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Conserved domains on  [gi|578802837|ref|XP_006712055|]
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echinoderm microtubule-associated protein-like 4 isoform X2 [Homo sapiens]

Protein Classification

HELP and WD40 domain-containing protein( domain architecture ID 13687743)

HELP and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 160-228 1.99e-34

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 125.74  E-value: 1.99e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578802837  160 KMFMRGRPITMFIPSD-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFN 228
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDlDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 434-795 3.25e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 3.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 434 SKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiravaegkadqflvgtsrnfilrgTFN 513
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-----------------------------------------LET 40

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 514 DGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTrLVdepGH-----CADFHPSGTVVAIGTHSGR 588
Cdd:cd00200   41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-LT---GHtsyvsSVAFSPDGRILSSSSRDKT 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 589 WFVLDAETRDLVSI---HTDgneqlSVM--RYSIDGTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSP 663
Cdd:cd00200  117 IKVWDVETGKCLTTlrgHTD-----WVNsvAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 664 DNKYIMSNSGDYEILYWDIPNGcklirnrsdckdidwttyTCVLGFQVFGVWpegsdgtdINALVRSHNRKVIAVADDFC 743
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLSTG------------------KCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDG 241

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578802837 744 KVHLFQypcSKAKAPSHKYSAHSSHVTNVSFtHNDSHLISTGGKDMSIIQWK 795
Cdd:cd00200  242 TIRVWD---LRTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
247-684 4.27e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 4.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 247 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIigLGTFERGVGCLDFSKADSGvhlcIIDDSNEHMLTVW 326
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 327 DWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH-IFFWTW-SGNSLTRKQGifgkyeKPKFVQCLAFLGNGDVL- 403
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLaTGKLLRTLTG------HSGAVTSVAFSPDGKLLa 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 404 TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdq 483
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 484 ygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsmehrLEWTRL 563
Cdd:COG2319  233 ------LATGKLLRTL---------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-----LATGEL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 564 VDEPGHCAD------FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYvvs 637
Cdd:COG2319  281 LRTLTGHSGgvnsvaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--- 357

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 578802837 638 eNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPN 684
Cdd:COG2319  358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 160-228 1.99e-34

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 125.74  E-value: 1.99e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578802837  160 KMFMRGRPITMFIPSD-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFN 228
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDlDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 434-795 3.25e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 3.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 434 SKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiravaegkadqflvgtsrnfilrgTFN 513
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-----------------------------------------LET 40

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 514 DGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTrLVdepGH-----CADFHPSGTVVAIGTHSGR 588
Cdd:cd00200   41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-LT---GHtsyvsSVAFSPDGRILSSSSRDKT 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 589 WFVLDAETRDLVSI---HTDgneqlSVM--RYSIDGTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSP 663
Cdd:cd00200  117 IKVWDVETGKCLTTlrgHTD-----WVNsvAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 664 DNKYIMSNSGDYEILYWDIPNGcklirnrsdckdidwttyTCVLGFQVFGVWpegsdgtdINALVRSHNRKVIAVADDFC 743
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLSTG------------------KCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDG 241

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578802837 744 KVHLFQypcSKAKAPSHKYSAHSSHVTNVSFtHNDSHLISTGGKDMSIIQWK 795
Cdd:cd00200  242 TIRVWD---LRTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
440-796 8.00e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 8.00e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 440 HDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDlNPEREIEVPDQYGTIRAVA---EGKadQFLVGTSRNFILRGTFNDGF 516
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAfspDGK--TLASGSADGTVRLWDLATGK 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 517 QI-EVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWT-RLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDA 594
Cdd:COG2319  154 LLrTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 595 ETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGD 674
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 675 YEILYWDIPNGcKLIRnrsdckdidwttytcvlgfqvfgvWPEGSDGtDINALVRSHNRKVIAVADDFCKVHLFQypcSK 754
Cdd:COG2319  310 GTVRLWDLATG-KLLR------------------------TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWD---LA 360

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 578802837 755 AKAPSHKYSAHSSHVTNVSFTHNDSHLIStGGKDMSIIQWKL 796
Cdd:COG2319  361 TGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
247-684 4.27e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 4.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 247 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIigLGTFERGVGCLDFSKADSGvhlcIIDDSNEHMLTVW 326
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 327 DWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH-IFFWTW-SGNSLTRKQGifgkyeKPKFVQCLAFLGNGDVL- 403
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLaTGKLLRTLTG------HSGAVTSVAFSPDGKLLa 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 404 TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdq 483
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 484 ygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsmehrLEWTRL 563
Cdd:COG2319  233 ------LATGKLLRTL---------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-----LATGEL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 564 VDEPGHCAD------FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYvvs 637
Cdd:COG2319  281 LRTLTGHSGgvnsvaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--- 357

