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Conserved domains on  [gi|578820923|ref|XP_006718435|]
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tetraspanin-18 isoform X1 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 13626501)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886
PubMed:  15763890|11756464|19709882|16024509

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 115-228 3.08e-35

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


:

Pssm-ID: 239409  Cd Length: 114  Bit Score: 122.26  E-value: 3.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923 115 AFIFRENLTREFFTKELTKHYQG-NNDTDVFSATWNSVMITFGCCGVNGPEDF-KFASVFRLLTLDSEEVPEACCRREPQ 192
Cdd:cd03156    1 LALFFKKDLEDSFKNLLKNNYGNyNSTGDAITSTWNRVMIELKCCGVNGPTDFvDSTSFFRQKNEPNSPYPESCCKRNSN 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578820923 193 SRDGVLlsrEECLLGRSLFLNKQGCYTVILNTFETY 228
Cdd:cd03156   81 SQIVDL---DCPKLGSPNSYNKKGCYEKLSNPIERY 113
Tetraspanin pfam00335
Tetraspanin family;
20-255 3.57e-13

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 65.80  E-value: 3.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923   20 KYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREIVAANPLLLtgAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFL 99
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYI--PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923  100 FILIIFLAELSAAILAFIFRE---NLTREFFTKELTKHYQGNNDT-DVFSATWNSVMITFGCCGvngpedfkfasvfrll 175
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDklsGLLSNWLKKSLEDGYRDWLDLySCLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923  176 tldseevpeaccrrepqsrdgvllsreecllgrslflnkqGCYTVILNTFETYVYLAGALAIGVLAIELFAMIFAMCLFR 255
Cdd:pfam00335 144 ----------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 115-228 3.08e-35

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 122.26  E-value: 3.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923 115 AFIFRENLTREFFTKELTKHYQG-NNDTDVFSATWNSVMITFGCCGVNGPEDF-KFASVFRLLTLDSEEVPEACCRREPQ 192
Cdd:cd03156    1 LALFFKKDLEDSFKNLLKNNYGNyNSTGDAITSTWNRVMIELKCCGVNGPTDFvDSTSFFRQKNEPNSPYPESCCKRNSN 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578820923 193 SRDGVLlsrEECLLGRSLFLNKQGCYTVILNTFETY 228
Cdd:cd03156   81 SQIVDL---DCPKLGSPNSYNKKGCYEKLSNPIERY 113
Tetraspanin pfam00335
Tetraspanin family;
20-255 3.57e-13

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 65.80  E-value: 3.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923   20 KYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREIVAANPLLLtgAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFL 99
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYI--PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923  100 FILIIFLAELSAAILAFIFRE---NLTREFFTKELTKHYQGNNDT-DVFSATWNSVMITFGCCGvngpedfkfasvfrll 175
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDklsGLLSNWLKKSLEDGYRDWLDLySCLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923  176 tldseevpeaccrrepqsrdgvllsreecllgrslflnkqGCYTVILNTFETYVYLAGALAIGVLAIELFAMIFAMCLFR 255
Cdd:pfam00335 144 ----------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 115-228 3.08e-35

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 122.26  E-value: 3.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923 115 AFIFRENLTREFFTKELTKHYQG-NNDTDVFSATWNSVMITFGCCGVNGPEDF-KFASVFRLLTLDSEEVPEACCRREPQ 192
Cdd:cd03156    1 LALFFKKDLEDSFKNLLKNNYGNyNSTGDAITSTWNRVMIELKCCGVNGPTDFvDSTSFFRQKNEPNSPYPESCCKRNSN 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578820923 193 SRDGVLlsrEECLLGRSLFLNKQGCYTVILNTFETY 228
Cdd:cd03156   81 SQIVDL---DCPKLGSPNSYNKKGCYEKLSNPIERY 113
Tetraspanin pfam00335
Tetraspanin family;
20-255 3.57e-13

