NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578811568|ref|XP_006715112|]
View 

natural cytotoxicity triggering receptor 3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 18-129 7.97e-82

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


:

Pssm-ID: 409520  Cd Length: 112  Bit Score: 238.34  E-value: 7.97e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRD 97
Cdd:cd20926    1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578811568  98 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 129
Cdd:cd20926   81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 18-129 7.97e-82

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 238.34  E-value: 7.97e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRD 97
Cdd:cd20926    1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578811568  98 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 129
Cdd:cd20926   81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-127 6.41e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.60  E-value: 6.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568   23 QPPEIRTLEGSSAFLPCSFNASQGrLAIGSVTWFRDEVVPGKEV-------RNGTPEFRGRLAPLASSRFlhdHQAELHI 95
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFliayysnGSEEGVKKGRFSGRGDPSN---GDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 578811568   96 RDVRGHDASIYVCRVeVLGLGVGTGNGTRLVV 127
Cdd:pfam07686  78 QNLTLSDSGTYTCAV-IPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-127 1.12e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568    24 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVVPgkevrngtpefrgrlaPLASSRFLHDH---QAELHIRDVRG 100
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKL----------------LAESGRFSVSRsgsTSTLTISNVTP 60

                           90       100
                   ....*....|....*....|....*..
gi 578811568   101 HDASIYVCRVEVlGLGVGTGnGTRLVV 127
Cdd:smart00410  61 EDSGTYTCAATN-SSGSASS-GTTLTV 85
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 18-129 7.97e-82

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 238.34  E-value: 7.97e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRD 97
Cdd:cd20926    1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578811568  98 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 129
Cdd:cd20926   81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-127 6.41e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.60  E-value: 6.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568   23 QPPEIRTLEGSSAFLPCSFNASQGrLAIGSVTWFRDEVVPGKEV-------RNGTPEFRGRLAPLASSRFlhdHQAELHI 95
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFliayysnGSEEGVKKGRFSGRGDPSN---GDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 578811568   96 RDVRGHDASIYVCRVeVLGLGVGTGNGTRLVV 127
Cdd:pfam07686  78 QNLTLSDSGTYTCAV-IPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-127 1.12e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568    24 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVVPgkevrngtpefrgrlaPLASSRFLHDH---QAELHIRDVRG 100
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKL----------------LAESGRFSVSRsgsTSTLTISNVTP 60

                           90       100
                   ....*....|....*....|....*..
gi 578811568   101 HDASIYVCRVEVlGLGVGTGnGTRLVV 127
Cdd:smart00410  61 EDSGTYTCAATN-SSGSASS-GTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 35-111 7.81e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 39.62  E-value: 7.81e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578811568  35 AFLPCSFNASQGrlaiGSVTWFRDevvpGKEVRNGTPEfrgrlaplasSRFLHDHQAELHIRDVRGHDASIYVCRVE 111
Cdd:cd00096    1 VTLTCSASGNPP----PTITWYKN----GKPLPPSSRD----------SRRSELGNGTLTISNVTLEDSGTYTCVAS 59
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 21-111 1.26e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.09  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568   21 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDevvpGKEVRNGTpefrgrlaplASSRFLHDHQAELHIR 96
Cdd:pfam13927   5 TVSPSSVTVREGETVTLTCE--------ATGspppTITWYKN----GEPISSGS----------TRSRSLSGSNSTLTIS 62

                          90
                  ....*....|....*
gi 578811568   97 DVRGHDASIYVCRVE 111
Cdd:pfam13927  63 NVTRSDAGTYTCVAS 77
I-set pfam07679
Immunoglobulin I-set domain;
21-111 2.17e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.78  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568   21 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDevvpGKEVRNGtpefrGRLaplassRFLHDHQ-AELHI 95
Cdd:pfam07679   4 TQKPKDVEVQEGESARFTCT--------VTGtpdpEVSWFKD----GQPLRSS-----DRF------KVTYEGGtYTLTI 60

