NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578798992|ref|XP_006710656|]
View 

immunoglobulin superfamily member 3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 712-809 2.66e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   712 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 791
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 578798992   792 LTVQRAEVSDSGSYYCHV 809
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 157-256 7.68e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.34  E-value: 7.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  157 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 236
Cdd:cd00099     5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                          90       100
                  ....*....|....*....|
gi 578798992  237 TIFHLQPSDQGEFYCEAAEW 256
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSES 95
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 846-945 8.32e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 8.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   846 QAQGNLSVLETRQVQLECVVLNRTSITSQlMVEWFVWKPNHPERETVARlsrdATFHYGEQAAKNNLKGRlhlESPSPGV 925
Cdd:pfam07686    1 QTPREVTVALGGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPTFLIAY----YSNGSEEGVKKGRFSGR---GDPSNGD 72

                           90       100
                   ....*....|....*....|
gi 578798992   926 YRLFIQNVAVQDSGTYSCHV 945
Cdd:pfam07686   73 GSLTIQNLTLSDSGTYTCAV 92
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 37-137 1.60e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 45.02  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   37 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 107
Cdd:cd00099    10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 578798992  108 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 137
Cdd:cd00099    73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 298-394 2.02e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    298 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 377
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 578798992    378 KYNCRVTEREKTVTGEF 394
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 446-539 8.12e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 8.12e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    446 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 525
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 578798992    526 SRKEDEGQYECHVT 539
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 712-809 2.66e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   712 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 791
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 578798992   792 LTVQRAEVSDSGSYYCHV 809
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 157-256 7.68e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.34  E-value: 7.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  157 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 236
Cdd:cd00099     5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                          90       100
                  ....*....|....*....|
gi 578798992  237 TIFHLQPSDQGEFYCEAAEW 256
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSES 95
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 714-836 9.11e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 51.50  E-value: 9.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  714 LTLVENKPIQLNCSVKSQTSQNshfaVLWYVHKPSDADGKLILKTTHNSAFEYGtyaeeeglRARLQFERhvSGGLFSLT 793
Cdd:cd04983     8 LSVQEGENVTLNCNYSTSTFYY----LFWYRQYPGQGPQFLIYISSDSGNKKKG--------RFSATLDK--SRKSSSLH 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 578798992  794 VQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTVK 836
Cdd:cd04983    74 ISAAQLSDSAVYFC-----ALSESGGTGKL---TFGKgTRLTVE 109
IGv smart00406
Immunoglobulin V-Type;
168-252 1.47e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.38  E-value: 1.47e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    168 LELTCEVASETIqhSHLSVAWLRQKVGeKPVEVISLSRDfmlhSSSEYAQRQSLGEVRLDK-LGRTTFRLTIFHLQPSDQ 246
Cdd:smart00406    2 VTLSCKFSGSTF--SSYYVSWVRQPPG-KGLEWLGYIGS----NGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDT 74


                    ....*.
gi 578798992    247 GEFYCE 252
Cdd:smart00406   75 GTYYCA 80
IGv smart00406
Immunoglobulin V-Type;
724-807 7.23e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.07  E-value: 7.23e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    724 LNCSVKsqTSQNSHFAVLWYVHKPSDAdgkliLKTTHNSAFEYGTYAEEeGLRARLQFERHVSGGLFSLTVQRAEVSDSG 803
Cdd:smart00406    4 LSCKFS--GSTFSSYYVSWVRQPPGKG-----LEWLGYIGSNGSSYYQE-SYKGRFTISKDTSKNDVSLTISNLRVEDTG 75


                    ....
gi 578798992    804 SYYC 807
Cdd:smart00406   76 TYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 846-945 8.32e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 8.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   846 QAQGNLSVLETRQVQLECVVLNRTSITSQlMVEWFVWKPNHPERETVARlsrdATFHYGEQAAKNNLKGRlhlESPSPGV 925
Cdd:pfam07686    1 QTPREVTVALGGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPTFLIAY----YSNGSEEGVKKGRFSGR---GDPSNGD 72

                           90       100
                   ....*....|....*....|
gi 578798992   926 YRLFIQNVAVQDSGTYSCHV 945
Cdd:pfam07686   73 GSLTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 37-137 1.60e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.02  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   37 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 107
Cdd:cd00099    10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 578798992  108 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 137
Cdd:cd00099    73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 39-146 3.86e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 3.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    39 EGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTmdSSFPYAIYTQRVRGGKIFIErvqgNSTLLHITDLQAR 118
Cdd:pfam07686   10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYS--NGSEEGVKKGRFSGRGDPSN----GDGSLTIQNLTLS 83