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 578802837 638 eNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPN 684
Cdd:COG2319  358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 235-588 9.83e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 9.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 235 RHYLGHTDCVKCLAIHPDKIRIATGqiagvDKDGRplqphVRVWDSVTLStlQIIGLGTFERGVGCLDFSkADSGvhlCI 314
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLETGE--LLRTLKGHTGPVRDVAAS-ADGT---YL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 315 IDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTdaNTIITCGKSH--IFFWTW-SGNSLTRKQGIFGkyekpkFV 391
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD------WV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 392 QCLAFLGNGDVLTGDSG-GVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH 470
Cdd:cd00200  139 NSVAFSPDGTFVASSSQdGTIKLWDLRTGKCV------------ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 471 dlnpereievpdqygtiravaegkadqflvgtsRNFILRGTFndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCL 550
Cdd:cd00200  207 ---------------------------------STGKCLGTL--------RGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 578802837 551 WNsMEHRLEWTRLV--DEPGHCADFHPSGTVVAIGTHSGR 588
Cdd:cd00200  246 WD-LRTGECVQTLSghTNSVTSLAWSPDGKRLASGSADGT 284
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 649-681 8.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.89e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578802837   649 CTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 681
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
650-681 1.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578802837  650 TGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 681
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 160-228 1.99e-34

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 125.74  E-value: 1.99e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578802837  160 KMFMRGRPITMFIPSD-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFN 228
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDlDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 434-795 3.25e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 3.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 434 SKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiravaegkadqflvgtsrnfilrgTFN 513
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-----------------------------------------LET 40

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 514 DGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTrLVdepGH-----CADFHPSGTVVAIGTHSGR 588
Cdd:cd00200   41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-LT---GHtsyvsSVAFSPDGRILSSSSRDKT 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 589 WFVLDAETRDLVSI---HTDgneqlSVM--RYSIDGTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSP 663
Cdd:cd00200  117 IKVWDVETGKCLTTlrgHTD-----WVNsvAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 664 DNKYIMSNSGDYEILYWDIPNGcklirnrsdckdidwttyTCVLGFQVFGVWpegsdgtdINALVRSHNRKVIAVADDFC 743
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLSTG------------------KCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDG 241

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578802837 744 KVHLFQypcSKAKAPSHKYSAHSSHVTNVSFtHNDSHLISTGGKDMSIIQWK 795
Cdd:cd00200  242 TIRVWD---LRTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
440-796 8.00e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 8.00e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 440 HDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDlNPEREIEVPDQYGTIRAVA---EGKadQFLVGTSRNFILRGTFNDGF 516
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAfspDGK--TLASGSADGTVRLWDLATGK 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 517 QI-EVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWT-RLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDA 594
Cdd:COG2319  154 LLrTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 595 ETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGD 674
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 675 YEILYWDIPNGcKLIRnrsdckdidwttytcvlgfqvfgvWPEGSDGtDINALVRSHNRKVIAVADDFCKVHLFQypcSK 754
Cdd:COG2319  310 GTVRLWDLATG-KLLR------------------------TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWD---LA 360

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 578802837 755 AKAPSHKYSAHSSHVTNVSFTHNDSHLIStGGKDMSIIQWKL 796
Cdd:COG2319  361 TGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
247-684 4.27e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 4.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 247 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIigLGTFERGVGCLDFSKADSGvhlcIIDDSNEHMLTVW 326
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 327 DWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH-IFFWTW-SGNSLTRKQGifgkyeKPKFVQCLAFLGNGDVL- 403
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLaTGKLLRTLTG------HSGAVTSVAFSPDGKLLa 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 404 TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdq 483
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 484 ygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsmehrLEWTRL 563
Cdd:COG2319  233 ------LATGKLLRTL---------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-----LATGEL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 564 VDEPGHCAD------FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYvvs 637
Cdd:COG2319  281 LRTLTGHSGgvnsvaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--- 357

