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Conserved domains on  [gi|578802337|ref|XP_006711881|]
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DNA-dependent metalloprotease SPRTN isoform X1 [Homo sapiens]

Protein Classification

SprT family zinc-dependent metalloprotease( domain architecture ID 10654076)

SprT family zinc-dependent metalloprotease, which contains an HExxH motif characteristic of zinc metallopeptidases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-169 5.74e-27

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


:

Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 105.48  E-value: 5.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802337    43 PDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYegkgGMCSIRLSEPLLKLRPRKDLVEV-------------- 108
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETllhelchaalylfg 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802337   109 -----------------------YHTFHDEVdeYRRHWWRCNgPCQHRppyYGYVKRATNRepsahdyWWAEHQKtCGGT 165
Cdd:smart00731  77 rgyghgdewkrwmrqvnglfperCHTFLIES--VKKYPYRCT-GCGQR---YLRVRRSNNV-------SRYRCGK-CGGK 142


                   ....
gi 578802337   166 YIKI 169
Cdd:smart00731 143 LILI 146
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 410-433 2.52e-09

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 52.22  E-value: 2.52e-09
                           10        20
                   ....*....|....*....|....
gi 578802337   410 MVNCPVCQNEVLESQINEHLDWCL 433
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDSCL 24
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-169 5.74e-27

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 105.48  E-value: 5.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802337    43 PDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYegkgGMCSIRLSEPLLKLRPRKDLVEV-------------- 108
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETllhelchaalylfg 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802337   109 -----------------------YHTFHDEVdeYRRHWWRCNgPCQHRppyYGYVKRATNRepsahdyWWAEHQKtCGGT 165
Cdd:smart00731  77 rgyghgdewkrwmrqvnglfperCHTFLIES--VKKYPYRCT-GCGQR---YLRVRRSNNV-------SRYRCGK-CGGK 142


                   ....
gi 578802337   166 YIKI 169
Cdd:smart00731 143 LILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 45-108 1.70e-18

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 80.39  E-value: 1.70e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578802337   45 LQALFVQFNDQFFWGQL-EAVEVKWSVRMTLCAGICSYEGKggmCSIRLSEPLLKLRPRKDLVEV 108
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLlPGVSVRWSKRLRTTAGRAHLKRK---NEIRLSEPLLDENPEEFLRET 62
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 410-433 2.52e-09

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 52.22  E-value: 2.52e-09
                           10        20
                   ....*....|....*....|....
gi 578802337   410 MVNCPVCQNEVLESQINEHLDWCL 433
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDSCL 24
RAD18 COG5432
RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];
409-442 8.56e-04

RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];


Pssm-ID: 227719 [Multi-domain]  Cd Length: 391  Bit Score: 41.61  E-value: 8.56e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 578802337 409 KMVNCPVCQNEVLESQINEHLDWCLEGDSIKVKS 442
Cdd:COG5432  159 DLVHCPACSNLVPHNQINQHLDSCLNSPSSPSSS 192
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-169 5.74e-27

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 105.48  E-value: 5.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802337    43 PDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYegkgGMCSIRLSEPLLKLRPRKDLVEV-------------- 108
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETllhelchaalylfg 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802337   109 -----------------------YHTFHDEVdeYRRHWWRCNgPCQHRppyYGYVKRATNRepsahdyWWAEHQKtCGGT 165
Cdd:smart00731  77 rgyghgdewkrwmrqvnglfperCHTFLIES--VKKYPYRCT-GCGQR---YLRVRRSNNV-------SRYRCGK-CGGK 142


                   ....
gi 578802337   166 YIKI 169
Cdd:smart00731 143 LILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 45-108 1.70e-18

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 80.39  E-value: 1.70e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578802337   45 LQALFVQFNDQFFWGQL-EAVEVKWSVRMTLCAGICSYEGKggmCSIRLSEPLLKLRPRKDLVEV 108
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLlPGVSVRWSKRLRTTAGRAHLKRK---NEIRLSEPLLDENPEEFLRET 62
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 410-433 2.52e-09

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 52.22  E-value: 2.52e-09
                           10        20
                   ....*....|....*....|....
gi 578802337   410 MVNCPVCQNEVLESQINEHLDWCL 433
Cdd:smart00734   1 LVQCPVCFREVPENLINSHLDSCL 24
RAD18 COG5432
RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];
409-442 8.56e-04

RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms];


Pssm-ID: 227719 [Multi-domain]  Cd Length: 391  Bit Score: 41.61  E-value: 8.56e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 578802337 409 KMVNCPVCQNEVLESQINEHLDWCLEGDSIKVKS 442
Cdd:COG5432  159 DLVHCPACSNLVPHNQINQHLDSCLNSPSSPSSS 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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