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 65.80  E-value: 3.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923   20 KYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREIVAANPLLLtgAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFL 99
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYI--PILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923  100 FILIIFLAELSAAILAFIFRE---NLTREFFTKELTKHYQGNNDT-DVFSATWNSVMITFGCCGvngpedfkfasvfrll 175
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDklsGLLSNWLKKSLEDGYRDWLDLySCLNSALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923  176 tldseevpeaccrrepqsrdgvllsreecllgrslflnkqGCYTVILNTFETYVYLAGALAIGVLAIELFAMIFAMCLFR 255
Cdd:pfam00335 144 ----------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 116-228 7.73e-11

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 57.13  E-value: 7.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923 116 FIFRENLtREFFTKELTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFKfasVFRLLtldseeVPEACCRREPQsrd 195
Cdd:cd03127    1 FVYRDQL-ESLVSDTLNDAWDEYYVDDDFQEAMDALQSTFECCGVNGPTDYL---DLRLL------VPSSCCKGTDG--- 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578820923 196 gvllsreecllGRSLFLNKQGCYTVILNTFETY 228
Cdd:cd03127   68 -----------NCGLNLYTEGCLEKLVDFLRSN 89
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 120-226 4.50e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 49.40  E-value: 4.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923 120 ENLTREFFTKELT---KHYQGNNDTdvfSATWNSVMITFGCCGVNGPEDFkfasvfrlltldSEEVPEACCRREPQSRdg 196
Cdd:cd03164    4 EKKLNNYVKEGLTdslEQYHKDNNT---SEAWDMIQSNLQCCGINGTTDW------------GSGVPSSCCSSDTEYK-- 66

                         90       100       110
                 ....*....|....*....|....*....|
gi 578820923 197 vllsreecllgrslflnKQGCYTVILNTFE 226
Cdd:cd03164   67 -----------------VEGCYKKLKNWFE 79
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 116-227 4.45e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 46.98  E-value: 4.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923 116 FIFRENLtREFFTKELTK--HYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFkfasvFRLLTLDSeeVPEACCRREpqs 193
Cdd:cd03165    1 FVFREKV-DLTAKDDLKEglELYGTRNNRGLTNAWDITQTEFRCCGVTNYTDW-----YEVLGENR--VPDSCCQED--- 69

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578820923 194 rdgvllsREECLLGRSLFLNKQGCYTVILNTFET 227
Cdd:cd03165   70 -------SQDCGRNPTELWWKTGCYEKVQQWLVD 96
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 119-190 1.75e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 42.72  E-value: 1.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578820923 119 RENLTREFftkelTKHYQGNNDTDVfSATWNSVMITFGCCGVNGPEDFKFASVFRLLTLDSEEVPEACCRRE 190
Cdd:cd03155   12 KESLKRTM-----QENYGQSGEEAL-TLTVDELQQEFKCCGSNNYTDWQDSEWINSNEANGRLVPDSCCKTV 77
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 116-227 3.04e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 39.27  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820923 116 FIFRENLTREFFtKELTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFkFASVFRLltldSEEVPEACCRRE----P 191
Cdd:cd03161    1 FVFRHEIKGTFL-RTYNEAVSNYNGDDERSDAVDTVQRTLHCCGVENYTDW-LNSPYFL----EKGIPLSCCKNRsdcsP 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 578820923 192 QS-RDGVLLSREecllgrslfLNKQGCYTVILNTFET 227
Cdd:cd03161   75 QDlKNLTKAATK---------VYQQGCFTLVTSFMEA 102
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 116-187 3.25e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 39.00  E-value: 3.25e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578820923 116 FIFRENLTREF---FTKELTKhYQGNNDtdvFSATWNSVMITFGCCGVNGPEDFKFasvFRLLTLDSeeVPEACC 187
Cdd:cd03166    1 YVFRDKVMSEFndsFNQMISN-YNKTND---FRKILDRMQKDLKCCGANNYTDWEN---IPSLDTDS--VPDSCC 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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