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Conserved domains on  [gi|578819165|ref|XP_006717788|]
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zinc finger SWIM domain-containing protein 8 isoform X11 [Homo sapiens]

Protein Classification

SWIM zinc finger domain-containing protein( domain architecture ID 10790860)

SWIM zinc finger domain-containing protein; SWIM domains are versatile and can interact with DNA or proteins in different contexts such as inhibiting DNA damage tolerance in yeast and protein-protein interactions in yeast and humans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SWIM COG4715
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
116-257 1.03e-08

Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];


:

Pssm-ID: 443750 [Multi-domain]  Cd Length: 508  Bit Score: 59.84  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  116 NEEDIRlysclANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVvppqmvppKG--AYNVAVMFDRCRVTSCSCTCGAG 193
Cdd:COG4715     7 TEDDIR-----RLAGPRIFERGREYAREGRVLDLDVEDGRLEATV--------QGseDYRVRVDLDDGGDLDSSCTCPYG 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578819165  194 AK-WCTHVVALCLFRIHNASAV----CLRAPVSESLSRLQRDQLQKFAQYLISELPQqiLPTAQRLLDE 257
Cdd:COG4715    74 GGgFCKHVVAVLLALLDQPEEGaprqSEREALEELLERLSKEELVELLLELAAEDPE--LRELRRALDD 140
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1507-1652 1.49e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.23  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1507 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 1566
Cdd:pfam03154  358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1567 PPSLAATAVSFP-------VPSMAPITVHPYH-------TEP-GLPLPTSVALSSVHPASTFPAIQGASLPALTTQPSPL 1631
Cdd:pfam03154  437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVpggpppiTPPsGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                          170       180
                   ....*....|....*....|...
gi 578819165  1632 VSGGFPPPE--EETHSQPVNPHS 1652
Cdd:pfam03154  517 VQIKEEALDeaEEPESPPPPPRS 539
 
Name Accession Description Interval E-value
SWIM COG4715
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
116-257 1.03e-08

Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];


Pssm-ID: 443750 [Multi-domain]  Cd Length: 508  Bit Score: 59.84  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  116 NEEDIRlysclANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVvppqmvppKG--AYNVAVMFDRCRVTSCSCTCGAG 193
Cdd:COG4715     7 TEDDIR-----RLAGPRIFERGREYAREGRVLDLDVEDGRLEATV--------QGseDYRVRVDLDDGGDLDSSCTCPYG 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578819165  194 AK-WCTHVVALCLFRIHNASAV----CLRAPVSESLSRLQRDQLQKFAQYLISELPQqiLPTAQRLLDE 257
Cdd:COG4715    74 GGgFCKHVVAVLLALLDQPEEGaprqSEREALEELLERLSKEELVELLLELAAEDPE--LRELRRALDD 140
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1507-1652 1.49e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.23  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1507 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 1566
Cdd:pfam03154  358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1567 PPSLAATAVSFP-------VPSMAPITVHPYH-------TEP-GLPLPTSVALSSVHPASTFPAIQGASLPALTTQPSPL 1631
Cdd:pfam03154  437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVpggpppiTPPsGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                          170       180
                   ....*....|....*....|...
gi 578819165  1632 VSGGFPPPE--EETHSQPVNPHS 1652
Cdd:pfam03154  517 VQIKEEALDeaEEPESPPPPPRS 539
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1502-1650 3.91e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165 1502 SPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAypqgvhPAFLGAQYPYSVTPPSLAATAVSFPVPS 1581
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA------AALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578819165 1582 MAPITVHPY--HTEPGLPL---PTSVALSSVHPASTFPAIQGASLPALTTQPSPLvsgGFPPPEEETHSQPVNP 1650
Cdd:PHA03247 2844 GPPPPSLPLggSVAPGGDVrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF---ALPPDQPERPPQPQAP 2914
 
Name Accession Description Interval E-value
SWIM COG4715
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
116-257 1.03e-08

Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];


Pssm-ID: 443750 [Multi-domain]  Cd Length: 508  Bit Score: 59.84  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  116 NEEDIRlysclANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVvppqmvppKG--AYNVAVMFDRCRVTSCSCTCGAG 193
Cdd:COG4715     7 TEDDIR-----RLAGPRIFERGREYAREGRVLDLDVEDGRLEATV--------QGseDYRVRVDLDDGGDLDSSCTCPYG 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578819165  194 AK-WCTHVVALCLFRIHNASAV----CLRAPVSESLSRLQRDQLQKFAQYLISELPQqiLPTAQRLLDE 257
Cdd:COG4715    74 GGgFCKHVVAVLLALLDQPEEGaprqSEREALEELLERLSKEELVELLLELAAEDPE--LRELRRALDD 140
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1507-1652 1.49e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.23  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1507 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 1566
Cdd:pfam03154  358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1567 PPSLAATAVSFP-------VPSMAPITVHPYH-------TEP-GLPLPTSVALSSVHPASTFPAIQGASLPALTTQPSPL 1631
Cdd:pfam03154  437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVpggpppiTPPsGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                          170       180
                   ....*....|....*....|...
gi 578819165  1632 VSGGFPPPE--EETHSQPVNPHS 1652
Cdd:pfam03154  517 VQIKEEALDeaEEPESPPPPPRS 539
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1502-1660 2.48e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 2.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1502 SPGLHPYTALQPHLPCSPQYL-THPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPvP 1580
Cdd:pfam03154  262 SPQPLPQPSLHGQMPPMPHSLqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP-P 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165  1581 SMAPITVHPYHTEPGLPLPTSvalssvhPASTFPAIQGASLPALTTQPSPL-VSGGFPPPEEethSQPVNPHSLHHLHAA 1659
Cdd:pfam03154  341 REQPLPPAPLSMPHIKPPPTT-------PIPQLPNPQSHKHPPHLSGPSPFqMNSNLPPPPA---LKPLSSLSTHHPPSA 410


                   .
gi 578819165  1660 Y 1660
Cdd:pfam03154  411 H 411
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1502-1650 3.91e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165 1502 SPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAypqgvhPAFLGAQYPYSVTPPSLAATAVSFPVPS 1581
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA------AALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578819165 1582 MAPITVHPY--HTEPGLPL---PTSVALSSVHPASTFPAIQGASLPALTTQPSPLvsgGFPPPEEETHSQPVNP 1650
Cdd:PHA03247 2844 GPPPPSLPLggSVAPGGDVrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF---ALPPDQPERPPQPQAP 2914
PHA03377 PHA03377
EBNA-3C; Provisional
 1498-1647 5.79e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 45.04  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165 1498 GHGHSPGlhPYTALQPHLPcsPQYLTHPAH---------PAHPMPHMPRPAVFPVPssaypqgvhpaflgaQYPYSVTPP 1568
Cdd:PHA03377  818 GHGHPQG--PWAPRPPHLP--PQWDGSAGHgqdqvsqfpHLQSETGPPRLQLSQVP---------------QLPYSQTLV 878

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819165 1569 SLAATAVSFPVPSmAPITVHPYH-TEPGLPLPTSVALSSVHPASTFPAI-------QGASLPALTTQPSPLvsggfPPPE 1640
Cdd:PHA03377  879 SSSAPSWSSPQPR-APIRPIPTRfPPPPMPLQDSMAVGCDSSGTACPSMpfasdysQGAFTPLDINAQTPK-----RPRV 952


                  ....*..
gi 578819165 1641 EETHSQP 1647
Cdd:PHA03377  953 EESSHGP 959
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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