                          90
                  ....*....|....*.
gi 578811568   96 RDVRGHDASIYVCRVE 111
Cdd:pfam07679  61 SNVQPDDSGKYTCVAT 76
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 21-110 4.68e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 38.20  E-value: 4.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  21 VSQPPEIRTLEGSSAFLPCSFnASQGRLAIGSVTWFRDEVVPGKEVRNGTPEF--------RGRLAPLASSRFLHDhqAE 92
Cdd:cd05718    3 VQVPTEVTGFLGGSVTLPCSL-TSPGTTKITQVTWMKIGAGSSQNVAVFHPQYgpsvpnpyAERVEFLAARLGLRN--AT 79

                         90
                 ....*....|....*...
gi 578811568  93 LHIRDVRGHDASIYVCRV 110
Cdd:cd05718   80 LRIRNLRVEDEGNYICEF 97
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 21-128 1.14e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 37.25  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  21 VSQPP-EIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEvvPGKE-------VRNGTPEFRGRLaplasSRFLHDHQ-- 90
Cdd:cd04983    1 VTQSPqSLSVQEGENVTLNCNYSTS----TFYYLFWYRQY--PGQGpqfliyiSSDSGNKKKGRF-----SATLDKSRks 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 578811568  91 AELHIRDVRGHDASIYVCRV-EVLGLGVGT-GNGTRLVVE 128
Cdd:cd04983   70 SSLHISAAQLSDSAVYFCALsESGGTGKLTfGKGTRLTVE 109
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 24-110 2.42e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.63  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568   24 PPEIRTLEGSSAFLPCSfnASQGRLAIgSVTWFRDevvpGKEVRNGTPEFRGRLaplassrflHDHQAELHIRDVRGHDA 103
Cdd:pfam00047   3 PPTVTVLEGDSATLTCS--ASTGSPGP-DVTWSKE----GGTLIESLKVKHDNG---------RTTQSSLLISNVTKEDA 66


                  ....*..
gi 578811568  104 SIYVCRV 110
Cdd:pfam00047  67 GTYTCVV 73
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 21-110 2.76e-03

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 36.25  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  21 VSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTW-FRDEvvpgkevrNGTPE------FRGRLAPLASSRF-------- 85
Cdd:cd05715    3 VYTPRELNVLNGSDVRLTCTFTSCYTVGDAFSVTWtYQPE--------GGNTTesmfhySKGKPYILKVGRFkdrvswag 74

                         90       100
                 ....*....|....*....|....*.
gi 578811568  86 -LHDHQAELHIRDVRGHDASIYVCRV 110
Cdd:cd05715   75 nPSKKDASIVISNLQFSDNGTYTCDV 100
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 21-127 3.68e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 35.77  E-value: 3.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  21 VSQPPEIRTL-EGSSAFLPCSFNasqGRLAIGSVTWFRdevvpgkEVRNGTPEF-------RGRLAPLASSRFLHDHQAE 92
Cdd:cd00099    1 VTQSPRSLSVqEGESVTLSCEVS---SSFSSTYIYWYR-------QKPGQGPEFliylsssKGKTKGGVPGRFSGSRDGT 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 578811568  93 ----LHIRDVRGHDASIYVC-RVEVLGLGVGT-GNGTRLVV 127
Cdd:cd00099   71 ssfsLTISNLQPEDSGTYYCaVSESGGTDKLTfGSGTRLTV 111
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 20-111 7.92e-03

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 35.06  E-value: 7.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578811568  20 WVSQPPEIRTLEGSSAFLPCSF------NASQGRLAIgsvtWFRD-------EVV----PGKEVRngtPEFRGRlaplas 82
Cdd:cd05712    2 GLQMPKSVTVQEGLCVLIPCSFsypadyWVSNPVHGY----WYRGgpypkyrPPVatnnRTREVH---ESTQGR------ 68

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578811568  83 SRFLHDHQAE---LHIRDVRGHDASIYVCRVE 111
Cdd:cd05712   69 FRLLGDPGKKncsLSISDARPEDSGKYFFRVE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH