcgeELI 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578798931 236 GRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNK 292
Cdd:PRK00279 159 QRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
PRK14527 PRK14527
adenylate kinase; Provisional
 351-525 3.25e-34

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 127.98  E-value: 3.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 351 KIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAmVASLGDTR 430
Cdd:PRK14527   7 KVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEPVR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 431 gFLIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYY 506
Cdd:PRK14527  86 -VIFDGFPRTLAQAEALDRLLEELGArllaVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVDYY 164

                        170
                 ....*....|....*....
gi 578798931 507 ETKTQLHKINAEGTPEDVF 525
Cdd:PRK14527 165 EARGHLKRVDGLGTPDEVY 183
PRK14531 PRK14531
adenylate kinase; Provisional
 349-533 4.36e-33

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 124.54  E-value: 4.36e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 349 KCKIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGD 428
Cdd:PRK14531   2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 429 trGFLIDGYPREVKQGEEFGRRIGD---P-QLVICMDCSADTMTNRLLQRSRSslpvDDTTKTIAKRLEAYYRASIPVIA 504
Cdd:PRK14531  81 --GWLLDGFPRTVAQAEALEPLLEElkqPiEAVVLLELDDAVLIERLLARGRA----DDNEAVIRNRLEVYREKTAPLID 154

                        170       180
                 ....*....|....*....|....*....
gi 578798931 505 YYETKTQLHKINAEGTPEDVFLQLCTAID 533
Cdd:PRK14531 155 HYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14532 PRK14532
adenylate kinase; Provisional
 353-534 1.93e-31

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 119.93  E-value: 1.93e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 353 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGdTRGF 432
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEA-AGGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 433 LIDGYPREVKQGEEF-------GRRIgdpQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAY 505
Cdd:PRK14532  82 IFDGFPRTVAQAEALdkmlasrGQKI---DVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPY 158

                        170       180
                 ....*....|....*....|....*....
gi 578798931 506 YETKTQLHKINAEGTPEDVflqlCTAIDS 534
Cdd:PRK14532 159 YAGQGKLTEVDGMGSIEAV----AASIDA 183
adk PRK02496
adenylate kinase; Provisional
 351-532 2.91e-31

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 119.47  E-value: 2.91e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 351 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTR 430
Cdd:PRK02496   3 RLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQP--DAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 431 -GFLIDGYPREVKQG---EEFGRRIGDP-QLVICMDCSADTMTNRLLQRSRSslpvDDTTKTIAKRLEAYYRASIPVIAY 505
Cdd:PRK02496  80 nGWILDGFPRKVTQAaflDELLQEIGQSgERVVNLDVPDDVVVERLLARGRK----DDTEEVIRRRLEVYREQTAPLIDY 155

                        170       180
                 ....*....|....*....|....*..
gi 578798931 506 YETKTQLHKINAEGTPEDVFLQLCTAI 532
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAVTTELKAAL 182
PRK14532 PRK14532
adenylate kinase; Provisional
 109-289 1.04e-30

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 118.00  E-value: 1.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSS-NRKwslIAKIITTGELAPQETTITEIKQKLMQIPDEE 187
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSElGQR---VKGIMDRGELVSDEIVIALIEERLPEAEAAG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 188 GIVIDGFPRDVAQALSFEDQICTP----DLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYF 263
Cdd:PRK14532  80 GAIFDGFPRTVAQAEALDKMLASRgqkiDVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPYY 159

                        170       180
                 ....*....|....*....|....*.
gi 578798931 264 QEKGLIMTFDADRDEDEVFYDISMAV 289
Cdd:PRK14532 160 AGQGKLTEVDGMGSIEAVAASIDAAL 185
AAA_17 pfam13207
AAA domain;
357-488 1.10e-30

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 116.18  E-value: 1.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  357 GGPGSGKGTQCEKLVEKYGFTHLSTGELLREElASESERSKlIRDIMERGDLVPSGIVLELLKEAMvASLGDTRGFLIDG 436
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREE-AKERGLVE-DRDEMRKLPLEPQKELQKLAAERI-AEEAGEGGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578798931  437 YPREVKQGEEFGR------RIGDPQLVICMDCSADTMTNRLLQRsRSSLPVDDTTKTI 488
Cdd:pfam13207  79 HPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEI 135
PRK14530 PRK14530
adenylate kinase; Provisional
 353-534 8.35e-30

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 116.43  E-value: 8.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 353 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLReelaseSERSKLIRDI----------MERGDLVPSGIVLELLKEAm 422
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALR------ANKQMDISDMdteydtpgeyMDAGELVPDAVVNEIVEEA- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 423 vasLGDTRGFLIDGYPREVKQGEEFGR----------RIGDPQLV-------ICMDCSA---------------DTMTNR 470
Cdd:PRK14530  79 ---LSDADGFVLDGYPRNLEQAEYLESitdldvvlylDVSEEELVdrltgrrVCPDCGAnyhvefnqpeeegvcDECGGE 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578798931 471 LLQRSrsslpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDS 534
Cdd:PRK14530 156 LIQRD------DDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
PRK14527 PRK14527
adenylate kinase; Provisional
 102-289 2.40e-28

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 111.42  E-value: 2.40e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 102 TRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKL 180
Cdd:PRK14527   2 TQTKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHV---ARGTELGQRAKpIMEAGDLVPDELILALIRDEL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 181 MQIPDEEgIVIDGFPRDVAQA----LSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNA 256
Cdd:PRK14527  79 AGMEPVR-VIFDGFPRTLAQAealdRLLEELGARLLAVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQT 157

                        170       180       190
                 ....*....|....*....|....*....|...
gi 578798931 257 APLVKYFQEKGLIMTFDADRDEDEVFYDISMAV 289
Cdd:PRK14527 158 QPLVDYYEARGHLKRVDGLGTPDEVYARILKAL 190
adk PRK02496
adenylate kinase; Provisional
 109-281 2.30e-27

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 108.68  E-value: 2.30e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAKI-ITTGELAPQETTITEIKQKLMQIPDEE 187
Cdd:PRK02496   4 LIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAI---KEQTPLGIKAQGyMDKGELVPDQLVLDLVQERLQQPDAAN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 188 GIVIDGFPRDVAQAlSFEDQICTP-----DLVVFLACANQRLKERLLKRaeqqGRPDDNVKATQRRLMNFKQNAAPLVKY 262
Cdd:PRK02496  81 GWILDGFPRKVTQA-AFLDELLQEigqsgERVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDY 155

                        170
                 ....*....|....*....
gi 578798931 263 FQEKGLIMTFDADRDEDEV 281
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAV 174
PRK14528 PRK14528
adenylate kinase; Provisional
 351-524 3.60e-26

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 105.48  E-value: 3.60e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 351 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 430
Cdd:PRK14528   3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREA-DCKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 431 GFLIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYY 506
Cdd:PRK14528  81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                        170
                 ....*....|....*...
gi 578798931 507 ETKTQLHKINAEGTPEDV 524
Cdd:PRK14528 161 AAQKKLSQVNGVGSLEEV 178
AAA_17 pfam13207
AAA domain;
113-242 4.24e-26

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 103.47  E-value: 4.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  113 GGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstsSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVID 192
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREEA----KERGLVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVD 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578798931  193 GFPRDVAQALSFED------QICTPDLVVFLACANQRLKERLLKRAEqQGRPDDNV 242
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT-RGRDDDSE 132
PRK14530 PRK14530
adenylate kinase; Provisional
 109-293 1.10e-24

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 102.17  E-value: 1.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLR--KKIHSTSSNRKWSLIAKIITTGELAPQEtTITEIKQKlmQIPDE 186
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRanKQMDISDMDTEYDTPGEYMDAGELVPDA-VVNEIVEE--ALSDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 187 EGIVIDGFPRDVAQALSFEDqICTPDLVVFLACANQRLKERLLKR----------------AEQQG-----------RPD 239
Cdd:PRK14530  83 DGFVLDGYPRNLEQAEYLES-ITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqPEEEGvcdecggeliqRDD 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578798931 240 DNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKL 293
Cdd:PRK14530 162 DTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDDAT 215
PRK14531 PRK14531
adenylate kinase; Provisional
 109-274 6.24e-24

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 98.73  E-value: 6.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSliAKIITTGELAPQETTITEIKQKlMQIPDEEG 188
Cdd:PRK14531   5 LLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEA--EAVMNRGELVSDALVLAIVESQ-LKALNSGG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 189 IVIDGFPRDVAQALSFE---DQICTP-DLVVFLACANQRLKERLLKRaeqqGRPDDNVKATQRRLMNFKQNAAPLVKYFQ 264
Cdd:PRK14531  82 WLLDGFPRTVAQAEALEpllEELKQPiEAVVLLELDDAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPLIDHYR 157

                        170
                 ....*....|
gi 578798931 265 EKGLIMTFDA 274
Cdd:PRK14531 158 QRGLLQSVEA 167
PLN02842 PLN02842
nucleotide kinase
 355-535 8.74e-24

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 104.56  E-value: 8.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 355 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLI 434
Cdd:PLN02842   2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 435 DGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQR-----------------------SRSSLPVDDTTKTIAKR 491
Cdd:PLN02842  82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppeseeikARLITRPDDTEEKVKAR 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 578798931 492 LEAYYRASIPVIAYYETKtqLHKINAEGTPEDVFLQLCTAIDSI 535
Cdd:PLN02842 162 LQIYKKNAEAILSTYSDI--MVKIDGNRPKEVVFEEISSLLSQI 203
PRK13808 PRK13808
adenylate kinase; Provisional
 353-524 2.25e-23

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 101.12  E-value: 2.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 353 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTRGF 432
Cdd:PRK13808   3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQP-DAANGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 433 LIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQR-----SRSSLP-VDDTTKTIAKRLEAYYRASIPV 502
Cdd:PRK13808  82 ILDGFPRTVPQAEALDALLKDKQLkldaVVELRVNEGALLARVETRvaemrARGEEVrADDTPEVLAKRLASYRAQTEPL 161

                        170       180
                 ....*....|....*....|..
gi 578798931 503 IAYYETKTQLHKINAEGTPEDV 524
Cdd:PRK13808 162 VHYYSEKRKLLTVDGMMTIDEV 183
PRK13808 PRK13808
adenylate kinase; Provisional
 107-285 9.17e-23

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 99.19  E-value: 9.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 107 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLMQIPD 185
Cdd:PRK13808   2 RLIL-LGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAV---AAGTPVGLKAKdIMASGGLVPDEVVVGIISDRIEQPDA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 186 EEGIVIDGFPRDVAQALSFE----DQICTPDLVVFLACANQRLKERLLKR-AEQQG-----RPDDNVKATQRRLMNFKQN 255
Cdd:PRK13808  78 ANGFILDGFPRTVPQAEALDallkDKQLKLDAVVELRVNEGALLARVETRvAEMRArgeevRADDTPEVLAKRLASYRAQ 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 578798931 256 AAPLVKYFQEKGLIMTFDADRDEDEVFYDI 285
Cdd:PRK13808 158 TEPLVHYYSEKRKLLTVDGMMTIDEVTREI 187
PRK14528 PRK14528
adenylate kinase; Provisional
 107-269 2.89e-22

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 94.31  E-value: 2.89e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 107 KIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSliAKIITTGELAPQETTITEIKQKLMQIPDE 186
Cdd:PRK14528   2 KNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEA--KRYMDAGDLVPDSVVIGIIKDRIREADCK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 187 EGIVIDGFPRDVAQALSFEDQI----CTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKY 262
Cdd:PRK14528  80 NGFLLDGFPRTVEQADALDALLknegKSIDKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDF 159


                 ....*..
gi 578798931 263 FQEKGLI 269
Cdd:PRK14528 160 YAAQKKL 166
PLN02674 PLN02674
adenylate kinase
 351-524 3.71e-22

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 95.72  E-value: 3.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 351 KIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 430
Cdd:PLN02674  32 KRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKP-SCQK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 431 GFLIDGYPREVKQGEEF-------GRRIgDPQLVICMDCS--ADTMTNR-----------------------------LL 472
Cdd:PLN02674 111 GFILDGFPRTVVQAQKLdemlakqGAKI-DKVLNFAIDDAilEERITGRwihpssgrtyhtkfappkvpgvddvtgepLI 189

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578798931 473 QRSrsslpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 524
Cdd:PLN02674 190 QRK------DDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEV 235
PLN02459 PLN02459
probable adenylate kinase
 356-522 1.02e-20

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 91.83  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 356 IGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGD-TRGFLI 434
Cdd:PLN02459  35 LGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgESGFIL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 435 DGYPREVKQGEEF------------------------GRRI----GDPQLVICMDCSADTMTNRLLQRSRSSLP------ 480
Cdd:PLN02459 115 DGFPRTVRQAEILegvtdidlvvnlklreevlvekclGRRIcsecGKNFNVADIDLKGEDGRPGIVMPPLLPPPecaskl 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578798931 481 ---VDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKIN-AEGTPE 522
Cdd:PLN02459 195 itrADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFElPGGIPE 240
PLN02842 PLN02842
nucleotide kinase
 110-286 3.06e-20

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 93.77  E-value: 3.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 110 LVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSliAKIITTGELAPQETTITEIKQKLmQIPD--EE 187
Cdd:PLN02842   1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRA--KEFMNSGRLVPDEIVIAMVTGRL-SREDakEK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 188 GIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKR-----------------------AEQQGRPDDNVKA 244
Cdd:PLN02842  78 GWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppeseeikARLITRPDDTEEK 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578798931 245 TQRRLMNFKQNAAPLVKYFQEkgLIMTFDADRDEDEVFYDIS 286
Cdd:PLN02842 158 VKARLQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEIS 197
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 344-507 1.15e-19

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 87.93  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 344 MEDLRKCKIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMV 423
Cdd:PTZ00088   1 MKLKGPLKIVLF-GAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 424 ASLGDT-RGFLIDGYPREVKQGEEFGrRIGDPQLV------------------ICMDCSADTMTNRLLQRSRSSLPV--- 481
Cdd:PTZ00088  80 KVTDDCfKGFILDGFPRNLKQCKELG-KITNIDLFvniylprnilikkllgrrICNTCNRNFNIAHIRSDPYDMPPIlpp 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578798931 482 ----------------DDTTKTIAKRLEAYYRASIPVIAYYE 507
Cdd:PTZ00088 159 adcegckgnpklqkrsDDTEEIVAHRLNTYESTNSPIIQFFK 200
PRK14526 PRK14526
adenylate kinase; Provisional
 351-524 2.79e-18

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 83.36  E-value: 2.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 351 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLkEAMVASLGDTR 430
Cdd:PRK14526   2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIV-EDKINTIKNND 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 431 GFLIDGYPREVKQGEEFGRRIGDPQLV-----------------ICMDCS---------------ADTMTNRLLQRSrss 478
Cdd:PRK14526  80 NFILDGFPRNINQAKALDKFLPNIKIInflideellikrlsgrrICKSCNnifniytlptkekgiCDVCKGDLYQRK--- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 578798931 479 lpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 524
Cdd:PRK14526 157 ---DDKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 105-267 1.02e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 73.68  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 105 RPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIP 184
Cdd:PTZ00088   5 GPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGK--EIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 185 DE--EGIVIDGFPRDVAQALSFEdQICTPDLVVFLACANQRLKERLLKR------------------------------- 231
Cdd:PTZ00088  83 DDcfKGFILDGFPRNLKQCKELG-KITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppadc 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578798931 232 ------AEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKG 267
Cdd:PTZ00088 162 egckgnPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNEN 203
PRK14526 PRK14526
adenylate kinase; Provisional
 109-281 4.40e-14

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 71.42  E-value: 4.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWslIAKIITTGELAPQETTITEIKQKLMQIPDEEG 188
Cdd:PRK14526   3 LVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKE--IKQIVENGQLVPDSITIKIVEDKINTIKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 189 IVIDGFPRDVAQALSFEDQICTPDLVVFL---ACANQRLKERLLKRA------------EQQG-----------RPDDNV 242
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFLideELLIKRLSGRRICKScnnifniytlptKEKGicdvckgdlyqRKDDKE 160

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 578798931 243 KATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 281
Cdd:PRK14526 161 ESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PRK14529 PRK14529
adenylate kinase; Provisional
 353-445 8.02e-14

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 70.90  E-value: 8.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 353 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGI----VLELLKEAmvaslgD 428
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDItipmILETLKQD------G 76

                         90
                 ....*....|....*..
gi 578798931 429 TRGFLIDGYPREVKQGE 445
Cdd:PRK14529  77 KNGWLLDGFPRNKVQAE 93
PLN02674 PLN02674
adenylate kinase
 102-289 1.24e-13

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 70.68  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 102 TRPRPKIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKL 180
Cdd:PLN02674  28 SKPDKRLIL-IGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAV---AAKTPLGIKAKeAMDKGELVSDDLVVGIIDEAM 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 181 MQIPDEEGIVIDGFPRDVAQALSFED----QICTPDLVVFLACANQRLKERLLKR----------------------AEQ 234
Cdd:PLN02674 104 KKPSCQKGFILDGFPRTVVQAQKLDEmlakQGAKIDKVLNFAIDDAILEERITGRwihpssgrtyhtkfappkvpgvDDV 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 235 QGRP-----DDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAV 289
Cdd:PLN02674 184 TGEPliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKAL 243
PLN02459 PLN02459
probable adenylate kinase
 82-273 5.28e-13

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 69.11  E-value: 5.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  82 SDTDLSETAELIEEYEV-FDPTRPRPKII--LVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSnrKWSLIA 158
Cdd:PLN02459   2 SERDAKSTSALADDLASaCDRSLAKGRNVnwVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGP--LGAQLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 159 KIITTGELAPQETTITEIKQKLMQIPD--EEGIVIDGFPRDVAQALSFEDqICTPDLVVFLACANQRLKERLLKR----- 231
Cdd:PLN02459  80 EIVNQGKLVPDEIIFSLLSKRLEAGEEegESGFILDGFPRTVRQAEILEG-VTDIDLVVNLKLREEVLVEKCLGRricse 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578798931 232 ------------AEQQGRP---------------------DDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFD 273
Cdd:PLN02459 159 cgknfnvadidlKGEDGRPgivmppllpppecasklitraDDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFE 233
PRK14529 PRK14529
adenylate kinase; Provisional
 109-231 4.25e-10

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 59.73  E-value: 4.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLmQIPDEE 187
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHI---GGGTELGKKAKeYIDRGDLVPDDITIPMILETL-KQDGKN 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 578798931 188 GIVIDGFPRDVAQALSFEDQICTP----DLVVFLACANQRLKERLLKR 231
Cdd:PRK14529  79 GWLLDGFPRNKVQAEKLWEALQKEgmklDYVIEILLPREVAKNRIMGR 126
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 352-416 1.17e-06

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 48.25  E-value: 1.17e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREE---LASESERSKLIRDIM---ERGDLVPSGIVLE 416
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEvgkLASEVAAIPEVRKALderQRELAKKPGIVLE 71
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
352-495 1.90e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.90  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLST----GELLREELASE---SERSKLIRDIMERgdlvpsgIVLELLKEamva 424
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAERLGAVRLRSdvvrKRLFGAGLAPLersPEATARTYARLLA-------LARELLAA---- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578798931 425 slgdtrGF--LIDG---YPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAY 495
Cdd:COG0645   70 ------GRsvILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE 139
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 109-140 2.06e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 44.40  E-value: 2.06e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 578798931 109 ILVIGGP-GSGKGTQSLKIAERYGFQYISVGEL 140
Cdd:cd02020    1 IIAIDGPaGSGKSTVAKLLAKKLGLPYLDTGGI 33
PRK04182 PRK04182
cytidylate kinase; Provisional
 352-392 2.82e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 44.80  E-value: 2.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLReELASE 392
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR-ELAKE 41
PRK04182 PRK04182
cytidylate kinase; Provisional
 109-143 3.19e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 44.80  E-value: 3.19e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 578798931 109 ILVIGG-PGSGKGTQSLKIAERYGFQYISVGELLRK 143
Cdd:PRK04182   2 IITISGpPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
106-240 4.23e-05

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 44.55  E-value: 4.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 106 PKIILVIGGPGSGKGTQSlKIAERYGFQYISVGELLRKK-----IHSTSSNrkwslIAKIITT-----GELAPQETTITE 175
Cdd:PRK01184   1 MKIIGVVGMPGSGKGEFS-KIAREMGIPVVVMGDVIREEvkkrgLEPTDEN-----IGKVAIDlrkelGMDAVAKRTVPK 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578798931 176 IKQKLMQIpdeegIVIDGFpRDVAQALSFEDQI-CTPDLVVFLACANQRLkERLLKRaeqqGRPDD 240
Cdd:PRK01184  75 IREKGDEV-----VVIDGV-RGDAEVEYFRKEFpEDFILIAIHAPPEVRF-ERLKKR----GRSDD 129
DD_AK5 cd22978
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar ...
 1-20 7.64e-05

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar proteins; AK5 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 5, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It is active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. It also displays broad nucleoside diphosphate kinase activity. AK5 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438547  Cd Length: 44  Bit Score: 40.21  E-value: 7.64e-05
                         10        20
                 ....*....|....*....|
gi 578798931   1 MCSKPEDPVEYLESCLQKVK 20
Cdd:cd22978   25 MYNRPDDPIEFLEDCLEKIR 44
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 103-253 9.74e-05

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 43.78  E-value: 9.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 103 RPRPKIILVIGGPGSGKGTQSLKIAERYGFQYI----SVGELLRK--------KIHsTSSNRKW-SLIAKIITTGELAPQ 169
Cdd:COG2074    3 MKRPRIILIGGASGVGKSTIAAELARRLGIPRVistdSIREVMRPiiskelvpTLH-TSSYEAYkSLSEEEIIAGFLDQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 170 ETTITEIKQklMQ---IPDEEGIVIDG---FPRDVAQALSFEDQICtpdLVVFLACANQRLKERLLKRAEQQGRpddnvK 243
Cdd:COG2074   82 EAVSPGIEA--VIeraLKEGESLVIEGvhlVPGFLAELKFNGGNVV---MLVLLVSDEELHRERFYSRARYTHA-----N 151

                        170
                 ....*....|.
gi 578798931 244 ATQRRLM-NFK 253
Cdd:COG2074  152 RPGERYLdHFE 162
AAA_18 pfam13238
AAA domain;
109-246 1.81e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 41.65  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931  109 ILVIGGPGSGKGTQSLKIAERYGFqYISVGELLRKKIHSTSSNRKWSLiAKIITTGELApqettitEIKQKLMQIPDEEG 188
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETRE-SKRLDEDKLD-------RLLDLLEENAALEE 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578798931  189 ---IVIDGFPrdvAQALSFEDqicTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQ 246
Cdd:pfam13238  72 ggnLIIDGHL---AELEPERA---KDLVGIVLRASPEELLERLEKRGYEEAKIKENEEAEI 126
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 352-402 3.64e-04

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 38.86  E-value: 3.64e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578798931 352 IIFIIGGPGSGKGTQCEKLVEKYG---FTHLSTGELLREELASESERSKLIRDI 402
Cdd:cd02019    1 IIAITGGSGSGKSTVAKKLAEQLGgrsVVVLDEIVILEGLYASYKSRDARIRDL 54
PRK03839 PRK03839
putative kinase; Provisional
 108-330 4.12e-04

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 41.24  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 108 IILVIGGPGSGKGTQSLKIAERYGFQYISVGEL-LRKKIHSTSSNrkwsliakiittgELapqETTITEIKQKLMQIPDE 186
Cdd:PRK03839   2 IIAITGTPGVGKTTVSKLLAEKLGYEYVDLTEFaLKKGIGEEKDD-------------EM---EIDFDKLAYFIEEEFKE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 187 EGIVIDGFprdvaqaLSfedQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKAtqrRLMNfkqnaAPLVKYFQEK 266
Cdd:PRK03839  66 KNVVLDGH-------LS---HLLPVDYVIVLRAHPKIIKERLKERGYSKKKILENVEA---ELVD-----VCLCEALEEK 127

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578798931 267 GLIMTFD-ADRDEDEVFYDISMAVDNKlfpnKEAAAGssdldpsmILDTGEIIDTGSDYEDQGDD 330
Cdd:PRK03839 128 EKVIEVDtTGKTPEEVVEEILELIKSG----KKRKVG--------IVDWSEVYDEIFPYLRLGID 180
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 107-161 5.08e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 37.47  E-value: 5.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578798931 107 KIILVIGGPGSGKgTQSL-KIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKII 161
Cdd:NF033453  17 KLILLVGPPGSGK-TALLrELAAKRGAPVINVNLELSRRLLELPEKQRALRAPRLL 71
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
108-193 6.27e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 37.88  E-value: 6.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798931 108 IILVIGG-PGSGKGTQSLKIAERYGFQYISvGELLRKkihsTSSNRKWSLI--------AKIITTGELAPQETTITEIKQ 178
Cdd:COG1102    1 MVITISRePGSGGTTIAKRLAEKLGLPLYD-GEILRE----AAKERGLSEEefekldekAPSLLYRDTAEEDEIDRALDK 75

                         90
                 ....*....|....*
gi 578798931 179 KLMQIPDEEGIVIDG 193
Cdd:COG1102   76 VIRELARKGNCVIVG 90
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 351-418 7.76e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 38.02  E-value: 7.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578798931 351 KIIFIIGGPGSGKGTQCEKLVE---KYGFTHLSTGELlreelaSESERSKLIRDIMERGDLVPSGIVLELL 418
Cdd:cd01672    1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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