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 578802837 638 eNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPN 684
Cdd:COG2319  358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 388-681 2.12e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 2.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 388 PKFVQCLAFLGNGDVL-TGDSGGVMLIWSKTTVEPtpgkgpkgvyqiSKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKII 466
Cdd:cd00200    9 TGGVTCVAFSPDGKLLaTGSGDGTIKVWDLETGEL------------LRTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 467 LWD-HDLNPEREIEVPDQYgtIRAVAEGKADQFLVGTSRNFILR--GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCA 543
Cdd:cd00200   77 LWDlETGECVRTLTGHTSY--VSSVAFSPDGRILSSSSRDKTIKvwDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 544 QDRQVCLWNSMEHRLEWTRlvdePGH-----CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSID 618
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATL----TGHtgevnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578802837 619 GTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 681
Cdd:cd00200  231 GYLLASGSEDGTIRVW----DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
323-685 3.18e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 3.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 323 LTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKyekpkFVQCLAFLGNGDV 402
Cdd:COG2319   18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-----AVLSVAFSPDGRL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 403 L-TGDSGGVMLIWSKTTVEPTPgkgpkgvyqiskQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWD-HDLNPEREIEV 480
Cdd:COG2319   93 LaSASADGTVRLWDLATGLLLR------------TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 481 PDqyGTIRAVAEGKADQFLVGTSRNFILR--GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsMEHRL 558
Cdd:COG2319  161 HS--GAVTSVAFSPDGKLLASGSDDGTVRlwDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LATGK 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 559 EWTRLVDEPG--HCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVV 636
Cdd:COG2319  238 LLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578802837 637 SEngrkysryGRC----TGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNG 685
Cdd:COG2319  318 AT--------GKLlrtlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362
WD40 COG2319
WD40 repeat [General function prediction only];
451-796 5.79e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 5.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 451 RNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDG-FQIEVQGHTDELWG 529
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGaLLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 530 LATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNE 608
Cdd:COG2319   84 VAFSPDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 609 QLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGcKL 688
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 689 IRnrsdckdidwttytcvlgfqvfgvwPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQypcSKAKAPSHKYSAHSSH 768
Cdd:COG2319  239 LR-------------------------TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHSGG 290

                        330       340
                 ....*....|....*....|....*...
gi 578802837 769 VTNVSFTHNDSHLIStGGKDMSIIQWKL 796
Cdd:COG2319  291 VNSVAFSPDGKLLAS-GSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 235-588 9.83e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 9.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 235 RHYLGHTDCVKCLAIHPDKIRIATGqiagvDKDGRplqphVRVWDSVTLStlQIIGLGTFERGVGCLDFSkADSGvhlCI 314
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLETGE--LLRTLKGHTGPVRDVAAS-ADGT---YL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 315 IDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTdaNTIITCGKSH--IFFWTW-SGNSLTRKQGIFGkyekpkFV 391
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD------WV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 392 QCLAFLGNGDVLTGDSG-GVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH 470
Cdd:cd00200  139 NSVAFSPDGTFVASSSQdGTIKLWDLRTGKCV------------ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 471 dlnpereievpdqygtiravaegkadqflvgtsRNFILRGTFndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCL 550
Cdd:cd00200  207 ---------------------------------STGKCLGTL--------RGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 578802837 551 WNsMEHRLEWTRLV--DEPGHCADFHPSGTVVAIGTHSGR 588
Cdd:cd00200  246 WD-LRTGECVQTLSghTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
212-552 9.93e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 9.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 212 PTGKIvyfIASV-----VVLFNYEERTQRHYL-GHTDCVKCLAIHPDKIRIATGqiagvDKDGRplqphVRVWDSVTLST 285
Cdd:COG2319  130 PDGKT---LASGsadgtVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKLLASG-----SDDGT-----VRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 286 LQIigLGTFERGVGCLDFSkADSGVhlcIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH- 364
Cdd:COG2319  197 LRT--LTGHTGAVRSVAFS-PDGKL---LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGt 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 365 IFFWTW-SGNSLTRKQGIFGKyekpkfVQCLAFLGNGDVL-TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDG 442
Cdd:COG2319  270 VRLWDLaTGELLRTLTGHSGG------VNSVAFSPDGKLLaSGSDDGTVRLWDLATGKLL------------RTLTGHTG 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 443 SVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQG 522
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWD--------------------LATGELLRTL---------------------TG 370

                        330       340       350
                 ....*....|....*....|....*....|
gi 578802837 523 HTDELWGLATHPFKDLLLTCAQDRQVCLWN 552
Cdd:COG2319  371 HTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
489-796 6.90e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 6.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 489 AVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLV-DEP 567
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGhTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 568 GHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYg 647
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTL- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 648 rcTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGcKLIRnrsdckdidwttytcvlgfqvfgVWPEGSDGtdINAL 727
Cdd:COG2319  159 --TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLR-----------------------TLTGHTGA--VRSV 210

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578802837 728 VRSHNRKVIAVADDFCKVHLFQypcSKAKAPSHKYSAHSSHVTNVSFTHnDSHLISTGGKDMSIIQWKL 796
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 226-552 4.06e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 4.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 226 LFNYEERTQRHYL-GHTDCVKCLAIHPDKIRIATGqiaGVDKDgrplqphVRVWDSVTLSTLQIigLGTFERGVGCLDFS 304
Cdd:cd00200   35 VWDLETGELLRTLkGHTGPVRDVAASADGTYLASG---SSDKT-------IRLWDLETGECVRT--LTGHTSYVSSVAFS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 305 KaDSGVHLCIIDDSNehmLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTdaNTIITCGKS--HIFFWtwSGNSLTRKQGIF 382
Cdd:cd00200  103 P-DGRILSSSSRDKT---IKVWDVETGKCLTTLRGHTDWVNSVAFSPD--GTFVASSSQdgTIKLW--DLRTGKCVATLT 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 383 GKYekpKFVQCLAFLGNG-DVLTGDSGGVMLIWSKTTVeptpgkgpkgvyQISKQIKAHDGSVFTLCQMRNGMLLTGGGK 461
Cdd:cd00200  175 GHT---GEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTG------------KCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 462 DRKIILWDhdlnpereievpdqygtiravaegkadqflvgtSRNFILRGTFndgfqievQGHTDELWGLATHPFKDLLLT 541
Cdd:cd00200  240 DGTIRVWD---------------------------------LRTGECVQTL--------SGHTNSVTSLAWSPDGKRLAS 278

                        330
                 ....*....|.
gi 578802837 542 CAQDRQVCLWN 552
Cdd:cd00200  279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 519-796 1.07e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 519 EVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsMEHRLEWTRLVdepGHcadfhpsgtvvaigTHSGRWFVLDAetrd 598
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLK---GH--------------TGPVRDVAASA---- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 599 lvsihtdgneqlsvmrysiDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGDYEIL 678
Cdd:cd00200   62 -------------------DGTYLASGSSDKTIRLWDL-ETGECVRTL---TGHTSYVSSVAFSPDGRILSSSSRDKTIK 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 679 YWDIPNGcKLIRNRSDCKDidwttytcvlgfqvfgvwpegsdgtDINALVRSHNRKVIAVADDFCKVHLFQYPCSKakaP 758
Cdd:cd00200  119 VWDVETG-KCLTTLRGHTD-------------------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK---C 169

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 578802837 759 SHKYSAHSSHVTNVSFTHNDSHLISTGGkDMSIIQWKL 796
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDL 206
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 559-679 2.45e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 45.43  E-value: 2.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 559 EWTRLVDEPGHCAD--FHPSGTVVAIGT-HSGRW--FVLDAETRDLVSIHTDGNEQLSVmRYSIDGTFLAVGSH-DNFIY 632
Cdd:COG0823   22 EPRRLTNSPGIDTSpaWSPDGRRIAFTSdRGGGPqiYVVDADGGEPRRLTFGGGYNASP-SWSPDGKRLAFVSRsDGRFD 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 578802837 633 LYVVSENGRKYSRYGRCTGHSSyithldWSPDNKYIM--SNSGDYEILY 679
Cdd:COG0823  101 IYVLDLDGGAPRRLTDGPGSPS------WSPDGRRIVfsSDRGGRPDLY 143
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 649-681 8.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.89e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578802837   649 CTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 681
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
650-681 1.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578802837  650 TGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 681
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
521-552 1.79e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578802837  521 QGHTDELWGLATHPFKDLLLTCAQDRQVCLWN 552
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 521-552 2.38e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.38e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 578802837   521 QGHTDELWGLATHPFKDLLLTCAQDRQVCLWN 552
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 579-685 4.46e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802837 579 VVAIGTHSGRW--FVLDAETRDLVSIhTDGNEQLSVMRYSIDGTFLAVGSHDNFIY-LYVVSENGRKYSRYgrcTGHSSY 655
Cdd:COG0823    1 LAFTLSRDGNSdiYVVDLDGGEPRRL-TNSPGIDTSPAWSPDGRRIAFTSDRGGGPqIYVVDADGGEPRRL---TFGGGY 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578802837 656 ITHLDWSPDNKYIM---SNSGDYEILYWDIPNG 685
Cdd:COG0823   77 NASPSWSPDGKRLAfvsRSDGRFDIYVLDLDGG 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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