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Conserved domains on  [gi|767942168|ref|XP_006715439|]
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adenylate kinase 9 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1065-1233 7.05e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 7.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1144
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1145 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1221
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942168 1222 QVDDQDIFDRLL 1233
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1485-1607 6.26e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.38  E-value: 6.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767942168 1565 aGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1607
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 105-348 1.03e-20

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 91.91  E-value: 1.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942168  344 PAEEL 348
Cdd:cd01428   190 DIDEV 194
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 1002-1057 8.21e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 8.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942168 1002 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 1057
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1065-1233 7.05e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 7.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1144
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1145 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1221
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942168 1222 QVDDQDIFDRLL 1233
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1485-1607 6.26e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.38  E-value: 6.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767942168 1565 aGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1607
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 105-348 1.03e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.91  E-value: 1.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942168  344 PAEEL 348
Cdd:cd01428   190 DIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1485-1607 1.20e-18

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 86.52  E-value: 1.20e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 767942168  1565 AGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1607
Cdd:TIGR01351   79 NGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 105-349 2.00e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.87  E-value: 2.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSrdqwdpeVIENH 256
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYH-------VKFNP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  257 RKKKKEAQKDGKGeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 334
Cdd:COG0563   144 PKVEGVCDKCGGE----------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 767942168  335 yLIELNGNKPAEELF 349
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
107-252 4.85e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 81.20  E-value: 4.85e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168   107 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 186
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767942168   187 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1485-1607 1.66e-16

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 80.17  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCnT 1564
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-A 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767942168 1565 AGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1607
Cdd:COG0563    79 NGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
PLN02842 PLN02842
nucleotide kinase
 109-349 4.82e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 83.37  E-value: 4.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  109 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 188
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  189 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 268
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  269 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 345
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 767942168  346 EELF 349
Cdd:PLN02842  190 EVVF 193
AAA_17 pfam13207
AAA domain;
1489-1611 1.21e-15

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 75.35  E-value: 1.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1489 VGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCNTAGVV 1568
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AGEGGVI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 767942168  1569 IDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1611
Cdd:pfam13207   76 VDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 1485-1607 2.17e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767942168 1565 aGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1607
Cdd:PRK00279   80 -GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1065-1233 4.05e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.46  E-value: 4.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1144
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1145 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1220
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942168 1221 IQVDDQDIFDRLL 1233
Cdd:COG0563   113 LDVDDEELVERLS 125
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 1002-1057 8.21e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 8.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942168 1002 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 1057
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1065-1233 1.07e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.55  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1144
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1145 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1223
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942168  1224 DDQDIFDRLL 1233
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 1065-1233 6.93e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.67  E-value: 6.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1144
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1145 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1217
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942168 1218 AVFIQVDDQDIFDRLL 1233
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
1069-1233 7.35e-07

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 50.32  E-value: 7.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1069 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1147
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1148 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1221
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942168  1222 QVDDQDIFDRLL 1233
Cdd:pfam13207  109 EADPEEILERRL 120
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 1007-1055 6.36e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 6.36e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942168  1007 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 1055
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1065-1233 7.05e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 7.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1144
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1145 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1221
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942168 1222 QVDDQDIFDRLL 1233
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1485-1607 6.26e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 95.38  E-value: 6.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767942168 1565 aGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1607
Cdd:cd01428    79 -GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 105-348 1.03e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.91  E-value: 1.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942168  344 PAEEL 348
Cdd:cd01428   190 DIDEV 194
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1485-1607 1.20e-18

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 86.52  E-value: 1.20e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 767942168  1565 AGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1607
Cdd:TIGR01351   79 NGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 105-349 2.00e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.87  E-value: 2.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSrdqwdpeVIENH 256
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYH-------VKFNP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  257 RKKKKEAQKDGKGeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 334
Cdd:COG0563   144 PKVEGVCDKCGGE----------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 767942168  335 yLIELNGNKPAEELF 349
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
107-252 4.85e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 81.20  E-value: 4.85e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168   107 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 186
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767942168   187 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1485-1607 1.66e-16

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 80.17  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCnT 1564
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDC-A 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767942168 1565 AGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1607
Cdd:COG0563    79 NGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
PLN02842 PLN02842
nucleotide kinase
 109-349 4.82e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 83.37  E-value: 4.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  109 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 188
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  189 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 268
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  269 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 345
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 767942168  346 EELF 349
Cdd:PLN02842  190 EVVF 193
AAA_17 pfam13207
AAA domain;
1489-1611 1.21e-15

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 75.35  E-value: 1.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1489 VGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCNTAGVV 1568
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AGEGGVI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 767942168  1569 IDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1611
Cdd:pfam13207   76 VDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 105-252 1.94e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:PRK00279    3 LILLGPPGAGKGTQAKFIAEKYG------IPhistgdMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767942168  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:PRK00279   77 -CKNGFLLDGFPrTIPQaEALD-----EMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKV 146
adk PRK00279
adenylate kinase; Reviewed
 1485-1607 2.17e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:PRK00279    2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767942168 1565 aGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1607
Cdd:PRK00279   80 -GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 99-244 1.33e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 75.22  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168   99 LSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:PTZ00088    3 LKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767942168  179 VCHF-GYIITEIPSlsqdamTTLQQIELIKNLNlkPDVIINIKCPDYDLCQRISGQRQHNNTGYIYS 244
Cdd:PTZ00088   83 DDCFkGFILDGFPR------NLKQCKELGKITN--IDLFVNIYLPRNILIKKLLGRRICNTCNRNFN 141
ADK pfam00406
Adenylate kinase;
1488-1607 2.92e-12

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 67.33  E-value: 2.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1488 IVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTaGV 1567
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKS--GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKN-GF 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767942168  1568 VIDGYPVTKHQMNLLEA--RSIIPM-VIFELSVPSKEIFKRLL 1607
Cdd:pfam00406   78 LLDGFPRTVPQAEALEEllERGIKLdYVIEFDVPDEVLVERLT 120
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1065-1233 4.05e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.46  E-value: 4.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1144
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1145 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1220
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942168 1221 IQVDDQDIFDRLL 1233
Cdd:COG0563   113 LDVDDEELVERLS 125
PRK14528 PRK14528
adenylate kinase; Provisional
 1485-1615 7.57e-12

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 66.19  E-value: 7.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:PRK14528    3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKN--QTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767942168 1565 aGVVIDGYPVTKHQMNLLEA------RSIIPMVifELSVPSKEIFKRLLLEKENEQR 1615
Cdd:PRK14528   81 -GFLLDGFPRTVEQADALDAllknegKSIDKAI--NLEVPDGELLKRLLGRAEIEGR 134
PRK14527 PRK14527
adenylate kinase; Provisional
 1481-1673 1.68e-11

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 65.20  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1481 TVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALR-YVLNNhpeTELALMLNWHLHKGMTAPDELAIQAL--ELSL 1557
Cdd:PRK14527    4 TKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRdHVARG---TELGQRAKPIMEAGDLVPDELILALIrdELAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1558 MESVcntaGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPyplHNSAQIVAVNNVk 1633
Cdd:PRK14527   81 MEPV----RVIFDGFPRTLAQAEaldrLLEELGARLLAVVLLEVPDEELIRRIVERARQEGRSD---DNEETVRRRQQV- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767942168 1634 YRKNIGEIRQYYQEQHQnWYVIDGFHSKWWVWNEVIKNVQ 1673
Cdd:PRK14527  153 YREQTQPLVDYYEARGH-LKRVDGLGTPDEVYARILKALG 191
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1482-1607 1.87e-11

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 64.84  E-value: 1.87e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1482 VPIrIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESV 1561
Cdd:TIGR01360    3 CKI-IFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVAS--GSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAAL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767942168  1562 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLL 1607
Cdd:TIGR01360   80 GTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLL 125
PRK14530 PRK14530
adenylate kinase; Provisional
 1485-1606 6.74e-10

