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Conserved domains on  [gi|578809165|ref|XP_006714297|]
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myozenin-2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Calsarcin super family cl05232
Calcineurin-binding protein (Calsarcin); This family consists of several mammalian ...
 1-187 1.30e-78

Calcineurin-binding protein (Calsarcin); This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.


The actual alignment was detected with superfamily member pfam05556:

Pssm-ID: 461676  Cd Length: 255  Bit Score: 234.95  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809165    1 MLSHNTM-MKQRKQQATAIMKEVHG--NDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENfqyqs 77
Cdd:pfam05556   1 MPLSGTPaPKEKKKKASKIIRELHGsePEASEMDLGKKISVPKDIMLEELSLLSNRGSKMFKMRQRRVEKFIYEN----- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809165   78 raqinhsiamqngkvdgsnleggsqqapltPPNTPDPRSPPNPDNIAPGYSGPLK-EIPPEKFN---------------- 140
Cdd:pfam05556  76 ------------------------------NPDTFDSRSMDNPQKFAPSYGGQLKaPVPPPKPGskgagggggsgggggd 125

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578809165  141 ------TTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNR 187
Cdd:pfam05556 126 gadggkTTAVPKTYISPWEQAMGGDPELLETLKPKMPGPEPKPDLPKYKSFNR 178
 
Name Accession Description Interval E-value
Calsarcin pfam05556
Calcineurin-binding protein (Calsarcin); This family consists of several mammalian ...
 1-187 1.30e-78

Calcineurin-binding protein (Calsarcin); This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.


Pssm-ID: 461676  Cd Length: 255  Bit Score: 234.95  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809165    1 MLSHNTM-MKQRKQQATAIMKEVHG--NDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENfqyqs 77
Cdd:pfam05556   1 MPLSGTPaPKEKKKKASKIIRELHGsePEASEMDLGKKISVPKDIMLEELSLLSNRGSKMFKMRQRRVEKFIYEN----- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809165   78 raqinhsiamqngkvdgsnleggsqqapltPPNTPDPRSPPNPDNIAPGYSGPLK-EIPPEKFN---------------- 140
Cdd:pfam05556  76 ------------------------------NPDTFDSRSMDNPQKFAPSYGGQLKaPVPPPKPGskgagggggsgggggd 125

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578809165  141 ------TTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNR 187
Cdd:pfam05556 126 gadggkTTAVPKTYISPWEQAMGGDPELLETLKPKMPGPEPKPDLPKYKSFNR 178
 
Name Accession Description Interval E-value
Calsarcin pfam05556
Calcineurin-binding protein (Calsarcin); This family consists of several mammalian ...
 1-187 1.30e-78

Calcineurin-binding protein (Calsarcin); This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.


Pssm-ID: 461676  Cd Length: 255  Bit Score: 234.95  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809165    1 MLSHNTM-MKQRKQQATAIMKEVHG--NDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENfqyqs 77
Cdd:pfam05556   1 MPLSGTPaPKEKKKKASKIIRELHGsePEASEMDLGKKISVPKDIMLEELSLLSNRGSKMFKMRQRRVEKFIYEN----- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809165   78 raqinhsiamqngkvdgsnleggsqqapltPPNTPDPRSPPNPDNIAPGYSGPLK-EIPPEKFN---------------- 140
Cdd:pfam05556  76 ------------------------------NPDTFDSRSMDNPQKFAPSYGGQLKaPVPPPKPGskgagggggsgggggd 125

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578809165  141 ------TTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNR 187
Cdd:pfam05556 126 gadggkTTAVPKTYISPWEQAMGGDPELLETLKPKMPGPEPKPDLPKYKSFNR 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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