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Conserved domains on  [gi|578808374|ref|XP_006714021|]
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biorientation of chromosomes in cell division protein 1-like 1 isoform X2 [Homo sapiens]

Protein Classification

UBX domain-containing protein; FRMD7 family protein( domain architecture ID 13708535)

UBX domain-containing protein similar to Schizosaccharomyces pombe protein C17C9.11c| FRMD7 family protein similar to Homo sapiens FERM domain-containing protein 7 (FRMD7) that plays a role in neurite development, and N-terminal region of Homo sapiens FERM, ARHGEF and pleckstrin domain-containing protein 1/2 that functions as guanine nucleotide exchange factor for RAC1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
57-150 2.71e-28

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


:

Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 110.75  E-value: 2.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374    57 IVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGML---ESGIDR 133
Cdd:pfam05205    2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYkkaEAGVDR 81
                           90
                   ....*....|....*....
gi 578808374   134 IISQVV--DPKINHTFRPQ 150
Cdd:pfam05205   82 LIDQVLdiEPKIREIRRPE 100
PTZ00121 super family cl31754
MAEBL; Provisional
213-1059 3.16e-17

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 89.82  E-value: 3.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  213 QEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKE-------RTSEDMADKEKSTADSGGEGLETAPKSEEFSDlpc 285
Cdd:PTZ00121 1161 EDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDarkaeaaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKK--- 1237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  286 PVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEktekkfDHSKKSEDTQKVKDEKQAK 365
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKA------DEAKKAEEKKKADEAKKKA 1311
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  366 E--KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDsdvdgltditvssvhtsdlssfEEDTEEEVVTSDSMEEGEITSDDE 443
Cdd:PTZ00121 1312 EeaKKADEAKKKAEEAKKKADAAKKKAEEAKKAA----------------------EAAKAEAEAAADEAEAAEEKAEAA 1369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  444 EKNKQNKTKtqTSDSSEGKTKSVRHAYvhkpylYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKA 523
Cdd:PTZ00121 1370 EKKKEEAKK--KADAAKKKAEEKKKAD------EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  524 EKTKSSKTKGQGRSSVDLEESSTKSLEP-KAARIKEVLKERKVLE--KKVALSKKRKKDSRNVEENSKKKQQYEEDSKET 600
Cdd:PTZ00121 1442 EAKKADEAKKKAEEAKKAEEAKKKAEEAkKADEAKKKAEEAKKADeaKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEA 1521
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  601 LKTSEHCEKEKISSSKELKhvhaKSEPSKPARRLSESLHVvdeNKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEAK----KAEEKKKADELKKAEEL---KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  681 ERSEICTEEPQKQKStlkneKHLKKDDSETPHLKSLlkkevksSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELH 760
Cdd:PTZ00121 1595 EEVMKLYEEEKKMKA-----EEAKKAEEAKIKAEEL-------KKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  761 SSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDEnVRKENNKKERRLSAEKTKAEH 840
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE-LKKAEEENKIKAEEAKKEAEE 1741
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  841 KSRRSSDSKIQKDSLGSKQHgitLQRRSESYSEDKcdmdstnmdsnLKPEEVVHKEKRRTKsllEEKLVLKSKSKTqgKQ 920
Cdd:PTZ00121 1742 DKKKAEEAKKDEEEKKKIAH---LKKEEEKKAEEI-----------RKEKEAVIEEELDEE---DEKRRMEVDKKI--KD 1802
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  921 VKVVETELQEGatkqattpkpDKEKNTEENDSekqrkskvedkpfEETGVEPVLETASSSahSTQKDSSHraklplAKEK 1000
Cdd:PTZ00121 1803 IFDNFANIIEG----------GKEGNLVINDS-------------KEMEDSAIKEVADSK--NMQLEEAD------AFEK 1851
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374 1001 YKSDKDSTSTRLERKLSDGHKSRSLKHS-SKDIKKKDENKSDDKDGKEVDSSHEKARGNS 1059
Cdd:PTZ00121 1852 HKFNKNNENGEDGNKEADFNKEKDLKEDdEEEIEEADEIEKIDKDDIEREIPNNNMAGKN 1911
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
57-150 2.71e-28

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 110.75  E-value: 2.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374    57 IVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGML---ESGIDR 133
Cdd:pfam05205    2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYkkaEAGVDR 81
                           90
                   ....*....|....*....
