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Conserved domains on  [gi|578803715|ref|XP_006712348|]
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AN1-type zinc finger protein 2B isoform X1 [Homo sapiens]

Protein Classification

zf-AN1 and UIM domain-containing protein( domain architecture ID 10477532)

zf-AN1 and UIM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 100-136 2.03e-10

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


:

Pssm-ID: 460208  Cd Length: 37  Bit Score: 55.00  E-value: 2.03e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578803715  100 CERAGCRQREMMKLTCERCSRNFCIKHRHPLDHDCSG 136
Cdd:pfam01428   1 CSFKGCKKKDFLPFKCRFCGKNFCLKHRLPEDHDCSG 37
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 10-46 2.68e-09

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


:

Pssm-ID: 460208  Cd Length: 37  Bit Score: 51.92  E-value: 2.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578803715   10 CSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHCGS 46
Cdd:pfam01428   1 CSFKGCKKKDFLPFKCRFCGKNFCLKHRLPEDHDCSG 37
UIM pfam02809
Ubiquitin interaction motif; This motif is called the ubiquitin interaction motif. One of the ...
 197-212 5.38e-04

Ubiquitin interaction motif; This motif is called the ubiquitin interaction motif. One of the proteins containing this motif is a receptor for poly-ubiquitination chains for the proteasome. This motif has a pattern of conservation characteriztic of an alpha helix.


:

Pssm-ID: 460703  Cd Length: 17  Bit Score: 36.59  E-value: 5.38e-04
                          10
                  ....*....|....*.
gi 578803715  197 SEDEALQRALEMSLAE 212
Cdd:pfam02809   1 DEDEDLQRALALSLQE 16
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
140-327 9.17e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 9.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803715 140 PTSRAGLAAISRAQAVASTSTVPSPSQTMPSCTSPSRATTRSPSWTAPPVIALQnglsedealqrALEMSLAETKPQVPR 219
Cdd:PRK12323 381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA-----------AARQASARGPGGAPA 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803715 220 PRAAARSRPTAACARALGLGREVhlrrtvaltPLGYTGRGGPEHPGGQRQAGVMWRSPWEPLEG---------LASAPAA 290
Cdd:PRK12323 450 PAPAPAAAPAAAARPAAAGPRPV---------AAAAAAAPARAAPAAAPAPADDDPPPWEELPPefaspapaqPDAAPAG 520

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578803715 291 WKRAASNCSLVGPSVDAGQALLLAPSSCHLPYAGAAP 327
Cdd:PRK12323 521 WVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAAT 557
 
Name Accession Description Interval E-value
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 100-136 2.03e-10

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 55.00  E-value: 2.03e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578803715  100 CERAGCRQREMMKLTCERCSRNFCIKHRHPLDHDCSG 136
Cdd:pfam01428   1 CSFKGCKKKDFLPFKCRFCGKNFCLKHRLPEDHDCSG 37
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 10-46 2.68e-09

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 51.92  E-value: 2.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578803715   10 CSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHCGS 46
Cdd:pfam01428   1 CSFKGCKKKDFLPFKCRFCGKNFCLKHRLPEDHDCSG 37
UIM pfam02809
Ubiquitin interaction motif; This motif is called the ubiquitin interaction motif. One of the ...
 197-212 5.38e-04

Ubiquitin interaction motif; This motif is called the ubiquitin interaction motif. One of the proteins containing this motif is a receptor for poly-ubiquitination chains for the proteasome. This motif has a pattern of conservation characteriztic of an alpha helix.


Pssm-ID: 460703  Cd Length: 17  Bit Score: 36.59  E-value: 5.38e-04
                          10
                  ....*....|....*.
gi 578803715  197 SEDEALQRALEMSLAE 212
Cdd:pfam02809   1 DEDEDLQRALALSLQE 16
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 105-137 8.33e-04

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 36.60  E-value: 8.33e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578803715   105 CRQRE-MMKLTCERCSRNFCIKHRHPLDHDCSGE 137
Cdd:smart00154   4 CRKKVgLTGFKCRHCGNLFCGEHRLPEDHDCPGD 37
UIM smart00726
Ubiquitin-interacting motif; Present in proteasome subunit S5a and other ubiquitin-associated ...
 197-216 6.94e-03

Ubiquitin-interacting motif; Present in proteasome subunit S5a and other ubiquitin-associated proteins.


Pssm-ID: 197845  Cd Length: 20  Bit Score: 33.65  E-value: 6.94e-03
                           10        20
                   ....*....|....*....|
gi 578803715   197 SEDEALQRALEMSLAETKPQ 216
Cdd:smart00726   1 DEDEDLQRALELSLQEAEES 20
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
140-327 9.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 9.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803715 140 PTSRAGLAAISRAQAVASTSTVPSPSQTMPSCTSPSRATTRSPSWTAPPVIALQnglsedealqrALEMSLAETKPQVPR 219
Cdd:PRK12323 381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA-----------AARQASARGPGGAPA 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803715 220 PRAAARSRPTAACARALGLGREVhlrrtvaltPLGYTGRGGPEHPGGQRQAGVMWRSPWEPLEG---------LASAPAA 290
Cdd:PRK12323 450 PAPAPAAAPAAAARPAAAGPRPV---------AAAAAAAPARAAPAAAPAPADDDPPPWEELPPefaspapaqPDAAPAG 520

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578803715 291 WKRAASNCSLVGPSVDAGQALLLAPSSCHLPYAGAAP 327
Cdd:PRK12323 521 WVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAAT 557
 
Name Accession Description Interval E-value
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 100-136 2.03e-10

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 55.00  E-value: 2.03e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578803715  100 CERAGCRQREMMKLTCERCSRNFCIKHRHPLDHDCSG 136
Cdd:pfam01428   1 CSFKGCKKKDFLPFKCRFCGKNFCLKHRLPEDHDCSG 37
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 10-46 2.68e-09

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 51.92  E-value: 2.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578803715   10 CSEPSCQRLDFLPLKCDACSGIFCADHVAYAQHHCGS 46
Cdd:pfam01428   1 CSFKGCKKKDFLPFKCRFCGKNFCLKHRLPEDHDCSG 37
UIM pfam02809
Ubiquitin interaction motif; This motif is called the ubiquitin interaction motif. One of the ...
 197-212 5.38e-04

Ubiquitin interaction motif; This motif is called the ubiquitin interaction motif. One of the proteins containing this motif is a receptor for poly-ubiquitination chains for the proteasome. This motif has a pattern of conservation characteriztic of an alpha helix.


Pssm-ID: 460703  Cd Length: 17  Bit Score: 36.59  E-value: 5.38e-04
                          10
                  ....*....|....*.
gi 578803715  197 SEDEALQRALEMSLAE 212
Cdd:pfam02809   1 DEDEDLQRALALSLQE 16
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 105-137 8.33e-04

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 36.60  E-value: 8.33e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578803715   105 CRQRE-MMKLTCERCSRNFCIKHRHPLDHDCSGE 137
Cdd:smart00154   4 CRKKVgLTGFKCRHCGNLFCGEHRLPEDHDCPGD 37
UIM smart00726
Ubiquitin-interacting motif; Present in proteasome subunit S5a and other ubiquitin-associated ...
 197-216 6.94e-03

Ubiquitin-interacting motif; Present in proteasome subunit S5a and other ubiquitin-associated proteins.


Pssm-ID: 197845  Cd Length: 20  Bit Score: 33.65  E-value: 6.94e-03
                           10        20
                   ....*....|....*....|
gi 578803715   197 SEDEALQRALEMSLAETKPQ 216
Cdd:smart00726   1 DEDEDLQRALELSLQEAEES 20
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
140-327 9.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 9.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803715 140 PTSRAGLAAISRAQAVASTSTVPSPSQTMPSCTSPSRATTRSPSWTAPPVIALQnglsedealqrALEMSLAETKPQVPR 219
Cdd:PRK12323 381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA-----------AARQASARGPGGAPA 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803715 220 PRAAARSRPTAACARALGLGREVhlrrtvaltPLGYTGRGGPEHPGGQRQAGVMWRSPWEPLEG---------LASAPAA 290
Cdd:PRK12323 450 PAPAPAAAPAAAARPAAAGPRPV---------AAAAAAAPARAAPAAAPAPADDDPPPWEELPPefaspapaqPDAAPAG 520

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578803715 291 WKRAASNCSLVGPSVDAGQALLLAPSSCHLPYAGAAP 327
Cdd:PRK12323 521 WVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAAT 557
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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