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Conserved domains on  [gi|578802199|ref|XP_006711824|]
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guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [Homo sapiens]

Protein Classification

guanine nucleotide-binding protein subunit gamma( domain architecture ID 11260168)

guanine nucleotide-binding protein (G protein) subunit gamma is part of heterotrimeric G protein and is required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
13-75 3.06e-28

G protein gamma subunit-like motifs;


:

Pssm-ID: 128520  Cd Length: 63  Bit Score: 95.81  E-value: 3.06e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578802199   13 ISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPASENPFREKKFFCTIL 75
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEDKTSCWIL 63
 
Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
13-75 3.06e-28

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 95.81  E-value: 3.06e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578802199   13 ISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPASENPFREKKFFCTIL 75
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEDKTSCWIL 63
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 13-69 4.82e-22

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 80.03  E-value: 4.82e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 578802199 13 ISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPASENPFREKK 69
Cdd:cd00068   1 VDQLKKEVEQLRKELSRERLKVSKAAAELLKYCEQNAENDPLLTGPPSPSNPWIEKK 57
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 9-75 1.96e-19

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 73.92  E-value: 1.96e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802199   9 STTSISQARKaVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPV---PASENPFREKKFFCTIL 75
Cdd:pfam00631  1 KQLKLKLKRE-IEQLREELKRERIKVSKACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDDGCCWIL 69
 
Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
13-75 3.06e-28

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 95.81  E-value: 3.06e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578802199   13 ISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPASENPFREKKFFCTIL 75
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEDKTSCWIL 63
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 13-69 4.82e-22

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 80.03  E-value: 4.82e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 578802199 13 ISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPASENPFREKK 69
Cdd:cd00068   1 VDQLKKEVEQLRKELSRERLKVSKAAAELLKYCEQNAENDPLLTGPPSPSNPWIEKK 57
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 9-75 1.96e-19

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 73.92  E-value: 1.96e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802199   9 STTSISQARKaVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPV---PASENPFREKKFFCTIL 75
Cdd:pfam00631  1 KQLKLKLKRE-IEQLREELKRERIKVSKACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDDGCCWIL 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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