gi 578808374   134 IISQVV--DPKINHTFRPQ 150
Cdd:pfam05205   82 LIDQVLdiEPKIREIRRPE 100
PTZ00121 PTZ00121
MAEBL; Provisional
213-1059 3.16e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 89.82  E-value: 3.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  213 QEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKE-------RTSEDMADKEKSTADSGGEGLETAPKSEEFSDlpc 285
Cdd:PTZ00121 1161 EDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDarkaeaaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKK--- 1237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  286 PVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEktekkfDHSKKSEDTQKVKDEKQAK 365
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKA------DEAKKAEEKKKADEAKKKA 1311
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  366 E--KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDsdvdgltditvssvhtsdlssfEEDTEEEVVTSDSMEEGEITSDDE 443
Cdd:PTZ00121 1312 EeaKKADEAKKKAEEAKKKADAAKKKAEEAKKAA----------------------EAAKAEAEAAADEAEAAEEKAEAA 1369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  444 EKNKQNKTKtqTSDSSEGKTKSVRHAYvhkpylYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKA 523
Cdd:PTZ00121 1370 EKKKEEAKK--KADAAKKKAEEKKKAD------EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  524 EKTKSSKTKGQGRSSVDLEESSTKSLEP-KAARIKEVLKERKVLE--KKVALSKKRKKDSRNVEENSKKKQQYEEDSKET 600
Cdd:PTZ00121 1442 EAKKADEAKKKAEEAKKAEEAKKKAEEAkKADEAKKKAEEAKKADeaKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEA 1521
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  601 LKTSEHCEKEKISSSKELKhvhaKSEPSKPARRLSESLHVvdeNKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEAK----KAEEKKKADELKKAEEL---KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  681 ERSEICTEEPQKQKStlkneKHLKKDDSETPHLKSLlkkevksSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELH 760
Cdd:PTZ00121 1595 EEVMKLYEEEKKMKA-----EEAKKAEEAKIKAEEL-------KKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  761 SSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDEnVRKENNKKERRLSAEKTKAEH 840
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE-LKKAEEENKIKAEEAKKEAEE 1741
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  841 KSRRSSDSKIQKDSLGSKQHgitLQRRSESYSEDKcdmdstnmdsnLKPEEVVHKEKRRTKsllEEKLVLKSKSKTqgKQ 920
Cdd:PTZ00121 1742 DKKKAEEAKKDEEEKKKIAH---LKKEEEKKAEEI-----------RKEKEAVIEEELDEE---DEKRRMEVDKKI--KD 1802
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  921 VKVVETELQEGatkqattpkpDKEKNTEENDSekqrkskvedkpfEETGVEPVLETASSSahSTQKDSSHraklplAKEK 1000
Cdd:PTZ00121 1803 IFDNFANIIEG----------GKEGNLVINDS-------------KEMEDSAIKEVADSK--NMQLEEAD------AFEK 1851
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374 1001 YKSDKDSTSTRLERKLSDGHKSRSLKHS-SKDIKKKDENKSDDKDGKEVDSSHEKARGNS 1059
Cdd:PTZ00121 1852 HKFNKNNENGEDGNKEADFNKEKDLKEDdEEEIEEADEIEKIDKDDIEREIPNNNMAGKN 1911
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
349-1168 7.54e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 61.91  E-value: 7.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   349 SKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSdvdGLTDITVSSVHTSDLSSFEEDTEEEVV 428
Cdd:pfam02463  175 LKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEE---YLLYLDYLKLNEERIDLLQELLRDEQE 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   429 TSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKsvrhayvhkpylyskyysdsDDELTVEQRRQSIAKEKEERLLRR 508
Cdd:pfam02463  252 EIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEE--------------------LKLLAKEEEELKSELLKLERRKVD 311
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   509 QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSK 588
Cdd:pfam02463  312 DEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK 391
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   589 KKQQYEEDSKETLKTSEhcEKEKISSSKELkhvHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRrtstpvimegVQ 668
Cdd:pfam02463  392 LKEEELELKSEEEKEAQ--LLLELARQLED---LLKEEKKEELEILEEEEESIELKQGKLTEEKEELE----------KQ 456
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   669 EETDTRDvKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLK-----SLLKKEVKSSKEKPEREKTPSEDKLSVKH 743
Cdd:pfam02463  457 ELKLLKD-ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKeskarSGLKVLLALIKDGVGGRIISAHGRLGDLG 535
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   744 KYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLssdDKTERKSKHRNERKLSVLGKDGKPVSEYI---IKTDENV 820
Cdd:pfam02463  536 VAVENYKVAISTAVIVEVSATADEVEERQKLVRALTEL---PLGARKLRLLIPKLKLPLKSIAVLEIDPIlnlAQLDKAT 612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   821 RKENNKKERRLSAEKTKAEHKSRRSSDSKiqKDSLGSKQHGITLQRRSESYSEDKcdMDSTNMDSNLKPEEVVHKEKRRT 900
Cdd:pfam02463  613 LEADEDDKRAKVVEGILKDTELTKLKESA--KAKESGLRKGVSLEEGLAEKSEVK--ASLSELTKELLEIQELQEKAESE 688
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   901 KSLLEEKLVLKSKSKTQGKQ-----------VKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETG 969
Cdd:pfam02463  689 LAKEEILRRQLEIKKKEQREkeelkklkleaEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSE 768
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   970 VEPVLETASSSAHSTQKDS----SHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDG 1045
Cdd:pfam02463  769 LSLKEKELAEEREKTEKLKveeeKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKL 848
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  1046 KEVDSshEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSG----DMTLIPEQEPME 1121
Cdd:pfam02463  849 EKLAE--EELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNlleeKENEIEERIKEE 926
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*..
