NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578801636|ref|XP_006711657|]
View 

protein dispatched homolog 1 isoform X2 [Homo sapiens]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
302-933 3.63e-43

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 170.04  E-value: 3.63e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  302 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 379
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  380 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 459
Cdd:COG1033   289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  460 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 539
Cdd:COG1033   367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  540 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 619
Cdd:COG1033   419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  620 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 699
Cdd:COG1033   465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  700 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 775
Cdd:COG1033   528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  776 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 855
Cdd:COG1033   593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  856 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 933
Cdd:COG1033   673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
302-933 3.63e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 170.04  E-value: 3.63e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  302 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 379
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  380 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 459
Cdd:COG1033   289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  460 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 539
Cdd:COG1033   367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  540 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 619
Cdd:COG1033   419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  620 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 699
Cdd:COG1033   465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  700 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 775
Cdd:COG1033   528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  776 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 855
Cdd:COG1033   593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  856 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 933
Cdd:COG1033   673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 241-899 9.31e-27

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 118.23  E-value: 9.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   241 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 317
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   318 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 384
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   385 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 464
Cdd:pfam02460  301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   465 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 536
Cdd:pfam02460  378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   537 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 616
Cdd:pfam02460  451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   617 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 693
Cdd:pfam02460  513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   694 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 771
Cdd:pfam02460  573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   772 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 851
Cdd:pfam02460  623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 578801636   852 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVA 899
Cdd:pfam02460  703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILG 750
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 785-931 1.11e-09

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 63.09  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   785 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 858
Cdd:TIGR03480  266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578801636   859 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 931
Cdd:TIGR03480  340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 791-930 6.92e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 40.56  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  791 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 862
Cdd:cd13134   134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  863 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 929
Cdd:cd13134   208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284


                  .
gi 578801636  930 T 930
Cdd:cd13134   285 Q 285
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
302-933 3.63e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 170.04  E-value: 3.63e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  302 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 379
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  380 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 459
Cdd:COG1033   289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  460 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 539
Cdd:COG1033   367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  540 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 619
Cdd:COG1033   419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  620 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 699
Cdd:COG1033   465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  700 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 775
Cdd:COG1033   528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  776 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 855
Cdd:COG1033   593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  856 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 933
Cdd:COG1033   673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 241-899 9.31e-27

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 118.23  E-value: 9.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   241 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 317
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   318 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 384
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   385 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 464
Cdd:pfam02460  301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   465 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 536
Cdd:pfam02460  378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   537 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 616
Cdd:pfam02460  451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   617 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 693
Cdd:pfam02460  513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   694 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 771
Cdd:pfam02460  573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   772 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 851
Cdd:pfam02460  623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 578801636   852 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVA 899
Cdd:pfam02460  703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILG 750
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
780-933 1.84e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 84.91  E-value: 1.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  780 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 859
Cdd:COG1033   210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578801636  860 VHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLIMCISWAFATFFF 933
Cdd:COG1033   290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
314-468 7.01e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 79.90  E-value: 7.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  314 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 392
Cdd:COG1033   612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578801636  393 DKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 468
Cdd:COG1033   687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 313-477 2.05e-13

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 69.15  E-value: 2.05e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   313 PAIAIVIVLLVMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfhfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 392
Cdd:pfam12349    6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   393 DKPhaeTSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHER----Y 468
Cdd:pfam12349   67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143


                   ....*....
gi 578801636   469 LLNIFTCFK 477
Cdd:pfam12349  144 RLDVACCIR 152
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 785-931 1.11e-09

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 63.09  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   785 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 858
Cdd:TIGR03480  266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578801636   859 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 931
Cdd:TIGR03480  340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 261-889 1.12e-09

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 63.00  E-value: 1.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   261 FSPTEKGESMM---NIYLDNFENWNSSDGVTTITgieFGIKHSLfQDYLLMDTVYPAIAIVIVLLVMCVYT--------- 328
Cdd:TIGR00917  522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   329 -KSMFITLMTMFAIISSLIVsyfLYRVVFHFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 392
Cdd:TIGR00917  598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   393 DKPHAETSE-TVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HER 467
Cdd:TIGR00917  675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   468 YLLNIFTCFKKPQQQIYDNKSCwTVACQKCHKVLFAISEASRIFFEKVLPCIVIkfrylwlFWFLALTVGGAYIVCINP- 546
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKGS-GQRKAGLLTRYFKEVYAPVLLHWIVKIVVIA-------FFVGLLMAGIALSTRVEIg 826

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   547 ---KMKLPSleLSEFQVFRSShpferydaeykklfMFERVHHGEELHMPITVIWGVSPEDNGNPL------NPKSKGKLT 617
Cdd:TIGR00917  827 ldqQIVLPQ--DSYLQIYFAS--------------LTPLLEVGPPFYIVIKGDYNYTDFESQNKLctmggcDKDSIVNVF 890

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   618 LDSSFnIASPASqAWILHF-----------CQKLRNQTFFYQTDEQDFtSCFIET-----------FKQWMENQDCDEPA 675
Cdd:TIGR00917  891 NNLSY-IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNALPS 967

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   676 lyPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPgprfdiNDTIRAVvlefQSTYLFTlayekmhqfykevds 755
Cdd:TIGR00917  968 --ADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNTQ------VDFINAM----RAAQEFA--------------- 1020

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   756 wisselSSAPEGLSNGWFVSNL--EFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIISIAGTIFVTVGS 832
Cdd:TIGR00917 1021 ------AKVSRSSKMEVYPYSVfyVFFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCVGI 1094

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 578801636   833 LVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAM 889
Cdd:TIGR00917 1095 MHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 258-464 1.04e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 59.85  E-value: 1.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   258 SMLFSPTEKgESMMNIYLDNFENWNSSDGVT-TITG--IEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVmcVY---TKSM 331
Cdd:TIGR00921  519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   332 FiTLMTMFAIISSLIVSYFLYRVVFhfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPHAETS--ETVSITLQ 408
Cdd:TIGR00921  596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578801636   409 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 464
Cdd:TIGR00921  664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 781-917 1.25e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   781 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 856
Cdd:pfam03176  135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578801636   857 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 917
Cdd:pfam03176  214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 314-480 4.69e-07

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 54.59  E-value: 4.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   314 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 388
Cdd:TIGR00833  180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   389 YTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 468
Cdd:TIGR00833  256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335

                          170
                   ....*....|..
gi 578801636   469 LLniftcFKKPQ 480
Cdd:TIGR00833  336 GL-----MKPGR 342
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 778-916 5.71e-07

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 54.00  E-value: 5.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  778 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLV--------LLGWELNVLESVT-- 847
Cdd:COG2409   507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  848 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRVGS-----AMAMAAltTFVAgamMMPSTVLAYT 912
Cdd:COG2409   587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRvitsaALIMAA--VFAA---FATSPLVFLK 655


                  ....
gi 578801636  913 QLGT 916
Cdd:COG2409   656 QIGF 659
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 314-464 9.87e-06

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 50.00  E-value: 9.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   314 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYRVVFHFeffpfmNL--TALIIL-VGIGADDA--FVLcdvw 387
Cdd:TIGR03480  276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAaFATLAVGHL------NLisVAFAVLfIGLGVDFAiqFSL---- 345

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578801636   388 NYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 464
Cdd:TIGR03480  346 RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRL 422
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 314-464 1.04e-05

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 49.21  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   314 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPfMNLTAL----IILVGIGADDAFVLcdVWNY 389
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIG-LSTFALnllvVLLIAVGTDYALFL--VSRY 225

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578801636   390 TKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 464
Cdd:pfam03176  226 REELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
COG4258 COG4258
Predicted exporter [General function prediction only];
849-933 1.67e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.47  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  849 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRVGSAMAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLIMCISW 926
Cdd:COG4258   310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383


                  ....*..
gi 578801636  927 AFATFFF 933
Cdd:COG4258   384 LTTLLWL 390
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 779-931 1.99e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 49.07  E-value: 1.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   779 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 858
Cdd:TIGR00921  558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578801636   859 AVHygVAYRLAPDPDREGKV---IFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLIMCISWAFATF 931
Cdd:TIGR00921  638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
362-479 3.07e-05

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 48.72  E-value: 3.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   362 PFMNLtaliilvGIGADDAFVLCDVWNYTKFDKPHAETSETVsitLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGV 441
Cdd:TIGR00918  464 PFLAL-------GVGVDDVFLLAHAFSETGQNIPFEERTGEC---LKRTGASVVLTSISNVTAFFMAALIPIPALRAFSL 533

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 578801636   442 YAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 479
Cdd:TIGR00918  534 QAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSP 575
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 314-466 6.33e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.52  E-value: 6.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   314 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSlivsyflyrVVFHFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 385
Cdd:TIGR00921  200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   386 vwnyTKFDKPHAE---TSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVV 462
Cdd:TIGR00921  269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344


                   ....
gi 578801636   463 VLHE 466
Cdd:TIGR00921  345 QSID 348
COG4258 COG4258
Predicted exporter [General function prediction only];
794-896 5.63e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  794 MGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 873
Cdd:COG4258   645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718

                          90       100
                  ....*....|....*....|...
gi 578801636  874 REGkvifSLSRVGSAMAMAALTT 896
Cdd:COG4258   719 DKG----ELARTLLSILLAALTT 737
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 780-923 6.78e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.06  E-value: 6.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   780 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 859
Cdd:TIGR00921  185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578801636   860 VHYGVAYRlapDPDREGK-----VIFSLSRVGSAMAMAALTTfVAGAMMMPSTVLAYTQ---LGTFMMLIMC 923
Cdd:TIGR00921  265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTT-SAGFAALALSEFPMVSefgLGLVAGLITA 332
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 779-917 7.46e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 43.99  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  779 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 854
Cdd:COG2409   160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578801636  855 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 917
Cdd:COG2409   239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 800-934 3.43e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 41.91  E-value: 3.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   800 VAFSVMLLTTW-NIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDregkv 878
Cdd:TIGR03480  723 VAITVLLLLTLrRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHRWRNGVDSG----- 797

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578801636   879 ifslSRVGSAMAMA----ALTTFVA-GAMMMPStvlaytQLGTFMM-LIMCISWAF---ATFFFQ 934
Cdd:TIGR03480  798 ----NLLQSSTARAvffsALTTATAfGSLAVSS------HPGTASMgILLSLGLGLtllCTLIFL 852
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 791-930 6.92e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 40.56  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  791 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 862
Cdd:cd13134   134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636  863 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 929
Cdd:cd13134   208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284


                  .
gi 578801636  930 T 930
Cdd:cd13134   285 Q 285
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
791-906 7.06e-03

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 41.02  E-value: 7.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801636   791 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIISIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 867
Cdd:TIGR00918  968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 578801636   868 LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 906
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH