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Conserved domains on  [gi|578813901|ref|XP_006715910|]
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18S rRNA (guanine-N(7))-methyltransferase isoform X1 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11688002)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 227-302 1.17e-20

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


:

Pssm-ID: 432656  Cd Length: 81  Bit Score: 84.22  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  227 LFSGP-STFIPEGLS-ENQDEVEPRESV-FTNERFPLRMSRRG--MVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRK 301
Cdd:pfam12589   1 LFVGGvQQQLPKGLGeDGEECSEEQNTVkYERRRRPRKKRKKKgkKAVKGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 578813901  302 P 302
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-207 1.03e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 78.11  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  65 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 140
Cdd:COG2226   13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578813901 141 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 207
Cdd:COG2226   90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 227-302 1.17e-20

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 84.22  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  227 LFSGP-STFIPEGLS-ENQDEVEPRESV-FTNERFPLRMSRRG--MVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRK 301
Cdd:pfam12589   1 LFVGGvQQQLPKGLGeDGEECSEEQNTVkYERRRRPRKKRKKKgkKAVKGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 578813901  302 P 302
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-207 1.03e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 78.11  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  65 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 140
Cdd:COG2226   13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578813901 141 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 207
Cdd:COG2226   90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 81-179 2.22e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.59  E-value: 2.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901   81 LDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnan 155
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|....
gi 578813901  156 kksenPAKRLYCFFASLFSVLVRG 179
Cdd:pfam13649  77 -----PDPDLEAALREIARVLKPG 95
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 32-153 1.82e-12

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 65.93  E-value: 1.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  32 VGKRQVAPVAGVARKGRriwgSRMIDIQTRMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAML 111
Cdd:PRK10258   4 VNKQAIAAAFGRAAAHY----EQHAELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPML 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 578813901 112 DEAVDREIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWlCN 153
Cdd:PRK10258  78 AQARQKDAADHYLAGDI-ESLPLATATFDLAWSNLAVQW-CG 117
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-187 2.72e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 2.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  80 LLDIGCGTGLSGSYL-SDEGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKPGTFDGCISISAVQWLcn 153
Cdd:cd02440    2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578813901 154 ankksenpAKRLYCFFASLFSVLVRGSRAVLQLY 187
Cdd:cd02440   80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 58-176 3.28e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 59.22  E-value: 3.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901   58 IQTRMAGRALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEGHY--WVGLDISPAMLDEAVDREIEGDL-LLGDMGQgIP 133
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 578813901  134 FKPGTFDGCISISAVQWLCNANKksenpakrlycFFASLFSVL 176
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 227-302 1.17e-20

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 84.22  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  227 LFSGP-STFIPEGLS-ENQDEVEPRESV-FTNERFPLRMSRRG--MVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRK 301
Cdd:pfam12589   1 LFVGGvQQQLPKGLGeDGEECSEEQNTVkYERRRRPRKKRKKKgkKAVKGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 578813901  302 P 302
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-207 1.03e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 78.11  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  65 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 140
Cdd:COG2226   13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578813901 141 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 207
Cdd:COG2226   90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
61-141 2.47e-15

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 72.72  E-value: 2.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  61 RMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQgIPFKPGTFD 140
Cdd:COG4976   33 LLAEELLARL--PPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLAD-LAEPDGRFD 109


                 .
gi 578813901 141 G 141
Cdd:COG4976  110 L 110
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 81-179 2.22e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.59  E-value: 2.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901   81 LDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnan 155
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|....
gi 578813901  156 kksenPAKRLYCFFASLFSVLVRG 179
Cdd:pfam13649  77 -----PDPDLEAALREIARVLKPG 95
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 81-184 2.58e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 64.61  E-value: 2.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901   81 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDL--LLGDMGQgIPFKPGTFDGCISISAVQWLcnankks 158
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLtfVVGDAED-LPFPDNSFDLVLSSEVLHHV------- 72

                          90       100
                  ....*....|....*....|....*.
gi 578813901  159 ENPAKrlycFFASLFSVLVRGSRAVL 184
Cdd:pfam08241  73 EDPER----ALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 63-206 7.08e-13

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 66.09  E-value: 7.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  63 AGRALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWV-GLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKP 136
Cdd:COG0500   15 AALLALLERLPKGGR--VLDLGCGTGRNLLALAARFGGRViGIDLSPEAIALARARAAKAglgnvEFLVADLAELDPLPA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901 137 GTFDGCISISAVQWLcnankkseNPAKRLYcFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGF 206
Cdd:COG0500   93 ESFDLVVAFGVLHHL--------PPEEREA-LLRELARALKPGGVLLLSASDAAAALSLARLLLLATASL 153
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 80-184 1.18e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 63.88  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  80 LLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR--EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnankk 157
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERaaELNVDFVQGDL-EDLPLEDGSFDLVICSEVLEHL------ 100

                         90       100
                 ....*....|....*....|....*..
gi 578813901 158 sENPAKrlycFFASLFSVLVRGSRAVL 184
Cdd:COG2227  101 -PDPAA----LLRELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
81-185 1.50e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  81 LDIGCGTGLSGSYLSDE--GHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPfkPGTFDGCISISAVQWLcnankks 158
Cdd:COG4106    6 LDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDP--PEPFDLVVSNAALHWL------- 76

                         90       100
                 ....*....|....*....|....*..
gi 578813901 159 ENPAKrlycFFASLFSVLVRGSRAVLQ 185
Cdd:COG4106   77 PDHAA----LLARLAAALAPGGVLAVQ 99
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 32-153 1.82e-12

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 65.93  E-value: 1.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  32 VGKRQVAPVAGVARKGRriwgSRMIDIQTRMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAML 111
Cdd:PRK10258   4 VNKQAIAAAFGRAAAHY----EQHAELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPML 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 578813901 112 DEAVDREIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWlCN 153
Cdd:PRK10258  78 AQARQKDAADHYLAGDI-ESLPLATATFDLAWSNLAVQW-CG 117
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 59-185 3.95e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 60.33  E-value: 3.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  59 QTRMAGRALELLYLPENKPcyLLDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR-EIEG-----DLLLGDMGQg 131
Cdd:COG2230   36 QEAKLDLILRKLGLKPGMR--VLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERaAEAGladrvEVRLADYRD- 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578813901 132 iPFKPGTFDGCISISAVQWLCNANKKSenpakrlycFFASLFSVLVRGSRAVLQ 185
Cdd:COG2230  113 -LPADGQFDAIVSIGMFEHVGPENYPA---------YFAKVARLLKPGGRLLLH 156
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-187 2.72e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 2.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  80 LLDIGCGTGLSGSYL-SDEGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKPGTFDGCISISAVQWLcn 153
Cdd:cd02440    2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578813901 154 ankksenpAKRLYCFFASLFSVLVRGSRAVLQLY 187
Cdd:cd02440   80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 58-176 3.28e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 59.22  E-value: 3.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901   58 IQTRMAGRALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEGHY--WVGLDISPAMLDEAVDREIEGDL-LLGDMGQgIP 133
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 578813901  134 FKPGTFDGCISISAVQWLCNANKksenpakrlycFFASLFSVL 176
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
PRK08317 PRK08317
hypothetical protein; Provisional
 81-184 6.83e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 58.41  E-value: 6.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  81 LDIGCGTGLSGSYLSD----EGHYwVGLDISPAMLDEAVDReIEGDLL-----LGDmGQGIPFKPGTFDGCISISAVQWL 151
Cdd:PRK08317  24 LDVGCGPGNDARELARrvgpEGRV-VGIDRSEAMLALAKER-AAGLGPnvefvRGD-ADGLPFPDGSFDAVRSDRVLQHL 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578813901 152 cnankksENPAKRLycffASLFSVLVRGSRAVL 184
Cdd:PRK08317 101 -------EDPARAL----AEIARVLRPGGRVVV 122
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 81-151 4.45e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.67  E-value: 4.45e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578813901   81 LDIGCGTGLSGSYLSDEGHYW--VGLDISPAMLDEAVDREIEGDLLLGDM-----GQGIPFKPGTFDGCISISAVQWL 151
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeyTGLDISPAALEAARERLAALGLLNAVRvelfqLDLGELDPGSFDVVVASNVLHHL 78
BchM-ChlM TIGR02021
magnesium protoporphyrin O-methyltransferase; This model represents the ...
 58-117 3.50e-05

magnesium protoporphyrin O-methyltransferase; This model represents the S-adenosylmethionine-dependent O-methyltransferase responsible for methylation of magnesium protoporphyrin IX. This step is essentiasl for the biosynthesis of both chlorophyll and bacteriochlorophyll. This model encompasses two closely related clades, from cyanobacteria (and plants) where it is called ChlM and other photosynthetic bacteria where it is known as BchM. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273930 [Multi-domain]  Cd Length: 219  Bit Score: 44.02  E-value: 3.50e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578813901   58 IQTRMAGRALELLYLPENKPC--YLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR 117
Cdd:TIGR02021  35 REGRAAMRRKLLDWLPKDPLKgkRVLDAGCGTGLLSIELAKRGAIVKAVDISEQMVQMARNR 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 80-146 4.17e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.99  E-value: 4.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578813901  80 LLDIGCGTG-LSGSY---LSDEGHYWvGLDISPAMLDEAVDREIEG------DLLLGDmGQGIPFKPGTFDgCISIS 146
Cdd:PRK00216  55 VLDLACGTGdLAIALakaVGKTGEVV-GLDFSEGMLAVGREKLRDLglsgnvEFVQGD-AEALPFPDNSFD-AVTIA 128
PRK14968 PRK14968
putative methyltransferase; Provisional
 81-140 4.97e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.27  E-value: 4.97e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578813901  81 LDIGCGTGLSGSYLSDEGHYWVGLDISPamldEAVDREIEGDLLLGDMGQGI---------PFKPGTFD 140
Cdd:PRK14968  28 LEVGTGSGIVAIVAAKNGKKVVGVDINP----YAVECAKCNAKLNNIRNNGVevirsdlfePFRGDKFD 92
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 63-148 1.43e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.56  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901   63 AGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMldeaVDREIEGDLLLGDMGQGIPFKPGTFDgC 142
Cdd:pfam13489   9 LADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIA----IERALLNVRFDQFDEQEAAVPAGKFD-V 83


                  ....*.
gi 578813901  143 ISISAV 148
Cdd:pfam13489  84 IVAREV 89
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 38-117 2.03e-03

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 38.66  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  38 APVAGV---ARKGRriwgSRMIDiqtrmagRALEllYLPEN---KPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAML 111
Cdd:PRK07580  32 APVSKVratVRAGH----QRMRD-------TVLS--WLPADgdlTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMV 98


                 ....*.
gi 578813901 112 DEAVDR 117
Cdd:PRK07580  99 EEARER 104
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 66-151 3.36e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 38.39  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901  66 ALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEghyW-----VGLDISPAMLDEAVDREIEGDLLLGDMGQgipFKPGTF 139
Cdd:PRK01683  20 ARDLLaRVPLENPRYVVDLGCGPGNSTELLVER---WpaariTGIDSSPAMLAEARSRLPDCQFVEADIAS---WQPPQA 93

                         90
                 ....*....|...
gi 578813901 140 DGCISISAV-QWL 151
Cdd:PRK01683  94 LDLIFANASlQWL 106
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 74-114 3.81e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 37.01  E-value: 3.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 578813901   74 ENKPCYLLDIGCGTG----LSGSYLSDEGHYwVGLDISPAMLDEA 114
Cdd:pfam13847   1 IDKGMRVLDLGCGTGhlsfELAEELGPNAEV-VGIDISEEAIEKA 44
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
49-146 4.78e-03

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 37.80  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813901   49 RIWGSRMIDiqtRMAGRalellylpenKPCYLLDIGCGTGLSGSYLSD---EGHYWVGLDISPAMLDEAVDREIEG---- 121
Cdd:pfam01209  28 RLWKDFTMK---CMGVK----------RGNKFLDVAGGTGDWTFGLSDsagSSGKVVGLDINENMLKEGEKKAKEEgkyn 94

                          90       100
                  ....*....|....*....|....*.
gi 578813901  122 -DLLLGDmGQGIPFKPGTFDgCISIS 146
Cdd:pfam01209  95 iEFLQGN-AEELPFEDDSFD-IVTIS 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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