gi 578808374  1122 IDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELR 1168
Cdd:pfam02463  927 AEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELG 973
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
499-709 2.64e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.46  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  499 KEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKgqgrsSVDLEESST--KSLEPKAARIKEVlKERKVLEKKVALSKKR 576
Cdd:NF033838  186 KKAELELVKEEAKEPRDEEKIKQAKAKVESKKAE-----ATRLEKIKTdrEKAEEEAKRRADA-KLKEAVEKNVATSEQD 259
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  577 KKDSRnVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKhvhaksepskPARRLSESLHVVDENKNESKLEREHKR 656
Cdd:NF033838  260 KPKRR-AKRGVLGEPATPDKKENDAKSSDSSVGEETLPSPSLK----------PEKKVAEAEKKVEEAKKKAKDQKEEDR 328
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578808374  657 RTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQkstlKNEKHLKKDDSE 709
Cdd:NF033838  329 RNYPTNTYKTLELEIAESDVKVKEAELELVKEEAKEP----RNEEKIKQAKAK 377
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
491-862 6.55e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 6.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   491 EQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSsktkgqgrssvdleESSTKSLEPKAAR--IKEVLKERKVLEK 568
Cdd:TIGR02169  186 IERLDLIIDEKRQQLERLRREREKAERYQALLKEKREY--------------EGYELLKEKEALErqKEAIERQLASLEE 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   569 KVALSKKRkkdsrnVEENSKKKQQYEEDSKE-TLKTSEHCEKEKISSSKELKHVHAKSEPSKpaRRLSEslhvvdenkNE 647
Cdd:TIGR02169  252 ELEKLTEE------ISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLE--RSIAE---------KE 314
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   648 SKLEREHKRRtstpvimegVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEkhLKKDDSETPHLKSLLKKEVKSSKEK 727
Cdd:TIGR02169  315 RELEDAEERL---------AKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE--YAELKEELEDLRAELEEVDKEFAET 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   728 PEREKTPSE--DKLSVKHKYKGDCMHKTGDETElHSSEKGLKVEENIQ-KQSQQTKLSSDDKTERKSKHRNERKLSVLGK 804
Cdd:TIGR02169  384 RDELKDYREklEKLKREINELKRELDRLQEELQ-RLSEELADLNAAIAgIEAKINELEEEKEDKALEIKKQEWKLEQLAA 462
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578808374   805 DGKPVSEYIIKTDENVR---KENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGI 862
Cdd:TIGR02169  463 DLSKYEQELYDLKEEYDrveKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGV 523
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
57-150 2.71e-28

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 110.75  E-value: 2.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374    57 IVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGML---ESGIDR 133
Cdd:pfam05205    2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYkkaEAGVDR 81
                           90
                   ....*....|....*....
gi 578808374   134 IISQVV--DPKINHTFRPQ 150
Cdd:pfam05205   82 LIDQVLdiEPKIREIRRPE 100
PTZ00121 PTZ00121
MAEBL; Provisional
213-1059 3.16e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 89.82  E-value: 3.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  213 QEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKE-------RTSEDMADKEKSTADSGGEGLETAPKSEEFSDlpc 285
Cdd:PTZ00121 1161 EDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDarkaeaaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKK--- 1237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  286 PVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEktekkfDHSKKSEDTQKVKDEKQAK 365
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKA------DEAKKAEEKKKADEAKKKA 1311
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  366 E--KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDsdvdgltditvssvhtsdlssfEEDTEEEVVTSDSMEEGEITSDDE 443
Cdd:PTZ00121 1312 EeaKKADEAKKKAEEAKKKADAAKKKAEEAKKAA----------------------EAAKAEAEAAADEAEAAEEKAEAA 1369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  444 EKNKQNKTKtqTSDSSEGKTKSVRHAYvhkpylYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKA 523
Cdd:PTZ00121 1370 EKKKEEAKK--KADAAKKKAEEKKKAD------EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAE 1441
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  524 EKTKSSKTKGQGRSSVDLEESSTKSLEP-KAARIKEVLKERKVLE--KKVALSKKRKKDSRNVEENSKKKQQYEEDSKET 600
Cdd:PTZ00121 1442 EAKKADEAKKKAEEAKKAEEAKKKAEEAkKADEAKKKAEEAKKADeaKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEA 1521
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  601 LKTSEHCEKEKISSSKELKhvhaKSEPSKPARRLSESLHVvdeNKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEAK----KAEEKKKADELKKAEEL---KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  681 ERSEICTEEPQKQKStlkneKHLKKDDSETPHLKSLlkkevksSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELH 760
Cdd:PTZ00121 1595 EEVMKLYEEEKKMKA-----EEAKKAEEAKIKAEEL-------KKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  761 SSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDEnVRKENNKKERRLSAEKTKAEH 840
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE-LKKAEEENKIKAEEAKKEAEE 1741
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  841 KSRRSSDSKIQKDSLGSKQHgitLQRRSESYSEDKcdmdstnmdsnLKPEEVVHKEKRRTKsllEEKLVLKSKSKTqgKQ 920
Cdd:PTZ00121 1742 DKKKAEEAKKDEEEKKKIAH---LKKEEEKKAEEI-----------RKEKEAVIEEELDEE---DEKRRMEVDKKI--KD 1802
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  921 VKVVETELQEGatkqattpkpDKEKNTEENDSekqrkskvedkpfEETGVEPVLETASSSahSTQKDSSHraklplAKEK 1000
Cdd:PTZ00121 1803 IFDNFANIIEG----------GKEGNLVINDS-------------KEMEDSAIKEVADSK--NMQLEEAD------AFEK 1851
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374 1001 YKSDKDSTSTRLERKLSDGHKSRSLKHS-SKDIKKKDENKSDDKDGKEVDSSHEKARGNS 1059
Cdd:PTZ00121 1852 HKFNKNNENGEDGNKEADFNKEKDLKEDdEEEIEEADEIEKIDKDDIEREIPNNNMAGKN 1911
PTZ00121 PTZ00121
MAEBL; Provisional
437-1157 7.83e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 88.27  E-value: 7.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  437 EITSDDEEKNKQNKTKtqtSDSSEGKTKSVRHAYVHKPYLYSKyysdSDDELTVEQRRQSIAKEKEERLlRRQINREKLE 516
Cdd:PTZ00121 1234 EAKKDAEEAKKAEEER---NNEEIRKFEEARMAHFARRQAAIK----AEEARKADELKKAEEKKKADEA-KKAEEKKKAD 1305
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  517 EKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEED 596
Cdd:PTZ00121 1306 EAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKK 1385
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  597 SKETLKTSEHCEK---EKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDT 673
Cdd:PTZ00121 1386 KAEEKKKADEAKKkaeEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKK 1465
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  674 RDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSEtphLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKT 753
Cdd:PTZ00121 1466 AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE---AKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKA 1542
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  754 gdeTELHSSEKGLKVEEniQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSA 833
Cdd:PTZ00121 1543 ---EEKKKADELKKAEE--LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE 1617
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  834 EKTKAEH----KSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSllEEKLV 909
Cdd:PTZ00121 1618 AKIKAEElkkaEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA--AEALK 1695
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  910 LKSKSKTQGKQVKVVETElqegatkqattpkpDKEKNTEENDSEKQRKSKVEDKPFEEtgvepvlETASSSAHSTQKDSS 989
Cdd:PTZ00121 1696 KEAEEAKKAEELKKKEAE--------------EKKKAEELKKAEEENKIKAEEAKKEA-------EEDKKKAEEAKKDEE 1754
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  990 HRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRR 1069
Cdd:PTZ00121 1755 EKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKE 1834
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374 1070 LCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTlipeqepmeidsEPGVENVFEVSKTQDNRNNNSQQDI 1149
Cdd:PTZ00121 1835 VADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLK------------EDDEEEIEEADEIEKIDKDDIEREI 1902

                  ....*...
gi 578808374 1150 DSENMKQK 1157
Cdd:PTZ00121 1903 PNNNMAGK 1910
PTZ00121 PTZ00121
MAEBL; Provisional
495-1182 3.02e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.80  E-value: 3.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  495 QSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSK 574
Cdd:PTZ00121 1022 QNFNIEKIEELTEYGNNDDVLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAE 1101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  575 KRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVH-----AKSEPSKPARRLSESLHVVDENKNESK 649
Cdd:PTZ00121 1102 EAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEdakrvEIARKAEDARKAEEARKAEDAKKAEAA 1181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  650 LEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHL-KSLLKKEVKSSKEKP 728
Cdd:PTZ00121 1182 RKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEAR 1261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  729 EREKTPSEDKLSVKHKYKGDCMHKTGDET---ELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNErklsvlgkD 805
Cdd:PTZ00121 1262 MAHFARRQAAIKAEEARKADELKKAEEKKkadEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKAD--------A 1333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  806 GKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHgitlQRRSESYSEDKCDMDSTnmds 885
Cdd:PTZ00121 1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAE----EKKKADEAKKKAEEDKK---- 1405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  886 nlKPEEVVHKEKRRTKSlLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKE--KNTEENDSEKQRKSKVEDK 963
Cdd:PTZ00121 1406 --KADELKKAAAAKKKA-DEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEEAKKADEAKKKAEEA 1482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  964 PFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDK 1043
Cdd:PTZ00121 1483 KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEE 1562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374 1044 DGKEVDSSHEKARGNSSLMEKKLSRRLcENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKksgdmtLIPEQEPMEID 1123
Cdd:PTZ00121 1563 KKKAEEAKKAEEDKNMALRKAEEAKKA-EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE------LKKAEEEKKKV 1635
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374 1124 SEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQK-DELRTCTADSKATAPAYK 1182
Cdd:PTZ00121 1636 EQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKaEEAKKAEEDEKKAAEALK 1695
PTZ00121 PTZ00121
MAEBL; Provisional
491-1087 2.91e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 73.25  E-value: 2.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  491 EQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSvdlEESSTKSLEPKAARIKEVLKERKVLEKKV 570
Cdd:PTZ00121 1113 EARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKA---EDARKAEEARKAEDAKKAEAARKAEEVRK 1189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  571 ALSKKRKKDSRNVEENSKkkqqYEEDSK-ETLKTSEhcEKEKISSSKELKHVHAKSEPSKPAR--------RLSESLHVV 641
Cdd:PTZ00121 1190 AEELRKAEDARKAEAARK----AEEERKaEEARKAE--DAKKAEAVKKAEEAKKDAEEAKKAEeernneeiRKFEEARMA 1263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  642 DENKNESKLEREHKRRTSTPVIMEGVQ--EETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSEtphLKSLLKK 719
Cdd:PTZ00121 1264 HFARRQAAIKAEEARKADELKKAEEKKkaDEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA---AKKKAEE 1340
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  720 EVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKglKVEENIQKQSQQTKLSSDDKTERKSKHRNERKL 799
Cdd:PTZ00121 1341 AKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKK--KAEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  800 SvlGKDGKPVSEYIIKTDENVRKENNKKE----RRLSAEKTKAEHKSRRSSDSKIQ---KDSLGSKQHGITLQRRSESyS 872
Cdd:PTZ00121 1419 K--ADEAKKKAEEKKKADEAKKKAEEAKKadeaKKKAEEAKKAEEAKKKAEEAKKAdeaKKKAEEAKKADEAKKKAEE-A 1495
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  873 EDKCDMDSTNMDSNLKPEEVVH-KEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEEND 951
Cdd:PTZ00121 1496 KKKADEAKKAAEAKKKADEAKKaEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEED 1575
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  952 SEKQRKSKVEDKPFEETGVEPVL----ETASSSAHSTQKDSSHRAKLPLAKeKYKSDKDSTSTRLERKLSDGHKSRSLKH 1027
Cdd:PTZ00121 1576 KNMALRKAEEAKKAEEARIEEVMklyeEEKKMKAEEAKKAEEAKIKAEELK-KAEEEKKKVEQLKKKEAEEKKKAEELKK 1654
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578808374 1028 SSKD--IKKKDENKSDDKDGKEVD----SSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEE 1087
Cdd:PTZ00121 1655 AEEEnkIKAAEEAKKAEEDKKKAEeakkAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE 1720
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
349-1168 7.54e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 61.91  E-value: 7.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   349 SKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSdvdGLTDITVSSVHTSDLSSFEEDTEEEVV 428
Cdd:pfam02463  175 LKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEE---YLLYLDYLKLNEERIDLLQELLRDEQE 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   429 TSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKsvrhayvhkpylyskyysdsDDELTVEQRRQSIAKEKEERLLRR 508
Cdd:pfam02463  252 EIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEE--------------------LKLLAKEEEELKSELLKLERRKVD 311
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   509 QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSK 588
Cdd:pfam02463  312 DEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK 391
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   589 KKQQYEEDSKETLKTSEhcEKEKISSSKELkhvHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRrtstpvimegVQ 668
Cdd:pfam02463  392 LKEEELELKSEEEKEAQ--LLLELARQLED---LLKEEKKEELEILEEEEESIELKQGKLTEEKEELE----------KQ 456
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   669 EETDTRDvKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLK-----SLLKKEVKSSKEKPEREKTPSEDKLSVKH 743
Cdd:pfam02463  457 ELKLLKD-ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKeskarSGLKVLLALIKDGVGGRIISAHGRLGDLG 535
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   744 KYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLssdDKTERKSKHRNERKLSVLGKDGKPVSEYI---IKTDENV 820
Cdd:pfam02463  536 VAVENYKVAISTAVIVEVSATADEVEERQKLVRALTEL---PLGARKLRLLIPKLKLPLKSIAVLEIDPIlnlAQLDKAT 612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   821 RKENNKKERRLSAEKTKAEHKSRRSSDSKiqKDSLGSKQHGITLQRRSESYSEDKcdMDSTNMDSNLKPEEVVHKEKRRT 900
Cdd:pfam02463  613 LEADEDDKRAKVVEGILKDTELTKLKESA--KAKESGLRKGVSLEEGLAEKSEVK--ASLSELTKELLEIQELQEKAESE 688
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   901 KSLLEEKLVLKSKSKTQGKQ-----------VKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETG 969
Cdd:pfam02463  689 LAKEEILRRQLEIKKKEQREkeelkklkleaEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSE 768
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   970 VEPVLETASSSAHSTQKDS----SHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDG 1045
Cdd:pfam02463  769 LSLKEKELAEEREKTEKLKveeeKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKL 848
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  1046 KEVDSshEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSG----DMTLIPEQEPME 1121
Cdd:pfam02463  849 EKLAE--EELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNlleeKENEIEERIKEE 926
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*..
gi 578808374  1122 IDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELR 1168
Cdd:pfam02463  927 AEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELG 973
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
494-1081 1.24e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.13  E-value: 1.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   494 RQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKgqgrssvDLEESSTKSLEPKAARIKEVLKERKVLEKKVALS 573
Cdd:pfam02463  145 EIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETE-------NLAELIIDLEELKLQELKLKEQAKKALEYYQLKE 217
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   574 KKRKKDS-----RNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNES 648
Cdd:pfam02463  218 KLELEEEyllylDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEE 297
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   649 KLErehkrrtstpvimEGVQEETDTRDVKRQVERSEictEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKP 728
Cdd:pfam02463  298 LKS-------------ELLKLERRKVDDEEKLKESE---KEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEEL 361
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   729 EREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKP 808
Cdd:pfam02463  362 EKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIEL 441
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   809 VSEYIIKTDENVRKENNKK-ERRLSAEKTKAEHKSRRSSDSKIQKDslgsKQHGITLQRRSESYSEDKCDMDSTNMDSNL 887
Cdd:pfam02463  442 KQGKLTEEKEELEKQELKLlKDELELKKSEDLLKETQLVKLQEQLE----LLLSRQKLEERSQKESKARSGLKVLLALIK 517
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   888 KPEEVVHKEKRRTKSLLEEKLVLKS--KSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPF 965
Cdd:pfam02463  518 DGVGGRIISAHGRLGDLGVAVENYKvaISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVL 597
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   966 EetgVEPVLETASSSAHSTQKDS-SHRAKLPLAKEKYKsDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKD 1044
Cdd:pfam02463  598 E---IDPILNLAQLDKATLEADEdDKRAKVVEGILKDT-ELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTK 673
                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 578808374  1045 GKEVdSSHEKARGNSSLMEKKLSRRLCENRRGSLSQE 1081
Cdd:pfam02463  674 ELLE-IQELQEKAESELAKEEILRRQLEIKKKEQREK 709
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
476-1089 1.31e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.88  E-value: 1.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   476 LYSKYYSDSDdelTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKssktkGQGRSSVDLEESSTKSlepkaar 555
Cdd:pfam05483   79 LYSKLYKEAE---KIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQF-----ENEKVSLKLEEEIQEN------- 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   556 iKEVLKERKVLEKKVALSKKrkKDSRNVEENskKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLS 635