                           90       100
                   ....*....|....*....|....*...
gi 578798992   119 DAGEYECHTPSTDKQYFGSysaKMNLVV 146
Cdd:pfam07686   84 DSGTYTCAVIPSGEGVFGK---GTRLTV 108
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 873-945 7.65e-05

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 43.28  E-value: 7.65e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578798992  873 SQLMVEWFVWKPNHPeretVARLSRDATfhyGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHV 945
Cdd:cd16089    30 TQVLVKWLVQRDSDP----VTIFLRDSS---GDHIQQAKYRGRLEVSKDTPGDVSLQLDTLEMDDRGHYTCQV 95
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 157-251 1.53e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   157 PQTLHRVEQDPLELTCEVASETIQHsHLSVAWLRQKVGEKPVEVISLSrdfmlHSSSEYAQRQSLGEVRLDKlGRTTFRL 236
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLIAYY-----SNGSEEGVKKGRFSGRGDP-SNGDGSL 75

                           90
                   ....*....|....*
gi 578798992   237 TIFHLQPSDQGEFYC 251
Cdd:pfam07686   76 TIQNLTLSDSGTYTC 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 298-394 2.02e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    298 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 377
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 578798992    378 KYNCRVTEREKTVTGEF 394
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 299-391 2.42e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 38.48  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  299 VGEPVEFRcileAQNVPDRYFAVSWAFNSSLIATMGPNAVPvlnSEFAHREARGQLKvaKESDSvfvLKIYHLRQEDSGK 378
Cdd:cd05775     9 LGGNVTLT----ISSLQDDIDEIKWKKTKDKIVEWENNIGP---TYFGSFKDRVLLD--KESGS---LTIKNLTKEDSGT 76

                          90
                  ....*....|...
gi 578798992  379 YNCRVTEREKTVT 391
Cdd:cd05775    77 YELEITSTNGKVL 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 446-539 8.12e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 8.12e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    446 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 525
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 578798992    526 SRKEDEGQYECHVT 539
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 712-809 2.66e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   712 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 791
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 578798992   792 LTVQRAEVSDSGSYYCHV 809
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 157-256 7.68e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.34  E-value: 7.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  157 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 236
Cdd:cd00099     5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                          90       100
                  ....*....|....*....|
gi 578798992  237 TIFHLQPSDQGEFYCEAAEW 256
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSES 95
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 714-836 9.11e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 51.50  E-value: 9.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  714 LTLVENKPIQLNCSVKSQTSQNshfaVLWYVHKPSDADGKLILKTTHNSAFEYGtyaeeeglRARLQFERhvSGGLFSLT 793
Cdd:cd04983     8 LSVQEGENVTLNCNYSTSTFYY----LFWYRQYPGQGPQFLIYISSDSGNKKKG--------RFSATLDK--SRKSSSLH 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 578798992  794 VQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTVK 836
Cdd:cd04983    74 ISAAQLSDSAVYFC-----ALSESGGTGKL---TFGKgTRLTVE 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 710-835 3.71e-07

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 49.64  E-value: 3.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  710 SKRTLTLVENKPIQLNCSVksqTSQNSHFAVLWYVHKPSDADgKLILKTTHNSAFEygtyaeEEGLRARLQFERHvSGGL 789
Cdd:cd00099     4 SPRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGP-EFLIYLSSSKGKT------KGGVPGRFSGSRD-GTSS 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 578798992  790 FSLTVQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTV 835
Cdd:cd00099    73 FSLTISNLQPEDSGTYYC-----AVSESGGTDKL---TFGSgTRLTV 111
IGv smart00406
Immunoglobulin V-Type;
168-252 1.47e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.38  E-value: 1.47e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    168 LELTCEVASETIqhSHLSVAWLRQKVGeKPVEVISLSRDfmlhSSSEYAQRQSLGEVRLDK-LGRTTFRLTIFHLQPSDQ 246
Cdd:smart00406    2 VTLSCKFSGSTF--SSYYVSWVRQPPG-KGLEWLGYIGS----NGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDT 74