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 60.96  E-value: 6.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALR---YVLNNHPETELALMLNWhLHKGMTAPDELAIQALElslmESV 1561
Cdd:PRK14530    5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRankQMDISDMDTEYDTPGEY-MDAGELVPDAVVNEIVE----EAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767942168 1562 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFeLSVPSKEIFKRL 1606
Cdd:PRK14530   80 SDADGFVLDGYPRNLEQAEYLESITDLDVVLY-LDVSEEELVDRL 123
PRK14528 PRK14528
adenylate kinase; Provisional
 106-269 1.20e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 59.64  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYI 185
Cdd:PRK14528    5 IFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREAD-CKNGFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  186 ITEIPSLSQ--DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQ-----RQHNNTGYIYSR-DQWDPE---VIE 254
Cdd:PRK14528   84 LDGFPRTVEqaDALD-----ALLKNEGKSIDKAINLEVPDGELLKRLLGRaeiegRADDNEATIKNRlDNYNKKtlpLLD 158

                         170
                  ....*....|....*
gi 767942168  255 NHRKKKKEAQKDGKG 269
Cdd:PRK14528  159 FYAAQKKLSQVNGVG 173
adk PRK02496
adenylate kinase; Provisional
 106-267 2.31e-09

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 58.99  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 185
Cdd:PRK02496    5 IFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN-GWI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  186 ITEIP-SLSQDAmtTLQqiELIKNLNLKPDVIINIKCPDYDLCQRISGQ-RQHNNTGYIYSR-----DQWDPeVIENHRK 258
Cdd:PRK02496   84 LDGFPrKVTQAA--FLD--ELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDTEEVIRRRlevyrEQTAP-LIDYYRD 158


                  ....*....
gi 767942168  259 KKKEAQKDG 267
Cdd:PRK02496  159 RQKLLTIDG 167
PRK14532 PRK14532
adenylate kinase; Provisional
 1486-1648 9.47e-09

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 57.14  E-value: 9.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1486 IIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHpeTELALMLNWHLHKGMTAPDELAIQALELSLMESVcNTA 1565
Cdd:PRK14532    3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASG--SELGQRVKGIMDRGELVSDEIVIALIEERLPEAE-AAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1566 GVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRlpyPLHNSAQIVaVNNVKYRKNIGEI 1641
Cdd:PRK14532   80 GAIFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKRFEEQGR---PDDNPEVFV-TRLDAYNAQTAPL 155


                  ....*..
gi 767942168 1642 RQYYQEQ 1648
Cdd:PRK14532  156 LPYYAGQ 162
PLN02200 PLN02200
adenylate kinase family protein
 1478-1616 1.51e-08

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 57.59  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1478 PKPTVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPEtELALMLNwHLHKGMTAPDELAIQALELSl 1557
Cdd:PLN02200   38 SKEKTPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSE-HGAMILN-TIKEGKIVPSEVTVKLIQKE- 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767942168 1558 MESVCNTAgVVIDGYPVTKHqmNLLEARSII---PMVIFELSVPSKEIFKRLLleKENEQRL 1616
Cdd:PLN02200  115 MESSDNNK-FLIDGFPRTEE--NRIAFERIIgaePNVVLFFDCPEEEMVKRVL--NRNQGRV 171
adk PRK02496
adenylate kinase; Provisional
 1484-1657 1.56e-08

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 56.30  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1484 IRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESvcN 1563
Cdd:PRK02496    2 TRLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKE--QTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQP--D 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1564 TA-GVVIDGYPVTKHQMNLLEA----------RSIipmvifELSVPSKEIFKRLLL---EKENEQrlpyPLHNSAQIvav 1629
Cdd:PRK02496   78 AAnGWILDGFPRKVTQAAFLDEllqeigqsgeRVV------NLDVPDDVVVERLLArgrKDDTEE----VIRRRLEV--- 144

                         170       180
                  ....*....|....*....|....*...
gi 767942168 1630 nnvkYRKNIGEIRQYYQEQHQnWYVIDG 1657
Cdd:PRK02496  145 ----YREQTAPLIDYYRDRQK-LLTIDG 167
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 1002-1057 8.21e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 8.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942168 1002 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 1057
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1065-1233 1.07e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.55  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1144
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1145 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1223
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942168  1224 DDQDIFDRLL 1233
Cdd:TIGR01351  113 PDEELVERLS 122
PLN02842 PLN02842
nucleotide kinase
 1487-1605 2.91e-07

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 55.25  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1487 IIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAG 1566
Cdd:PLN02842    1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSA--GTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKG 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 767942168 1567 VVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKR 1605
Cdd:PLN02842   79 WLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDR 117
adk PRK02496
adenylate kinase; Provisional
 1065-1233 6.93e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.67  E-value: 6.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1144
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1145 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1217
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942168 1218 AVFIQVDDQDIFDRLL 1233
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
1069-1233 7.35e-07

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 50.32  E-value: 7.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1069 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1147
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1148 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1221
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942168  1222 QVDDQDIFDRLL 1233
Cdd:pfam13207  109 EADPEEILERRL 120
PLN02674 PLN02674
adenylate kinase
 1485-1583 9.46e-07

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 52.20  E-value: 9.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:PLN02674   33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVA--AKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQK 110

                          90
                  ....*....|....*....
gi 767942168 1565 aGVVIDGYPVTKHQMNLLE 1583
Cdd:PLN02674  111 -GFILDGFPRTVVQAQKLD 128
PRK14531 PRK14531
adenylate kinase; Provisional
 1485-1607 1.35e-06

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 50.58  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGmtapdELAIQALELSLMES---V 1561
Cdd:PRK14531    4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVA--AGSALGQEAEAVMNRG-----ELVSDALVLAIVESqlkA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942168 1562 CNTAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSvpSKEIFKRLL 1607
Cdd:PRK14531   77 LNSGGWLLDGFPRTVAQAEALEPlleelkQPIEAVVLLELD--DAVLIERLL 126
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1483-1607 1.50e-06

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 51.34  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1483 PIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESV- 1561
Cdd:PTZ00088    6 PLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKA--KTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTd 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767942168 1562 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIfELSVPSKEIFKRLL 1607
Cdd:PTZ00088   84 DCFKGFILDGFPRNLKQCKELGKITNIDLFV-NIYLPRNILIKKLL 128
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1486-1519 4.78e-06

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 48.96  E-value: 4.78e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767942168  1486 IIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALR 1519
Cdd:TIGR02173    3 ITISGPPGSGKTTVAKILAEKLSLKLISAGDIFR 36
ADK pfam00406
Adenylate kinase;
1068-1233 7.02e-06

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 48.46  E-value: 7.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1068 LVGPQGSGK-TMCGRqLAEKLNIFHIQFEEVLQEklllktekkvgpefeedsenEQAAKQELEELAiqanvkveeentKK 1146
Cdd:pfam00406    1 LLGPPGAGKgTQAEK-IVQKYGLPHLSTGDLLRA--------------------EIKSGTELGKEA------------KE 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1147 QLPEVQLTEEEEVIKssLMENEplppeilevilsewwLKEPIRSTGFILDGFPRYPEEAQFLGD---RGFFPDAAVFIQV 1223
Cdd:pfam00406   48 YMDKGELVPDEVVVG--LVKER---------------LEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFDV 110

                          170
                   ....*....|
gi 767942168  1224 DDQDIFDRLL 1233
Cdd:pfam00406  111 PDEVLVERLT 120
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1486-1615 7.29e-06

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 48.52  E-value: 7.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1486 IIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNwHLHKGMTAPDELAIQALElSLMESVCNTA 1565
Cdd:TIGR01359    2 VFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENGSLIES-YIKEGKIVPSEVTVELLK-KAIQEDGSSK 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767942168  1566 GVVIDGYPvtKHQMNL-----LEARSIIPMVIFELSVPSKEIFKRLLLEKENEQR 1615
Cdd:TIGR01359   80 KFLIDGFP--RNEENLeawekLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGR 132
PRK04182 PRK04182
cytidylate kinase; Provisional
 1485-1515 1.64e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 47.49  E-value: 1.64e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIG 1515
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAG 32
adk PRK00279
adenylate kinase; Reviewed
 1064-1233 1.97e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.84  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1064 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqaakqeleelaiqANVKVEEEN 1143
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR-----------------------------------AAVKAGTEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1144 TKKqlpevqlteeeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQ----FLGDRGFFPDAAV 1219
Cdd:PRK00279   46 GKE-------------AKSYMDAGELVPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVI 111

                         170
                  ....*....|....
gi 767942168 1220 FIQVDDQDIFDRLL 1233
Cdd:PRK00279  112 EIDVPDEELVERLS 125
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 1485-1516 6.96e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 44.78  E-value: 6.96e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGG 1516
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGG 32
PLN02200 PLN02200
adenylate kinase family protein
 102-235 7.31e-05

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 46.42  E-value: 7.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  102 PVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCH 181
Cdd:PLN02200   43 PFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767942168  182 FgyIITEIPSlsqdamTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQ 235
Cdd:PLN02200  123 F--LIDGFPR------TEENRIAFERIIGAEPNVVLFFDCPEEEMVKRVLNRNQ 168
PRK14526 PRK14526
adenylate kinase; Provisional
 1484-1583 1.20e-04

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 45.23  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1484 IRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALElSLMESVCN 1563
Cdd:PRK14526    1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILN--STPLGKEIKQIVENGQLVPDSITIKIVE-DKINTIKN 77

                          90       100
                  ....*....|....*....|
gi 767942168 1564 TAGVVIDGYPVTKHQMNLLE 1583
Cdd:PRK14526   78 NDNFILDGFPRNINQAKALD 97
PRK13808 PRK13808
adenylate kinase; Provisional
 1484-1584 1.49e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 46.03  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1484 IRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGMTAPDELAIQALElSLMESVCN 1563
Cdd:PRK13808    1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVA--AGTPVGLKAKDIMASGGLVPDEVVVGIIS-DRIEQPDA 77

                          90       100
                  ....*....|....*....|.
gi 767942168 1564 TAGVVIDGYPVTKHQMNLLEA 1584
Cdd:PRK13808   78 ANGFILDGFPRTVPQAEALDA 98
PRK13808 PRK13808
adenylate kinase; Provisional
 106-230 1.95e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 45.65  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 185
Cdd:PRK13808    4 ILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-GFI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767942168  186 ITEIPSlsqdamtTLQQIE----LIKNLNLKPDVIINIKCPDYDLCQRI 230
Cdd:PRK13808   83 LDGFPR-------TVPQAEaldaLLKDKQLKLDAVVELRVNEGALLARV 124
AAA_18 pfam13238
AAA domain;
1066-1139 3.88e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.42  E-value: 3.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942168  1066 ICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKV 1139
Cdd:pfam13238    1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGN 74
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 1040-1110 5.25e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 44.52  E-value: 5.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767942168 1040 EAKEKFLEHPEDYVAHEEPlkaPPLRICLVGPQGSGKTMCGRQLAEKL--NIFHIQFEEVLQeKLLLKTEKKV 1110
Cdd:COG0464   171 ELVALPLKRPELREEYGLP---PPRGLLLYGPPGTGKTLLARALAGELglPLIEVDLSDLVS-KYVGETEKNL 239
AAA_17 pfam13207
AAA domain;
108-229 5.42e-04

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 41.84  E-value: 5.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168   108 FGKPGVGKTTLARYITQAWKcirveaLPILE--EQIAAETESG--VMLQSMLISGQSIPDELVIKLMLEKLNSpEVCHFG 183
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLG------FPHISagDLLREEAKERglVEDRDEMRKLPLEPQKELQKLAAERIAE-EAGEGG 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 767942168   184 YIITEIPS-LSQDAMTTLQQIELIKnlNLKPDVIINIKCPDYDLCQR 229
Cdd:pfam13207   74 VIVDGHPRiKTPAGYLPGLPVEVLR--ELKPDAIILLEADPEEILER 118
PLN02459 PLN02459
probable adenylate kinase
 1487-1592 5.43e-04

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 44.07  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1487 IIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVCN-TA 1565
Cdd:PLN02459   33 VFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKS--SGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgES 110

                          90       100
                  ....*....|....*....|....*..
gi 767942168 1566 GVVIDGYPVTKHQMNLLEARSIIPMVI 1592
Cdd:PLN02459  111 GFILDGFPRTVRQAEILEGVTDIDLVV 137
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 1062-1116 8.14e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.88  E-value: 8.14e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767942168 1062 PPLRICLVGPQGSGKTMCGRQLAEKLNI--FHIQFEEvLQEKLLLKTEKKVGPEFEE 1116
Cdd:cd19481    25 LPKGILLYGPPGTGKTLLAKALAGELGLplIVVKLSS-LLSKYVGESEKNLRKIFER 80
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 1459-1517 1.46e-03

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 41.45  E-value: 1.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942168 1459 KETKE--KFMKNPIKYiRQPKPKPtvPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGA 1517
Cdd:cd19501    14 EELKEvvEFLKNPEKF-TKLGAKI--PKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGS 71
THEP1 COG1618
Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];
1485-1516 1.94e-03

Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];


Pssm-ID: 441225 [Multi-domain]  Cd Length: 175  Bit Score: 41.04  E-value: 1.94e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITSEYGLKHLSIGG 1516
Cdd:COG1618     2 KIFITGRPGVGKTTLLLKVVEELRDEGLRVGG 33
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
1038-1102 2.41e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 41.79  E-value: 2.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1038 SAEAKEKFLEHPEDYVAHEEPLK---APPLRICLVGPQGSGKTMCGRQLAEKLN--IFHIQFEEVLQEKL 1102
Cdd:COG1223     7 QEEAKKKLKLIIKELRRRENLRKfglWPPRKILFYGPPGTGKTMLAEALAGELKlpLLTVRLDSLIGSYL 76
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
1064-1182 2.74e-03

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 42.58  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168 1064 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllKTEKKVGPEFEEDSEN--EQAAKQELEELAIQANVKV-- 1139
Cdd:PRK13951    1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIER----REGRSVRRIFEEDGEEyfRLKEKELLRELVERDNVVVat 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942168 1140 --------EEENTKKQLPEVQLTEEEEVIKSSL-MENEPLPPEILEVILSEW 1182
Cdd:PRK13951   77 gggvvidpENRELLKKEKTLFLYAPPEVLMERVtTENRPLLREGKERIREIW 128
AAA_18 pfam13238
AAA domain;
1486-1613 4.25e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 39.33  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  1486 IIIVGPPKSGKTTVAKKItseygLKHLSIGGALR-YVLNNHPETElalmlNWHLHKGMTAPDELAIQALELSLMESVCNT 1564
Cdd:pfam13238    1 ILITGTPGVGKTTLAKEL-----SKRLGFGDNVRdLALENGLVLG-----DDPETRESKRLDEDKLDRLLDLLEENAALE 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942168  1565 AG--VVIDGypvtkhQMNLLEARSIIPMVIFELSVPSKEIFKRLLLEKENE 1613
Cdd:pfam13238   71 EGgnLIIDG------HLAELEPERAKDLVGIVLRASPEELLERLEKRGYEE 115
rho_factor_C cd01128
C-terminal ATP binding domain of transcription termination factor rho; Transcription ...
 1485-1534 5.36e-03

C-terminal ATP binding domain of transcription termination factor rho; Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal oligonucleotide/oligosaccharide binding fold (OB-fold) domain which binds cysteine-rich nucleotides, and a C-terminal ATP binding domain. This alignment is of the C-terminal ATP binding domain.


Pssm-ID: 410872 [Multi-domain]  Cd Length: 249  Bit Score: 40.65  E-value: 5.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767942168 1485 RIIIVGPPKSGKTTVAKKITseyglkhlsiggalRYVLNNHPETELALML 1534
Cdd:cd01128    18 RGLIVAPPKAGKTTLLQNIA--------------NAIAKNHPEVELIVLL 53
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 1007-1055 6.36e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 6.36e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942168  1007 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 1055
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
PRK14526 PRK14526
adenylate kinase; Provisional
 105-244 8.12e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 39.83  E-value: 8.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVcHFGY 184
Cdd:PRK14526    3 LVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDNF 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942168  185 IITEIPSlsqdamTTLQQIELIKNL-NLKpdvIINIKCPDYDLCQRISGQRQHNNTGYIYS 244
Cdd:PRK14526   82 ILDGFPR------NINQAKALDKFLpNIK---IINFLIDEELLIKRLSGRRICKSCNNIFN 133
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 99-217 9.21e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 38.67  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942168   99 LSKPVCFVVFGKPGVGKTTLARYItqAWKCIRVEAlPILeeqiaaETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:cd00009    16 LPPPKNLLLYGPPGTGKTTLARAI--ANELFRPGA-PFL------YLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767942168  179 VchfgYIITEIPSLSQDAMTTLQQI--ELIKNLNLKPDVII 217
Cdd:cd00009    87 V----LFIDEIDSLSRGAQNALLRVleTLNDLRIDRENVRV 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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