Cdd:pfam05483  144 -KDLIKENNATRHLCNLLKE--TCARSAEKT--KKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLK 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   636 ESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEicTEEPQKQKSTLKNEKHLKKDDSETPHLKS 715
Cdd:pfam05483  219 EDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESR--DKANQLEEKTKLQDENLKELIEKKDHLTK 296
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   716 LLKKEVKSSKEKPEREKTPSEDklsVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDD--KTERKSKH 793
Cdd:pfam05483  297 ELEDIKMSLQRSMSTQKALEED---LQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEEllRTEQQRLE 373
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   794 RNERKLSVLGKDGKPVSEyiiKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK--DSLGSKQHGIT--LQRRSE 869
Cdd:pfam05483  374 KNEDQLKIITMELQKKSS---ELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKiaEELKGKEQELIflLQAREK 450
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   870 SYSEDKCDMDSTNMDsnlkpEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEE 949
Cdd:pfam05483  451 EIHDLEIQLTAIKTS-----EEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINC 525
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   950 NDSEKQRKSKVEDKPFEETGVEPVLETASSSAhsTQKDSSHRAKLPlakekyKSDKDSTSTRLErKLSDGHKSRSLKHSS 1029
Cdd:pfam05483  526 KKQEERMLKQIENLEEKEMNLRDELESVREEF--IQKGDEVKCKLD------KSEENARSIEYE-VLKKEKQMKILENKC 596
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  1030 KDIKKKDENKSddKDGKEVDSSHEKARGNSSLMEKKLSrrLCENRRGSLSQEMAKGEEKL 1089
Cdd:pfam05483  597 NNLKKQIENKN--KNIEELHQENKALKKKGSAENKQLN--AYEIKVNKLELELASAKQKF 652
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
767-1054 3.02e-05

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 50.04  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  767 KVEENIQKQSQQtklssDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDenvrkenNKKERRLSAEKTKAEHKSRRSS 846
Cdd:PTZ00108 1136 KFEEALEEQEEV-----EEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKK-------KKSSADKSKKASVVGNSKRVDS 1203
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  847 DSKIQKDSLGSKqhgiTLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVET 926
Cdd:PTZ00108 1204 DEKRKLDDKPDN----KKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVS 1279
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  927 ELQEGATKQATTPKPDKEKNTEENDSEKQRKskveDKPFEETGVEPVLETASSSAHSTQKDSshraklplaKEKYKSDKD 1006
Cdd:PTZ00108 1280 AVQYSPPPPSKRPDGESNGGSKPSSPTKKKV----KKRLEGSLAALKKKKKSEKKTARKKKS---------KTRVKQASA 1346
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 578808374 1007 STSTRLERKLSdghksrslKHSSKDIKKKDENKSDDKDGKEVDSSHEK 1054
Cdd:PTZ00108 1347 SQSSRLLRRPR--------KKKSDSSSEDDDDSEVDDSEDEDDEDDED 1386
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
288-999 1.51e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 44.58  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   288 EEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEkkfdhSKKSEDTQKVKDEKQAKEK 367
Cdd:pfam02463  278 EKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKE-----KEEIEELEKELKELEIKRE 352
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   368 EVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTsdLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNK 447
Cdd:pfam02463  353 AEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE--LKSEEEKEAQLLLELARQLEDLLKEEKKEELE 430
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   448 QNKTKTQTSDSSEGKTKSVRHayvHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTK 527
Cdd:pfam02463  431 ILEEEEESIELKQGKLTEEKE---ELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS 507
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   528 SSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALS--KKRKKDSRNVEENSKKKQQYEEDSKETLKTSE 605
Cdd:pfam02463  508 GLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVsaTADEVEERQKLVRALTELPLGARKLRLLIPKL 587
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   606 HCEKEKISsskELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEI 685
Cdd:pfam02463  588 KLPLKSIA---VLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEV 664
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   686 CTEEPQKQKSTLKNEKHLKKDDSETphLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKykgdcmhktGDETELHSSEKG 765
Cdd:pfam02463  665 KASLSELTKELLEIQELQEKAESEL--AKEEILRRQLEIKKKEQREKEELKKLKLEAEE---------LLADRVQEAQDK 733
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   766 LKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEhKSRRS 845
Cdd:pfam02463  734 INEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALE-EELKE 812
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   846 SDSKIQKDSLGSKQHG-----ITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQ 920
Cdd:pfam02463  813 EAELLEEEQLLIEQEEkikeeELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKE 892
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   921 VKVV-ETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKE 999
Cdd:pfam02463  893 EKEKeEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEEL 972
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
486-1068 1.89e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  486 DELTVEQRRQSIAKEKEERLLRRQIN--REKLE--EKRKQKAEKTKSSKTKGQGRssvdleessTKSLEPKAARIKEVLK 561
Cdd:PRK03918  192 EELIKEKEKELEEVLREINEISSELPelREELEklEKEVKELEELKEEIEELEKE---------LESLEGSKRKLEEKIR 262
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  562 E-RKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSK---ETLKTSEHCEKEKISSSKELKHVHAK-SEPSKPARRLSE 636
Cdd:PRK03918  263 ElEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEfyeEYLDELREIEKRLSRLEEEINGIEERiKELEEKEERLEE 342
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  637 SLhvvdenKNESKLEREHKRrtstpvIMEGVQEETDTRDVKRQVER--SEICTEEPQKQKSTLKNEKHLKKDDSEtpHLK 714
Cdd:PRK03918  343 LK------KKLKELEKRLEE------LEERHELYEEAKAKKEELERlkKRLTGLTPEKLEKELEELEKAKEEIEE--EIS 408
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  715 SLLKKEVKSSKEKPEREKTPSEDKlsvkhKYKGDCMHKTGDETELHssEKGLKVEENIQKQSQQTKLSSDDKTERKSKhR 794
Cdd:PRK03918  409 KITARIGELKKEIKELKKAIEELK-----KAKGKCPVCGRELTEEH--RKELLEEYTAELKRIEKELKEIEEKERKLR-K 480
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  795 NERKLsvlgkdgkpvseyiiktdENVRkennKKERRLSAEKTKAEH-KSRRSSDSKIQKDSlgskqhgitLQRRSESYSE 873
Cdd:PRK03918  481 ELREL------------------EKVL----KKESELIKLKELAEQlKELEEKLKKYNLEE---------LEKKAEEYEK 529
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  874 -----DKCDMDSTNMDSNLKPEEVVHKEKR---RTKSLLEEKL--VLKSKSKTQGKQVKVVETELQ--EGATKQATTPKP 941
Cdd:PRK03918  530 lkeklIKLKGEIKSLKKELEKLEELKKKLAeleKKLDELEEELaeLLKELEELGFESVEELEERLKelEPFYNEYLELKD 609
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  942 DKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSShraklplaKEKYKSDKDSTsTRLERKLSdghk 1021
Cdd:PRK03918  610 AEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYS--------EEEYEELREEY-LELSRELA---- 676
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 578808374 1022 srSLKHSSKDIKK-KDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSR 1068
Cdd:PRK03918  677 --GLRAELEELEKrREEIKKTLEKLKEELEEREKAKKELEKLEKALER 722
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
499-709 2.64e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.46  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  499 KEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKgqgrsSVDLEESST--KSLEPKAARIKEVlKERKVLEKKVALSKKR 576
Cdd:NF033838  186 KKAELELVKEEAKEPRDEEKIKQAKAKVESKKAE-----ATRLEKIKTdrEKAEEEAKRRADA-KLKEAVEKNVATSEQD 259
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374  577 KKDSRnVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKhvhaksepskPARRLSESLHVVDENKNESKLEREHKR 656
Cdd:NF033838  260 KPKRR-AKRGVLGEPATPDKKENDAKSSDSSVGEETLPSPSLK----------PEKKVAEAEKKVEEAKKKAKDQKEEDR 328
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578808374  657 RTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQkstlKNEKHLKKDDSE 709
Cdd:NF033838  329 RNYPTNTYKTLELEIAESDVKVKEAELELVKEEAKEP----RNEEKIKQAKAK 377
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
491-862 6.55e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 6.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   491 EQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSsktkgqgrssvdleESSTKSLEPKAAR--IKEVLKERKVLEK 568
Cdd:TIGR02169  186 IERLDLIIDEKRQQLERLRREREKAERYQALLKEKREY--------------EGYELLKEKEALErqKEAIERQLASLEE 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   569 KVALSKKRkkdsrnVEENSKKKQQYEEDSKE-TLKTSEHCEKEKISSSKELKHVHAKSEPSKpaRRLSEslhvvdenkNE 647
Cdd:TIGR02169  252 ELEKLTEE------ISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLE--RSIAE---------KE 314
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   648 SKLEREHKRRtstpvimegVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEkhLKKDDSETPHLKSLLKKEVKSSKEK 727
Cdd:TIGR02169  315 RELEDAEERL---------AKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE--YAELKEELEDLRAELEEVDKEFAET 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   728 PEREKTPSE--DKLSVKHKYKGDCMHKTGDETElHSSEKGLKVEENIQ-KQSQQTKLSSDDKTERKSKHRNERKLSVLGK 804
Cdd:TIGR02169  384 RDELKDYREklEKLKREINELKRELDRLQEELQ-RLSEELADLNAAIAgIEAKINELEEEKEDKALEIKKQEWKLEQLAA 462
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578808374   805 DGKPVSEYIIKTDENVR---KENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGI 862
Cdd:TIGR02169  463 DLSKYEQELYDLKEEYDrveKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGV 523
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
489-589 8.16e-03

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 40.22  E-value: 8.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578808374   489 TVEQRRQSIAKEKEERLLRRQINREKLEEK-------------RKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAAR 555
Cdd:pfam10147   88 SLAQMLESNRAQKAEKEARRQAREQEIAKKmakmpqwiadwnaQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDER 167
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 578808374   556 IKEVLKERKVLEKK-VALSKKRKKDSRNVEENSKK 589
Cdd:pfam10147  168 FKEMLQQKEKEDKKkVKEAKRKEKEEKRMAKLVEA 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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