                    ....*.
gi 578798992    247 GEFYCE 252
Cdd:smart00406   75 GTYYCA 80
IGv smart00406
Immunoglobulin V-Type;
724-807 7.23e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.07  E-value: 7.23e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    724 LNCSVKsqTSQNSHFAVLWYVHKPSDAdgkliLKTTHNSAFEYGTYAEEeGLRARLQFERHVSGGLFSLTVQRAEVSDSG 803
Cdd:smart00406    4 LSCKFS--GSTFSSYYVSWVRQPPGKG-----LEWLGYIGSNGSSYYQE-SYKGRFTISKDTSKNDVSLTISNLRVEDTG 75


                    ....
gi 578798992    804 SYYC 807
Cdd:smart00406   76 TYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 846-945 8.32e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 8.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   846 QAQGNLSVLETRQVQLECVVLNRTSITSQlMVEWFVWKPNHPERETVARlsrdATFHYGEQAAKNNLKGRlhlESPSPGV 925
Cdd:pfam07686    1 QTPREVTVALGGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPTFLIAY----YSNGSEEGVKKGRFSGR---GDPSNGD 72

                           90       100
                   ....*....|....*....|
gi 578798992   926 YRLFIQNVAVQDSGTYSCHV 945
Cdd:pfam07686   73 GSLTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 37-137 1.60e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.02  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   37 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 107
Cdd:cd00099    10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 578798992  108 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 137
Cdd:cd00099    73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 39-146 3.86e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 3.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    39 EGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTmdSSFPYAIYTQRVRGGKIFIErvqgNSTLLHITDLQAR 118
Cdd:pfam07686   10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYS--NGSEEGVKKGRFSGRGDPSN----GDGSLTIQNLTLS 83

                           90       100
                   ....*....|....*....|....*...
gi 578798992   119 DAGEYECHTPSTDKQYFGSysaKMNLVV 146
Cdd:pfam07686   84 DSGTYTCAVIPSGEGVFGK---GTRLTV 108
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 873-945 7.65e-05

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 43.28  E-value: 7.65e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578798992  873 SQLMVEWFVWKPNHPeretVARLSRDATfhyGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHV 945
Cdd:cd16089    30 TQVLVKWLVQRDSDP----VTIFLRDSS---GDHIQQAKYRGRLEVSKDTPGDVSLQLDTLEMDDRGHYTCQV 95
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 157-253 1.17e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.17e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    157 PQTLHRVEQDPLELTCEVASEtiqhSHLSVAWLRQKVgekpvEVISLSRDFMLHSSSeyaqrqslgevrldklgrTTFRL 236
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGG-----KLLAESGRFSVSRSG------------------STSTL 53

                            90
                    ....*....|....*..
gi 578798992    237 TIFHLQPSDQGEFYCEA 253
Cdd:smart00410   54 TISNVTPEDSGTYTCAA 70
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 707-807 1.35e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 42.65  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  707 VSKSKRTLTLVENKPIQLNCSVKSQtsqnsHFAVLWYVHKPsdadGK-LILKTTHNSAFEYgtyaEEEGL-RARLQFERH 784
Cdd:cd05899     1 VTQSPRYLIKRRGQSVTLRCSQKSG-----HDNMYWYRQDP----GKgLQLLFYSYGGGLN----EEGDLpGDRFSASRP 67

                          90       100
                  ....*....|....*....|...
gi 578798992  785 vSGGLFSLTVQRAEVSDSGSYYC 807
Cdd:cd05899    68 -SLTRSSLTIKSAEPEDSAVYLC 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 157-251 1.53e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   157 PQTLHRVEQDPLELTCEVASETIQHsHLSVAWLRQKVGEKPVEVISLSrdfmlHSSSEYAQRQSLGEVRLDKlGRTTFRL 236
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLIAYY-----SNGSEEGVKKGRFSGRGDP-SNGDGSL 75

                           90
                   ....*....|....*
gi 578798992   237 TIFHLQPSDQGEFYC 251
Cdd:pfam07686   76 TIQNLTLSDSGTYTC 90
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 27-125 1.60e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.40  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    27 QVTVQEGPLYRTEGSHITIWCNVSGYQGPSeqnFQWsiYLPSSPEREVQIVSTMDSsfpyaiytqrvrggkifiervqGN 106
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGSPPPT---ITW--YKNGEPISSGSTRSRSLS----------------------GS 55

                           90
                   ....*....|....*....
gi 578798992   107 STLLHITDLQARDAGEYEC 125
Cdd:pfam13927   56 NSTLTISNVTRSDAGTYTC 74
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 718-823 1.89e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 42.35  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  718 ENKPIQLNCSVKSQTsqNSHFAVLWYVHKPSDADGKLI-LKTTHNSAFEYGTYAEEegLRARLQFERHVSgglfSLTVQR 796
Cdd:cd04982    12 ESKSVTISCKVSGID--FSTTYIHWYRQKPGQALERLLyVSSTSAVRKDSGKTKNK--FEARKDVGKSTS----TLTITN 83

                          90       100
                  ....*....|....*....|....*..
gi 578798992  797 AEVSDSGSYYCHVeeWLLSPNYaWYKL 823
Cdd:cd04982    84 LEKEDSATYYCAY--WESGSGY-YIKV 107
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 33-137 1.08e-03

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 40.24  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992   33 GPLYRTeGSHITIWCNVSGYQGPSEQnFQWSIYLPS-SPerevQIVSTMDSSFpyaiytQRVRGGKIFIERVQGNSTL-L 110
Cdd:cd16095     9 GGSHPA-GKTLSLKCQTSGFQFNTSQ-LSWYLWVPGhAP----LWLTSLDHIS------TKVSEDRITSSREDTNSQIfL 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 578798992  111 HITDLQARDAGEYEC-----HTPSTDKQYFGS 137
Cdd:cd16095    77 QIKGLGLRDSGQYHCarrvgYGDDTDKLIFGP 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 712-835 1.38e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 1.38e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    712 RTLTLVENKPIQLNCSVksqtSQNSHFAVLWYVHKPsdadgKLILKTTHnsafeygtyaeeeglrarlqFERHVSGGLFS 791
Cdd:smart00410    2 PSVTVKEGESVTLSCEA----SGSPPPEVTWYKQGG-----KLLAESGR--------------------FSVSRSGSTST 52

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 578798992    792 LTVQRAEVSDSGSYYCHVEewllspNYAWyklaeEVSGRTEVTV 835
Cdd:smart00410   53 LTISNVTPEDSGTYTCAAT------NSSG-----SASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 298-394 2.02e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    298 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 377
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 578798992    378 KYNCRVTEREKTVTGEF 394
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 299-391 2.42e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 38.48  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  299 VGEPVEFRcileAQNVPDRYFAVSWAFNSSLIATMGPNAVPvlnSEFAHREARGQLKvaKESDSvfvLKIYHLRQEDSGK 378
Cdd:cd05775     9 LGGNVTLT----ISSLQDDIDEIKWKKTKDKIVEWENNIGP---TYFGSFKDRVLLD--KESGS---LTIKNLTKEDSGT 76

                          90
                  ....*....|...
gi 578798992  379 YNCRVTEREKTVT 391
Cdd:cd05775    77 YELEITSTNGKVL 89
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 875-945 4.53e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 38.20  E-value: 4.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578798992  875 LMVEWFVWKPNHPERETVARLSRDATFHYGEqaaknNLKGRLHLESP-SPGVYRLFIQNVAVQDSGTYSCHV 945
Cdd:cd20960    34 LDIEWLLLPSDKVEKVVITYSGDRVYNHYYP-----ALKGRVAFTSNdLSGDASLNISNLKLSDTGTYQCKV 100
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 162-256 4.73e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 38.11  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  162 RVEQDPLELTCEVASETIQHShlSVAWLRQKVGEKPVEVIS-LSRDFMLHSSSEYAQRQslgEVRLDKlGRTTFRLTIFH 240
Cdd:cd04982    10 REESKSVTISCKVSGIDFSTT--YIHWYRQKPGQALERLLYvSSTSAVRKDSGKTKNKF---EARKDV-GKSTSTLTITN 83

                          90
                  ....*....|....*.
gi 578798992  241 LQPSDQGEFYCeaAEW 256
Cdd:cd04982    84 LEKEDSATYYC--AYW 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 446-539 8.12e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 8.12e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992    446 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 525
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 578798992    526 SRKEDEGQYECHVT 539
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 151-257 8.13e-03

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 37.37  E-value: 8.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578798992  151 LQTTAMPQTLHRVEQDPLELTCEvASETIQHSHLsvAWLRQKVGEKPVEVISLSrdfmlhssseyAQRQSLGEVRLDKLG 230
Cdd:cd04980     1 IVMTQSPASLSVSPGERVTISCK-ASQSISSNYL--AWYQQKPGQAPKLLIYYA-----------STLHSGVPSRFSGSG 66

                          90       100
                  ....*....|....*....|....*...
gi 578798992  231 -RTTFRLTIFHLQPSDQGEFYCEAAEWI 257
Cdd:cd04980    67 sGTDFTLTISSVEPEDAAVYYCQQGYTF 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH