NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578811237|ref|XP_006714980|]
View 

cyclin-J-like protein isoform X1 [Homo sapiens]

Protein Classification

cyclin-J family protein( domain architecture ID 15334186)

cyclin-J family protein is involved in cell cycle regulation

Gene Ontology:  GO:0000079|GO:0016538
PubMed:  23861057|30185601

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 190-291 4.11e-36

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 128.25  E-value: 4.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLLASVSQKDHHChTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 269
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHD-GLPSELLEKVKEYVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTW 79

                         90       100
                 ....*....|....*....|..
gi 578811237 270 TRDLQRISSYSLEHLSTCIEIL 291
Cdd:cd20529   80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 30-161 1.46e-25

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 99.99  E-value: 1.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237  30 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLANgvsllsprlkcsgmisah 109
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAA------------------ 61

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578811237 110 cnlhlpgssnspasaphppptppqvaettgKFEDREDHVPKLEQINSTRILS 161
Cdd:cd20528   62 ------------------------------KFEELDDNIPKISDLNRYLCNS 83
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 190-291 4.11e-36

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 128.25  E-value: 4.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLLASVSQKDHHChTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 269
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHD-GLPSELLEKVKEYVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTW 79

                         90       100
                 ....*....|....*....|..
gi 578811237 270 TRDLQRISSYSLEHLSTCIEIL 291
Cdd:cd20529   80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 30-161 1.46e-25

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 99.99  E-value: 1.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237  30 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLANgvsllsprlkcsgmisah 109
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAA------------------ 61

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578811237 110 cnlhlpgssnspasaphppptppqvaettgKFEDREDHVPKLEQINSTRILS 161
Cdd:cd20528   62 ------------------------------KFEELDDNIPKISDLNRYLCNS 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 190-292 2.69e-17

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 77.66  E-value: 2.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237  190 PTPAHFLDYYLLASVSQKDHHCHTwpttcprktkeclkeYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYW 269
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLELRT---------------LAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-SPEW 64

                          90       100
                  ....*....|....*....|...
gi 578811237  270 TRDLQRISSYSLEHLSTCIEILL 292
Cdd:pfam02984  65 TETLEHYTGYSEEDLKPCVKLLL 87
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 43-91 3.86e-05

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 41.81  E-value: 3.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578811237    43 LTLLSSHCQLCPAARHLAVYLLDHFMDRYNVtTSKQLYTVAVSCLLLAN 91
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKF-LKYSPSLIAAAALYLAS 50
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 230-292 6.18e-05

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 41.42  E-value: 6.18e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578811237   230 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyWTRDLQRISSY-SLEHLSTCIEILL 292
Cdd:smart00385  20 AVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPP-WTKELVHYTGYfTEEEILRMERLLL 82
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 33-90 1.43e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 41.35  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578811237   33 LKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVAVSCLLLA 90
Cdd:pfam00134  28 PKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK-LQLVGVTCLFIA 84
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
36-292 4.41e-03

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 39.37  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237  36 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVAVSCLLLAngvsllsprlkcsgmisahcnlhlp 115
Cdd:COG5024  213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK-YQLVGISALFIA------------------------- 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 116 gssnspasaphppptppqvaettGKFEdrEDHVPKLEQINstrILSSQNFTltKKELLSTELLLLEAFSWNLCLPTPAHF 195
Cdd:COG5024  267 -----------------------SKYE--EVNCPSIKDLV---YATDGAFT--RDDIIRAERYMLEVLDFNISWPSPMSF 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 196 LDYylLASVSQKDHhchtwpttcprktkeCLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyWTRDLQR 275
Cdd:COG5024  317 LRR--ISKASDYDI---------------FSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQ-WDRTLIH 378

                        250
                 ....*....|....*...
gi 578811237 276 ISS-YSLEHLSTCIEILL 292
Cdd:COG5024  379 YSGnYTNPDLKPLNESNK 396
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 190-291 4.11e-36

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 128.25  E-value: 4.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLLASVSQKDHHChTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 269
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHD-GLPSELLEKVKEYVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTW 79

