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Conserved domains on  [gi|578810917|ref|XP_006714860|]
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F-box only protein 38 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO38 cd22107
F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called ...
 30-73 1.91e-22

F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called FBX38, or modulator of KLF7 activity (MoKA), is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It may coactivate the transcription factor Kruppel-like factor 7 (KLF7), but does not seem to promote KLF7 ubiquitination. FBXO38 acts as a crucial regulator of programmed cell death protein-1 (PD-1) protein turnover in T cells by mediating PD-1 ubiquitination and regulating anti-tumor immunity of T cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438879  Cd Length: 44  Bit Score: 91.17  E-value: 1.91e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578810917   30 MNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRV 73
Cdd:cd22107     1 LSQLSLELLCHIFSYLPLKDVMKMECLSRKLQEAVTLYLRLVKS 44
 
Name Accession Description Interval E-value
F-box_FBXO38 cd22107
F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called ...
 30-73 1.91e-22

F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called FBX38, or modulator of KLF7 activity (MoKA), is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It may coactivate the transcription factor Kruppel-like factor 7 (KLF7), but does not seem to promote KLF7 ubiquitination. FBXO38 acts as a crucial regulator of programmed cell death protein-1 (PD-1) protein turnover in T cells by mediating PD-1 ubiquitination and regulating anti-tumor immunity of T cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438879  Cd Length: 44  Bit Score: 91.17  E-value: 1.91e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578810917   30 MNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRV 73
Cdd:cd22107     1 LSQLSLELLCHIFSYLPLKDVMKMECLSRKLQEAVTLYLRLVKS 44
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 32-65 2.02e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 2.02e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578810917    32 QLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVT 65
Cdd:pfam00646    3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
 
Name Accession Description Interval E-value
F-box_FBXO38 cd22107
F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called ...
 30-73 1.91e-22

F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called FBX38, or modulator of KLF7 activity (MoKA), is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It may coactivate the transcription factor Kruppel-like factor 7 (KLF7), but does not seem to promote KLF7 ubiquitination. FBXO38 acts as a crucial regulator of programmed cell death protein-1 (PD-1) protein turnover in T cells by mediating PD-1 ubiquitination and regulating anti-tumor immunity of T cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438879  Cd Length: 44  Bit Score: 91.17  E-value: 1.91e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578810917   30 MNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRV 73
Cdd:cd22107     1 LSQLSLELLCHIFSYLPLKDVMKMECLSRKLQEAVTLYLRLVKS 44
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 31-65 8.96e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 37.81  E-value: 8.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578810917   31 NQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVT 65
Cdd:cd09917     1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 32-65 2.02e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 2.02e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578810917    32 QLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVT 65
Cdd:pfam00646    3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 33-64 3.11e-03

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 36.84  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578810917   33 LSHEVLCHIFRYLPLQDIMCMECLSRKLKEAV 64
Cdd:cd22082     5 LPEEVLLHILKGLPIKDLLNMRAVHSRFKDLI 36
F-box_FBXL15 cd22126
F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins; FBXL15, also ...
 35-69 8.60e-03

F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins; FBXL15, also called F-box only protein 37 (FBXO37), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Smad ubiquitination regulatory factor 1 (SMURF1), thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance. It also mediates ubiquitination of SMURF2 and WWP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438898  Cd Length: 44  Bit Score: 35.17  E-value: 8.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578810917   35 HEVLC-HIFRYLPLQDIMCMECLSRKLKEAVTLYLR 69
Cdd:cd22126     7 EDVLFpHILPHLSLKDLFNLRRVSKAFKSLVDEYFS 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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