                         90       100
                 ....*....|....*....|..
gi 578811237 270 TRDLQRISSYSLEHLSTCIEIL 291
Cdd:cd20529   80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 30-161 1.46e-25

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 99.99  E-value: 1.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237  30 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLANgvsllsprlkcsgmisah 109
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAA------------------ 61

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578811237 110 cnlhlpgssnspasaphppptppqvaettgKFEDREDHVPKLEQINSTRILS 161
Cdd:cd20528   62 ------------------------------KFEELDDNIPKISDLNRYLCNS 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 190-292 2.69e-17

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 77.66  E-value: 2.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237  190 PTPAHFLDYYLLASVSQKDHHCHTwpttcprktkeclkeYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYW 269
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLELRT---------------LAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-SPEW 64

                          90       100
                  ....*....|....*....|...
gi 578811237  270 TRDLQRISSYSLEHLSTCIEILL 292
Cdd:pfam02984  65 TETLEHYTGYSEEDLKPCVKLLL 87
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 190-297 5.97e-14

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 66.95  E-value: 5.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYL-LASVSQKDHHChtwpttcprktkeclkeyAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPY 268
Cdd:cd20537    1 PTPLSFLRRYLsLLGLDEKVRHL------------------ARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPP 62

                         90       100
                 ....*....|....*....|....*....
gi 578811237 269 WTRDLQRISSYSLEHLSTCIEILLVVYDN 297
Cdd:cd20537   63 SPQLLQLVTGYSENDLQECAKELLELLAQ 91
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 190-297 1.98e-10

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 58.09  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLLASVSQKDhhchtwpttcprktkecLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 269
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKK-----------------LENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEW 63

                         90       100
                 ....*....|....*....|....*...
gi 578811237 270 TRDLQRISSYSLEHLSTCIEILLVVYDN 297
Cdd:cd20511   64 TSTLEFHTGYSESQLMECARLMVRLHSK 91
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 190-291 7.83e-09

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 53.02  E-value: 7.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLlaSVSQKDHhchtwpttcPRKTKECLkeyAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyW 269
Cdd:cd20506    1 PTIKTFLRRFL--RAAQASV---------PDLKLEFL---ANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHP-W 65

                         90       100
                 ....*....|....*....|..
gi 578811237 270 TRDLQRISSYSLEHLSTCIEIL 291
Cdd:cd20506   66 NPTLEHYTGYKAADLKPCVQAL 87
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 190-297 9.93e-09

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 52.68  E-value: 9.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLlasvsqkdHHCHTWPTTcprktkECLkeyAHYFLEVTLQD-HIFYKFQPSVVAAACVGASRICLQlSPY 268
Cdd:cd20505    1 PTSNWFLERFL--------KHSNADEKT------KSL---AMYLCELSLIDaDPYLKYLPSVIAAAAVCLANHTLG-NEV 62

                         90       100
                 ....*....|....*....|....*....
gi 578811237 269 WTRDLQRISSYSLEHLSTCIEILLVVYDN 297
Cdd:cd20505   63 WPQKLARSTGYSLEDLLPCLRDLHRTFLN 91
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 230-292 1.23e-06

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 47.22  E-value: 1.23e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578811237 230 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYWTRDLQRISSYSLEHLSTCIEILL 292
Cdd:cd20512   23 AKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLG-RGDWNDNLVHYSGYTESQLIPCADIML 84
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 190-295 3.41e-06

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 45.68  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYllASVSQKDHHCHTwpttcprktkeclkeYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYW 269
Cdd:cd20509    1 PLPLHFLRRF--SKAGGADAQKHT---------------LAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILD-EPEW 62

                         90       100
                 ....*....|....*....|....*.
gi 578811237 270 TRDLQRISSYSLEHLSTCIEILLVVY 295
Cdd:cd20509   63 TPTLEHYSTYSEEDLLPIVQKMAKLV 88
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 43-91 3.86e-05

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 41.81  E-value: 3.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578811237    43 LTLLSSHCQLCPAARHLAVYLLDHFMDRYNVtTSKQLYTVAVSCLLLAN 91
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKF-LKYSPSLIAAAALYLAS 50
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 230-292 6.18e-05

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 41.42  E-value: 6.18e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578811237   230 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyWTRDLQRISSY-SLEHLSTCIEILL 292
Cdd:smart00385  20 AVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPP-WTKELVHYTGYfTEEEILRMERLLL 82
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 190-269 1.21e-04

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 40.96  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLLASVSQKDhhchtwPTTCPRKtkecLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 269
Cdd:cd20721    1 PTILTFLRMYIERLSLESG------AAHASRP----LERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAW 70
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 33-90 1.43e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 41.35  E-value: 1.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578811237   33 LKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVAVSCLLLA 90
Cdd:pfam00134  28 PKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK-LQLVGVTCLFIA 84
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 190-289 3.79e-04

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 39.64  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 190 PTPAHFLDYYLLASVSqkdhhchTWPTTCPRKTKEClKEYAHYFLEVTLQDHIFYKFQPSVVAAACVgasRICLQLSPYW 269
Cdd:cd20722    1 PTLQFFLEHFSSLRLE-------NRELSCAEEARKA-RALARYLAELSLADYAFNQYPPSLLAICSL---ELADRMLQHR 69

                         90       100
                 ....*....|....*....|
gi 578811237 270 TRDLQRISSYSLEHLSTCIE 289
Cdd:cd20722   70 SPITERLSGYPQSALEDCVG 89
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 40-90 8.14e-04

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 38.16  E-value: 8.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578811237  40 VDILTLLSSHCQLCPAARHLAVYLLDHFMDRyNVTTSKQLYTVAVSCLLLA 90
Cdd:cd00043    3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSK-GLLLGRSPELIAAACLYLA 52
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 230-291 9.76e-04

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 38.80  E-value: 9.76e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578811237 230 AHYFLEVTLQDHIFYKFQPSVVAAACVGASrICLQLSPYWTRDLQRISSYSLEHLSTCIEIL 291
Cdd:cd20510   24 ARYILELSLMEYQFVQERASKLAAAALLLA-LKMKNLGEWTPTLEYYSGYSAEDLLPLVRKL 84
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 36-90 3.33e-03

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 36.92  E-value: 3.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578811237  36 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK-QLytVAVSCLLLA 90
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLlQL--LGITCLFIA 54
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 230-287 3.94e-03

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 36.83  E-value: 3.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578811237 230 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTC 287
Cdd:cd20522    3 ASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSC 60
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 191-254 4.19e-03

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 36.14  E-value: 4.19e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578811237 191 TPAHFLDYyLLASVSQKDHHCHtwpttcprktkecLKEYAHYFLEVTLQDHIFYKFQPSVVAAA 254
Cdd:cd20544    2 TPFSFLDY-FISKIGLSDSREE-------------LLSRATELLLSTTKDIRFLEYRPSVIAAA 51
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
36-292 4.41e-03

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 39.37  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237  36 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVAVSCLLLAngvsllsprlkcsgmisahcnlhlp 115
Cdd:COG5024  213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK-YQLVGISALFIA------------------------- 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 116 gssnspasaphppptppqvaettGKFEdrEDHVPKLEQINstrILSSQNFTltKKELLSTELLLLEAFSWNLCLPTPAHF 195
Cdd:COG5024  267 -----------------------SKYE--EVNCPSIKDLV---YATDGAFT--RDDIIRAERYMLEVLDFNISWPSPMSF 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811237 196 LDYylLASVSQKDHhchtwpttcprktkeCLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyWTRDLQR 275
Cdd:COG5024  317 LRR--ISKASDYDI---------------FSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQ-WDRTLIH 378

                        250
                 ....*....|....*...
gi 578811237 276 ISS-YSLEHLSTCIEILL 292
Cdd:COG5024  379 YSGnYTNPDLKPLNESNK 396
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 218-291 5.06e-03

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 36.44  E-value: 5.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578811237 218 CPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRD-----LQRISSYSLEHLSTCIEIL 291
Cdd:cd20516   15 LDSEDVDKVRKHAETFIALCATDYKFSSYPPSMIAAASILAALRGLLLHSGNSKEdllekLQQLTRIDEDLLRACQEQI 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH